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Discrimination of biothiols in different media with NBD-F as the probe

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Chinese Chemical Letters 2016年第3期27卷 330-334页

作者： Lun Song li-min ma Qian Sun Wei-Bing Zhang min-Bo Lan Jun-Hong Qian Shanghai Key Laboratory of Functional materials Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and Technology Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and Technology

4-Fluoro-7-nitrobenzo-2-oxa-1,3-diazole（NBD-F） was employed as a colorimetric probe for differential detection of biothiols in different media. The spectral response and the selectivity of NBD-F toward thiols were significantly improved by surfactant micelles. Mercapto group exhibited high reactivity in all the solvents（including Tris–HCl buffer solution, CTAB and SDS micelles）. The 4-thioether derivatives of NBDF reacting with Cys and Hcy but not GSH could transfer to the corresponding 4-amino-substituents via intramolecular nucleophilic aromatic substitution, thus, GSH could be discriminated from Cys/Hcy. In CTAB micelles, the reaction product of NBD-F with Cys is non-fluorescent and it absorbs in longwavelength region. According to the spectral responses of NBD-F toward different low-molecularweight thiols, we could identify Cys, Hcy and GSH from each other.

关键词： NBD-F Biothiols Surfactant micelles Fluorescent probe

Identification of Early Warning Signals of Infectious Diseases in Hospitals by Integrating Clinical Treatment and Disease Prevention

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Current Medical Science 2024年第2期44卷 273-280页

作者： Lei ZHANG min-ye li Chen ZHI min ZHU Hui ma Sixth Medical Center Chinese PLA General HospitalBeijing100048China The Nursing Department Chinese PLA General HospitalBeijing 100853China

The global incidence of infectious diseases has increased in recent years,posing a significant threat to human *** typically serve as frontline institutions for detecting infectious ***,accurately identifying warning signals of infectious diseases in a timely manner,especially emerging infectious diseases,can be ***,there is a pressing need to integrate treatment and disease prevention data to conduct comprehensive analyses aimed at preventing and controlling infectious diseases within *** paper examines the role of medical data in the early identification of infectious diseases,explores early warning technologies for infectious disease recognition,and assesses monitoring and early warning mechanisms for infectious *** propose that hospitals adopt novel multidimensional early warning technologies to mine and analyze medical data from various systems,in compliance with national strategies to integrate clinical treatment and disease ***,hospitals should establish institution-specific,clinical-based early warning models for infectious diseases to actively monitor early signals and enhance preparedness for infectious disease prevention and control.

关键词： infectious disease disease prevention and control medical data warning signals

Prevalence and risk factors of diabetes mellitus among elderly patients in the Lugu community

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World Journal of Diabetes 2024年第4期15卷 638-644页

作者： li-Zhen Zhao Wei-min li Ying ma Lugu Community Health Service Center West Campus Beijing Chao-yang Hospital Affiliated to Capital Medical UniversityBeijing 100043China

BACKGROUND Age is a significant risk factor of diabetes mellitus(DM).With the develop of population aging,the incidence of DM remains *** the epidemiology of DM among elderly individuals in a certain area contributes to the DM interventions for the local elderly individuals with high risk of *** To explore the prevalence of DM among elderly individuals in the Lugu community and analyze the related risk factors to provide a valid scientific basis for the health management of elderly *** A total of 4816 elderly people who came to the community for physical examination were retrospectively *** prevalence of DM among the elderly was *** individuals were divided into a DM group and a non-DM group according to the diagnosis of DM to compare the differences in diastolic blood pressure(DBP)and systolic blood pressure(SBP),fasting blood glucose,body mass index(BMI),waist-to-hip ratio(WHR)and incidence of hypertension(HT),coronary heart disease(CHD),and chronic kidney disease(CKD).RESULTS DM was diagnosed in 32.70%of the 4816 elderly *** BMI of the DM group(25.16±3.35)was greater than that of the non-DM group(24.61±3.78).The WHR was 0.90±0.04 in the non-DM group and 0.90±0.03 in the DM group,with no significant *** left SBP and SBP in the DM group were 137.9 mmHg±11.92 mmHg and 69.95 mmHg±7.75 mmHg,respectively,while they were 126.6 mmHg±12.44 mmHg and 71.15 mmHg±12.55 mmHg,respectively,in the non-DM *** findings indicate higher SBP and lower DBP in DM patients than in those without *** the DM group,1274 patients were diagnosed with HT,accounting for 80.89%.Among the 3241 non-DM patients,1743(53.78%)were hypertensive and 1498(46.22%)were *** DM group had more cases of HT than did the non-DM *** were more patients with CHD or CKD in the DM group than in the non-DM *** were more patients who drank alcohol more frequently(≥3 times)in the DM group than in the no

关键词： Diabetes mellitus Type 2 diabetes mellitus Elderly Risk factors

Design and grindability assessment with cup shaped electroplated CBN wheel grinding turbine disc slots of powder metallurgy superalloy FGH96

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Chinese Journal of Aeronautics 2024年第9期37卷 521-534页

作者： Benkai li Wenfeng DING YeJun ZHU Changhe li Yanbin ZHANG min YANG Xiao ma mingzheng liU Xin CUI School of Mechanical Engineering Qingdao University of TechnologyQingdao 266520China National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Engineering Nanjing Agricultural UniversityNanjing 210031China

The machining surface integrity of aero-engine turbine disc slots has a significant impact on their fatigue life and service performance,and achieving efficiency and high-precision machining is still a great *** high machining requirements of future aeroengine turbine disc slots will be difficult to satisfy using the broaching *** addition,existing methods of slot machin-ing face difficulties in ensuring surface *** study explored a cup shaped electroplated Cubic Boron Nitride(CBN)abrasive wheel for profile grinding the turbine disc slots of FGH96 powder metallurgy *** matrix structure of the cup shaped abrasive wheel was designed and verified.A profile grinding experiment was conducted for fir-tree slots on a five-axis machining *** accuracy and the surface integrity were *** show that the key dimension detection results of the slots were within the allowable tolerance ***,an average sur-face roughness Ra of 0.55μm was achieved,the residual stress was compressive,the plastic defor-mation layer thickness was less than 5μm,and the hardening layer thickness was less than 20μ*** research findings provide a new approach to machining the slots of aviation engine turbine discs and guidance for the high-quality processing of complex components.

关键词： Profile grinding Surface integrity Cup shaped CBN abrasive wheel Turbine disc slots FGH96

Labial inverse dilaceration of bilateral maxillary central incisors: A case report

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World Journal of Clinical Cases 2024年第1期12卷 180-187页

作者： Jun-min Wang li-Feng Guo li-Qiong ma Jing Zhang Stomatological Hospital and College Key Laboratory of Oral Diseases Research of Anhui ProvinceAnhui Medical UniversityHefei 230032Anhui ProvinceChina Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Dilaceration is a rare dental developmental anomaly characterized by an abrupt deviation along the longitudinal axis of the root in which an angulation forms between the root and the ***,we report on dilacerated bilateral maxi-llary central incisors in mixed *** SUMmaRY A 10-year-old girl presented with a chief complaint of unerupted central *** oral examination and radiography provided the basis for a diagnosis of dilaceration of the maxillary central *** surgical exposure of the impacted teeth,a button with an attached chain was applied to the palatal surface of teeth 11 and *** 8 mo,a button was bonded to the labial surface of the crown to fix an elastic chain and move the teeth toward the maxillary ***,a fixed appliance was applied to tooth alignment to Class 1 malocclusion using a 0.019×0.025-inch nickel-titanium *** 3 years of follow-up,the clinical findings and radiographic assessment showed that the roots had developed with vital dental pulp and healthy periodontium,were acceptable aesthetically,and showed no *** The rare occurrences of dilacerated bilateral maxillary central incisors can be successfully treated through surgical exposure and orthodontics.

关键词： Dilaceration Traumatic injury Central incisors Child Primary tooth Case report

The Non-inclusion Diagnosability of Hypercubes Under the PMC Model

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Journal of the Operations Research Society of China 2024年第2期12卷 478-484页

作者： Mei-Jie ma min Xu Tong-Tong Ding Xiang-Jun li Qiang Zhu School of mathematics and Statistics Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina School of mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875China School of Information and mathematics Yangtze UniversityJingzhou 434023HubeiChina School of mathematics and Statistics XiDian UniversityXi'an 710071ShaanXiChina

Diagnosability of a multiprocessor system is an important measure of the reliability of interconnection ***-level diagnosis is a primary strategy to identify the faulty processors in a multiprocessor *** on a sound assumption proposed by Zhu et ***,we proposed a new diagnosability named non-inclusion diagnosability and showed that the non-inclusion diagnosability t_(N)(Q_(n))of the hypercube under the PMC model is *** is,assume that if two vertex sets F_(1) and F_(2) are both consistent with a syndrome and F_(1)C F_(2),then F_(2) is not the faulty set which we are looking for;the faulty set F is 1-step diagnosable if|F|≤2n-2 in Q_(n) under the PMC model.

关键词： Interconnection network Diagnosability Hypercube PMC model

Pseudomonotonicity of Nonlinear Transformations on Euclidean Jordan Algebras

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Acta mathematicae Applicatae Sinica 2024年第1期40卷 192-204页

作者： Yuan-min li School of mathematics and Statistics Xidian UniversityXi’an710071China

In this paper, we have introduced the concepts of pseudomonotonicity properties for nonlinear transformations defined on Euclidean Jordan algebras. The implications between this property and other P-properties have been studied. More importantly, we have solved the solvability problem of the nonlinear pseudomonotone complementarity problems over symmetric cones.

关键词： Euclidean Jordan algebra nonlinear transformation complementarity problem pseudomonotone

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma lin li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

On the Security of Homomorphic Encryption Schemes with Restricted Decryption Oracles

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Journal of Systems Science & Complexity 2024年第5期37卷 2240-2261页

作者： ma Guangsheng li Hongbo School of mathematics and Physics North China Electric Power UniversityBeijing 100096China Academy of mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Fully homomorphic encryption(FHE)can be used for privacy-preserving aggregation of medical *** this typical application,the security against passive attacks has been well studied by li and Micciancio(2021).In this paper,the authors further consider a“nearly passive”kind of attack,where the attacker may behave like a passive attacker in the view of the third-party *** capture the security against this hard-to-detect attack,the authors propose a new notion of IND-CPA^(rD)*** authors show that the standard LWE encryption and its related FHE schemes can not defend against IND-CPA^(rD)attack,even under a stricter rule limiting the content and number of queries made by the *** make the application of FHE schemes more secure,the authors discuss some possible modifications that may serve as countermeasures to IND-CPA^(rD)attack.

关键词： Homomorphic encryption privacy secure cloud computing security