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Rare Metals 2024年第9期43卷 4198-4221页

作者： Miao Ma li-xiao shen Jing liu Bin Xu Yun-Long Zhang Lei Zhao Zhen-Bo Wang School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China College of Environmental and Chemical Engineering Yanshan UniversityQinhuangdao 066004China Unipower Hydrogen Technology(Jiangsu)Corporation Changzhou 213176China

Proton exchange membrane fuel cells(PEMFCs)have been identified as a highly promising means of achieving sustainable energy conversion.A crucial factor in enhancing the performance of PEMFCs for further potential energy applications is the advancement in the field of catalyst engineering that has led to remarkable performance enhancement in facilitating the oxygen reduction reaction(ORR).Subsequently,it is important to acknowledge that the techniques used in preparation of membrane electrode assemblies(MEAs),the vital constituents of PEMFCs,also possess direct and critical influence on exhibiting the full catalytic activity of meticulously crafted ***,a succinct summary of the most recent advancements in Pt catalysts for ORR was offered and their underly catalytic mechanism were ***,both laboratory-scale and industrial-scale MEA fabrication techniques of Pt catalysts were ***,a detailed analysis of the connections between materials,process,and performance in MEA fabrication was presented in order to facilitate the development of optimal catalyst layers.

关键词： Pt catalysts Oxygen reduction reaction Membrane electrode assemblies MEA fabrication techniques

Bilateral iridocorneal endothelial syndrome-Chandler’s syndrome:a case report and literature review

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 773-776页

作者： xiao-Hua Pan Yu-Fei Tao Ming-Min Yang xiao-li shen Jiao Si Ming li Ning Fan shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina

Dear Editor,I ridocorneal endothelial syndrome(ICE)is a rare ocular disease first proposed by Eagle et al[1]in *** is mainly characterized by corneal endothelial abnormalities,accompanied by iris atrophy,iris pigmented nodules and peripheral anterior *** syndrome is typically unilateral,and classified into three clinical variants based on the changes of the cornea and iris,including progressive iris atrophy,Chandler’s syndrome,and Cogan-Reese syndrome.

关键词： corneal atrophy clinical

Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress- and mitochondrial-mediated apoptosis

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Food Science and Human Wellness 2024年

作者： Huiqiong Deng Wenying Chen lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao liu xiao li shen School of Public Health， Zunyi Medical University Chongqing Fuling District Center for Disease Control and Prevention Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes Research and Development Department，Allife Medicine Inc.

Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A (OTA). Our prior research has indicated that ursolic acid (UA)， which is widely present in fruits and medicinal plants， has the potential to alleviate nephrotoxicity triggered by OTA. Additionally， excessive induction of endoplasmic reticulum (ER)-phagy exacerbates OTA-induced apoptosis. Therefore， further investigation is essential to comprehend whether UA can mitigate OTA-induced apoptosis by influencing ER-phagy. This objective is accomplished through a series of experiments involving assessments of cell viability， apoptosis， fluorescence microscopy， and western blot analysis. The outcomes of these experiments reveal that pre-treatment with 4 μmol/L UA for 2 h can markedly reverse the elevated apoptotic rate， the co-localization of ER and lysosomes， and the protein expressions of GRP78， p-eIF2α， Chop， Bax， and Bak， as well as the reduced cell viability and the protein expressions of Lonp1， Trap1， p62， Tex264， FAM134B， Bcl-2， and Bcl-xl， all caused by exposure to 1 μmol/L OTA for 24 h in human proximal tubule epithelial-originated kidney-2 (HK-2) cells (P lified by UA pre-treatment (P < 0.05). In conclusion， OTA triggers a harmful feedback loop between ER stress (ERS) and excessive ER-phagy， thereby further promoting ERS- and mitochondrial-mediated apoptosis in vitro. However， this effect is significantly mitigated by UA through the inhibition of autophagosome-lysosome fusion， consequently blocking the excessive ER-phagic flux.

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The natural sources,extraction,and nephroprotective function of oleanolic acid and ursolic acid:a review

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Food and Health 2024年第3期6卷 20-32页

作者： Wen-Ying Chen Hong-Wei Wang Song Yao Yao Zhou Shuang-Chao liu xiao li shen School of Public Health Zunyi Medical UniversityZunyi 563000GuizhouChina Key Laboratory of Maternal&Child Health and Exposure Science of Guizhou Higher Education Institutes Zunyi 563000GuizhouChina

Oleanolic acid(OA)and ursolic acid(UA)are commonly present in the cuticular wax of many edible fruits and medicinal *** and UA belong to the group of bioactive pentacyclic triterpenoids,exhibiting a wide range of beneficial effects including protection for the kidneys,liver,heart,gastrointestinal tract,and spinal ***,OA and UA exhibit antioxidant,anti-ferroptotic,anti-apoptotic,anti-inflammatory,anti-tumor,anti-viral,anti-diabetic,anti-microbial,anti-parasitic,analgesic,wound-healing,hypolipidemic,and hypoglycemic properties,often without notable side *** to the extensive array of their positive functions,it is not feasible to thoroughly cover all aspects in this ***,the primary focus lies on reviewing the natural sources,extraction,and nephroprotective properties of OA and *** summarize,current literatures highlight the nephroprotective mechanisms of OA and UA,primarily involving inhibiting oxidative stress,endoplasmic reticulum stress,glycative stress,dyslipidemia,inflammation,apoptosis,pyroptosis,and renal fibrosis,promoting diuresis,as well as fine-tuning autophagy.

关键词： oleanolic acid ursolic acid natural sources nephroprotective nephrotoxicity

Generation of functionally mature neurons from a telomerase-immortalized human glial progenitor cell line

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Neural Regeneration Research 2009年第2期4卷 106-110页

作者： Yun Bai xiaoyan Zhang Aili Lu Juniun xiao li shen Department of Cell Biology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China

BACKGROUND： It has long been thought that neurons and glial cells are produced from distinct progenitor pools, but recent studies suggest that the glial progenitor cell in the subventricular zone can generate neurons in the adult rodent brain. OBJECTIVE： To investigate the ability of a telomerase-immortalized human glial progenitor cell line to differentiate into functionally mature neurons. DESIGN, TIME AND SETTING： The cellular and molecular biology experiment was performed at the Cell Biology Laboratory in the School of Basic Medical Sciences, Peking University Health Science Center, between July 2007 and May 2008. MATERIALS： A telomerase reverse transcriptase immortalized human glial progenitor cell line, was established in our laboratory. Dibutyryl cyclic AMP was purchased from Sigma （USA）. Specific antibodies against glial fibrillary acidic protein, ~ -tubulin-Ⅲand A2B5 were purchased from Chemicon, USA. Polyclonal antibodies against nestin and MAP2ab were obtained from Neomarker, USA. METHODS： The telomerase immortalized human glial progenitor cell line was passaged and maintained in growth medium consisting of DMEM/F12 （1：1） with N2 supplement （1%, v/v）, L-Glutamine （2 mmol/L）, epidermal growth factor （20 ng/mL）, basic fibroblast growth factor （20 ng/mL） and 3% fetal bovine serum. Neuronal differentiation was induced by the addition of 1 mmol/L dibutyryl cyclic AMP and 10% fetal bovine serum. MAIN OUTCOME MEASURES： Neuronal differentiation was evaluated by RT-PCR, quantitative PCR, immunofluorescence staining, Western blot analysis and electrophysiology. RESULTS： After dibutyryl cyclic AMP induction in the telomerase immortalized human glial progenitor cells, the expression of neuronal-specific marker mRNAs and proteins increased significantly. Concurrently, an apparent fast inward Na^＋ current was evoked in the cells after induction. CONCLUSION： This study suggests that some human glial progenitor ceils are indeed capable of generating functionall

关键词： telomerase immortalization human glial progenitor cells neuronal differentiation

A CELL-CENTERED GODUNOV METHOD BASED ON STAGGERED DATA DISTRIBUTION,PART Ⅰ:ONE-DIMENSIONAL CASE

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Journal of Computational Mathematics 2024年第4期42卷 1172-1196页

作者： Jiayin Zhai xiao li Zhijun shen Institute of Applied Physics and Computational Mathematics LCPP.O.Box 8009-26Beijing 100088China College of Big Data and Internet Shenzhen Technology UniversityShenzhen 518118China Center for Applied Physics and Technology HEDPSPeking UniversityChina

This paper presents a cell-centered Godunov method based on staggered data distribu-tion in Eulerian *** motivation is to reduce the intrinsic entropy dissipation of classical Godunov methods in the calculation of an isentropic or rarefaction *** the same time,the property of accurate shock capturing is also *** analyzing the factors that cause nonphysical entropy in the conventional Godunov methods,we introduce two velocities rather than a single velocity in a cell to reduce kinetic energy dissipation.A series of redistribution strategies are adopted to update subcell quantities in order to improve *** examples validate that the present method can dramatically reduce nonphysical entropy *** subject classification:35Q35,76N15,76M12.

关键词： Godunov method Riemann solver Rarefaction wave Nonphysical entropy increase.

Protection of MES23.5 dopaminergic cells by obestatin is mediated by proliferative rather than anti-apoptotic action

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Neuroscience Bulletin 2014年第1期30卷 118-124页

作者： xiao-li shen Feng-Ju Jia Ning Song Jun-Xia Xie Hong Jiang Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology Medical College of Qingdao University

Obestatin is an endogenous peptide sharing a precursor with ghrelin. This study aims to investigate whether and how obestatin protects MES23.5 dopaminergic cells against 1-methyl-4- phenylpyridinium （MPP^＋）-induced neurotoxicity. MES23.5 cells were pretreated with obestatin （10^-13- 10^-6 mol/L） for 20 min prior to incubation with 200 μmol/L MPP^＋ for 12 or 24 h, or treated with obestatin alone （10^-13 to 10^-6 mol/L） for 0, 6, 12, and 24 h. The methyl thiazolyl tetrazolium （MTT） assay was used to measure cell viability. Flow cytometry was used to measure the caspase-3 activity and the mitochondrial transmembrane potential. Proliferating cell nuclear antigen （PCNA） protein levels were determined by Western blotting. Obestatin （10^-13 to 10^-7 mol/L） pretreatment blocked or even reversed the MPP^＋ induced reduction of viability in MES23.5 cells, but had no effect on MPP^＋-induced mitochondrial transmembrane potential collapse and caspase-3 activation. When applied alone, obestatin increased viability. Elevated PCNA levels occurred with 10^-7, 10^-9, 10^-11 and 10^-13 mol/L obestatin treatment for 12 h. The results suggest that the protective effects of obestatin against MPP^＋ in MES23.5 cells are due to its proliferation-promoting rather than anti-apoptotic effects.

关键词： obestatin MPP^+ proliferation apoptosis dopaminergic cells

Enhancing energetic performance of metal-organic complex-based metastable energetic nanocomposites by spray crystallization

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Defence Technology（防务技术） 2023年第6期24卷 203-213页

作者： Ke-xin Wang li-xiao shen Bin Yuan Yan li Shun-guan Zhu lin Zhang Zhen-xin Yi Chen-guang Zhu School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210941China

Energetic metal-organic complexes have been involved in nanothermites as novel ***,the existing preparation methods often lead to mixing inhomogeneity and small contact area of ingredients,the reactivity and functionality of the novel energetic nanocomposites are still *** this work,spray crystallization(SC)method was used to prepare novel energetic nanocomposites,the high-energy metal-organic complex[Ni(CHZ)_(3)](ClO_(4))_(2)(CHZ=1,3-diaminourea)was composited with nanoaluminum(n-Al).Results showed that n-Al/[Ni(CH_(2))_(3)](ClO_(4))_(2)energetic nanocomposites prepared by SC method increased heat release to 2977.6 J/g and peak pressure to 3.91 MPa with higher pressurization rate(1324.06 MPa/s),decreased sensitivity thresholds(>100 mJ)to electrostatic discharge(ESD)and enhanced detonation ability compared with[Ni(CHZ)_(3)](ClO_(4))_(2)alone and physically mixed(PM)n-Al/[Ni(CHZ)_(3)](ClO_(4))_(2).These results proved that it is significant to introduce energetic metal-organic complexes with inherent high energy in new-concept n-Al/energetic metal-organic complexes nanocomposites through SC method for a better performance of its application.

关键词： Energetic metal-organic complexes Nano aluminum Energetic nanocomposites Spray crystallization Thermite reaction

Understanding the failure mechanism towards developing high-voltage single-crystal Ni-rich Co-free cathodes

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Green Energy & Environment 2024年第6期9卷 1045-1057页

作者： Jixue shen Bao Zhang Changwang Hao xiao li Zhiming xiao Xinyou He Xing Ou Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha410083China Zhejiang Power New Energy Co. Ltd.Zhuji311899China Material Science and Chemistry Engineering College China University of GeosciencesWuhan430074China

Benefited from its high process feasibility and controllable costs,binary-metal layered structured liNi_(0.8)Mn_(0.2)O_(2)(NM)can effectively alleviate the cobalt supply crisis under the surge of global electric vehicles(EVs)sales,which is considered as the most promising nextgeneration cathode material for lithium-ion batteries(liBs).However,the lack of deep understanding on the failure mechanism of NM has seriously hindered its application,especially under the harsh condition of high-voltage without sacrifices of reversible ***,singlecrystal liNi_(0.8)Mn_(0.2)O_(2) is selected and compared with traditional liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM),mainly focusing on the failure mechanism of Cofree cathode and illuminating the significant effect of Co element on the li/Ni antisite defect and dynamic ***,the presence of high li/Ni antisite defect in NM cathode easily results in the extremely dramatic H2/H3 phase transition,which exacerbates the distortion of the lattice,mechanical strain changes and exhibits poor electrochemical performance,especially under the high cutoff ***,the reaction kinetic of NM is impaired due to the absence of Co element,especially at the single-crystal ***,the negative influence of li/Ni antisite defect is controllable at low current densities,owing to the attenuated ***,Co-free NM can exhibit better safety performance than that of NCM *** findings are beneficial for understanding the fundamental reaction mechanism of single-crystal Ni-rich Co-free cathode materials,providing new insights and great encouragements to design and develop the next generation of liBs with low-cost and high-safety performances.

关键词： li/Ni antisite defect Dynamic characteristic High-voltage Single-crystal Ni-rich Co-free cathodes lithium-ion batteries

Quantum support vector machine for multi classification

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Communications in Theoretical Physics 2024年第7期76卷 57-62页

作者： li Xu xiao-yu Zhang Ming li Shu-qian shen College of Science China University of PetroleumQingdao 266580China

Classical machine learning algorithms seem to be totally incapable of processing tremendous data,while quantum machine learning algorithms could deal with big data unhurriedly and provide exponential acceleration over classical *** this paper,we propose two quantum support vector machine algorithms for multi *** is the quantum version of the directed acyclic graph support vector *** other one is to use the Grover search algorithm before measurement,which amplifies the amplitude of the phase storing of the classification *** k classification,the former provides quadratic reduction in computational complexity when *** latter accelerates the training speed significantly and more importantly,the classification result can be read out with a probability of at least 50%using only one *** conduct numerical simulations on two algorithms,and their classification success rates are 96%and 88.7%,respectively.

关键词： quantum support vector machine quantum feature mapping Grover search algorithm