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Reversibly Tuning Electrochemiluminescence with Stimulated Emission Route for Single-Cell Imaging

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Research 2024年第3期2023卷 205-215页

作者： cheng Ma Xiaodan Gou Zejing Xing Min-xuan Wang Wenlei Zhu Qin xu Dechen Jiang Jun-Jie Zhu School of Chemistry and Chemical Engineering Yangzhou University.Yangzhou 225002P.R.China State Key Laboratory of Analytical Chemistry for life Science State Key Laboratory of Pollution Control and Resource ReuseSchool of Chemistry and Chemical EngineeringSchool of the EnvironmentNanjing UniversityNanjing 210023P.R.China.

Electrochemiluminescence (ECL) has established itself as an excellent transduction technique in biosensing and light-emitting device, while conventional ECL mechanism depending on spontaneous emission of luminophores lacks reversibility and tunable emission characters, limiting the universality of ECL technique in the fields of fundamental research and clinical applications. Here, we report the first observation of stimulated emission route in ECL and thus establish a reversible tuning ECL microscopy for single-cell imaging. This microscopy uses a focused red-shifted beam to transfer spontaneous ECL into stimulated ECL, which enables selective and reversible tuning of ECL emission from homogeneous solution, single particles, and single cells. After excluding other possible competitive routes, the stimulated ECL emission route is confirmed by a dual-objective system in which the suppressed spontaneous ECL is accompanied by the enhanced stimulated ECL. By incorporating a commercial donut-shaped beam, the sharpness of single-cell matrix adhesion is improved 2 to 3 times compared with the counterpart in confocal ECL mode. The successful establishment of this stimulated emission ECL will greatly advance the development of light-emitting device and super-resolution ECL microscopy.

关键词： tuning beam limiting

替考拉宁与利奈唑胺治疗肾功能不全革兰阳性菌感染患者的临床疗效及安全性评价

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中华医院感染学杂志 2024年第16期34卷 2422-2427页

作者：王丽陈瑞许彬唐莲陆件南京医科大学附属苏州医院南京医科大学姑苏学院苏州市立医院重症医学科江苏苏州215002 南京医科大学附属苏州医院南京医科大学姑苏学院苏州市立医院药剂科江苏苏州215002

目的比较替考拉宁与利奈唑胺治疗肾功能不全革兰阳性菌感染患者的临床疗效、血药谷浓度监测及安全性。方法收集苏州市立医院本部重症医学科2018年6月-2023年3月收治的革兰阳性菌感染肾功能不全患者83例,分为替考拉宁治疗组43例和利奈唑... 详细信息

目的比较替考拉宁与利奈唑胺治疗肾功能不全革兰阳性菌感染患者的临床疗效、血药谷浓度监测及安全性。方法收集苏州市立医院本部重症医学科2018年6月-2023年3月收治的革兰阳性菌感染肾功能不全患者83例,分为替考拉宁治疗组43例和利奈唑胺治疗组40例,比较两组患者的临床治疗有效率、革兰阳性菌清除率、血药谷浓度监测及不良反应发生率等情况。结果替考拉宁治疗组和利奈唑胺治疗组临床有效率和28d死亡率差异无统计学意义,但是革兰阳性菌清除率分别为72.1%和90.0%,差异有统计学意义(P=0.039);替考拉宁治疗组和利奈唑胺治疗组的药物不良反应发生率差异有统计学意义(P<0.001);利奈唑胺治疗组的主要不良反应为血小板减少(42.5%);替考拉宁治疗组血药浓度达标率和超标率分别为79.1%和7.0%,利奈唑胺治疗组分别为2.5%和92.5%,差异具有统计学意义(均P<0.001)。结论在革兰阳性菌感染合并肾功能不全的患者中,相对于利奈唑胺,使用替考拉宁的用药安全性更高;而与替考拉宁相比较,利奈唑胺抗感染疗效更好,但血药浓度超标率及药物不良反应发生率相对较高。

关键词：革兰阳性菌感染肾功能不全替考拉宁利奈唑胺临床疗效安全性

Breaking the efficiency limitations of dissipative Kerr solitons using nonlinear couplers

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 88-94页

作者： Ming li Xiao-Xiao xue Yan-Lei Zhang Xin-Biao xu Chun-Hua Dong Guang-Can Guo Chang-ling Zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Centerfor Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Department of Electronic Engineering Beijing National Research Center for Information Science and TechnologyTsinghua University Beijing 100084China

Dissipative Kerr solitons(DKS) have long been suffering from poor power conversion efficiency when driven by continuous-wave lasers. By deriving the critical coupling condition of a multimode nonlinear optics system in a generalized theoretical framework,two efficiency limitations of the conventional pump method of DKS are revealed: the effective coupling rate is too small and is also power-dependent. A general approach is provided to resolve this challenge by introducing two types of nonlinear couplers to couple the soliton cavity and CW input through nonlinear processes. The collective coupler opens multiple coupling channels and the self-adaptive coupler builds a power-independent effective external coupling rate to the DKS for approaching the generalized critical coupling condition, which promises near-unity power conversion efficiencies. For instance, a conversion efficiency exceeding 90% is predicted for aluminum nitride microrings with a nonlinear coupler utilizing second-harmonic generation. The mechanism applies to various nonlinear processes, including Raman and Brillouin scattering, and thus paves the way for micro-solitons toward practical applications.

关键词： Kerr frequency comb conversion efficiency nonlinear coupler

海藻酸盐纳米载体递送亲脂性活性物质及其应用研究进展

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食品科学 2024年第17期45卷 242-252页

作者：徐薇李慧雪刘霄莹孙亚鹏张润峰陈山广西大学轻工与食品工程学院广西南宁530004

亲脂性活性物质因其天然优势和潜在的功能特性备受食品和保健品领域关注,然而其存在疏水性和对环境(如氧气、光、温度)敏感的缺陷,摄食后会在消化道环境中部分或完全降解,难以被人体有效吸收和利用。利用稳定性强且具有屏障效应的海藻... 详细信息

亲脂性活性物质因其天然优势和潜在的功能特性备受食品和保健品领域关注,然而其存在疏水性和对环境(如氧气、光、温度)敏感的缺陷,摄食后会在消化道环境中部分或完全降解,难以被人体有效吸收和利用。利用稳定性强且具有屏障效应的海藻酸盐纳米递送载体可有效解决上述问题并延长亲脂性活性物质释放时间。本文综述海藻酸盐的结构及其凝胶性、pH值响应性和生物学活性等功能特性,重点介绍海藻酸盐纳米载体,如纳米乳液、纳米颗粒、纳米凝胶、纳米纤维递送亲脂性活性物质的研究现状及不同纳米载体类型的优缺点,并对其在食品领域应用现状进行总结,旨在为亲脂性活性物质在食品领域的应用提供参考。

关键词：海藻酸盐纳米载体亲脂性活性物质应用

Growth,optical dispersion and magnetic behavior of Dy^(3+) doped yttrium iron garnet crystals

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Journal of Rare Earths 2024年第6期42卷 1110-1117,I0004页

作者： Yating Fang Hui Shen Yudie Ma Shijie liao Shuang Xia Tian Tian Ding Zhou Yunfeng Ma Jiayue xu Institute of Crystal Growth School of Materials Science and EngineeringShanghai Institute of Technology National Engineering Center of Electromagnetic Radiation Control Materials School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of China

Y_(3)Fe_(5)O_(12)(YIG)crystals are highly desirable for the fabrication of mid-infrared isolators with the rapid growth of optical communications,although it is rather challenging to grow large size and high-quality single ***^(3+)doping is expected to improve the optical and magneto-optical prope ***,high quality Dy:YIG crystals and the adjustment of Dy^(3+)on the structure and optical behavior of YIG crystal remain unclear,impeding its practical ***,a series of Y_(3-x)Dy_(x)Fe_(5)O_(12)(x=0,0.5,1.0,1.5,3)solid solution crystals was grown by the flux-Bridgman method and single crystals up to 25 mm were *** the introduction of Dy^(3+),lattice parameters are gradually enlarged from 1.2379 nm(YIG)to 1.2420 nm(DyIG).Typical Dy^(3+)absorption peaks are observed around 1070,1265 and 1670 *** refractive index decreases from 2.37(500 nm)to 2.10(2500 nm)for YIG crystal,and it reduces from 2.47(500 nm)to 2.16(2500 nm)for DyIG *** optical bandgaps remain almost unchanged for Dy:YIG *** optical dispersion of the refractive indices was finely fitted by the Wemple and DiDomenico(WDD)and the Sellmeier models,*** the increase of Dy^(3+)content,the saturation magnetization(Ms)decreases significantly from 23.62 emu/g(YIG)to 5.33 emu/g(DyIG).Small coercive field is persisted for this system,endowing small external magnetic *** results provide valuable references for the manipulation of rare earths on the properties of magnetooptical crystals,which is beneficial to the design of high-performance garnet crystals for the application of optical switching and non-reciprocal related devices.

关键词： Magneto-optical crystal Yttrium iron garnet Dy^(3+)doping Crystal growth Optical dispersion Rare earths

Dynamic modeling of cavitation bubble clusters:Effects of evaporation,condensation,and bubble-bubble interaction

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Chinese Physics B 2024年第4期33卷 527-535页

作者：许龙姚昕锐沈阳 College of Science China Jiliang UniversityHangzhou 310018China

We present a dynamic model of cavitation bubbles in a cluster,in which the effects of evaporation,condensation,and bubble-bubble interactions are taken into *** different ultrasound conditions,we examine how the dynamics of cavitation bubbles are affected by several factors,such as the locations of the bubbles,the ambient radius,and the number of *** the variations of bubble radius,energy,temperature,pressure,and the quantity of vapor molecules are *** findings reveal that bubble-bubble interactions can restrict the expansion of bubbles,reduce the exchange of energy among vapor molecules,and diminish the maximum internal temperature and pressure when *** ambient radius of bubbles can influence the intensities of their oscillations,with clusters comprised of smaller bubbles creating optimal conditions for generating high-temperature and high-pressure ***,an increase in the number of bubbles can further inhibit cavitation *** frequency,pressure and waveform of the driving wave can also exert a significant influence on cavitation activities,with rectangular waves enhancing and triangular waves weakening the cavitation of bubbles in the *** results provide a theoretical basis for understanding the dynamics of cavitation bubbles in a bubble cluster,and the factors that affect their behaviors.

关键词： bubble dynamics bubble-bubble interaction mass exchange ultrasound waveform

An Integrated Control Framework for Torque Vectoring and Active Suspension System

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 62-73页

作者： Jiwei Feng Jinhao liang Yanbo Lu Weichao Zhuang Dawei Pi Guodong Yin liwei xu Pai Peng Chaobin Zhou School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Mechano-Electronic Engineering Lanzhou University of TechnologyLanzhou 730050China

Four-wheel independently driven electric vehicles(FWID-EV)endow a flexible and scalable control framework to improve vehicle *** paper integrates the torque vectoring and active suspension system(ASS)to enhance the vehicle’s longitudinal and vertical motion control *** the nonlinear characteristic of the tire model leads to a relatively heavier computational *** facilitate the controller design and ease the load,a half-vehicle dynamics system is built and simplified to the linear-time-varying(LTV)*** a model predictive controller is developed by formulating the objective function by comprehensively considering the safety,energy-saving and comfort *** in-wheel motor efficiency and the power loss of tire slip are treated as optimization indices in this work to reduce energy ***,the effectiveness of the proposed controller is verified through the rapid-control-prototype(RCP)*** results demonstrate the enhancement of the energy-saving as well as comfort on the basis of vehicle stability.

关键词： Four-wheel independently driven electric vehicles Tire nonlinearity linear-time-varying(LTV)model Model predictive control Rapid control prototype

Experimental investigation of bed-to-wall heat transfer in fluidized beds of a Geldart B sorbent particle under a full spectrum of fluidization regime

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Particuology 2024年第10期93卷 235-246页

作者： chenhuan xu Yongmin Zhang liang Wang Yiming Zhang Tianlei Yang Feng Qiu Cenfan liu Shuai Jiang Ke Dong State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Beijing DERUNchen Environmental Protection Technology Co. LtdBeijing100022China Key Laboratory of Special Equipment Safety and Energy-saving for State Market Regulation China Special Equipment Inspection and Research InstituteBeijing100029China

Fluidization technology has been used in CO_(2) capture processes, the successful design and operation of the heat exchangers involved in this process require much information on the bed-to-wall heat transfer of the sorbent particles in fluidized states. In this study, the bed-to-wall heat transfer coefficient (h) of a solid amine sorbent was measured by a heat transfer probe in a large-scale circulating fluidized bed cold model unit, where full spectrum of fluidization regimes can be realized. The corresponding hydrodynamic signals were also studied by pressure sensors and optical fiber probes to further explain the newly discovered phenomenon. The results show that in a dense bed, due to the counterbalanced effect of time fraction of packet and packet renewal frequency, h of the Geldart B particle reaches a peak within the bubbling fluidized regime, and the radial distribution of h are opposite in bubbling and turbulent fluidized regimes. In a fast fluidization regime, gas convection becomes the dominant factor affecting h when the solids holdup is low enough. Correlations were provided or recommended to guide the design of heat exchangers in the fluidized bed CO_(2) capture processes.

关键词： Bed-to-wall heattransfer Solid amine sorbent Geldart B particle Full spectrum of fluidization regime Correlation

基于学习进阶的中高职一体化课程设计研究——以汽车发动机构造与检修课为例

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中国职业技术教育 2024年第14期 71-79页

作者：朱福根陈琳刘美灵许洁李艳浙江交通职业技术学院汽车学院浙江大学教育学院杭州汽车高级技工学校浙江交通职业技术学院

中高职一体化是一种推进中高职衔接、加强中高职贯通的培养模式。对现有中高职一体化研究现状分析,初步探明由于缺乏理论指导,当前中高职一体化课程存在课程内容重复、教学方式单一、学生学习积极性差等问题。以OECD学习框架2030、学习... 详细信息

中高职一体化是一种推进中高职衔接、加强中高职贯通的培养模式。对现有中高职一体化研究现状分析,初步探明由于缺乏理论指导,当前中高职一体化课程存在课程内容重复、教学方式单一、学生学习积极性差等问题。以OECD学习框架2030、学习进阶理论、社会分工理论为基础构建了基于学习进阶的中高职一体化课程设计模型。选取汽车检测与维修技术专业核心课程“汽车发动机构造与检修”,从学习进阶理论的五大要素进阶终点、进阶维度、成就水平、学业表现和评测工具进行中高职一体化课程设计,提出实施建议,以期实现中高职一体化由形式上的合作走向内涵式融合发展。

关键词：职业教育中高职一体化学习进阶课程设计汽车发动机构造与检修