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liver and spleen volume variations in patients with hepatic fibrosis

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World Journal of Gastroenterology 2009年第26期15卷 3298-3302页

作者： Peng liu Peng li wen He li-Qin Zhao Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM： To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages. METHODS： Multidetector computed tomography （MDCT） scan was performed in 85 hepatic fibrosis patients. liver volume （LV） and spleen volume （SV） were measured. Fifteen healthy individuals served as a control group （SO）. The patients were divided into stage 1 （S1） group （n = 34）, stage 2 （S2） group （n = 25）, stage 3 （S3） group （n = 16）, and stage 4 （S4） group （n = 10） according to their histopathological stage of liver fibrosis. RESULTS： The LV and standard LV （SLV） had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups （LV： F = 0.245, P = 0.912; SLV： F = 1.902, P = 0.116）. The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups （P 〈 0.01）. The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups （P 〈 0.01）.CONCLUSION： The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.

关键词： Hepatic fibrosis Volume measurement liver volume Standard liver volume Spleen volume liver volume/spleen volume ratio Standard liver volume/spleen volume ratio

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课堂教学数字化分析系统的设计及实现

深圳职业技术大学学报 2024年第2期23卷 68-74页

作者：范士喜杨倩倩李文莉深圳职业技术大学教育技术与信息中心广东深圳518055

课堂教学是教育的重要环节,其效果的分析与评价对于人才培养质量以及教师授课水平提高具有重要意义。教育部陆续发布多个文件强调“课堂教学的多元化、过程性评价”,体现了对课堂分析评价的重视。国内外学者对课堂教学分析已经积累了较... 详细信息

课堂教学是教育的重要环节,其效果的分析与评价对于人才培养质量以及教师授课水平提高具有重要意义。教育部陆续发布多个文件强调“课堂教学的多元化、过程性评价”,体现了对课堂分析评价的重视。国内外学者对课堂教学分析已经积累了较为丰富的理论和方法。但是,这些理论和方法主要是依靠专业的人员或者有经验的教师开展,数据采集难度大,过程性分析和评价精度不足,且难以大规模开展。近年来,有学者将视频分析、眼动分析、脑电波分析等技术应用于师生课堂的行为分析,或者面向网络学习平台开展教学实时分析。但采集哪些数据,如何从采集的数据形成有效的评价分析指标方面的研究才刚刚开始。文章基于音视频采集分析技术,研究了一套课堂教学分析指标体系,实现了一个数字化的课堂教学分析系统,在师生无感知的情况下对课堂教学全过程数据进行智能化分析。系统的应用实现了对课堂教学活动的真实全过程记录与分析,对于丰富课堂分析评价理论,探索数字化智能化课堂分析方法具有一定的理论和应用价值。

关键词：课堂教学数字化分析指标体系教学评价

Fragmentation process of soil aggregates under concentrated water flow in red soil hilly region with different land use patterns

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Journal of Mountain Science 2023年第11期20卷 3233-3249页

作者： wen li-li WANG Jin-yue DENG Yu-song DUAN Xiao-qian Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Agricultural environment and Agricultural product safety College of AgricultureGuangxiUniversityNanning 530004China

The hilly area of red soil in the central subtropical region of China has a long history of severe soil erosion due to its abundance of water,heat,and intense agricultural and forestry *** Sandshale red soil area is hot and rainy,the local land utilization rate and replanting index are high,and the soil easily weathers and erodes,resulting in infertile and sandy soils,extensive soil erosion and large erosion,with far-reaching *** this study,the stability of soil aggregates was studied by the wet sieving method and Le Bissonais(LB)method in six land use patterns in the Sandshale red soil area,including natural forest(NF),Pinus massoniana(PM),Eucalyptus urophylla×***(EU),orchard(OR),wasteland(WL)and arable land(AL).The transport damage characteristics of the soil aggregates under concentrated water flow were analyzed by using the soil aggregates to simulate the soil surface roughness in the field using a steel scouring flume with a variable *** results showed that:(1)the total soil porosity of the natural forest was the highest,with 56.51%in A layer,which was 4.99%higher than the B layer,and the organic matter content ranged from 10.69 to 29.94 ***-1 and was highest in NF and lowest in AL;(2)the maximum mean weight diameter(MWD)obtained by the wet sieving method was 4.81 mm for natural forest,and the MWD was the lowest in OR and AL at *** MWD measured by the LB method was also highest in NF and lowest in *** contents of Fed and Ald have a strong correlation with the stability parameters of soil aggregates;(3)the Wr/Wi results for the six land use patterns were NF>PM>EU>WL>OR>AL;the NF had the strongest soil aggregate stability,followed by WL,PM and EU,and AL and OR had the weakest;the stability of soil aggregates gradually weakened as the soil depth *** analysis shows that forest land has high soil stability and obvious advantages in soil erosion *** the construction of artificial f

关键词： Soil aggregates Land use Aggregate stability Fragmentation process

An Estimation Method of Stress in Soft Rock Based on In-situ Measured Stress in Hard Rock

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Journal of China University of Mining and Technology 2007年第3期17卷 310-315,320页

作者： li wen-ping li Xiao-qin SUN Ru-hua School of Resources and Earth Science China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The law of variation of deep rock stress in gravitational and tectonic stress fields is analyzed based on the Hoek-Brown strength criterion. In the gravitational stress field,the rocks in the shallow area are in an elastic state and the deep,relatively soft rock may be in a plastic state. However,in the tectonic stress field,the relatively soft rock in the shallow area is in a plastic state and the deep rock in an elastic state. A method is proposed to estimate stress values in coal and soft rock based on in-situ measurements of hard rock. Our estimation method relates to the type of stress field and stress state. The equations of rock stress in various stress states are presented for the elastic,plastic and critical states. The critical state is a special stress state,which indicates the conversion of the elastic to the plastic state in the gravitational stress field and the conversion of the plastic to the elastic state in the tectonic stress field. Two cases stud-ies show that the estimation method is feasible.

关键词： rock stress gravity stress tectonic stress critical depth estimation method

Polyimide covalent organic frameworks as efficient solid-state li^(+) electrolytes

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Science China Chemistry 2024年第5期67卷 1647-1652页

作者： Xu liu Shi Wang Siqi liu Chengfang liu Xiangchun li Jian Wu Dazhi li Shihao Xu Chongyang liu wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing 210023China

Covalent organic frameworks(COFs) are attractive porous crystalline materials with extremely high stability, easy functionalization, and open channels, which are expected to be unique ion conductors/transporters in lithium ion batteries(liBs). Despite recent advances, low ion conductivity and low transference number, resulting in low charging/discharging rate, low energy density, and short battery life, are the main issues that limit their direct application as solid electrolytes in liBs. Here, we designed and synthesized a novel polyimide COF, namely, TAPA-PDI-COF, with abundant C=O groups, which has been successfully employed as high-performance solid electrolytes by doping TAPA-PDI-COF and succinonitrile(SN). Both the well-defined nanochannels of COFs and SN confined in the well-aligned channels restricted the free migration of anions, while C=O on COFs and CN groups of SN enhanced li^(+) transport, thus achieving a high ion conductivity of 0.102 m S cm^(-1)at 80 °C and a high lithium-ion transference number of 0.855 at room temperature. According to density functional theory(DFT)calculations, li-ion migration mainly adopted in-plane transport rather than the axial pathway, which may be due to the shorter hopping distances in the planar pathway. The results suggest an effective strategy for the design and development of all-solidstate ionic conductors for achieving high-performance liBs.

关键词： lithium ion batteries(liBs) covalent organic frameworks(COFs) solid-state ion conductors solid-state electrolytes ion conductivity

A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo li Tingxia Zhou Ziwang Zhang wen Shi Yexiang Tong Jianxin Shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

UPLC-MS/MS同时测定通迪胶囊中的马兜铃酸Ⅰ和马兜铃酸Ⅱ

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中国现代中药 2024年第8期26卷 1307-1311页

作者：梁晟孙辉丁野李文莉刘静戴忠湖南省药品检验检测研究院/国家药品监督管理局药用辅料工程技术研究重点实验室湖南长沙410001 中国食品药品检定研究院北京100050

目的:建立通迪胶囊中马兜铃酸Ⅰ(AA-Ⅰ)和AA-Ⅱ的超高效液相色谱-质谱法。方法:采用Shiseido Shim-pack velox C18色谱柱(100 mm×2.1 mm,1.8μm),以乙腈(A)-0.1%甲酸水溶液(含甲酸铵,B)为流动相梯度洗脱,流速为0.3 mL·min^(–1),采用... 详细信息

目的:建立通迪胶囊中马兜铃酸Ⅰ(AA-Ⅰ)和AA-Ⅱ的超高效液相色谱-质谱法。方法:采用Shiseido Shim-pack velox C18色谱柱(100 mm×2.1 mm,1.8μm),以乙腈(A)-0.1%甲酸水溶液(含甲酸铵,B)为流动相梯度洗脱,流速为0.3 mL·min^(–1),采用多反应监测,AA-Ⅰ以m/z 358.9→298.0(定量)和m/z 358.9→296.0(定性)为监测离子对;AA-Ⅱ以m/z 329.0→268.0(定量)和m/z 329.0→294.0(定性)为监测离子对,建立了液相色谱-质谱法检测方法,并对样品进行分析。结果:AA-Ⅰ在1.0524~420.9600 pg、AA-Ⅱ在1.002~100.200 ng时与峰面积线性关系良好(r>0.999),加样回收率分别为97.63%、92.34%,RSD分别为2.24%、1.49%,15批样品中AA-Ⅰ和AA-Ⅱ的质量分数分别为3.760~20.790、0.010~0.156μg·g^(–1)。结论:该方法灵敏、快速、准确、专属性强,可用于测定通迪胶囊中AA-Ⅰ和AA-Ⅱ的含量,可为通迪胶囊用药安全提供参考。

关键词：通迪胶囊马兜铃酸Ⅰ 马兜铃酸Ⅱ 含量测定液相色谱-质谱法

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Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults： a retrospective study spanning 15 years

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Chinese Medical Journal 2011年第21期124卷 3490-3494页

作者： TAO Jian-ling liU li-li wen Yu-bing GAO Rui-tong li Hang li Ming-xi li Xue-mei li Xue-wang Division of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China

Background Cyclosporine is effective in treating nephrotic syndrome （NS） with idiopathic membranous nephropathy （IMN） in adults. But high relapse rate remains a major concern. The way to manipulate cyclosporine is inconclusive. The aim of this study was to introduce the way how to titrate the cyclosporine to maintain complete remission without relapse. Methods Patients with biopsy-proven IMN with NS treated with cyclosporine for at least 1 month from 1996 to 2011 at Peking Union Medical College Hospital were reviewed. Results Mean age of the 51 eligible patients was 52 years, with 39 men. Mean proteinuria was （7.47±3.14） g/d, serum albumin （24.50±6.29） g/L, and serum creatinine （82.62±21.18） μmol/L. Cyclosporine was commenced at a mean dose of （3.46±0.63） mg·kg^-1·d^-1. Oral prednisone （0.40±0.29） mg·kg^-1·d^-1 was given concomitantly in 38 patients. Cyclosporine was administered for a median of 16 months （range 1-93 months） and stopped in non-responders by month six. By month 3 （n=47）, the number in complete remission （CR） and partial remission （PR） was 3 and 24, which shifted to 12 and 17 by month 6 （n=41）. Male gender, heavy proteinuria, low serum albumin level, and high serum creatinine level were significant determinants in poor response by month six （P 〈0.05 in all variables compared with responders）. There was a significant reversible serum creatinine increase within 25% during month 3 to 12 （P 〈0.05 in all variables compared with baseline value）. Eleven patients maintained cyclosporine for more than 24 months with a cyclosporine dose of （1.04±1.06） mg·kg^-1·d^-1. Nine patients were in CR. Renal function, systolic and diastolic blood pressure remained stable. Renal impairment （〉30% rise of serum creatinine）, secondary infection, hypertension, gingival hyperplasia and liver impairment occurred in 6, 4, 10, 4, and 1 patients, respectively. Conclusions The observation time for cyclosporine to effectively induce CR of NS in IMN adults should be at least six month

关键词： cyclosporine idiopathic membranous nephropathy nephrotic syndrome treatment

Metabolic diversification of anaerobic methanotrophic archaea in a deep-sea cold seep

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Marine life Science & Technology 2020年第4期2卷 431-441页

作者： wen-li li Yu-Zhi Wu Guo-wei Zhou Hui Huang Yong Wang Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanya 572000China HKUST-CAS Sanya Joint Laboratory of Marine Science Research Chinese Academy of SciencesSanya 572000China

Anaerobic methanotrophic archaea(ANME)can assimilate methane and govern the greenhouse effect of deep-sea cold *** this study,a total of 13 ANME draft genomes representing five ANME types(ANME-la,ANME-lb,ANME-2a,ANME-2b and ANME-2c),in size between 0.8 and 1.8 Mbp,were obtained from the Jiaolong cold seep in the South China *** small metagenome-assembled genomes(MAGs)contained all the essential pathways for methane oxidization and carbon dioxide *** genes related to nitrate and sulfate reduction were absent from the MAGs,indicating their syntrophic dependence on partner *** from acetate secretion and sugar storage,propanoate synthesis pathway,as an alternative novel carbon flow,was identified in all the MAGs and transcriptionally *** type-specific features of the MAGs,the genes encoding archaellum and bacteria-derived chemotaxis were specific to ANME-2,perhaps for fitness under fluctuation of methane and sulfate concentration *** genomic and transcriptomic results strongly suggested that ANME could carry out simple carbon metabolism from Cl assimilation to C3 biosynthesis in the SCS cold seep,which casts light on a novel approach for synthetic biology.

关键词： ANME Metabolic diversification Transcriptome Propanoate synthesis