检索结果-南通市图书馆

A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin

World Journal of Gastroenterology 2009年第8期15卷 912-918页

作者： Jun-Fen Fu Yan-Lan fang li liang Chun-lin Wang fang Hong Guan-Ping Dong Department of Endocrinology The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM： To create a rabbit model of pediatric nonalcoholic steatohepatitis （NASH） and to evaluate the role of adiponectin in the process. METHODS： Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups：（1） the normal control group （n = 10） was fed with standard diet for 12 wk; （2） the model group A （n = 11）; and （3） model group B （n = 11） were fed with a highfat diet （standard diet ＋ 10% lard ＋ 2% cholesterol） for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin （IL）-6, IL-10 and tumor necrosis factor （TNF）-α were measured. RESULTS： Typical histological hepatic lesions of NASH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and B in weight gain （1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01）, liver weight （93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01）, Lg （ALT）（1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01）, and Lg （TG）（1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01）. Weight gain was much more in model group B than in model group A （1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05）. But, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines （IL-6 and TNF-α） increased in model group B compared with that of control and model group A （IL-6：1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α： 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05）, whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control （adiponectin： A： 21.87±4.84 and B： 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10： A： 1.72± 0.38 and B： 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01）. Lg （TC） and the degree of liver fatty infiltration was an independent determi

关键词： Nonalcoholic steatohepatitis Pediatricanimal model Adiponectin Interleukin 6 Tumornecrosis factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spontaneous regression of retinopathy of prematurity:incidence and predictive factors

引用

International Journal of Ophthalmology(English edition) 2013年第4期6卷 475-480页

作者： Rui-Hong Ju Jia-Qing Zhang Xiao-Yun Ke Xiao-He Lu li-fang liang Wu-Jun Wang Department of Ophthalmology Zhujiang HospitalSouthern Medical University Department of Cardiothoracic Surgery Zhujiang HospitalSouthern Medical University Department of Cardiothoracic Surgery Nanfang HospitalSouthern Medical University

AIMTo evaluate the incidence of spontaneous regression of changes in the retina and vitreous in active stage of retinopathy of prematurity(ROP) and identify the possible relative factors during the regression.

关键词： retinopathy of prematurity spontaneous regression incidence duration of ROP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of annealing treatment on the structural, optical, and electrical properties of Al-doped ZnO thin films

引用

Rare Metals 2007年第3期26卷 247-253页

作者： li li fang liang CHEN Ximing liU Gaobin liU Jun YANG Fengfan FU Guangzong KONG Chunyang College of Photoelectric Engineering Chongqing University of Posts and Telecommunications Chongqing 400065 China Department of Applied Physics Chongqing University Chongqing 400044 China Department of Physics Chongqing Normal University Chongqing 400047 China

Highly conductive and transparent Al-doped ZnO （AZO） thin films were prepared from a zinc target containing Al （1.5 wt.%） by direct current （DC） and radio frequency （RF） reactive magnetron sputtering. The structural, optical, and electrical properties of AZO films as-deposited and submitted to annealing treatment （at 300 and 400℃, respectively） were characterized using various techniques. The experimental results show that the properties of AZO thin films can be further improved by annealing treatment. The crystallinity of ZnO films improves after annealing treatment. The transmittances of the AZO thin films prepared by DC and RF reactive magnetron sputtering are up to 80% and 85% in the visible region, respectively. The electrical resistivity of AZO thin films prepared by DC reactive magnetron sputtering can be as low as 8.06 x 10-4 Ωcm after annealing treatment. It was also found that AZO thin films prepared by RF reactive magnetron sputtering have better structural and optical properties than that prepared by DC reactive magnetron sputtering.

关键词： AZO thin films structure optical and electrical properties annealing transmittance spectra electrical resistivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Configuration Reversion of the Metal Chelates of N-hydroxyethyl Ethylenediaminetriacetic Acid——Dynamic NMR Study

引用

Chemical Research in Chinese Universities 1992年第2期8卷 129-131页

作者： li Fei, SONG Rui-fang and li liang (Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)

The intramolecular acetate rearrangement of the aminocarboxylate metal chelates with the hexdentate-coordinate has been investigated by dynamic NMR in recent years. However, the intramolecular processes of the metal q... 详细信息

关键词： Intramolecular rearrangement Mechanism Dynamic NMR Metal che-late Quinquedentate HEDTA ligand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

引用

Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang li Shan Guo Zhuang Tong Xiaotao Zhou Xu li Zhaohui Hou Shuquan liang Guozhao fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

FBG Hydrophone: Theory and Experiment

引用

Journal of Electronic Science and Technology of China 2008年第4期6卷 462-465页

作者： Wen-Tao Zhang fang li Yu-liang liu Optoelectronic SystemLaboratory Institute of Semiconductors Chinese Academy of SciencesBeijing 100083 China

A fiber Bragg grating （FBG） hydrophone with enhanced sensitivity is demonstrated. A novel piston-like diaphragm with a hard core fixed at the center is used as the sensing element. Theoretical analysis shows that the Young＇s modulus of the diaphragm and the radius of the hard core have significant effect on the pressure sensitivity. Experiments are carried out to test this effect and the performance of the hydrophone. The static measure- ment result is in good agreement with the theoretical result and an acoustic sensitivity of 7 nm/MPa has been achieved.

关键词： Diaphragm fiber Bragg grating,hydrophone.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

引用

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na li Zhengxiang Zhou Ru Ye liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

冲击荷载作用下装配式钢筋混凝土梁力学性能研究

引用

工程力学 2017年第4期34卷 196-205页

作者：闫秋实邵慧芳李亮北京工业大学城市与工程安全减灾教育部重点实验室北京100124

为了研究装配式钢筋混凝土梁(简称PC梁)的抗冲击力学性能,通过对5根PC梁和1根作为对比的现浇钢筋混凝土梁(简称RC梁)进行落锤冲击试验,研究了不同拼装位置和套筒灌浆料饱满度对PC梁的抗冲击性能影响。详细地分析了各个试件的破坏形态、... 详细信息

为了研究装配式钢筋混凝土梁(简称PC梁)的抗冲击力学性能,通过对5根PC梁和1根作为对比的现浇钢筋混凝土梁(简称RC梁)进行落锤冲击试验,研究了不同拼装位置和套筒灌浆料饱满度对PC梁的抗冲击性能影响。详细地分析了各个试件的破坏形态、冲击力、支座反力、跨中位移、整体变形耗能能力等性能。结果表明:1)冲击作用位置,拼装位置以及冲击荷载强度共同影响构件的破坏形态。随着冲击位置远离于构件拼装位置,PC梁破坏形态、接触刚度、整体抗冲击刚度等力学性能均接近于RC梁的力学性能,其抗冲击性能的设计可以参考RC梁进行设计;2)相同强度的冲击荷载作用下,预制试件拼装位置与冲击位置相同时,PC梁破坏形态表现为拼装处严重的局部破坏,刚度退化较大,整体变形耗能不如其他拼装位置的梁以及RC梁,考虑此工况的构件需采取合理的措施,提高其抗冲击能力;3)套筒灌浆饱满度对梁的抗冲击性能有影响较大,其决定PC梁的破坏形态以及刚度;4)拼装位置处交接面的边界条件是影响PC梁抗冲击性能数值分析是否准确的关键因素。

关键词：装配式钢筋混凝土梁落锤试验冲击荷载动力性能灌浆套筒

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

高职教学方法的有效选择和优化组合运用探索

引用

职业技术教育 2014年第32期35卷 37-40页

作者：李芳良广西南宁地区教育学院广西南宁530001

人才培养类型、规格的特殊性与高职生的学习特点,决定了高职教学方法有其独特性。实践表明,高职教学方法类型多样,教学中只有针对不同的教学目的、教学内容、教学对象、教学环境及教师自身的兴趣、爱好和业务能力,灵活选择不同的教学方... 详细信息

人才培养类型、规格的特殊性与高职生的学习特点,决定了高职教学方法有其独特性。实践表明,高职教学方法类型多样,教学中只有针对不同的教学目的、教学内容、教学对象、教学环境及教师自身的兴趣、爱好和业务能力,灵活选择不同的教学方法并综合运用,才能获得良好教学效果。

关键词：高等职业教育教学方法有效选择优化组合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implementation of Phase Generated Carrier Technique for FBG Laser Sensor Multiplexed System Based on Compact RIO

引用

Journal of Electronic Science and Technology of China 2008年第4期6卷 385-388页

作者： Lei Feng Jun He Jing-Yuan Duan fang li Yu-liang liu Optoelectronics System Laboratory Institute of Semiconductors ChineseAcademy of Sciences Beijing 100083 China

This paper presents the fundamental technique of phase generated carrier （PGC） and its realization on compact reconfigurable input and output （RIO） which adopts real-time and field programmable grate array （FPGA） techniques. Improvement of the PGC technique is also introduced by using peak-to-peak value detection method to reduce the influence of variation of the light intensity. A four-element fibre Bragg gratings （FBG） laser sensor system is conducted in the experiment and the demodulated results demonstrate correlation coefficient as high as 0.995 with the reference signal and the dynamic range to be 120dB@63Hz.

关键词： Compact reconfigurable input andoutput (RIO) demodulation fibre Bragg gratings(FBG) laser sensor multiplexed system phase generatedcarrier (PGC).

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：