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Use of slgE/T-IgE in Predicting Systemic Reactions： Retrospective Analysis of 54 Honeybee Venom Allergy Cases in North China

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Chinese Medical Journal 2016年第17期129卷 2091-2095页

作者： Kai Guan li-sha li Jia yin Department of Allergy Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing 100730 China

Background： Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee veuom allergy, Methods： Retrospective review of honeybee venom allergy versus nonallergy patients presenled v,ith positive honeybee venom （iI） sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups. Patient residence and exposure types were analyzed. The slgE/T-IgE among allergy and control groups was compared, Results： Gender ratio male：female was 32：22： median age was 39 years （31. 50）. 48% （26/54） of patients live in urban areas. 52% （28/54） in rural areas. Based on bee sting reactions, patients were divided into common localized reactions （32/54）. large localized reactions （7/54）, and systemic reactions （15/54）, In the systemic reaction group, patients presented as Type Ⅱ （6/15）, Type Ⅲ （6/15）. There is significant difference （P 〈 0,001 ） between the three groups in regards to exposure types. In the systemic reaction group. 8.7% （13/15） of patients are beekeepers. A significant difference （P 〈 0.001 ） was observed between allergic and control groups based on slgE/T-lgE results. As well as significant difference observed between the systemic reaction group to the other two reaction groups in regards to slgE/T-IgE results. Six systemic reaction patients presented with large localized reactions before onset of system symptoms 1 month to 1year of being stung. Conclusions： Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy,

关键词： Honeybee Venom Allergy Localized Reaction: Systemic Reaclion

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Microwave-assisted heating synthesis:a generaland rapid strategy for large-scale productionof highly crystalline g-C3N4 with enhancedphotocatalytic H2 production

Microwave-assisted heating synthesis:a generaland rapid stra...

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中部四省化学化工学会2016年学术年会

作者： Yu-Peng Yuan li-sha yin shao-Wen Cao li-Na Gu Geng-Sheng Xu Pingwu Du Hua Chai Yu-Sen liao Can Xue

The metal-free photocatalyst,g-CN,is very attractive for solarhydrogen ***,g-CN is mainly fabricated by theconversion of nitrogen-rich precursors at high temperature(400°C–600 °C) for a long reaction time(several hours to days).Herein we report a rapid synthetic strategy named "microwave(MW)-assisted heating synthesis",which allows the highly crystallineg-CN photocatalyst to be fabricated in *** obtainedg-CN displays enhanced photocatalytic H ***,the described synthetic strategy is a general approachthat can also be applicable to other nitrogen-rich organic precur-sors,such as melamine,cyanamide,and ***,thepresent process enables scale-up production of g-CN for severalgrams in minutes.

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数媒时代焦虑、抑郁与社会比较的关系

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心理科学进展 2025年第1期33卷 92-106,I0001-I0007页

作者：赵立白莎首都经济贸易大学工商管理学院北京100070

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。... 详细信息

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。研究发现,消极社会比较(传统上行比较和下行同化比较)可能会引发焦虑和抑郁,社交网络平台对此负面影响具有催化作用;而情绪比较和下行对比比较可以缓解焦虑和抑郁,网络健康社区促进了情绪比较的积极作用的发挥。研究推进了社会比较理论在情绪情感领域的应用,确定了焦虑、抑郁与网络健康社区可供性的关联,也为网络社区服务、运营和设计的原则提供参考和借鉴以帮助个体应对心理健康问题。研究还指出焦虑、抑郁和社会比较关系后续研究的可能路径和方向。

关键词：社会比较焦虑抑郁社交网络平台网络健康社区

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-Ze Wang, Yu-Chang liu, Ting-Ting Zhao, Quan-liang li, Chen-sha Cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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奈比洛尔对自发性高血压大鼠心肌连接蛋白43重构的影响

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中国药物与临床 2017年第3期17卷 323-326页

作者：魏泽卉李志东殷莎张飞王燕山西医科大学基础医学院药理教研室太原030001

目的探讨奈比洛尔对自发性高血压大鼠(SHR)心肌连接蛋白43(Cx43)重构的影响。方法动物随机分成:SHR组(等量蒸馏水,灌胃),奈比洛尔组(奈比洛尔8 mg·kg^(-1)·d^(-1),灌胃),WKY(Wistar-Kyoto)组(等量蒸馏水,灌胃)。给药8周,期间每周测定... 详细信息

目的探讨奈比洛尔对自发性高血压大鼠(SHR)心肌连接蛋白43(Cx43)重构的影响。方法动物随机分成:SHR组(等量蒸馏水,灌胃),奈比洛尔组(奈比洛尔8 mg·kg^(-1)·d^(-1),灌胃),WKY(Wistar-Kyoto)组(等量蒸馏水,灌胃)。给药8周,期间每周测定尾动脉收缩压。试验结束后,3%戊巴比妥钠(30 mg/kg)麻醉大鼠,分离心脏,利用免疫组织化学方法和蛋白质印迹技术观察心肌Cx43的分布和表达的影响。结果与WKY组相比,SHR收缩压持续上升,奈比洛尔则可显著降低收缩压。免疫组织化学与蛋白质印迹法结果显示,WKY组Cx43阳性表达规则分布于闰盘,SHR组Cx43阳性颗粒排列紊乱位于侧边或胞内,且蛋白表达水平明显降低。奈比洛尔可使Cx43规则分布于闰盘处,Cx43表达升高。结论奈比洛尔在显著降压的同时,可改善SHR心肌Cx43分布和表达。

关键词：心肌大鼠奈比洛尔 Cx43

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西昌2014年大气边界层风场特征分析

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西昌学院学报（自然科学版） 2015年第4期29卷 55-58,62页

作者：李颖莎晏惠芬莫芳房鹏凉山州气象局四川西昌615000

利用西昌探空站2014年高空风资料,对大气边界层内距地300、600及900 m的风向频率、平均风速按月、季度进行统计计算,以此分析西昌地区大气边界层风场特征。结果表明:西昌地区大气边界层内风随季节变化较大。对于风向:夏季,各高度上通常... 详细信息

利用西昌探空站2014年高空风资料,对大气边界层内距地300、600及900 m的风向频率、平均风速按月、季度进行统计计算,以此分析西昌地区大气边界层风场特征。结果表明:西昌地区大气边界层内风随季节变化较大。对于风向:夏季,各高度上通常以SSW和N为主导并有多个次多风向;冬、春、秋季,300 m高度上主要是偏南风,600、900 m高度上风向主要集中在SSW方向上;风速最大出现在春季,最小在夏季。

关键词：西昌大气边界层风场特征

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu sha-sha Cui Ting-Ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance

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Chinese Journal of Natural Medicines 2022年第2期20卷 102-110页

作者： CHEN Tian-Tian DU sha-li WANG Shi-Jun WU li yin Lu Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjing 210023China shandong Co-innovation Center of TCM Formula School of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinan 250355China

The infiltration of immune cells into the hepatocellular carcinoma microenvironment is the main reason why hepatocellular carcinoma patients are prone to carcinoma recurrence and the disease are ***,the infiltration of Treg cells is the main *** Zhechong pill(DHZCP)is a traditional Chinese herbal compound successful in the treatment of hepatitis and hepatocellular *** can heal and nourish while slowing the onset of the disease,thereby strengthening the body’s immune *** can localize tumors and ultimately achieve the goal of eliminating *** this study,an orthotopic liver cancer model of mice was used to explore the mechanism of DHZCP enhancing anti-tumor immunity,which showed more Th1 cells in the peripheral blood and spleen after DHZCP treatment,while more IFN-γwas secreted to activate CD8^(+)T cells and Treg cell production was inhibited,thereby suppressing the growth of ***,we also analyzed the potential components of DHZCP from the perspective of modern targets using network pharmacology methods and experimental results.

关键词： Network pharmacology Hepatocellular Dahuang Zhechong pill Balance Th1-Treg

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Influence of standardized nursing intervention combined with mindfulness stress reduction training on the curative effect in patients with acute pancreatitis

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World Journal of Clinical Cases 2023年第35期11卷 8276-8283页

作者： sha li Dan yin Xiao-Chun Guo Department of Gastroenterology Wuhan Third HospitalWuhan 430000Hubei ProvinceChina The Critical Care Medicine Department The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of Gastroenterology The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality *** is of great significance to take scientific intervention measures for patients with AP in *** To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect,negative emotion,and quality of life in patients with acute *** A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group(n=40).Patients in control group were given the standardized nursing intervention,and the observation group were given standardized nursing plus mindfulness stress reduction training *** time of clinical symptom disappeared or improved,complication occurrence rate,emotional state,and quality of life score of the two groups were observed and *** In comparison with the control group,the bowel sound recovery time,ventosity and abdominal pain improvement time,and venting and cacation time in observation group were shorter,and the total incidence rate of complications was reduced,showing statistically significant difference(Plife quality in physiology,psychology,environment and social relations in observation group were higher than those in control group,and the differences were statistically significant(Plication of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect,which can help to ameliorate the clinical symptoms,anxiety and depression of patients,reduce

关键词： Acute pancreatitis Standardized nursing Mindfulness stress reduction training Negative emotion Quality of life

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Distinguishable multi-substance detection based on three-channel NIR fluorescent probe in physiology and pathology of living cells and zebrafish

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Chinese Chemical Letters 2021年第12期32卷 3870-3875页

作者： sha li Fangjun Huo Yongkang Yue Kaiqing Ma ying Wen Caixia yin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Mitochondria is the main organelle for the production of reactive sulfur species(RSS), such as homocysteine(Hcy), cysteine(Cys), glutathione(GSH) and sulfur dioxide(SO_(2)). These compounds participate in a large number of physiological processes and play an extremely important role in maintaining the balance of life systems. Abnormal concentration and metabolism are closely related to many diseases. Due to their similarities in chemical properties, it is challenging to develop a single fluorescent probe to distinguish them simultaneously. Here, we synthesized the probe PI-CO–NBD with three fluorophores, NBD-Cl and benzopyranate as the reaction sites of GSH/Cys/Hcy and SO_(2), respectively. Three biothiols all could cleavage ether bond to release benzopyrylium and coumarin moiety, which emitted red and blue fluorescence,but Cys/Hcy also could do intramolecular rearrangement after nucleophilic substitution, resulting in yellow fluorescence. Thus the probe can distinguish Cys/Hcy and GSH. Subsequently, only SO_(2)could quench red fluorescence by adding C=C of benzopyrylium. The probe also could localize well in mitochondria by oxonium ion for all kinds of cells. The probe not only could detect above sulfur-containing active substances of intracellular and extracellular but also monitor the level of them under oxidative stress and apoptosis process in living cells and zebrafish.

关键词： Mitochondrial-targeted Discrimination detection Distinguishable Multi-substance Three channels

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