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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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一种故障诊断方法的改进

太原理工大学学报 2005年第2期36卷 207-210页

作者：李冰清冯秀芳李祝平太原理工大学信息工程学院山西太原030024

在粗糙集理论与神经网络结合的故障诊断方法中,当故障诊断系统中条件属性的个数较多时,可采用一种先分块建立决策表再约简的方法。笔者对该方法的可行性和算法的时间复杂度进行了分析,结果证明,分块建立决策表是可行的,可以降低约简的... 详细信息

在粗糙集理论与神经网络结合的故障诊断方法中,当故障诊断系统中条件属性的个数较多时,可采用一种先分块建立决策表再约简的方法。笔者对该方法的可行性和算法的时间复杂度进行了分析,结果证明,分块建立决策表是可行的,可以降低约简的复杂度,从而缩短约简工作的时间。

关键词：分块决策表粗糙集神经网络故障诊断

前列地尔结合盐酸异丙嗪治疗急诊眩晕症的效果探析

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当代医学 2017年第12期23卷 6-8页

作者：黎平祝易忠萍乡市人民医院江西萍乡337000

目的探讨前列地尔结合盐酸异丙嗪治疗急诊眩晕症的效果。方法选取60例急诊眩晕症患者作为研究对象,按入院编号随机选取30例设为观察组,采用结合盐酸异丙嗪治疗,将另外30例患者设为对照组,采用前列地尔治疗。对比观察组和对照组患者的治... 详细信息

目的探讨前列地尔结合盐酸异丙嗪治疗急诊眩晕症的效果。方法选取60例急诊眩晕症患者作为研究对象,按入院编号随机选取30例设为观察组,采用结合盐酸异丙嗪治疗,将另外30例患者设为对照组,采用前列地尔治疗。对比观察组和对照组患者的治疗效果。结果观察组患者治疗后社会功能(4.1±1.5)分、躯体健康(3.9±1.4)分、心理功能(4.2±1.5)分、物质生活态度(3.9±1.3)分,与对照组治疗后社会功能(2.4±1.6)分、躯体健康(2.4±1.3)分、心理功能(2.6±1.4)分、物质生活态度(2.3±1.6)分相比明显较高(P<0.05)。观察组患者治疗后药效发挥时间(1.4±0.6)d与对照组(2.9±0.5)d相比明显较短(P<0.05)。观察组患者治疗总有效率(96.7%)与对照组(73.3%)相比明显较高(P<0.05)。观察组患者不良反应发生率(0.00%)与对照组(16.67%)患者相比明显较低(P<0.05)。结论前列地尔结合盐酸异丙嗪能有效改善患者生活质量,提高患者治疗效果,且能减少患者不良反应发生状况,安全可靠,可在急诊眩晕症治疗中推广运用。

关键词：前列地尔盐酸异丙嗪急诊眩晕症

Inhibition of the α-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells

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Cell Research 2006年第7期16卷 622-631页

作者： li Qu~(1,*) Ji Yu Ju~(1,*) Shuang ling Chen~1 Yan Shi~1 Zhi Guang Xiang~1 Yi Qun Zhou~1 Yun Tian~1 Yin liu~1 li ping zhu~1 ~1Department of Immunology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China DepartmentofImmunology InstituteofBasicMedicalSciencesChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100005China

Protein N-glycosylation plays very important roles in immunity and α-mannosidase is one of the key enzymes in *** paper reports that inhibition of α-mannosidase Man2cl gene expression enhances adhesion of JurkatT *** comparison to the controls with normal expression of the enzyme,Jurkat cells with the inhibition of Man2clgene expression（AS cell）formed larger aggregates in culture,indicating an enhancement of adhesion between the *** differential display analysis discovered up-regulation of several adhesion molecule genes in the AS *** the pivotal role played by CD54-LFA-1 interaction in immune cell interaction,this study focused on the contributionof enhanced expression of CD54 and LFA-1 to the enhanced adhesion of AS Jurkat *** facts,including increasedbinding of AS cells to ICAM-1-Fc,Mg2+activation of the binding of AS cells to ICAM-1-Fc and enhanced aggregationof AS cells,together with the inhibiting effect of a blocking CD 11a mAb on the binding to ICAM-1-Fc and aggregationof the cells demonstrate an important contribution of enhanced CD54-LFA-1 interaction to increased adhesion betweenAS *** enhanced CD54-LFA-1 interaction also resulted in increased adhesion between AS Jurkat T cells and RajiB *** addition,AS cells showed cytoskeletal *** data imply a biological significance of MAN2C1in T-cell functioning.

关键词： Man2cl Jurkat T cell adhesion CD54-LFA-1 cytoskeleton

CO2精制工艺的开发与研究——催化燃烧法脱除CO2中的微量乙烯

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天然气化工—C1化学与化工 1993年第3期18卷 28-33页

作者：吴善良李平朱兵华东化工学院催化研究所

分析比较了CO_2精制工艺的方法,研究了用催化燃烧法脱除CO_2中的微量乙烯,以获得高纯度的CO_2。制备了3种涂层载体,得到了比表面较大的异丙醇铝涂层。并研究了催化剂的制备方法及催化剂的热稳定性;经考察,在Pt-CM催化剂上,当空速为15000... 详细信息

分析比较了CO_2精制工艺的方法,研究了用催化燃烧法脱除CO_2中的微量乙烯,以获得高纯度的CO_2。制备了3种涂层载体,得到了比表面较大的异丙醇铝涂层。并研究了催化剂的制备方法及催化剂的热稳定性;经考察,在Pt-CM催化剂上,当空速为15000h^(-3),氧的加入量为3倍理论量,乙烯浓度为5000ppm,乙烯转化率达50%和90%时,反应温度分别为220℃和230℃。

关键词：精制催化燃烧法乙烯二氧化碳

Study on Production Performance of Alfalfa in Yellow River beach areas

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Study on Production Performance of Alfalfa in Yellow River b...

河南省畜牧兽医学会第七届理事会第二次会议暨2008年学术研讨会

作者： Gao Yong-ge liu xiang li li li He-ping zhu wei-ran Wang Lei Wang Yan-hua Forage Grass and Feedstuff Station of Animal Husbandry Bureau of Henan Province,Jing San Road 91,Zhengzhou,Henan 450002,China

In order to study the growth law of alfalfa,and choose suitable varieties with high yield and good quality for cultivation,4 alfalfa varieties,including liangmu 400,Affinity,Baoding alfalfa and Seven leaves alfalfa were studied in Yellow River beach areas of Zhengzhou,Henan Province,China,in 2004,2005 and 2006 using a randomized block design with three *** plot was cut four times each year over the 3-year period to evaluate production performance of the tested *** results were obtained from the experiment.(1)As alfalfa growth year increased,the dry matter yields *** third year had the highest yield among the three years for the four *** dry matter yield of the four varieties in 2006 were higher than that of ones in 2005, and 2005 were higher than that of ones in 2004,and the third yield’s dry matter yield nearly was the sum of the previous two years. The production performance of liangmu400 was the best in the four varieties,providing a scientific base for choosing varieties in *** order to increase dry matter yield,we should select liangmu400 in the industrialization production of alfalfa.(2) Cutting times had significant effect on dry matter herbage yield,the yield of first cutting was the highest,then the second,and the fourth,the third were the lowest,and dry matter yield of the first cutting were extremely significantly higher than that of the other three cuttings except for Seven leaf alfalfa (Pliangmu 400" was the tallest among the four varieties,significantly different from the other three varieties (Pliangmu 400,Affinity and S

关键词： alfalfa production performance dry matter yield plant height correlation

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无髯鸢尾新品种DUS测试性状筛选

植物遗传资源学报 2017年第5期18卷 905-912页

作者：李丛丛高亦珂阮丽丽范诸平刘蓉张启翔北京林业大学园林学院/花卉种质创新与分子育种北京市重点实验室/国家花卉工程技术研究中心/城乡生态环境北京实验室北京100083

植物新品种特异性、一致性和稳定性(DUS)测试是新品种保护的基础和依据,测试性状的筛选是DUS测试的核心。为制定无髯鸢尾DUS测试指南,初步确定测试性状43个,结合性状间R型聚类分析性状间相关性,去除相关性大、贡献较小的雌蕊长、叶长性... 详细信息

植物新品种特异性、一致性和稳定性(DUS)测试是新品种保护的基础和依据,测试性状的筛选是DUS测试的核心。为制定无髯鸢尾DUS测试指南,初步确定测试性状43个,结合性状间R型聚类分析性状间相关性,去除相关性大、贡献较小的雌蕊长、叶长性状,最终确定操作性强、区别明显的测试性状41个;利用品种间Q型聚类分析确定测试指南的分组性状4个;对性状进行分级及分布分析,保证无髯鸢尾测试指南的可行性,为无髯鸢尾品种测试与授权提供技术支持。

关键词：无髯鸢尾 DUS测试性状筛选

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界面交联制备聚多巴胺复合纳滤膜的性能调控

高分子学报 2018年第12期28卷 1524-1531页

作者：唐安琪路景驭冯炜林张培斌朱利平高分子合成与功能构造教育部重点实验室浙江大学高分子科学与工程学系

通过多巴胺在水溶液中的自聚-组装,形成聚多巴胺(PDA)纳米聚集体,进一步以尺寸可调的PDA纳米聚集体为水相反应物,以酰氯为油相单体,通过界面交联法制备了渗透选择性优异的复合纳滤膜,其分离性能可通过水相pH值进行调控.采用紫外吸收光... 详细信息

通过多巴胺在水溶液中的自聚-组装,形成聚多巴胺(PDA)纳米聚集体,进一步以尺寸可调的PDA纳米聚集体为水相反应物,以酰氯为油相单体,通过界面交联法制备了渗透选择性优异的复合纳滤膜,其分离性能可通过水相pH值进行调控.采用紫外吸收光谱和动态光散射等表征了PDA聚集体在水相中的结构特点,分析了复合膜表面的微观结构与物化性质.研究发现,随着水相pH值由中性(pH=6)向强碱性(pH=13)逐渐过渡,复合膜的Na2SO4截留率呈先增后减趋势.在水相pH=12时,制得的复合膜于0.4MPa下纯水通量可达64L m^-2h^-1,Na2SO4的截留率达90%,对染料日落黄的截留率达97%.与文献报道的PDA表面沉积法相比,此方法大大缩短了PDA沉积时间,提高了制膜效率,所制备的复合纳滤膜分离性能可调.

关键词：多巴胺纳滤界面交联分离精度

HA20-lys10在大肠埃希菌中的融合表达纯化和凝胶阻滞试验

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复旦学报（医学版） 2004年第1期31卷 32-35页

作者：孙兴会张宇清王霞侯敏谭理李平朱运松复旦大学上海医学院生物化学与分子生物学系上海200032

目的表达和纯化流感病毒血凝素HA2氨基末端20个氨基酸与10个赖氨酸的融合蛋白HA20-lys10,并观察其与质粒结合的能力。方法用PCR方法构建流感病毒血凝素HA2氨基末端20个氨基酸与10个赖氨酸的融合基因HA20—lys10,并克隆于pET32a(+)原... 详细信息

目的表达和纯化流感病毒血凝素HA2氨基末端20个氨基酸与10个赖氨酸的融合蛋白HA20-lys10,并观察其与质粒结合的能力。方法用PCR方法构建流感病毒血凝素HA2氨基末端20个氨基酸与10个赖氨酸的融合基因HA20—lys10,并克隆于pET32a(+)原核表达载体。将重组表达质粒pET-HA-K转化大肠埃希菌BL21(DE3),当A(Abs)_(600nm)达到0.6时,加入终浓度为1mmol/L IPTG诱导目的蛋白的表达。表达产物用亲和层析一步法进行纯化,然后用凝胶阻滞试验观察重组蛋白结合质粒的能力。结果 IPTG诱导后可获得相对分子质量约为27 000的目的蛋白,表达蛋白以可溶形式存在,占菌体蛋白20％以上。表达菌超声后,表达产物经亲和层析一步纯化后可获得纯度达85％以上目的蛋白。凝胶阻滞试验发现,纯化的重组蛋白在一定条件下可以与质粒结合,使质粒的迁移率明显改变。结论融合蛋白HA20—lys10有望用于受体介导基因转移,以提高基因转移的效率。

关键词： HA20-Iys10 大肠埃希菌凝胶阻滞试验融合基因基因表达基因纯化