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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-ming Pan Wei li Rui-Qiong Ma Jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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地方高校《特种水泥》课程的教学改革与探讨

广州化工 2018年第12期46卷 166-167页

作者：张杨李宏林李明玲徐小勇巢湖学院安徽合肥238000

水泥工业是国民经济的重要基础产业,已经成为国民经济社会发展水平和综合实力的重要标志。虽然传统的硅酸盐水泥在建材行业广泛应用,但是硅酸盐水泥不能满足当代各种基础工程的需求,而要满足某些基础工程的特殊要求,则需要采用特种水泥... 详细信息

水泥工业是国民经济的重要基础产业,已经成为国民经济社会发展水平和综合实力的重要标志。虽然传统的硅酸盐水泥在建材行业广泛应用,但是硅酸盐水泥不能满足当代各种基础工程的需求,而要满足某些基础工程的特殊要求,则需要采用特种水泥。针对《特种水泥》课程教学方法和教学内容的改革问题等进行了探讨,为教学质量和内容适应特种水泥生产应用提出了改革思路。

关键词：特种水泥教学内容教学方法

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地方高校创新实验室建设与管理探索与实践

广州化工 2017年第9期45卷 221-223页

作者：李明玲高晓宝李雷高华敏巢湖学院化学与材料工程学院安徽合肥238000

大学生创新实验室在学生创新能力、实践能力的培养中起着非常重要的作用。本文介绍了地方新建本科院校在经费、场地有限的情况下,建设与管理化学类创新实验室的基本思路,通过制定完善的管理制度、创新运行模式、实行开放式管理等,建立... 详细信息

大学生创新实验室在学生创新能力、实践能力的培养中起着非常重要的作用。本文介绍了地方新建本科院校在经费、场地有限的情况下,建设与管理化学类创新实验室的基本思路,通过制定完善的管理制度、创新运行模式、实行开放式管理等,建立了适合新建地方本科院校创新实验室建设与管理的模式。经过实践,创新实验室开放运行取得了一定的效果,使本科生的创新实践能力上了一个台阶。

关键词：地方本科院校创新实验室建设管理运行

Two-Dimensional Indium Tellurides Layered Compounds Containing Supertetrahedral T2 and T3 Clusters

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Two-Dimensional Indium Tellurides Layered Compounds Containi...

On Douglas General(α,β)-metrics

中国化学会第六届全国结构化学学术会议

作者： Hua lin,~(?) li-ming Wu,~+ and ling Chen~(*,+) Key Laboratory of Optoelectronic Materials Chemistry and Physics,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,Fujian 350002, People’s Republic of China,and Graduate University of Chinese Academy of Sciences, Beijing 100039,People’s Republic of China

Two new indium tellurides,CsInTe and CsMnInTe,were prepared by solid-state *** compounds crystallize in space group C2/c(No.15),with a = 12.355(7)-12.400(7) A,b = 12.362(7)-12.400(7) A,c = 18.11(2)-24.32(2) A,β= 99.891(6)-97.31(2)°and Z = *** remarkable structure feature is the novel two-dimensional anionic layers made by supertetrahedral T2 clusters in the

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Acta Mathematica Sinica,English Series 2017年第7期33卷 951-968页

作者： Xiao ming WANG Ben ling li Department of Mathematics Ningbo UniversityNingbo 315211P.R.China

Douglas metrics are metrics with vanishing Douglas curvature which is an important projective invariant in Finsler geometry. To find more Douglas metrics, in this paper we consider a class of Finsler metrics called general （α, β）-metrics, which are defined by a Riemannian metric and a . We obtain the differential equations that characterizes these metrics with vanishing Douglas curvature. By solving the equivalent PDEs, the metrics in this class are totally determined. Then many new Douglas metrics are constructed.

关键词： Finsler metric general (α β)-metrics Douglas metric Douglas curvature

富集文库—菌落原位杂交法筛选栉孔扇贝的微卫星标记

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水产学报 2008年第3期32卷 353-361页

作者：战爱斌胡景杰胡晓丽王明玲彭薇李艳李纪勤包振民中国海洋大学海洋生命学院海洋生物遗传与种质工程实验室中国海洋大学海洋生命学院海洋生物遗传与种质工程实验室山东青岛266003

应用微卫星富集文库—菌落原位杂交法,筛选得到了40个栉孔扇贝的微卫星标记。用固定了(AG)15和(AC)15探针的尼龙膜(Hybond N+)捕捉含有微卫星DNA的片段,经洗脱、PCR扩增和TA克隆,构建栉孔扇贝的微卫星富集文库。利用ECL试剂盒(Amersham... 详细信息

应用微卫星富集文库—菌落原位杂交法,筛选得到了40个栉孔扇贝的微卫星标记。用固定了(AG)15和(AC)15探针的尼龙膜(Hybond N+)捕捉含有微卫星DNA的片段,经洗脱、PCR扩增和TA克隆,构建栉孔扇贝的微卫星富集文库。利用ECL试剂盒(Amersham公司)标记的(AG)15和(AC)15探针进行菌落原位杂交筛选微卫星富集文库,阳性克隆经测序获得微卫星DNA。富集文库中1200个重组克隆经过菌落原位杂交后,532个(44.3%)为阳性克隆。任意挑选100个克隆测序,结果显示所有的克隆都至少含有一个微卫星位点。利用软件设计了65对特异性PCR引物,40对能扩增出清晰的带谱;利用48个栉孔扇贝个体评价微卫星位点,分析表明37个位点具有多态性。不同的位点获得的等位基因数目为2~14个不等,37个多态性位点共获得258个等位基因,平均每个位点获得7.0个等位基因。观测杂合度(Ho)、期望杂合度(He)及多态性信息含量值(PIC)的范围分别为0.1000~1.0000、0.1197~0.9831和0.1172~0.9782。结果表明,富集文库—菌落原位杂交法适合大规模筛选目标物种的微卫星标记。

关键词：栉孔扇贝富集文库菌落原位杂交微卫星标记多态性

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尺寸对椭圆钴纳米环磁特性的影响

福建师范大学学报（自然科学版） 2012年第6期28卷 52-55,59页

作者：叶晴莹陈水源李铭领吴洋洋黄志高福建师范大学物理与能源学院福建福州350108

利用Monte-Carlo方法模拟了不同长、短轴以及不同内径的椭圆钴纳米环的磁特性.模拟结果表明:对于偏心率较小的椭圆钴纳米环,当内径不大时,系统的磁滞回线与圆形钴纳米环的磁滞回线相当类似;当内径较大时,系统的磁滞回线与圆形钴纳米环... 详细信息

利用Monte-Carlo方法模拟了不同长、短轴以及不同内径的椭圆钴纳米环的磁特性.模拟结果表明:对于偏心率较小的椭圆钴纳米环,当内径不大时,系统的磁滞回线与圆形钴纳米环的磁滞回线相当类似;当内径较大时,系统的磁滞回线与圆形钴纳米环的结果有很大的不同.当椭圆的偏心率增大时,由于存在较多的过渡状态,系统磁滞回线的台阶变得更为平滑,这可以通过系统的磁化过程进行解释.当椭圆的偏心率较大时,由于出现了大量的过渡状态,系统的磁滞回线呈现的台阶变得更加平滑.

关键词：椭圆钴纳米环 Monte-Carlo方法偏心率内径磁特性

Influence of Finish Rolling Temperature on Microstructure and Mechanical Properties of a 19Cr1.5Mo0.5W Ferritic Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2020年第7期33卷 991-1000页

作者： Hou-Long liu ling-ling liu ming-Yu Ma li-Qing Chen State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

A 444-type heat-resistant ferritic stainless steel containing 0.05 wt% Ce(rare earth element) and 2 wt%(Mo+W) was adopted as an experimental material to study the effect of finish rolling temperature on microstructure and texture evolution as well as on mechanical properties and *** rolling processes contain hot rolling at two different finish rolling temperatures(860℃ and 770℃) and annealing,cold rolling and subsequent *** was found that the microstructures after hot rolling and annealing could be refined by lowering finish rolling *** resultant microstructures after cold rolling and annealing were hereditarily *** finish rolling temperature can weaken α-fiber texture in hotrolled or cold-rolled ferritic stainless steel strip,while γ-fiber texture in the final product was homogeneously ***,enhanced mechanical property and formability in terms of strength and average plastic strain ratio could be obtained via decreasing finish rolling temperature.

关键词： steel Microstructure microstructure

Actomyosin is Involved in the Organization of the Microtubule Preprophase Band in Arabidopsis Suspension Cultured Cells

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Journal of Integrative Plant Biology 2006年第1期48卷 53-61页

作者： Chun-li li Zhi-ling Chen ming Yuan State Key Laboratory of Plant Physiology and Biochemistry Department of Plant Sciences College of Biological Sciences China Agricultural University Beijing 100094 China College of life Sciences Capital Normal University Beijing 100037 China

The microtubule preprophase bands （PPBs） participate in the sequence of events to position cell plates in most plants. However, the mechanism of PPB formation remains to be clarified. In the present study, the organization of PPBs in Arabidopsis suspension cultured cells was investigated by confocal laser scanning microscopy combined with pharmacological treatments of reagents specific for the cytoskeleton elements. Double staining of F-actin and microtubules （MTs） showed that actin filaments were arranged randomly and no colocalization with cortical MTs was observed in the interphase cells. However, cortical actin filaments showed colocalization with MTs during the formation of PPBs. A broad actin band formed with the broad MT band in the initiation of PPB and narrowed down together with the MT band to form the PPB. Nevertheless, broad MT bands were formed but failed to narrow down in cells treated with the F-actin disruptor latrunculin A. In contrast, in the presence of the F-actin stabilizer phalloidin, PPB formation did not exhibit any abnormality. Therefore, the integrity, but not the dynamics, of the actin cytoskeleton is necessary for the formation of normal PPBs. Treatment with 2, 3-butanedine monoxime, a myosin inhibitor, also resulted in the formation of broad MT bands, indicating that actomyosin may be involved in the rearrangement of MTs to form the PPBs. Double staining of MTs and myosin revealed that myosin concentrated on the PPB region during PPB formation. It is suggested that the actin cytoskeleton at the PPB site may serve as a rack to transport cortical MTs by using myosin when the broad MT band narrows down to form the PPB.

关键词： Arabidopsis suspension cultured cell 2,3-butanedine monoxime microfilament microtubule preprophase band myosin.