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Reversal of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR by LY980503

World Journal of Gastroenterology 2007年第15期13卷 2234-2237页

作者： Da-Long Wu ying Xu li-xin yin Huan-Zhang Lu Department of Pharmacology School of Medicine Jiaxing Colloge Jiaxing 314001 Zhejiang Province China Department of Histology and Embryology School of Medicine Jiaxing College Jiaxing 314001 Zhejiang Province China Department of Chemical Synthesis Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China Department of Clinical Pharmacology Affiliated Hospital Academy of Military Medical Sciences Beijing 100039 China

AIM： To investigate the reversal effect of LY980503, a benflumetol derivative, on multidrug resistance in vincristine （VCR） -resistant human gastric carcinoma cell line SGC7901/VCR. METHODS： Cells of a human gastric cancer cell line, SGC7901, and its VCR-resistant variant, SGC7901/VCR, were cultivated with LY980503 and/or doxorubicin （DOX）. The cytotoxicity of drugs in vitro was assayed by M-IF method. Based on the flow cytometric technology, the uptake of DOX was detected in these cells by measuring DOX -associated mean fluorescence intensity （MFI）. RESULTS： SGC7901/VCR cells were 23.5 times more resistant to DOX in comparison with 5GC7901 cells. LY980503 at the concentrations of 2.0 μmol/L -10 μmol/ L had no obvious cytotoxicity to SGC7901 and SGC7901/ VCR cells. After simultaneous treatment with LY980503 at the concentrations of 2.0, 4.0 and 10 μmol/L, the ICso of DOX to SGC7901/VCR cells decreased from 1.6 ± 0.12 μmol/L to 0.55 ± 0.024, 0.25 ± 0.032 and 0.11 ± 0.015 μmol/L, respectively, thus, increasing the DOX sensitivity by 2.9-fold （P 〈 0. 05）, 6.4-fold （P 〈 0. 01） and 14.5-fold （P 〈 0. 01）, respectively. In the uptake study of DOX, simultaneous incubation of SGC7901/VCR cells with LY980503 significantly increased the DOX -associated MFI in SGC7901/VCR cells. No such results were found in parental SGC7901 cells.CONCLUSION： LY980503 at non-cytotoxic concentrations can effectively circumvent resistance of SGC7901/VCR cells to DOX by increasing intracellular DOX accumulation.

关键词： Hultidrug resistance Benflumetol Doxorubicin Gastric cancer Reversal

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Spirodiclofen Derivatives as Highly Potential Acaricides: Synthesis, Structure and Bioactivity

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Chemical Research in Chinese Universities 2011年第6期27卷 968-972页

作者： FENG Xian-guo XU liang-zhong KONG Fan-rui li Hong-xin yin Rui-feng College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

A series of new compounds as highly potential acaricides was synthesized based on the structure of spiro-diclofen. Their structures were identified by 1H NMR spectroscopy and element analysis. The bioassay indicated that most of the compounds exhibited excellent acaricidal activities, what’s more, the bioactivities of some new compounds were better than that of the commercial spirodiclofen at a concentration of 20 μg/mL. The relationship between structure and biological activity was also discussed.

关键词： Spirodiclofen derivative Acaricide Aricidal activity Multiple methyl

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Necrotizing fasciitis of cryptoglandular infection treated with multiple incisions and thread-dragging therapy:A case report

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World Journal of Clinical Cases 2021年第28期9卷 8537-8544页

作者： Xiao-Chun Tao De-Chang Hu li-xin yin Chen Wang Jin-Gen Lu Department of Anorectal LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Necrotizing fasciitis is a fulminant necrotizing soft tissue disease with a high fatality *** always starts with impact on the deep fascia rapidly and might result in secondary necrosis of the subcutaneous tissue,fascia,and ***,timely and multiple surgical operations are needed for the ***,the damage of skin and soft tissue caused by multiple surgical operations may require dermatoplasty and other treatments as a *** SUMMARY Here,we report a case of 50-year-old male patient who was admitted to our hospital with symptoms of necrotizing fasciitis caused by cryptoglandular infection in the perianal and perineal *** symptoms of necrotizing fasciitis,also known as the cardinal features,include hyperpyrexia,excruciatingly painful lesions,demonstration gas in the tissue,an obnoxious foul odor and *** results of postoperative pathology met the *** on the premise of complete debridement,multiple incisions combined with thread-dragging therapy(a traditional Chinese medicine therapy)and intensive supportive therapies including comprising antibiotics,nutrition and fluids were *** outcome of the treatment was *** patient recovered quickly and achieved ideal anal function and *** Timely and effective debridement and multiple incisions combined with thread-dragging therapy are an integrated treatment for necrotizing fasciitis.

关键词： Necrotizing fasciitis Cryptoglandular infection Traditional Chinese medicine Multiple incisions and thread-dragging therapy Integrated treatment Case report

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High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： Yi li Bei-Qi Wang xin-yin Zhang Shi-Jie Wang Cong-Yi li Hui-Long Yang Ran-Ran Su Tong liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

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Research on Stock Price Prediction Method Based on the GAN-LSTM-Attention Model

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Computers, Materials & Continua 2025年第1期82卷 609-625页

作者： Peng li Yanrui Wei lili yin College of Computer Science and Technology Harbin University of Science and TechnologyHarbin150006China

Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and *** paper introduces a generative adversarial network model that incorporates an attention mechanism(GAN-LSTM-Attention)to improve the accuracy of stock price ***,the generator of this model combines the Long and Short-Term Memory Network(LSTM),the Attention Mechanism and,the Fully-Connected Layer,focusing on generating the predicted stock *** discriminator combines the Convolutional Neural Network(CNN)and the Fully-Connected Layer to discriminate between real stock prices and generated stock ***,to evaluate the practical application ability and generalization ability of the GAN-LSTM-Attention model,four representative stocks in the United States of America(USA)stock market,namely,Standard&Poor’s 500 Index stock,Apple Incorporatedstock,AdvancedMicroDevices Incorporatedstock,and Google Incorporated stock were selected for prediction experiments,and the prediction performance was comprehensively evaluated by using the three evaluation metrics,namely,mean absolute error(MAE),root mean square error(RMSE),and coefficient of determination(R2).Finally,the specific effects of the attention mechanism,convolutional layer,and fully-connected layer on the prediction performance of the model are systematically analyzed through ablation *** results of experiment show that the GAN-LSTM-Attention model exhibits excellent performance and robustness in stock price prediction.

关键词： Stock price prediction generative adversarial network attention mechanism time-series prediction

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大车前体外再生体系的建立和优化

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生物工程学报 2005年第6期21卷 916-922页

作者：李平陈华李银心中国科学院植物研究所光合作用与环境分子生理学重点实验室

大车前不仅有很高的药用价值,在生态学研究方面也是重要模式植物。关于大车前的组培,目前报道很少。我们通过不定芽直接再生和愈伤组织诱导两种途径,建立了大车前(PlantagomajorL.‘GiantTurkish.’)的快速高效组培再生系统。完整的成... 详细信息

大车前不仅有很高的药用价值,在生态学研究方面也是重要模式植物。关于大车前的组培,目前报道很少。我们通过不定芽直接再生和愈伤组织诱导两种途径,建立了大车前(PlantagomajorL.‘GiantTurkish.’)的快速高效组培再生系统。完整的成熟种子培养在添加IAA和TDZ的MS培养基中,不经过愈伤的分化阶段,从子叶节的部位产生不定芽,直接不定芽的诱导频率达到100%。在0.2mgliAA和1.0mgLTDZ作用下,培养4～5周后平均每个外植体产生再生芽的数目达到14.6个。对同一个外植体诱导得到的9株再生植株进行的RAPD检测表明,部分植株在DNA水平上发生了变异。以叶片作为外植体,在添加1.0mgLNAA的MS固体培养基中培养3周后,伤口处形成愈伤组织,产生愈伤的频率平均为98%。愈伤组织在添加4.0mgL6BA的MS固体培养基中分化得到再生芽,分化频率为25%,平均每块愈伤产生再生芽2.8个。两种途径得到的再生芽转到12MS培养基上均可生根、长成完整植株,小苗移栽到温室90%能够存活。

关键词：大车前(Plantago major L.'Giant Turkish.’) 愈伤诱导植株再生不定芽

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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting li Zhiying Tian Qichao li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

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A Review on Thermal Management of li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： CHEN Zhifeng JIA li yin liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of li-ion battery and maintain li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei yin liting yin Shiyuan Qu Fan Zhang Kan li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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