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DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy

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Acta Pharmaceutica Sinica B 2015年第4期5卷 330-336页

作者： Yue Sheng Bo sun Xin Xie na li Deli Dong The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Research Ministry of Education Department of PharmacologyHarbin Medical University

Our previous work found that DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl]quinoline) was a novel autophagy inhibitor. Here, we aimed to investigate the effects of DMH1 on chemotherapeutic drug-induced autophagy as well as the efficacy of chemotherapeutic drugs in different cancer cells. We found that DMH1 inhibited tamoxifen- and cispcis-diaminedichloroplatinum(II)(CDDP)-induced autophagy responses in MCF-7 and HeLa cells, and potentiated the anti-tumor activity of tamoxifen and CDDP for both cells. DMH1 inhibited 5-fluorouracil(5-FU)-induced autophagy responses in MCF-7 and HeLa cells, but did not affect the anti-tumor activity of 5-FU for these two cell lines. DMH1 itself did not induce cell death in MCF-7 and HeLa cells, but inhibited the proliferation of these cells. In conclusion, DMH1 inhibits chemotherapeutic drug-induced autophagy response and the enhancement of efficacy of chemotherapeutic drugs by DMH1 is dependent on the cell sensitivity to drugs.

关键词： Autophagy Tamoxifen 5-Fluorouracil Cancer cells

Preparation and film-growing mechanism of hydrous zirconia coated on TiO_2

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 660-667页

作者： Jie li Ti-chang sun Yong Wang li-na Wang Jing-kui Qu Tao Qi School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China national Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Institute of Process Engineering Chinese Academy of SciencesBeijing 100190 China Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

To overcome the photochemical activity of rutile used as a pigment and improve its durability in application, hydrous zirconia-coated TiO2 was prepared by the precipitation method. High-resolution transmission electron microscope （HRTEM） and X-ray photoelectron spectroscopy （XPS） were used to characterize the morphology and surface structure of hydrous zirconia-coated TiO2. The ζ-potential and ultraviolet （UV） absorption of both coated and uncoated rutile were examined. The results show that hydrous zirconia can not only improve the durability but also raise the lightness. A suitable ZrO2 content of hydrous zirconia-coated TiO2 is about 1.0wt%, and a dense film on the surface of rutile can be formed with better pigmentary properties. Based on the thermodynamic analysis, the zirconia-coating process and the film growth mechanism were discussed.

关键词： coatings rutile zirconia materials preparation mechanism

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu sun Jianping GU W.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell Rna sequencing

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Science China life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Novel 2D/2D NiCo_(2)O_(4)/ZnCo_(2)O_(4)@rGO/CNTs self-supporting composite electrode with high hydroxyl ion adsorption capacity for asymmetric supercapacitor

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Journal of Materials Science & Technology 2022年第32期127卷 236-244页

作者： Xiumei Chen na Xin Yuxin li Cong sun Longhua li Yulong Ying Weidong Shi Yu liu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

The energy storage device has been urgently studied and developed to meet the increasing demand for energy and sustainable *** to the excellent conductivity of graphene and high performance of ZnCo_(2)O_(4)and NiCo_(2)O_(4),we design a self-supporting electrode based on vertically grown twodimensional/two-dimensional(2D/2D)NiCo_(2)O_(4)/ZnCo_(2)O_(4)hierarchical flakes on the carbon-based conductive substrate(NiCo_(2)O_(4)/ZnCo_(2)O_(4)@graphene/carbon nanotubes,NZ@GC).The density functional theory calculations indicate that the high OH-adsorption capacity of the NiCo_(2)O_(4)/ZnCo_(2)O_(4)nanosheets can significantly enhance the electrochemical reaction ***@GC shows a high capacitance of 1128.6 F g^(-1)at 1 A g^(-1).The capacitance retains 84.0%after 6000 cycles even at 10 A g^(-1).A hybrid supercapacitor is fabricated using NZ@GC and activated carbon,exhibiting a large energy density of 50.8 W h kg^(-1)at the power density of 800 W kg^(-1).After 9000 charge/discharge cycles,the supercapacitor still has 86.1%capacitance *** NZ@GC film has showed the potential as promising electrodes in high efficiency electrochemical energy storage devices.

关键词： Supercapacitor ZnCo2O4 NiCo2O4 Energy density Excellent conductivity High capacitance

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低场MRI在胼胝体病变诊断中的应用价值

实用医技杂志 2004年第8A期11卷 1522-1523页

作者：陈颖李娜孙慧珍王永秀莱芜市人民医院山东莱芜271100

目的 :分析 6 0例胼胝体病变低场 MRI表现 ,探讨低场 MRI对于胼胝体病变诊断的准确性及其临床价值。材料和方法 :对 6 0例颅脑胼胝体病变病例进行低场 MR扫描 ,做出相应诊断 ,并与临床治疗过程相结合。结果 :6 0例病例中 ,发育不良 16... 详细信息

目的 :分析 6 0例胼胝体病变低场 MRI表现 ,探讨低场 MRI对于胼胝体病变诊断的准确性及其临床价值。材料和方法 :对 6 0例颅脑胼胝体病变病例进行低场 MR扫描 ,做出相应诊断 ,并与临床治疗过程相结合。结果 :6 0例病例中 ,发育不良 16例 ,损伤 15例 ,梗塞 13例 ,出血 9例 ,胼胝体肿瘤 7例。结论 :低场

关键词：低场MRI 胼胝体病变应用价值

Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection

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Virologica Sinica 2019年第1期34卷 78-87页

作者： Yanqin Ding na li Jinhan sun linran Zhang Jianhui Guo Xueqi Hao Yuning sun Department of Biochemistry and Molecular Biology Key Laboratory of Fertility Preservation and Maintenance of Ministry of EducationSchool of Basic Medical ScienceNingxia Medical University School of Clinical Medicine Hainan Medical University Department of Respiratory and Critical Care General Hospital of Ningxia Medical UniversityNingxia Medical University

Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus Dna replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873 D infected with minute virus of canines(MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC Dna replication and reduce viral gene expression at both mRna and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC ***, OMT significantly increased cell viability, decreased MVC-infected cell apoptosis, and reduced the expression of activated caspase 3. Our results suggest that OMT has potential application in combating parvovirus infection.

关键词： Oxymatrine (OMT) Minute virus of canines (MVC) Infection Replication Apoptosis

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IL-21与COPD发病机制的研究进展

国际呼吸杂志 2017年第19期37卷 1503-1506页

作者：张超凡杜春华李娜王芳芳孙家兴青岛大学附属医院呼吸内科 266003

IL-21是近年来发现的一种细胞因子，主要由活化的CD4^＋T细胞产生，在Thl7细胞中大量分泌，IL-21与其受体结合后，参与免疫应答与炎症反应。COPD是一种由吸烟所诱发的T细胞介导的炎症及自身免疫性的疾病。COPD的发病机制复杂，其中免疫... 详细信息

IL-21是近年来发现的一种细胞因子，主要由活化的CD4^＋T细胞产生，在Thl7细胞中大量分泌，IL-21与其受体结合后，参与免疫应答与炎症反应。COPD是一种由吸烟所诱发的T细胞介导的炎症及自身免疫性的疾病。COPD的发病机制复杂，其中免疫失衡在COPD发生发展中起着重要作用，多种细胞因子的变化与COPD有关，IL-21就是其中的一种。本文就IL-21与COPD的气道炎症、肺气肿、肺动脉高压的发病机制的研究作一综述。

关键词：白介素21 白介素21受体慢性阻塞性肺疾病

VARIABIliTY SETS AND HAMILTON SEQUENCES

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Chinese Annals of Mathematics,Series B 2005年第4期26卷 543-550页

作者： sun na WU SHENGJIAN Key Laboratory of Pure and Applied Mathematics School of Mathematical Sciences Peking University Beijing 100871 China.

This paper studies extremal quasiconformal mappings. Some properties of the variability set are obtained and the Hamilton sequences which are induced by point shift differentials are also discussed.

关键词： Quasiconformal mapping Point shift differentials Hamilton sequence Extremal mapping