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m^(6)A调控细胞自噬和铁死亡途径影响肿瘤细胞生长

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中国生物化学与分子生物学报 2024年第9期40卷 1222-1229页

作者：李名杨陶爽李国辉江苏大学生命科学学院生物科学系江苏镇江212013 江苏大学附属武进医院乳腺外科江苏常州213164

N6-甲基腺苷(m^(6)A)修饰是RNA中腺苷酸(A)第6位N上发生的甲基化,是真核生物mRNA中最丰富的表观转录组学修饰。m^(6)A修饰不仅能调控胞内基因组转录水平,也直接影响癌基因、抑癌基因和多种非编码RNA(ncRNA)的表达水平,与肿瘤的发生、发... 详细信息

N6-甲基腺苷(m^(6)A)修饰是RNA中腺苷酸(A)第6位N上发生的甲基化,是真核生物mRNA中最丰富的表观转录组学修饰。m^(6)A修饰不仅能调控胞内基因组转录水平,也直接影响癌基因、抑癌基因和多种非编码RNA(ncRNA)的表达水平,与肿瘤的发生、发展直接相关;另外,m^(6)A修饰也能调控细胞自噬和铁死亡代谢途径中相关基因的表达水平,从而调控细胞自噬和铁死亡等胞内代谢途径,其调控异常直接影响肿瘤细胞的增殖或者死亡。本文主要对m^(6)A修饰调控细胞自噬和铁死亡途径相关基因的表达,及其与肿瘤发生、发展相关的基因表达调控,促进或抑制体内肿瘤细胞的生长进行综述,不仅为进一步揭示肿瘤的发生、发展机制提供参考,也为肿瘤治疗提供新的靶标提供科学依据。

关键词： N6-甲基腺苷细胞自噬铁死亡肿瘤

“守备任莫重此矣”:明代凤阳守备太监职任考

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蚌埠学院学报 2024年第4期13卷 122-128页

作者：李明阳安徽财经大学马克思主义学院安徽蚌埠233030

成化年间,明廷在凤阳设置守备太监一职,至南明弘光政权覆亡而终止,一百七十余年中至少有二十六人担任过凤阳内守备一职。他们之中,基本来自明中央宦官二十四衙门中的司礼监、内官监、御马监、御用监及神宫监等衙门之中。其职责范围包括... 详细信息

成化年间,明廷在凤阳设置守备太监一职,至南明弘光政权覆亡而终止,一百七十余年中至少有二十六人担任过凤阳内守备一职。他们之中,基本来自明中央宦官二十四衙门中的司礼监、内官监、御马监、御用监及神宫监等衙门之中。其职责范围包括:守护皇陵、兼管皇城、看管高墙,监管罪宗、统摄军民及岁贡时鲜等。在各时期尤其是朝局的剧烈变化之下,他们的职权范围也随之波动起伏。

关键词：凤阳守备太监明成化年间宦官

黑龙江省高校网球专业学生心理压力来源和应对策略研究

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哈尔滨体育学院学报 2024年第4期42卷 86-91页

作者：李明阳哈尔滨体育学院体育教育训练学院黑龙江哈尔滨150008

目的:探究网球运动员主要压力来源并探寻解决之道。方法:通过对网球运动员应用自制量表进行问卷调查,并利用t检验和方差分析进行统计。结果:高校网球学生心理压力来源由大到小依次是实习压力,训练压力,学业压力和就业压力。女生在训练... 详细信息

目的:探究网球运动员主要压力来源并探寻解决之道。方法:通过对网球运动员应用自制量表进行问卷调查,并利用t检验和方差分析进行统计。结果:高校网球学生心理压力来源由大到小依次是实习压力,训练压力,学业压力和就业压力。女生在训练和实习压力两个方面显著高于男生,且具有统计学差异(P<0.01)。不同年级的学生在实习压力、训练压力、就业压力和学业压力四个维度有统计学差异(P<0.01)。面临压力时,网球专业的学生更愿意通过自己的努力实现目标。应对策略:对不同性别学生进行针对性心理教育,对不同年级的学生设置不同的培养重点。

关键词：网球专业学生心理压力策略

中国省级增长不确定性的层级分解及其对产出和通胀的影响分析

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中央财经大学学报 2024年第10期 87-101页

作者：刘达禹向思宇李铭洋吉林大学数量经济研究中心吉林大学东北亚研究院

目前,中国经济增长复苏偏弱,并呈现出区域分化态势。从纵深维度对省级增长不确定性进行分解,并对其产出效应和通胀效应进行测度是实现宏观经济波动精准溯源的基本前提,亦是实现宏观经济分层治理的必要保障。为此,本文运用SV-TVP-DF模型... 详细信息

目前,中国经济增长复苏偏弱,并呈现出区域分化态势。从纵深维度对省级增长不确定性进行分解,并对其产出效应和通胀效应进行测度是实现宏观经济波动精准溯源的基本前提,亦是实现宏观经济分层治理的必要保障。为此,本文运用SV-TVP-DF模型将中国各省份增长不确定性分解为全国一致成分、区域协同成分以及省级个体成分,随后利用方差分解和PCH-VAR模型考察了各级不确定性对产出波动和物价波动的异质性影响,研究发现:第一,重大危机事件发生后,各级不确定性均迅速攀升,其中东部各省份不确定性变动较大,是增长不确定性的主要引领者;第二,全国增长不确定性和省级个体不确定性是产出和物价波动的核心驱动因素,其中产出波动主要受全国一致成分影响,物价波动则由省级不确定性撬动;第三,就防范和化解增长不确定性而言,现阶段应采取适度积极的财政政策配合合理宽松的信贷政策来引导经济复苏。这不仅可以有效提振经济活力,而且也能够把物价波动控制在适宜范围,同时还能增强经济复苏的确定性和稳定性。

关键词：增长不确定性宏观经济波动 SV-TVP-DF模型 PCH-VAR模型

新文科语境下智能技术融入产品设计专业教学路径探索

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白城师范学院学报 2024年第4期38卷 90-96页

作者：钟蕾李铭洋李杨天津理工大学艺术学院天津300384

以新文科背景下的人工智能技术发展趋势为出发点,构建智能技术融入产品设计专业教学路径,提高学生的理论学习与实践能力,从而提升其未来的职业竞争力。文章对产品设计教学内容进行整合,提炼出智能技术融入专业教学的路径,构建人工智能... 详细信息

以新文科背景下的人工智能技术发展趋势为出发点,构建智能技术融入产品设计专业教学路径,提高学生的理论学习与实践能力,从而提升其未来的职业竞争力。文章对产品设计教学内容进行整合,提炼出智能技术融入专业教学的路径,构建人工智能语境下的教学内容横向知识逻辑和纵向进阶式教学流程,探索智能技术融入的“教—学—用”育人路径,并明确智能技术在专业课程中的引入范围、引入方式和应用智能技术验证创意思路和设计实践效果,为产品设计专业教育领域的变革提供可参考的范式。

关键词：新文科智能技术产品设计人才培养教学路径

On the energy conservation and critical velocities for the propagation of a "steady-shock" wave in a bar made of cellular material

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Acta Mechanica Sinica 2013年第3期29卷 420-428页

作者： li-li Wang li-ming yang Yuan-Yuan Ding Mechanics and Material Science Research Center Ningbo University

The propagation of shock waves in a cellular bar is systematically studied in the framework of continuum solids by adopting two idealized material models, viz. the dynamic rigid, perfectly plastic, locking （D-R-PP-L） model and the dynamic rigid, linear hardening plastic, locking （D-R-LHP-L） model, both considering the effects of strain-rate on the material properties. The shock wave speed relevant to these two models is derived. Consider the case of a bar made of one of such material with initial length L 0 and initial velocity v i impinging onto a rigid target. The variations of the stress, strain, particle velocity, specific internal energy across the shock wave and the cease distance of shock wave are all determined analytically. In particular the ＂energy conservation condition＂ and the ＂kinematic existence condition＂ as proposed by Tan et al. （2005） is re-examined, showing that the ＂energy conservation condition＂ and the consequent ＂critical velocity＂, i.e. the shock can only be generated and sustained in R-PP-L bars when the impact velocity is above this critical velocity, is incorrect. Instead, with elastic deformation, strain-hardening and strain-rate sensitivity of the cellular materials being considered, it is appropriate to redefine a first and a second critical impact velocity for the existence and propagation of shock waves in cellular solids. Starting from the basic relations for shock wave propagating in D-R-LHP-L cellular materials, a new method for inversely determining the dynamic stress-strain curve for cellular materials is proposed. By using e.g. a combination of Taylor bar and Hopkinson pressure bar impact experimental technique, the dynamic stress-strain curve of aluminum foam could bedetermined. Finally, it is demonstrated that this new formulation of shock theory in this one-dimensional stress state can be generalized to shocks in a one-dimensional strain state, i.e. for the case of plate impact on cellular materials, by simply making proper

关键词： Cellular solids 1D shock theory D-R-PP-L model D-R-SHP-L model Energy conservation across shock Critical velocities

Notes on ＂Finite Groups with Nilpotent Local Subgroups＂

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Journal of Mathematical Research and Exposition 2008年第3期28卷 609-612页

作者： li yang ming Department of Mathematics Guangdong College of Education Guangdong 510310 China

A finite group G is called PN-group if G is not nilpotent and for every p-subgroup P of G, there holds that either P is normal in G or P lohtain in Z∞（G） or NG（P） is nilpotent, arbitary p ∈ π（G）. In this paper, we prove that PN-group is meta-nilpotent, especially, PN-group is solvable. In addition, we give an elementary, intuitionistic, compact proof of the structure theorem of PN- group.

关键词： PN-group meta-nilpotent group structure theorem.

Two-Dimensional Organometallic TM3–C12S12 Monolayers for Electrocatalytic Reduction of CO2

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Energy & Environmental Materials 2019年第3期2卷 193-200页

作者： Jin-Hang liu li-ming yang Eric Ganz Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Key Laboratory of Material Chemistry for Energy Conversion and StorageMinistry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan China School of Physics and Astronomy University of MinnesotaMinneapolis MN USA

Organometallic nanosheets are a versatile platform for design of efficient electrocatalyst materials due to their high surface area and uniform dispersion of metal active *** this paper,we systematically investigate the electrocatalytic performance of the first transition metal series TM3–C12S12 monolayers on CO2 using spin-polarized density functional *** calculations show that M3–C12S12 exhibits excellent catalytic activity and selectivity in the catalytic reduction in *** main reduction products of Sc,Ti,and Cr are CH4.V,Mn,Fe and Zn mainly produce HCOOH,and Co produces HCHO,while CO is the main product for Ni and *** Sc,Ti,and Cr,the overpotentials are>0.7 V,while for V,Mn,Fe,Co,Ni,Cu,Zn,the overpotentials are very low and range from 0.27 to 0.47 ***,our results indicate that many of the M3–C12S12 monolayers are expected to be excellent and efficient CO2 reduction catalysts.

关键词： density functional theory electrocatalytic reduction of CO2 organometallic TM3-C12S12 Monolayers single atom catalyst two-dimensional materials

Single-atom catalysts based on two-dimensional metalloporphyrin monolayers for ammonia synthesis under ambient conditions

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Nano Research 2022年第5期15卷 4039-4047页

作者： Chun-Xiang Huang Sheng-Yao Lv Cong li Bin Peng Guoliang li li-ming yang Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Key Laboratory of Material Chemistry for Energy Conversion and StorageMinistry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationCenter for Computational Quantum ChemistrySchool of ChemistrySouth China Normal UniversityGuangzhou 510006China

We systematically investigated the catalytic performance of 3d,4d,and 5d transition metals anchored onto two-dimensional extended porphyrin(PP)substrates as nitrogen reduction reaction(NRR)electrocatalysts,employing density functional theory(DFT)calculations and four-step high-throughput *** novel metalloporphyrin(MPP,M=Zr,Nb,Hf,and Re)single-atom catalyst candidates have been identified due to their excellent catalytic performance(low onset potential,high stability,and selectivity).Through comprehensive reaction path search,the maximum Gibbs free energy changes for NRR on the ZrPP(enzymatic-consecutive hybrid path),NbPP(consecutive path),HfPP(enzymatic-consecutive hybrid path),and RePP(distal path)catalysts are 0.38,0.41,0.53,and 0.53 eV,*** structures,projected density of states,and charge/spin distributions show that the high catalytic activity is due to significant orbital hybridizations and charge transfer between N_(2) and MPP *** hope our work will promote experimental synthesis of these NRR electrocatalysts and provide new opportunities to the electrochemical conversion of N_(2) to NH_(3) under ambient conditions.

关键词： electrocatalytic nitrogen reduction reaction two-dimensional(2D)extended metalloporphyrin(MPP)monolayer singleatom catalyst two-dimensional materials high-throughput screening first-principles calculations