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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan li Xi liu Wenping liang Yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng li Pasquale Cepparulo Amy Kemper Chao li li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao li Chang liu Shusheng Tao Jieming Cai Biao Zhong Jie li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

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巡飞弹空中自适应快速初始姿态估计

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光学精密工程 2017年第2期25卷 493-501页

作者：李增彦李小民刘秋生周兆英军械工程学院无人机工程系河北石家庄050003 清华大学精密仪器系北京100084 军械工程学院弹药工程系河北石家庄050003

为了解决巡飞弹空中上电后在无参考姿态条件下的初始姿态确定问题,采用低成本磁力计、陀螺仪和加速度计(MARG)传感器设计姿态航向参考系统(AHRS),并提出了一种自适应参考矢量权重的快速初始姿态估计(AFCF)算法。首先,提出了三轴传感器... 详细信息

为了解决巡飞弹空中上电后在无参考姿态条件下的初始姿态确定问题,采用低成本磁力计、陀螺仪和加速度计(MARG)传感器设计姿态航向参考系统(AHRS),并提出了一种自适应参考矢量权重的快速初始姿态估计(AFCF)算法。首先,提出了三轴传感器使用前的快速误差校准方法;然后,采用快速互补滤波算法进行姿态估计,分析了其权重函数对于初始姿态估计及收敛性等的影响;接着,提出自适应参考矢量权重及自适应姿态估计方法;最后,利用高精度MTI(Milliren Technologies,Inc)传感器数据对算法进行了验证,并在低成本MARG姿态航向参考系统中对算法进行了实现,对比了改进算法及扩展卡尔曼滤波(EKF)算法的性能。实验结果与分析表明:动态条件下采用MTI传感器数据,改进算法能够在初始时刻收敛,比快速互补滤波(FCF)算法提前约4s;解算精度约为±0.6°,初始时刻精度明显优于FCF;硬件测试则表明改进算法的处理时间为0.062ms,仅为EKF算法的1/9,解算精度约为±1.3°,能够满足姿态测量过程快速收敛、高精度、实时性等要求。

关键词：巡飞弹初始姿态估计互补滤波最优矢量估计

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北京城乡中老年人健康体检当前行为与潜在需求研究

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人口与发展 2018年第2期24卷 79-89页

作者：李敏刘华富北京农学院文法学院北京102206 首都经济贸易大学经济学院北京100070 北京经济管理职业学院金融学院北京100102

在人口老龄化和健康中国背景下,探讨北京城乡中老年人健康体检当前行为和潜在需求。使用描述性统计,分析健康体检当前参与状况、体检间隔、驱动方式、潜在健康体检需求和相关服务需求;使用回归分析考察健康体检当前行为和潜在需求的影... 详细信息

在人口老龄化和健康中国背景下,探讨北京城乡中老年人健康体检当前行为和潜在需求。使用描述性统计,分析健康体检当前参与状况、体检间隔、驱动方式、潜在健康体检需求和相关服务需求;使用回归分析考察健康体检当前行为和潜在需求的影响因素。城乡中老年人对健康体检认知较好,以年度定期体检为主,机构选择以医院为主,专业体检机构呈上升态势,单位组织、社区/村委会组织和自发体检为主要驱动方式,健康体检潜在需求远高于当前行为;性别、经济收入、居住地和健康体检认知对健康体检当前行为影响显著,经济收入和健康体检认知对潜在需求有显著影响。就提高健康体检参与率提出相关建议。

关键词：城乡地区健康体检体检认知当前行为潜在需求

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Seasonal variations and bioavailability of inorganic phosphorus in soils of Yeyahu Wetland in Beijing,China

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International Journal of Sediment Research 2011年第2期26卷 181-192页

作者： ZHANG Jing,li min,liu Shuang,liu Yujin,ZHANG liqiang,CAO Qi,and SUN Dezhi 1 Ph.D.student,~ 2 Assoc,Prof,~(3,6) Master,~7 Prof,College of Environmental Science and Engineering,Beijing Forestry University,Beijing,P.R.China,100083 ~(4,5) Senior Engineer,Beijing Yanqing Yeyahu Wetland Nature Reserve,Beijing,P.R.China,102101 [a]Ph.D. student College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 [b]Assoc. Prof. College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 [c]Master College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 [f]Master College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 [g]Prof. College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 [d]Senior Engineer Beijing Yanqing Yeyahu Wetland Nature Reserve Beijing P.R. China 102101 [e]Senior Engineer Beijing Yanqing Yeyahu Wetland Nature Reserve Beijing P.R. China 102101

Phosphorus(P) in soils has an important influence on the development and productivity of wetland. The objective of this study was to investigate the distribution,bioavailability and seasonal variations of inorganic phosphorus(IP) in soils of Yeyahu *** results showed that the concentration of Ca-bound P(Ca-P) remained the main occurrence in all IP fractions despite the season,at the same time the Al-bound P(Al-P) was always the lowest IP fraction despite the ***-P and Fe-bound P (Fe-P) concentration were all reached the highest value in May and the lowest in November,which was opposite to the occluded P(Oc-P) *** notable higher Oc-P concentration in November observed in this study was probably due to the decomposition of plants and the subsequently releasing of oxides to ***-P didn’t change much with season *** P(Ex-P) and Oc-P were all positively correlated with soil moisture content and organic matter content,but Al-P was negatively correlated with these two soil *** a stable form,Ca-P was not associated with soil ***-P,Fe-P and Ca-P might contribute to the storage of P in studied wetland with the principle component analysis *** concentration rank order of the bio-available P in soils was generally as follows:Olsen-P > Algal available P(AAP) > Water soluble P(WSP) > Readily desorbed P(RDP).Olsen-P was positively correlated with Ex-P and Oc-P,and it was thought to be a more suitable indicator for bio-available P in soils.

关键词： Inorganic phosphorus fractions Distribution Bioavailability Seasonal variations

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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政府购买体育服务的项目制选择与治理成效

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北京体育大学学报 2016年第11期39卷 1-8页

作者：李克敏刘春华天津市体育局天津300051 天津财经大学博士后流动站天津300222 天津体育学院天津300381

旨在探究政府购买体育服务选择项目制的根源及治理效果,推动政府体育购买的专业化、精准化和便捷化,为进一步完善政府购买公共体育服务提供理论参考。以文献资料法为主,通过对社会制度变迁中社会治理方式的变化分析体育购买服务选择项... 详细信息

旨在探究政府购买体育服务选择项目制的根源及治理效果,推动政府体育购买的专业化、精准化和便捷化,为进一步完善政府购买公共体育服务提供理论参考。以文献资料法为主,通过对社会制度变迁中社会治理方式的变化分析体育购买服务选择项目制而非社区制的原因以及体育项目制的特征。研究发现:由于社区体育设施基础薄弱、社区体育组织能力不足以及财政转移支付的全面深入,项目制成为了当前政府购买体育公共服务的主要方式,这是制度主体和客观历史条件的选择,是多中心治理体系的要求,其有效促进了社会组织的发展以及专业性服务的提供;建议继续深化体育行政体制改革,以政策为保障,以制度为依托,以创新为动力,积极吸纳社会资源与组织参与社会治理,发展和完善政府购买体育的模式和机制。研究项目制并不是为了否认其它模式,它们处于同一起跑线,都是新近政府行为中付诸实践的组织模式,不存在制度依赖、路径依赖以及存增量依赖问题。

关键词：公共体育服务政府购买社会治理社区体育项目制社区制

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