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The role of proteasomes in tumorigenesis

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Genes & Diseases 2024年第4期11卷 155-169页

作者： xiangyi zhou Ruqing Xu Yue Wu li zhou Tingxiu xiang Department of Oncology The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Protein homeostasis is the basis of normal life activities,and the proteasomefamily plays an extremely important function in this *** proteasome 2os is a concentric circle structure with twoαrings and twoβrings *** proteasome 2os can perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits(such as 19S,11S,and 200 PA),which is performed by its active subunitβ1,β2,andβ*** proteasome can degrade misfolded,excess proteins tomaintain *** the same time,it can be utilized by tumors to degrade over-proliferate and unwanted proteins to support their *** can affect the development of tumors from several aspects including tumor signaling pathways such as NF-kB and p53,cell cycle,immune regulation,and drug ***-encoding genes have been found to be overexpressed in a variety of tumors,providing a potential novel target for cancer *** addition,proteasome inhibitors such as bortezomib,carfilzomib,and ixazomib have been put into clinical application as the first-line treatment of multiple *** and more studies have shown that it also has different therapeutic effects in other tumors such as hepatocellular carcinoma,non-small cell lung cancer,glioblastoma,and ***,proteasome inhibitors are not much effective due to their tolerance and singleness in other ***,further studies on their mechanisms of action and drug interactions are needed to investigate their therapeutic potential.

关键词： Bortezomib Cancer therapy Immunoproteasome Multiplemyeloma Proteasome 20S Proteasome inhibitor Thymoproteasom

分化型甲状腺癌^(131)I治疗后颈部转移淋巴结与刺激状态下甲状腺球蛋白之间关系

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医药论坛杂志 2024年第12期45卷 1238-1242页

作者：李祥周李彦鹏温鑫闫志华程兵郑州大学第一附属医院核医学科郑州450003

目的探讨分化型甲状腺癌(differentiated thyroid cancer,DTC)术后^(131)I治疗后局部淋巴结转移与刺激状态下甲状腺球蛋白(stimulated thyroglobulin,sTg)之间关系。方法回顾性分析2016年9月至2020年9月于郑州大学第一附属医院核医学科... 详细信息

目的探讨分化型甲状腺癌(differentiated thyroid cancer,DTC)术后^(131)I治疗后局部淋巴结转移与刺激状态下甲状腺球蛋白(stimulated thyroglobulin,sTg)之间关系。方法回顾性分析2016年9月至2020年9月于郑州大学第一附属医院核医学科行^(131)I 100~150 mCi治疗157例的分化型甲状腺癌患者临床资料,所有患者^(131)I治疗4~5月后停服左甲状腺素钠片3~4周均确诊颈部淋巴结转移病灶。统计患者颈部转移淋巴结个数及直径、颈部淋巴结分区、sTg、性别等临床资料。对sTg值与颈部转移淋巴结病灶个数及直径之间行Spearman相关分析;对于颈部淋巴结复发不同区域之间、sTg阳性与sTg阴性组间患者性别、患者病灶复发部位(颈部单侧或双侧)间差异行χ^(2)检验;对sTg阳性与sTg阴性组间患者所检出病灶个数行t检验。结果在刺激状态下,157例颈部淋巴结转移患者中,Ⅲ区与Ⅳ区是常见转移部位(P<0.05),颈部单侧转移较双侧转移多见(P<0.05)。sTg与颈部转移淋巴结个数及直径之间成线性关系(分别为r=0.517、P<0.05;r=0.361、P<0.05);sTg阳性与sTg阴性患者中性别、病灶数目、病灶复发部位之间差别有统计学意义(P<0.05)。结论sTg可作为DTC术后^(131)I治疗后肿瘤标志物,能反映DTC患者^(131)I治疗后颈部复发淋巴结个数与大小;且sTg阳性与sTg阴性患者之间性别、病灶数目及病灶部位之间有差别;但sTg阴性,不能排除体内无转移病灶。

关键词：分化型甲状腺癌甲状腺球蛋白甲状腺球蛋白抗体 ^(131)I 颈部淋巴结

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

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World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei zhou Maiying Fan xiang li Fang Yu En zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

Transfer-free chemical vapor deposition graphene for nitride epitaxy: challenges, current status and future outlook

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Science China Chemistry 2024年第3期67卷 824-840页

作者： xiang Gao Senlin li Jingfeng Bi Kaixuan zhou Meng li Zhongfan liu Jingyu Sun College of Energy Soochow Institute for Energy and Materials InnovationsSUDA-BGI Collaborative Innovation CenterKey Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China Beijing Graphene Institute Beijing 100095China Xiamen Silan Advanced Compound Semiconductor Co.Ltd. Xiamen 361026China

Graphene, a two-dimensional material with outstanding electrical and mechanical properties, has attracted considerable attention in the field of semiconductor technologies due to its potential use as a buffer layer for the epitaxial Ⅲ-nitride growth. In recent years, significant progress has been made in the chemical vapor deposition growth of graphene on various insulating substrates for the nitride epitaxy, which offers a facile, inexpensive, and easily scalable methodology. However, certain challenges are still present in the form of producing high-quality graphene and achieving optimal interface compatibility with Ⅲ-nitride *** this review, we provide an overview of the bottlenecks associated with the transferred graphene fabrication techniques and the state-of-the-art techniques for the transfer-free graphene growth. The present contribution highlights the current progress in the transfer-free graphene growth on different insulating substrates, including sapphire, quartz, SiO_(2)/Si, and discusses the potential applications of transfer-free graphene in the Ⅲ-nitride epitaxy. Finally, it includes the prospects of the transfer-free graphene growth for the Ⅲ-nitride epitaxy and the challenges that should be overcome to realize its full potential in this field.

关键词： Transfer-free chemical vapor deposition graphene for nitride epitaxy challenges current status and future outlook graphene

Penumbra lunar eclipse observations reveal anomalous thermal performance of Lunakhod 2 reflectors

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Chinese Physics B 2022年第5期31卷 212-218页

作者： Tian-Quan Gao Cai-Shi Zhang Hong-Chao Zhao li-xiang zhou Xian-lin Wu Hsienchi Yeh Ming li MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinCNSA Research Center for Gravitational WavesSun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

As the signal reflected by the corner-cube reflector arrays is very weak and easily submerged during the full moon,we analyze the influence of the thermal effect of corner-cube reflector arrays on the intensity of lunar laser ranging *** ranging measurements during the penumbra lunar eclipse verify suspected thermal deformation in the Lunakhod 2 *** levels vary over two orders of magnitude as the penumbra eclipse *** can be explained by the change in the dihedral angle of the corner-cube reflectors caused by the *** results show that when the dihedral angle errors reach 1,the energy is reduced by 100 times compared with the ideal corner-cube *** the experiment,our findings suggest that when the corner-cube reflector arrays enter the penumbra of the earth,the effective echo signal level which reaches 0.18 photons/s far exceeds the historical level of the full ***,11 minutes after the penumbra lunar eclipse,the effective echo rate of Lunakhod 2 will drop two orders of *** mechanism can explain the acute signal deficit observed at full moon.

关键词： lunar laser ranging corner-cube reflector arrays dihedral angle errors penumbra lunar eclipse

Consensus on glycemic management for patients with coronary heart disease and type 2 diabetes

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Journal of Geriatric Cardiology 2024年第7期21卷 689-702页

作者： li-Nong JI Yun-Dai CHEN Jing liU xiang-Hai zhou Cardiovascular Subcommittee of Chinese International Exchange and Promotion Association for Medical and Healthcare Peking University People's Hospital Chinese PLA General Hospital

The prevalence of patients with coronary heart disease(CHD)and diabetes mellitus is notably high,posing sig-nificant residual cardiovascular risks even after routine interventions such as antihypertensive,lipid-lowering,and antithrombot-ic *** studies have demonstrated that certain glucose-lowering medications confer cardiovascular benefits for pa-tients with type 2 ***,a survey indicates that cardiologists may not be fully acquainted with the optimal screen-ing timing,indicators,and diagnostic criteria for type 2 diabetes,and there is insufficient awareness and a low rate of prescrip-tion of novel glucose-lowering medications with proven cardiovascular efficacy,such as glucagon-like peptide-1 receptor agon-ists(GLP-1 RAs)and sodium-glucose co-transporter-2 inhibitors(SGLT-2i).In this context,based on domestic and international guidelines or consensus and the latest evidence-based evidence,this consensus aims to standardize the glycemic management for patients with acute coronary syndrome,chronic coronary syndrome,and perioperative management for percutaneous coronary *** highlights the key points of screening and diagnosis of type 2 diabetes,and the comprehensive management of cardiovascular risk in patients with *** consensus elaborates on the principles and algorithms of glycemic management for CHD patients,without involving acute complications of diabetes,clarifies the clinical practice of glucose-lowering medications with cardiovascular benefits,and promotes the standardized use of these medications in cardiovascular and other related spe-cialty ***,it addresses the glucose-lowering treatment to comprehensively reduce cardiovascular risks.

关键词： coronary patients routine

Non-perturbative dynamics of flat-band systems with correlated disorder

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Chinese Physics B 2024年第9期33卷 547-551页

作者： Qi li Junfeng liu Ke liu Zi-xiang Hu zhou li GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510535China Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics Guangzhou 510700China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China University of Chinese Academy of Sciences Beijing 100039China

We develop a numerical method for the time evolution of Gaussian wave packets on flat-band lattices in the presence of correlated *** achieve this,we introduce a method to generate random on-site energies with prescribed *** verify this method with a one-dimensional(1D)cross-stitch model,and find good agreement with analytical results obtained from the disorder-dressed evolution *** allows us to reproduce previous findings,that disorder can mobilize 1D flat-band states which would otherwise remain *** explained by the corresponding disorder-dressed evolution equations,such mobilization requires an asymmetric disorder-induced coupling to dispersive bands,a condition that is generically not fulfilled when the flat-band is resonant with the dispersive bands at a Dirac point-like *** exemplify this with the 1D lieb *** analytical expressions are not available for the two-dimensional(2D)system due to its complexity,we extend the numerical method to the 2D a–T3 model,and find that the initial flat-band wave packet preserves its localization when a=0,regardless of disorder and ***,when a̸=0,the wave packet shifts in real *** interpret this as a Berry phase controlled,disorder-induced wave-packet *** addition,we present density functional theory calculations of candidate materials,specifically Hg1−*** flat-band emerges near the G point(α=0)in the Brillouin zone.

关键词： flat-band system dynamics correlated disorder

Miniaturized power detection module operating in millimeter wave band

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Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： xiang zhou Zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

Synthesis of Planar-Chiral[2.2]Paracyclophane-Based Oxazole-Pyrimidine ligands and Application in Nickel-Catalyzed 1,2-Reduction ofα,β-Unsaturated Ketones

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Chinese Journal of Chemistry 2024年第7期42卷 705-710页

作者： Juan Wang Qing-Xian Xie xiang li Chang-Bin Yu Yong-Gui zhou School of Chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMCOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis