检索结果-南通市图书馆

Carcinoembryonic antigen,carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

引用

World Journal of Gastrointestinal Oncology 2023年第8期15卷 1475-1485页

作者： Ran Wang Chun-Lei Zuo Rui Zhang li-mei zhu Department of Medical Laboratory The First People’s Hospital of LianyungangLianyungang 222002Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor of the digestive system with a high degree of *** usually develops insidiously without any specific symptoms in the early *** one of the diseases caused by abnormal gene changes,GC has abnormal expression of various oncogenes and products during its *** markers such as carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 724(CA724)are not expressed or lowly expressed in normal people,but significantly increased after *** the changes in the levels of tumor markers such as CEA,CA199 and CA724 is conducive to early diagnosis and evaluation of the occurrence of some solid *** To investigate the expression of CEA,CA199 and CA724 in GC and their correlation with clinical features,hoping to provide more effective markers for the early preventive diagnosis of *** Of 87 patients with GC admitted to our hospital from September 2020 to December 2021 were included in the GC group,and another 80 healthy people who came to our hospital for physical examination with normal results during the same period were selected as the control *** serum CEA,CA199,and CA724 levels were compared between the two groups,and the serum CEA,CA199,and CA724 levels were compared in patients with GC at different TNM stages,and the differences in the positive rates of CEA,CA199,and CA724 alone and in combination in detecting TNM stages of GC and GC were *** addition,the relationship between the levels of tumor markers CEA,CA199 and CA724 and the clinicopathological characteristics of GC patients was also *** relationship between the serum levels of CEA,CA199 and CA724 and the survival period of GC patients was analyzed by *** The serum levels of CEA,CA199 and CA724 in GC group were significantly higher than those in control group(P<0.05).With the increase of TNM stage,the serum CEA,CA199 and CA724 expression levels

关键词： Carcinoembryonic antigen Carbohydrate antigen 199 Carbohydrate antigen 724 Gastric cancer TNM stage Clinicopathologic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma

引用

Chinese Journal of Cancer 2011年第5期30卷 336-343页

作者： li Guo zhu-mei Cui Jia Zhang Yu Huang Department of Gynecology Affiliated Hospital of Qingdao Medical College Qingdao Shandong 266003 P. R. China

Recent evidence suggests that the chemokine axis of CXC chemokine ligand-12 and its receptor CXC chemokine receptor-4(CXCL12/CXCR4) is highly expressed in gynecological tumors and the axis of CXC chemokine ligand-16 and CXC chemokine receptor-6(CXCL16/CXCR6) is overexpressed in inflammation-associated *** study aimed to determine the relationship between CXCL12/CXCR4,CXCL16/CXCR6 and ovarian carcinoma's clinicopathologic features and ***,the expression of these proteins in ovarian tissues was detected by tissue microarray and *** expressions of CXCL12/CXCR4 and CXCL16/CXCR6 were significantly higher in epithelial ovarian carcinomas than in normal epithelial ovarian tissues or benign epithelial ovarian *** expression of chemokines CXCL12 and CXCL16 were positively correlated with their receptors CXCR4 and CXCR6 in ovarian carcinoma,respectively(r = 0.300,P liferation,invasion,and metastasis of epithelial ovarian carcinoma.

关键词：趋化因子受体上皮组织卵巢癌淋巴结 CXCR4 轴移相病理特征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic Performance of the GenoType MTBDRplus and MTBDRs/Assays to Identify Tuberculosis Drug Resistance in Eastern China

引用

Chinese Medical Journal 2017年第13期130卷 1521-1528页

作者： Qiao liu Guo-li li Cheng Chen Jian-Ming Wang Leonardo Martinez Wei Lu li-mei zhu Department of Chronic Communicable Disease Center for Disease Control and Prevention of Jiangsu Province Nanjing Jiangsu 210009 China Department of Epidemiofogy and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China Department of Epidemiology and Biostatistics University of Georgia School of Public Health Athens 21401 Georgia USA Center for Global Health University of Georgia School of Public Health Athens 21401 Georgia USA

Background： The WHO recently has recommended the GenoType MTBDRph/s version 1.0 and MTBDRs/version 1.0 assays for widespread use in countries endemic with drug-resistant tuberculosis. Despite this, these assays have rarely been evaluated in China, where the burden of drug-resistant tuberculosis is among the highest globally. Methods： Mycobacterium tuberculosis clinical isolates were obtained between January 2008 and December 2008. Isolates were tested for drug resistance against rifampicin （RFP） and isoniazid （INH） using the GenoType MTBDRplus assay and drug resistance against ethambutol （EMB）, ofloxacin （OFX）, and kanamycin （KM） using the Genotype MTBDILsl assay. These results were compared with conventional drug-susceptibility testing （DST）. Results： Readable results were obtained from 235 strains by GenoType MTBDRphts assay. Compared to DST, the sensitivity of GenoType MTBDRplus assay to detect RFP, INH, and multidrug resistance was 97.7%, 69.9%, and 69.8%, respectively, whereas the specificity for detecting RFP, INH, and multidrug resistance was 66.7%, 69.2%, and 76.8%, respectively. The sensitivity and specificity of the GenoType MTBDRsl assay were 90.9% and 95.2% for OFX, 77.8% and 99.5% for KM, 63.7% and 86.4% for EMB, respectively. Mutations in codon S531L of the rpoB gene and codon S315T1 ofKatG gene were dominated in multidrug-resistant tuberculosis （MDR-TB） strains. Conclusions： In combination with DST, application of the GenoType MTBDRplus and MTBDRsl assays may be a useful supplementary tool to allow a rapid and sale diagnosis of multidrug resistance and extensively drug-resistant tuberculosis.

关键词： GenoType MTBDRplus Assay: GenoType MTBDRsl Assay Multidrug-resistant Tuberculosis Rapid Diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dickkopf-1 has an Inhibitory Effect on Mesenchymal Stem Cells to Fibroblast Differentiation

引用

Chinese Medical Journal 2016年第10期129卷 1200-1207页

作者： Yan li Sang-Sang Qiu Yan Shao Hong-Huan Song Gu-li li Wei Lu li-mei zhu Department of Chronic Communicable Disease Jianqsu Provincial Center for Disease Prevention and Control Nanjing Jiangsu 210009 China Department of Infection Management Affiliated Wuxi People's Hospital to Nanjing Medical University Wuxi Jiangsu 214023 China

Background： Mesenchymal stem cells （MSCs） are bone marrow stem cells which play an important role in tissue repair. The treatment with MSCs will be likely to aggravate the degree of fibrosis. The Wnt/β-catenin signaling pathway is involved in developmental and physiological processes, such as fibrosis. Dickkopfs （DKKs） are considered as an antagonist to block Wnt/β-catenin signaling pathway by binding the receptor of receptor-related protein （LRP5/6）. DKK1 was chosen in attempt to inhibit fibrosis of MSCs by lowering activity of Wnt/β-catenin signaling pathway. Methods： Stable MSCs were randomly divided into four groups： MSCs control, MSCs ＋ transforming growth factor-β （TGF-β）, MSCs ＋ DKK1, and MSCs ＋ TGF-β ＋ DKK1. Flow cytometry was used to identify MSCs. Cell viability was evaluated by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphenyl-2-H-tetrazolium bromide test. lmmunofluorescence was used to detect protein expression in the Wnt/β-catenin signaling pathways. Western blotting analysis was employed to test expression of fibroblast surface markers and, finally, real-time reverse transcription polymerase chain reaction was employed to test mRNA expression offibroblast surface markers and Wnt/β-catenin signaling proteins. Results： Cultivated MSCs were found to conform to the characteristics of standard MSCs： expression of cluster of differentiation （CD） 73, 90, and 105, not expression of 34, 45, and 79. We found that DKK1 could maintain the normal cell morphology of MSCs. Western blotting analysis showed that fibroblast surface markers were expressed in high quantities in the group MSCs ＋ TGF-β. However, the expression was lower in the MSCs ＋ TGF-β ＋ DKK1. Immunofluorescence showed high expression of all Wnt/β-catnin molecules in the MSCs ＋ TGF-β group but expressed in lower quantities in MSCs ＋ TGF-β ＋ DKK1 group. Finally, mRNA expression of fibroblast markers vimentin, α-smooth muscle actin and Wnt/β-catenin signaling proteins β-catenin, T-cell factor, and glycogen syntha

关键词： Dickkopfs-1 Fibrosis Mesenchymal Stem Cells Wnt/β-catenin Signaling Pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of hepatitis B virus on p53 expression in hepatoma cell line SMMU-7721

引用

World Journal of Gastroenterology 2005年第39期11卷 6212-6215页

作者： Jian-Hui Qu Ming-Hua zhu Jing lin Can-Rong Ni Fang-mei li Zhi zhu Guan-Zhen Yu Department of Pathology the Second Military Medical University Shanghai 200433 China

AIM： To investigate the contribution of HBV in the development of hepatocarcinoma by examining the effects of HBV on p53 function in SMMU-7721 cell line, METHODS： Ptasrnid pCMVp53 was transfected or cotransfected with pCMVHBVa （wild-type HBV） or PCMVHBVb （mutation type HBV） into the hepatoma cell line SMMU-7721 by lipofectamine. Apoptosis cells were labeled with annexin V-FITC and confirmed by flow cytometry. Reporter plasmid PG13-CAT or p21-1uc was cotransfected, respectively, into each group to determine the transactivation activity of p53 and its effect on p21 promoter. Western blot was performed to observe p53 expression in hepatoma cell line of each group. RESULTS： The group transfected with pCMVp53 alone exhibited higher luciferase activity and higher apoptosis rate, otherwise, the p53 expression and reporter activity of PG13-CAT or P21-1uc as well as cell apoptosis rate were obviously higher in the group cotransfected of pCMVp53 with pCMVHBVa, but not in the other cotransfected group, CONCLUSION： Transient transfection of HBV into the SMMU-7721 cell line can enhance p53 expression and its effects on development of hepatocarcinoma.

关键词： Hepatitis B virus p53 p21 Hepatoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

活塞环Cu-Sn镀层对球墨铸铁缸套摩擦性能影响

引用

内燃机学报 2017年第5期35卷 473-479页

作者：李斌沈岩李承娣金梅朱峰徐久军大连海事大学船机修造工程交通行业重点实验室辽宁大连116026

针对高强化工况下活塞环Cu-Sn镀层对珩磨球墨铸铁缸套摩擦磨损性能的影响,采用往复式摩擦磨损试验机,选择单层镀Cr活塞环和多层镀Cu-Sn/Cr活塞环开展摩擦磨损试验,测量摩擦系数和缸套磨损量,分析磨损后的摩擦面形貌和成分.结果表明:相... 详细信息

针对高强化工况下活塞环Cu-Sn镀层对珩磨球墨铸铁缸套摩擦磨损性能的影响,采用往复式摩擦磨损试验机,选择单层镀Cr活塞环和多层镀Cu-Sn/Cr活塞环开展摩擦磨损试验,测量摩擦系数和缸套磨损量,分析磨损后的摩擦面形貌和成分.结果表明:相比单层镀Cr活塞环,多层镀Cu-Sn/Cr活塞环与球墨铸铁缸套配对时的摩擦系数和缸套磨损量分别降低2.6%和51.8%;磨损后的缸套表面形貌呈现平坦凸峰,形成了更为平整的平台结构.活塞环Cu-Sn镀层在摩擦磨损过程中会镶嵌到缸套表面,有助于在摩擦表面形成化学反应膜,改善摩擦副微凸体间的接触和摩擦状态,提升球墨铸铁缸套的摩擦磨损性能.

关键词： Cu-Sn镀层活塞环球墨铸铁缸套摩擦磨损性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

问卷调查数据质量策略在院校研究中的应用

引用

复旦教育论坛 2013年第2期11卷 46-53页

作者：刘勤李竹梅多伦多大学安大略教育研究院复旦大学高等教育研究所上海200433

本文旨在基于调查总误差理论(total survey error theory),为高校的院校研究人员构建一套问卷调查的数据质量策略。本文首先描述了院校研究的特征,论述了院校研究数据质量问题上有关文献中的空缺之处,然后介绍了如何从质量的视角考察调... 详细信息

本文旨在基于调查总误差理论(total survey error theory),为高校的院校研究人员构建一套问卷调查的数据质量策略。本文首先描述了院校研究的特征,论述了院校研究数据质量问题上有关文献中的空缺之处,然后介绍了如何从质量的视角考察调查过程以及调查总误差的主要组成部分。本文中提出的数据质量策略从五种调查误差和院校研究调查项目的典型特征出发,该策略由确定每种调查误差的质量标准,进而确定每个质量标准的质量控制和质量保证程序组成。结论部分提出这一策略对院校研究人员的启示,并阐述一些总结性思考。附录中提供了一份检查调查数据质量的核查列表。

关键词：院校研究问卷调查数据质量调查总误差理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distal tibial fracture： An ideal indication for external fixation using locking plate

引用

Chinese Journal of Traumatology 2016年第2期19卷 104-108页

作者： Jing-wei Zhang Nabil A. Ebraheim Ming li Xian-Feng He Joshua Schwind li-mei zhu Yi-Hui Yu Orthopaedic Surgery Ningbo 6th Hospital 1059 East Zhongshan Road Ningbo 315040 Zhejiang Province China Department of Orthopaedic Surgery University of Toledo Toledo OH 42614 USA

Objective： To evaluate the feasibility and efficiency of one-stage external fixation by using locking plate in distal tibial fractures. Methods： In this non-control prospective study, 28 patients with distal tibial fractures were included and underwent one-stage external fixation by using locking plate. There were 21 males and 7 females, with a mean age of 43 years （19-63）. According to AO/OTA fracture classification, there were 9 cases of Type A1, 9 of Type A2, 10 of Type A3 fractures. There were 21 close and 7 open fractures. The locking plate was placed on the anteromedial aspect of the tibia with 4-5 bicortical screws inserted in both distal metaphysis and diaphysis. The radiographic and clinic results were evaluated. Results： All patients were followed up for the average of 16 months （ranging from 12 to 21 months）. The average surgery duration was 38 （25-60） minutes. The mean time to fracture healing were 14.6 ± 2.67, 17.5 ± 3.66, and 18.4±3.37 （p 〈 0.05） weeks in type A1, A2, and A3 fractures respectively. By the end of the follow-ups, the mean AOFAS score were 96.11 ± 2.32, 92.67 ± 1.80 and 92.00± 2.06 （p 〉 0.05） in type A1, A2, and A3 fractures respectively. None of nonunion, deep infection, or breakage of screw or plate were observed. Conclusions： Distal tibial fracture was the ideal indication for external fixation using locking plate. The external plating is characterized by ease of performance, less invasive, fewer soft tissue impingement, improved cosmesis, and convenient for removal.

关键词： Tibia fractureSurgeryExternal fixationLocking plate

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

发掘现代大学体育的通识教育内涵

引用

复旦教育论坛 2011年第6期9卷 41-44页

作者：王震李竹梅复旦大学体育教学部上海200433 复旦大学高等教育研究所上海200433

通识教育作为一种大学教育理念,以"人"为逻辑起点,体现着强烈的人文精神。大学体育同样具有深厚的人文性。然而,忽视作为身体主体的"人"的教育,是当前大学体育教育之病。发掘体育的人文内涵,丰富大学的通识教育,将大学体育纳入通识教育... 详细信息

通识教育作为一种大学教育理念,以"人"为逻辑起点,体现着强烈的人文精神。大学体育同样具有深厚的人文性。然而,忽视作为身体主体的"人"的教育,是当前大学体育教育之病。发掘体育的人文内涵,丰富大学的通识教育,将大学体育纳入通识教育视野,是提高大学体育质量的应有之义。

关键词：通识教育大学体育人文关怀

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modification of Maxwell model for conductivity prediction of carbon nanotubes-filled polymer composites with tunneling effect

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 25-36页

作者： Jue zhu Longyuan li Ningtao zhu Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and Pipeline Key Laboratory of Impact and Safety Engineering (Ningbo University) Ministry of Education School of Engineering Computing and Mathematics University of Plymouth Xi'an Zhanshi Testing & Engineering Co.Ltd.

Carbon nanotubes(CNTs) have garnered great attention in recent years due to their outstanding electrical, thermal, and mechanical properties. The incorporation of small amounts of CNTs in polymers can substantially improve the sensitivity of the polymer's electrical conductivity. This paper presents a modified Maxwell model to evaluate the electrical conductivity of CNTs-filled polymer composites by introducing a transition zone to account for the tunneling effect. In this modified Maxwell model, the CNTs-filled polymer composite is modeled as a three-phase composite, consisting of a matrix(polymer), inclusions(CNTs), and a transition zone(tunneling zone). The effective electrical conductivity(EEC) of the composite is calculated based on the volume fractions and electrical conductivities of the matrix, inclusions, and transition zone. The model's validity is confirmed through the use of available test data, which demonstrates its capability to accurately capture the nonlinear conductivity behavior observed in CNTs-polymer composites. This study offers valuable insights into the design of high-performance conductive polymer nanocomposites, and enhances the understanding of electrical conduction mechanisms in CNT-dispersed polymer composites.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：