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Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial ceils in response to stimulation by peroxynitrite and antagonism of puerarin

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Chinese Medical Journal 2011年第16期124卷 2522-2529页

作者： HAO li-na zhang Yan-qing SHEN Yu-hua WANG Zhi-yun WANG Yan-hua Department of Ophthalmology Hebei Province People's HospitalShijiazhuang Hebei 050051 China

Background Retinal pigment epithelial （RPE） cell is a monolayer of multifunctional cells between the retina and the choroid. Peroxynitrite （ONOO-） is known to induce toxicity on RPE cells. This study aimed to evaluate ONOO- induced expression of inducible nitric oxide synthase （iNOS） and complement 3 （C3） via Fas/FasL pathway in RPE cells and the values of puerarin as a therapeutic target for inhibiting the apoptosis of RPE cells. Methods RPE cells were obtained from eyes of C57BL/6 mice. RPE cells were divided into control, ONOO-and puerarin groups. Control group was treated with saline, ONOO-group was treated with ONOO-, and puerarin group was treated with puerarin after added with ONOO-. All changes were observered at 6, 12 and 24 hours after treatment. Western blotting analysis was used to determine the expression of nitrotyrosine （NT, the foot print of ONOO-） and C3; flow cytometry was used to determine the apoptosis of RPE cells. Immunohistochemistry and Western blotting were used to determine Fas/FasL signal transduction. Gene array analysis, reverse transcription polymerase chain reaction （RT-PCR） and Western blotting were used to determine the expression of iNOS mRna and iNOS protein in RPE cells. Results There were minor expression of NT, C3, Fas/FasL and iNOS mRna in control group, and strong expression of NT and C3 in ONOO- group, while in puerarin group weak expressions of NT and C3 were detected as time passed by （P 〈0.001）. Apoptosis of RPE cells occured and reached a higher level at 6 and 24 hours after addition of ONOO- respectively in ONOO- group, but delayed apoptosis in puerarin group （P 〈0.05）. Compared to control group, the expression of Fas/FasL was up-regulated in ONOO- group, but was down-regulated in puerarin group （P 〈0.001）. Similarly, the expressions of iNOS mRna and iNOS protein in ONOO-group were up-regulated in ONOO- group, but down-regulated in puerarin group （P 〈0.001）. Conclusions ONOO- expresseion in RPE cells may constitute the n

关键词： retinal pigment epithelial cells oxidative cell signal complement puerarin

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A review of the treatment of ankylosing spondylitis from liver and kidney

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TMR Integrative Medicine 2019年第9期3卷 1-6页

作者： Teng Huang ling-Jing zhang li-na zhang Zhi-Yong Zhao Bin Hao Hebei University College of Traditional Chinese Medicine Baoding Hebei China Hebei University College of Life Sciences Baoding Hebei China Chinese People's liberation Army 252 Hosptital Traditional Chinese Medicine Department Baoding Hebei China

Ankylosing spondytitis is a kind of arthropathy of rheumatic immune disease. The pathogenesis of ankylosing spondytitis is not very ctear in current medicat research. Because of the recurrence of the disease and the prolongation of the disease, the quality of tife of the patients has been seriously affected. Traditional Chinese medicine has tong known its etiotogy and pathogenesis, and it is very effective in ctinicat treatment. Based on the theory of traditional Chinese medicine and modern physicians' understanding of its etiotogy and pathogenesis, and starting from the function and characteristics of tiver and kidney, this paper explores the basis of treating ankylosing spondytitis from tiver and kidney, with a view to providing new ideas for the ctinicat treatment of ankylosing spondytitis.

关键词： Ankylosing spondytitis Etiology and pathogenesis Treatment of tiver and kidney

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An chromatic dispersion monitoring method based on spectral-shift of SOA

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Optoelectronics Letters 2007年第5期3卷 359-362页

作者： CHEN Ming YIN Fei-fei HE li-na zhang Ye-jin YANG Si-gang CHEN Hong-wei XIE Shi-zhong Department of Electronic Engineering of Tsinghua University Beijing 100084 China

A remnant dispersion monitoring method based on spectral-shift of SOA in high speed optical communication system with CSRZ format and single channel speed of 40 Gbit/s is proposed. The system performance can be optimized by careful choosing bandwidth and center wavelength of the optical fiber grating filter. The dynamical monitoring range is ±60 ps/nm and the monitoring precision is about 5 ps/nm. This method can be suitable for the application in dynamical dispersion compensation of high speed optical communication systems.

关键词：彩色色散监视器光谱转移高速光学通信系统通道

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Blocking Cyclic Adenosine Diphosphate Ribose-mediated Calcium Overload Attenuates Sepsis-induced Acute Lung Injury in Rats

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Chinese Medical Journal 2016年第14期129卷 1725-1730页

作者： Qian-Yi Peng Yu Zou li-na zhang Mei-lin Ai Wei liu Yu-Hang Ai Department of Critical Care Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Anesthesia Xiangya Hospital Central South University Changsha Hunan 410008 China

Background： Acute lung injury （Ali） is a common complication of sepsis that is associated with high mortality, lntracellular Ca^2＋ overload plays an important role in the pathophysiology of sepsis-induced ALl, and cyclic adenosine diphosphate ribose （cADPR） is an important regulator of intracellular Ca^2＋ mobilization. The cluster of differentiation 38 （CD38）/cADPR pathway has been found to play roles in multiple inflammatory processes but its role in sepsis-induced ALl is still unknown. This study aimed to investigate whether the CD38/cADPR signaling pathway is activated in sepsis-induced ALl and whether blocking cADPR-mediated calcium overload attenuates ALl. Methods： Septic rat models were established by cecal ligation and puncture （CLP）. Rats were divided into the sham group, the CLP group, and the CLP＋ 8-bromo-cyclic adenosine diphosphate ribose （8-Br-cADPR） group. Nicotinamide adenine dinucleotide （naD＋）, cADPR, CD38, and intracellular Ca^2＋ levels in the lung tissues were measured at 6, 12, 24, and 48 h after CLP surgery. Lung histologic injury, tumor necrosis factor （TNF）-a, malondialdehyde （MDA） levels, and superoxide dismutase （SOD） activities were measured. Results： naD＋, cADPR, CD38, and intracellular Ca-＋ levels in the lungs of septic rats increased significantly at 24 h after CLP surgery. Treatment with 8-Br-cADPR, a specific inhibitor of cADPR, significantly reduced intracellular Ca^2＋ levels （P = 0.007）, attenuated lung histological injury （P = 0.023）, reduced TNF-a and MDA levels （P 〈 0.001 and P = 0.002, respectively） and recovered SOD activity （P = 0.031） in the lungs of septic rats. Conclusions： The CD38/cADPR pathway is activated in the lungs of septic rats, and blocking cADPR-mediated calcium overload with 8-Br-cADPR protects against sepsis-induced ALl.

关键词： Acute Lung Injury Calcium Overload Cyclic Adenosine Diphosphate Ribose Sepsis

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The effect of music therapy on rehabilitation of children with cerebral palsy: a meta-analysis

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TMR Integrative Medicine 2019年第14期3卷 1-9页

作者： Yu-Hui Ma li-na zhang Qian Cui Xiao-Ming Jin Guo-Wei zhang College of Chinese Medicine Hebei University Baoding Hebei Province China

Objective: To evaluate the ctinicat efficacy of music therapy in the treatment of children with cerebrat patsy by systematic review and meta-anatysis. Methods: A comprehensive search of China Knowledge Network, Wan fang, VIP database and foreign databases PubMed and Cochrane library was conducted from the setup of database to March 2019. After reading and screening them carefully, 14 qualified literates were got. Then extracted relevant data, and evaluated the quality and risk bias with Revman5.3.3 software. Results: There is no significant difference between music therapy in improving ctinostatism and the ability of rowing over (P > 0.05). However, music therapy has significant difference in improving sitting, running, and jumping movements, and it can atso relieve muscte spasm, improve muscte tension and stabilize children's emotions in the course of treatment and the P values of which were att tess than 0.05. Conclusion: The music therapy has a certain effect for the treatment of pediatric cerebrat patsy, especiatty in improving children's gross and fine motor abilities, which has a certain ctinicat guiding significance for rehabilitation of children with cerebrat patsy. Key words: Pediatric cerebrat patsy, Music therapy, Meta-anatysisy Ctinicat efficacyObjective: To evaluate the ctinicat efficacy of music therapy in the treatment of children with cerebrat patsy by systematic review and meta-anatysis. Methods: A comprehensive search of China Knowledge Network, Wan fang, VIP database and foreign databases PubMed and Cochrane library was conducted from the setup of database to March 2019. After reading and screening them carefuLy, 14 qualified [iterates were got. Then extracted relevant data, and evaluated the quality and risk bias with Revman5.3.3 software. Results: There is no significant difference between music therapy in improving ctinostatism and the ability of rowing over (P > 0.05). However, music therapy has significant difference in improving sitting, run

关键词： Pediatric cerebrat patsy Music therapy Meta-anatysis Ctinicat efficacy

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Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

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World Journal of Clinical Cases 2024年第16期12卷 2704-2712页

作者： Jie Wu Ying Zheng li-na zhang Cai-li Gu Wang-li Chen Min-Qiang Chang Department of Respiratory and Oncology 72nd Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina Department of Otorhinolaryngology 72^(nd)Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina

Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory *** specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)***-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis *** this review,we discuss regulation of immune response in respiratory diseases especially *** further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious *** also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.

关键词： nanomedicines Immunotherapeutics Respiratory diseases COVID-19 Thrombosis

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Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemiareperfusion injury in aged rats

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Neural Regeneration Research 2014年第11期9卷 1122-1128页

作者： Xiangyu Ji li'na zhang Ran liu Yingzhi liu Jianfang Song He Dong Yanfang Jia Zangong Zhou Department of Anesthesiology Affiliated Hospital of Qingdao University Department of Anesthesiology Qingdao Municipal Hospital Department of General Surgery Affiliated Hospital of Qingdao University

Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our exper-imental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral isch-emia-reperfusion injury.

关键词： nerve regeneration cerebral ischemia reperfusion injury hippocampus cognitivefunction apoptosis mitochondria differential proteomics rats aged neural regeneration

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考虑年均倒塌概率的结构倒塌安全储备可接受值

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工程力学 2017年第4期34卷 88-100页

作者：羡丽娜何政张延泰辽宁工程技术大学建筑工程学院阜新123000 东北大学资源与土木工程学院沈阳110004 大连理工大学土木工程学院大连116024 大连理工大学海岸和近海工程国家重点实验室大连116024

推导出结构年均倒塌概率与结构倒塌安全储备之间的关系,并提出依据年均倒塌概率可接受值计算可接受倒塌安全储备系数CMR的方法。利用全概率理论,将倒塌易损性与地震危险性进行耦合,得到结构年均倒塌概率,采用中值倒塌地震强度建立年均... 详细信息

推导出结构年均倒塌概率与结构倒塌安全储备之间的关系,并提出依据年均倒塌概率可接受值计算可接受倒塌安全储备系数CMR的方法。利用全概率理论,将倒塌易损性与地震危险性进行耦合,得到结构年均倒塌概率,采用中值倒塌地震强度建立年均倒塌概率与结构倒塌安全储备系数CMR的关系。结合大震倒塌概率可接受值确定年均倒塌概率可接受值,进而计算结构可接受倒塌安全储备系数CMR。结合我国抗震规范规定的加速度反应谱建立CMR谱,给出了乙类、丙类结构在不同设防烈度下的可接受年均倒塌概率值以及可接受CMR值。研究表明:结构可接受年均倒塌风险越低,结构的倒塌安全储备可接受值越大,并呈现幂函数的数学关系,而可接受年均倒塌概率又与大震强度、地震危险性以及总倒塌不确定性有关。依据我国抗震设计规范背景建议的特定可接受年均倒塌概率下的可接受CMR谱,可以反映不同周期区间结构随总倒塌不确定性变化的规律,可用于结构倒塌安全储备的快速评估。基于CECS392建议的可接受大震倒塌概率计算得到乙类建筑的可接受年均倒塌概率远小于丙类建筑,均随着设防烈度的提高而下降,相应的CMR可接受值则呈现增加趋势。

关键词：倒塌安全储备系数(CMR) 年均倒塌概率可接受值倒塌易损性地震危险性全概率

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The inheritance path research of the processing of Chinese materia medica in Anguo herbs market

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TMR Theory and Hypothesis 2019年第1期2卷 128-134页

作者： Ying Chen li-na zhang Yu-Hui Ma Miao-Miao lin Xing zhang Yu Wang Guo-Wei zhang College of Traditional Chinese Medicine Hebei UniversityBaodingChina

Anguo,known as Qizhou in ancient time,its herbs industry began in Song Dynasty,boomed in Ming,and flourished in *** the development of Qizhou herbs industry,a number of special processing techniques of Chinese Materia Medicine were produced."Qizhou's Four Uniqueness",of which,the most representative medicine includes"Hundred pieces areca","Cicada feather of Qingxia","Yunpian deer antler"and"Pound Rhinoceros unicornis L".To investigate the present inheritance situation of the traditional processing technology of Chinese Materia Medicine in Anguo herbs market,we will consult literature including the ancient books and records,Anguo local chronicles and visit the inheritors of the traditional processing technology in Anguo,and research the processing technology historical *** study aims to create the Anguo herbs cultural card,and enrich the cultural heritage of Chinese medicine industry of Anguo country even Hebei province.

关键词： Qizhou's Four Uniqueness Processing of Chinese Materia Medicine Anguo Herbs Market Inheritance Path

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Terahertz spectral analysis of Yunpian Lurong

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TMR Modern Herbal Medicine 2019年第2期2卷 83-90页

作者： li-na zhang Yu-Hui Ma Ze-Jia zhang Kai-Xuan Hou Yan-Ming Wu Guo-Wei zhang College of Traditional Chinese Medicine Hebei University Baoding China School of Electronics and Information Engineering Hebei University Baoding China

Objective: Provide a rapid and simple method to identify Yunpian Lurong. Method: Terahertz spectroscopy was used to detect Yunpian Lurong. Result: Compared with the reference wave, the spectral amplitude of Yunpian Lurong decreases significantly. The frequency - domain spectra of Yunpian Lurong are different from conventional Lurong. Compared with the spectrum of free space, both of them have obvious absorption to THz wave, but the intensity and location of absorption are different, which provides a basis for the identification of Yunpian Lurong. The refractive index of the two samples is obviously different, which may be related to the different internal structure and composition content of the samples. The absorption coefficient of the two samples are different as well, when the frequency ranges from 0 to 2.4 THz, the absorption coefficients of the two kinds of Lurong samples have obvious difference, which makes it easy to distinguish the Yunpian Lurong. Conclusion: This study proves that terahertz spectroscopy can be used as an efficient and convenient method to identify Yunpian Lurong.

关键词： Terahertz Time-domain Spectroscopy Yunpian Lurong Index of Refraction Absorption Coefficients

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