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Effects of pre-pregnancy body mass index on pregnancy outcomes

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Chinese Medical Journal 2013年第23期126卷 4585-4587页

作者： li Chun-ming li Guang-hui CHEN Yi RUAN Yan WANG Xin ZHANG Wei-yuan Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Prevalence of overweight and obesity has continued to increase among women of child bearing age all over the world in recent decades. Its impact on short-term and long-term maternal and fetal outcomes continued to grow, such as increased risk of gestational diabetes mellitus, gestational hypertension, preeclampsia, fetal macrosomia, perinatal mortality and chance for cesarean deliveries） What＇s more, underweight before pregnancy also has some hazardous effects on pregnant women and fetus, such as increased risk of delivering infants small for gestational age and preterm delivery.2 The present study determined the prevalence of each body mass index （BMI） group of an obstetric population of the mainland of China, and effects of the maternal pre-pregnancy BMI on multiple antepartum, intrapartum and neonatal outcomes.

关键词： body mass index obesity gestational diabetes mellitus preeclampsia fetal macrosomia

Apoptosis mechanisms of human gastric cancer cell line MKN-45 infected with human mutant p27

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World Journal of Gastroenterology 2005年第47期11卷 7536-7540页

作者： Jin-Shui Zhu Long Wang Guo-Qiang Cheng Qin li Zu-ming Zhu li Zhu Department of Gastroenterology Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200233 China

AIM: To explore the inducing effect of human mutant p27 gene on the apoptosis of the human gastric cancer cell line MKN-45 and its associated mechanisms. METHODS: The recombinant adenovirus Ad-p27mt was constructed to infect the human gastric cancer cell line MKN-45. Using flow cytometry, TUNEL assay and DNA fragment analysis, we measured the apoptotic effect of Ad-p27mt on the human gastric cancer cells. RESULTS: Ad-p27mt was successfully constructed and the infection efficiency reached 100%. After 18 h of infection, we observed an apoptotic hypodiploid peak on the flow cytometer before G1-S and apoptotic characteristic bands in the DNA electrophoresis. The apoptotic rate detected by TUNEL method was significantly higher in the Ad-p27mt group (89.4±3.12%)compared to the control group (3.12±0.13%, P ＜ 0.01).CONCLUSION: Human mutant p27 can induce apoptosis of the human gastric cancer cells in vitro.

关键词： Gastric cancer Human mutant p27 Cell line MKN-45

The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

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中国园林 2007年第7期 28-29页

作者： XIE Jun-fei, li Yan-ming, li Shu-hua

1 Preface In urban green space system, urban parks, with wide space, perfect facilities, low density of building, can provide excellent emergency shelter condition. Due to

关键词： The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

Underuse of statins in patients with atherosclerotic ischemic stroke in China

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Chinese Medical Journal 2012年第10期125卷 1703-1707页

作者： li Xi GAO Yan FENG Fang liU Jia-min ZHANG Hai-bo ZHANG Dan HUNDEI Wu-han-bi-li-ge CHEN Fang CHEN Yi-ping CHEN Zheng-ming Martin Landray Jane Armitage JIANG li-xin li li-ming Department of Epidemiology ＆ Biostatistics School of Public Health Peking University Health Science Center Beijing 100191 China China Oxford Centre for International Health Research State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Clinical Trial Service Unit Oxford University Oxford OX3 7LF UK

Background Well designed randomized trials and meta-analyses have clearly shown that statins reduce the risk of major vascular events, including ischemic stroke, in a wide range of patients and their routine use is recommended for patients at an increased cardiovascular risk. Survivors of a first ischemic stroke are at a risk of recurrence and of other vascular events and statins are generally recommended to reduce this risk. This study investigated how widely statins were being used for such patients in China. Methods Totally 6422 patients with a history of ischemic stroke were identified by reviewing medical records at 51 highest-ranking hospitals in 14 cities in China, and invited to attend a screening clinic to assess eligibility for a randomized trial. Their current statin and other drug uses were recorded alongside clinical and demographic characteristics. Univariate chi-square test and multivariate Logistic regression were used to determine the factors associated with treatment. Results Only 24% of these patients reported currently taking a statin. The most important predictor of statin use among these patients was prior history of coronary heart disease. History of diabetes or hypertension, as well as treated in university affiliated hospitals is related to increased use. The status had improved significantly during a 2-year period. Atorvastatin （40%） and simvastatin （39%） were the most commonly used. Conclusions In China, statins are still underused for secondary prevention among survivors of ischemic stroke. Reasons for this Door use need to be understood in order to increase use of these evidence based therapies.

关键词： hydroxymethylglutaryl-CoA reductase inhibitors ischemic stroke, secondary prevention

A Teleoperation System Based on Predictive Simulation and Its Application to Spacecraft Maintenance

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International Journal of Plant Engineering and Management 2008年第1期13卷 1-9页

作者： li ming-fu li Shi-qi ZHAO Di ZHU Wen-ge School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China

A teleoperation system based on predictive simulation is proposed for the sake of compensating the large time delay in the process of teleoperation to a degree and providing a friendly operating interface. The framework and function architecture of the system is discussed firstly. Then, the operator interface and a graphics simulation system is described in detail. Furthermore, a predictive algorithm aiming at position control based teleoperation is studied in our research, and the relative framework of predictive simulation is discussed. Finally, the system is applied to spacecraft breakdown maintenance; multi-agent reinforcement learning based semi-autonomous teleoperation is discussed at the same time for safe operation.

关键词： teleoperation predictive simulation virtual reality reinforcement learning

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三层三跨钢框架-钢板剪力墙抗震性能试验

东北大学学报（自然科学版） 2013年第8期34卷 1196-1201页

作者：牟在根薛园李黎明北京科技大学土木与环境工程学院北京100083 北京赛博思建筑设计有限公司北京100037

两边连接竖向加劲钢板剪力墙是一种新型的结构形式.为了探讨钢板墙与钢框架的协同作用机理,寻求钢板墙、梁、柱合理的刚度匹配,对钢板剪力墙布置位置不同的两个1∶3的三层三跨试件进行低周往复循环加载,观察和总结结构的协同作用机理;... 详细信息

两边连接竖向加劲钢板剪力墙是一种新型的结构形式.为了探讨钢板墙与钢框架的协同作用机理,寻求钢板墙、梁、柱合理的刚度匹配,对钢板剪力墙布置位置不同的两个1∶3的三层三跨试件进行低周往复循环加载,观察和总结结构的协同作用机理;通过屈服点、极值点、延性系数、滞回曲线、骨架曲线、能量耗散系数、割线刚度等力学性能指标衡量其抗震性能,并且比较了钢板墙分布位置对结构的影响.试验证明,这种新型的结构形式有着优越的抗震性能,特别适合在地震高烈度区进行推广.

关键词：两边连接竖向加劲钢板剪力墙循环加载抗震性能

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Centrosome and vascular microenvironmental homeostasis

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Microenvironment & Microecology Research 2021年第1期3卷 12-16页

作者： Yang Yang Pei-Pei liu ming-li li Shu-Ang li Yi Luan Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

The homeostasis of vascular microenvironment is essential to maintain the normal vascular structure and function,while its disorder leads to vascular dysfunction,and cardiovascular and cerebrovascular *** is an important organelle existing in mammalian cells as well as the microtubule organizing center,playing an important role in maintaining vascular structure and *** study reviewed the role of centrosome in the regulation of vascular microenvironmental *** proteins intricately regulate microtubule dynamics and stabilization,and diverse microtubule-relatived cellular activities,including the division,polarization and directional migration of vascular endothelial cells,smooth muscle cells and other types of *** addition,primary cilia formed by centrosome are essential in vascular *** endothelial cells usually acquire excess centrosomes,and excess centrosomes are regulated by several angiogenic ***,uncovering the detailed molecular mechanisms underlying centrosome affecting vascular microenvironmental homeostasis are needed for the treatment of cardiovascular and cerebrovascular diseases.

关键词： Vascular microenvironment Homeostasis Centrosome Microtubule Cardiovascular and cerebrovascular diseases

拯救布雷顿森林体系:战后美国推动西欧国际货币合作的困境、妥协与实现

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史学集刊 2024年第3期 61-72页

作者：李黎明东北师范大学历史文化学院吉林长春130024

二战后欧洲出现的严重经济困难和“美元荒”问题,成为美国在西欧确立布雷顿森林体系的现实障碍。在冷战爆发的背景下,为拯救布雷顿森林体系,美国在马歇尔计划的制订过程中做出妥协与让步,淡化了经济援助与西欧国际货币合作目标之间的关... 详细信息

二战后欧洲出现的严重经济困难和“美元荒”问题,成为美国在西欧确立布雷顿森林体系的现实障碍。在冷战爆发的背景下,为拯救布雷顿森林体系,美国在马歇尔计划的制订过程中做出妥协与让步,淡化了经济援助与西欧国际货币合作目标之间的关系。在马歇尔计划实施后,美国通过经济合作署严格控制西欧国家对美元援助的使用,强化了对西欧国家的经济干预能力,并通过建立欧洲支付联盟,逐步主导西欧国际货币合作进程,最终在西欧地区确立了布雷顿森林体系。上述历史过程在一定程度上反映出美元霸权具有协商性的一面。

关键词：马歇尔计划布雷顿森林体系西欧国际货币合作美元霸权