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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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大学生生命观：内涵、结构及教育导引

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大学教育科学 2017年第1期 21-26页

作者：李志跃许忠明吉林大学廉政研究与教育中心齐鲁工业大学纪委监察处齐鲁工业大学文法学院

大学生生命观的建构应该立足于达成本能、情感与智慧的完美结合,从自然生命、社会生命、精神生命三个层次上进行整体性的构建,以此促进自然生命、社会生命和精神生命三个维度的不断拓展和深度融合。长期以来,传统教育工作能够看到自然... 详细信息

大学生生命观的建构应该立足于达成本能、情感与智慧的完美结合,从自然生命、社会生命、精神生命三个层次上进行整体性的构建,以此促进自然生命、社会生命和精神生命三个维度的不断拓展和深度融合。长期以来,传统教育工作能够看到自然生命和社会生命的重要性,但对精神生命往往缺乏重视和探索。人的自然生命固然是精神生命的基础和原点,但精神生命对自然生命的维持、保护和引导却是至关重要的。精神生命是在动物本能生命基础上产生的高级生命形式,是自然界中绽放的最美丽"花朵"。教师是学生精神灵魂的指导者,他在学生的精神生命中占据着至高无上的地位,发挥着无与伦比的影响作用,并反过来对学生的社会生命和自然生命起到重要的引导作用。

关键词：大学生生命观自然生命社会生命精神生命教育导引

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lightweight Al-Nb-Ti-V-Cr high entropy alloys with high hardness and enhanced mechanical properties via doping Co

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China Foundry 2025年

作者： Fang-dong xu De-zhi Chen Rui-run Chen Bin Gan Jing-yue Yu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of CoxAlNbTiVCr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti VCr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of Co changes the microstructure of LHEAs from a single B2 structure to a mixture dendrite structure,which consists of B2 phase,C14 and C15 Laves *** the C14 and C15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEC）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of B2 and Laves phase in *** the Co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti VCr alloy exhibits the maximum Vickers hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

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Diagnostic value of 64-slice spiral CT culprit lesions score on acute coronary syndrome

Diagnostic value of 64-slice spiral CT culprit lesions score...

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第十三次全国心血管病学术会议

作者： liAO Peng-fei,MIAO Pei-zhi,li Ning,xu Yong-hua,GU Shui-ming Department of Cardiology,Shanghai xuhui Central Hospital, Shanghai 200031,China

Objective To detect culprit coronary lesions score and other aspects with 64-slice spiral CT(64-SCT),and to investigate its value on Acute Coronary Syndrome(ACS).Methods A total of 110 coronary artery disease(CAD) patients(ACS, 43 cases;stable angina pectoris,SAP,67 cases) were examined by *** of coronary culprit lesions indica-

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开关线性复合变换低阻输出特性对系统的优化

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上海交通大学学报 2003年第9期37卷 1375-1379页

作者：周谦之李定许海斌安徽工业大学电气信息学院马鞍山243002

为了在现有电力电子技术基础上进一步提高功率变换器的综合性能,揭示了一种由电力电子开关电路与线性电路有机结合而派生的开关线性复合功率变换器(SLH).简述了该类变换器的基本工作原理,列举了并联型和串联型两种电路拓扑及其特点,说明... 详细信息

为了在现有电力电子技术基础上进一步提高功率变换器的综合性能,揭示了一种由电力电子开关电路与线性电路有机结合而派生的开关线性复合功率变换器(SLH).简述了该类变换器的基本工作原理,列举了并联型和串联型两种电路拓扑及其特点,说明了 SLH的低阻输出特性对提高功率变换器静动态性能的作用,并对SLH与典型的PWM+LC滤波单元的变换器进行了比较分析,给出了用于电源和传动系统不同负载条件下的测试数据和典型波形.结果表明,SLH在高效与优波兼顾、多类负载适应性和抗负载扰动能力方面具有综合优化性能.

关键词：功率变换器开关线性复合谐波负载扰动低输出电阻

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High-precision tip positioning composite feedforward control of linear colocated motion systems with Bi-Loop iterative feedforward tuning

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Science China Technological Sciences 2025年

作者： Junyu HU Yourui TAO Shanhu li xu HAN College of Mechanical and Vehicle Engineering Hunan University State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology

To enhance the tip positioning accuracy and robustness against disturbances of linear colocated motion systems, a novel composite feedforward (COMFF) control with Bi-Loop iterative feedforward tuning (IFFT) is proposed. The tip positioning error consists of the coupled tip residual vibration and linear motor tracking error. Given the influence of nonlinear friction and load flexibility, the topology of COMFF is designed as decoupled structures so that COMFF can suppress the tip residual vibration and compensate for the linear motor tracking error compatibly. Furthermore, Bi-Loop IFFT is built to improve the robustness of COMFF in high-precision motor tracking performance. In the state space of the linear motor tracking error based on the projection theorem, two loops are performed in parallel along the iteration direction. One is the P-type iteration loop that drives linear motor tracking errors to converge to the zero state. The other is the observation loop constructed by the recursive least square with forgetting factors to accelerate the P-type iteration loop. Driven by the P-type iteration loop with the aid of the observation loop, the proposed COMFF is integrated with fast convergence and high robustness when confronted with model disturbances. The effectiveness of the proposed COMFF combined with Bi-Loop IFFT is validated by experiments.

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi Wen Xin Xiong Ting xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua li Xiaojiang li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Effects of mesoscale gravity waves on sporadic E simulated by a one-dimensional dynamic model

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Earth and Planetary Physics 2025年第1期9卷 1-9页

作者： xu Zhou ZeZhong li XinAn Yue liBo liu Key Laboratory of Earth and Planetary Physics/Heilongjiang Mohe National Geophysical Observatory/Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China

In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively *** this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high *** by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower *** effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the *** mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their *** addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.

关键词： sporadic E ion tidal layer gravity waves numerical simulation

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保护陆生生态的土壤铜环境基准研究

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中国环境科学 2022年第10期42卷 4720-4730页

作者：黄兴华李勖之王国庆姜锦林龙涛王小治生态环境部南京环境科学研究所国家环境保护土壤环境管理与污染控制重点实验室江苏南京210042 扬州大学环境科学与工程学院江苏扬州225127

通过调研国内外Cu生态毒理研究,收集并筛选土壤Cu的10%效应浓度(EC_(10))和无效应浓度(NOEC),分组构建陆生植物/无脊椎动物和土壤生态过程的物种敏感性分布模型(SSD),结合模型平均法推导不同土地利用方式下重金属Cu的生态安全阈值.针对... 详细信息

通过调研国内外Cu生态毒理研究,收集并筛选土壤Cu的10%效应浓度(EC_(10))和无效应浓度(NOEC),分组构建陆生植物/无脊椎动物和土壤生态过程的物种敏感性分布模型(SSD),结合模型平均法推导不同土地利用方式下重金属Cu的生态安全阈值.针对保护陆生植物/无脊椎动物,自然保护地和农业用地土壤、公园用地、住宅用地和工/商用地的土壤Cu生态阈值分别为10.9~38.9,21.0~77.5,36.6~124,47.6~151mg/kg;针对保护生态过程,自然保护地和农业用地土壤、公园用地、住宅用地和工/商用地的土壤Cu生态阈值分别为4.49~72.2,19.9~135,60.9~220,96.8~277mg/kg.

关键词：铜毒性数据物种敏感分布曲线模型平均生态安全阈值

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian xu Lu liu Yu Zhang Feng Tian Jiao Jiao li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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