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Discovery of the choristodere Hyphalosaurus baitaigouensis from the Lower Cretaceous Jiufotang Formation of western liaoning,China and its paleobiogeographic significance

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Journal of Palaeogeography 2024年第3期13卷 547-562页

作者： li-jun zhang Shu-An Ji Hai-Chun zhang South China Sea Culture Museum Hainan Tropical Ocean UniversitySanya 572022Hainan ProvinceChina Key Laboratory of Stratigraphy and Paleontology Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina

The water-living reptile genus Hyphalosaurus was previously discovered in the Lower Cretaceous Yixian Formation bearing the middle Jehol Biota in western liaoning,*** complete skeletons of Hyphalosaurus are reported for the first time from the Jiufotang Formation bearing the late Jehol Biota at two sites in western *** show the typical characteristics of Hyphalosaurus baitaigouensis in terms of the contact between some cranial bones and the number of cervical and dorsal vertebrae,and therefore are assigned to *** discovery extends the stratigraphic range of this species from the Yixian Formation to the overlying Jiufotang *** paper further briefly compares the main characteristics of the two skeletons,summarizes the temporal and spatial distribution of Hyphalosaurus,and discusses the palaeogeographic evolution of western liaoning at the middle and late Jehol Biota stages based on the aquatic habits of Hyphalosaurus and the geological background of western *** analytical results show that the volcanic downwarped lakes,with distinct geographical divisions in western liaoning during the deposition of the Yixian Formation,had not completely disappeared till the deposition of the Jiufotang *** palaeo-lake in the Fuxin-Yixian Basin underwent the process of generation,expansion and shrinkage during the depositional period of the Yixian Formation and finally merged into a large *** palaeo-Dalinghe River,which connected the main basins in western liaoning during the depositional period of the Jiufotang Formation,was formed simultaneously.

关键词： Western liaoning Jehol biota Jiufotang formation Hyphalosaurus baitaigouensis Palaeobiogeography

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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao li-jun zhang Yue-Mei Zhao Lei Chen Jin-lin zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

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N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 659-669页

作者： Yan-Rong Wen Xia-Wen lin Yu-Wen Zhou Lei Xu jun-li zhang Cui-Ying Chen Jian He Department of Nuclear Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Research and Development Sysdiagno(Nanjing)Biotech Co.LtdNanjing 210008Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage *** detection of pancreatic cancer(PC)can significantly increase survival *** To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan *** An extensive patient cohort was used to determine a biomarker signature,in-cluding patients with PDAC that was well-defined at an early stage(stages I and II).The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I,22 with stage II,4 with stage III,16 with stage IV PDAC,and 88 *** used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan sig-nature-based diagnosis model called the“Glyco-model”.RESULTS The biomarker signature was created to discriminate samples derived from patients with PC from those of controls,with a receiver operating characteristic area under the curve of *** addition,the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls,with a receiver operating characteristic area under the curve of ***-model demonstrated favorable diagnostic performance in all stages of *** diagnostic sensitivity for stage I PDAC was 89.66%.Core Tip:This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer(PC).Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma(PDAC),resulting in the identification of nine early-stage PDAC N-glycan ***,utilizing these biosignatures,a diagnostic model named the“Glyco-model”was developed,demonstrating promising diagnostic performance across all stages of *** study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%.Co

关键词： Glycomics N-glycans Biomarkers Pancreatic cancer Predictive modeling

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Study on the processing technology of Polygonatum cyrtonema Hua decoction pieces based on softening method and drying method

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Natural Therapy Advances 2024年第3期7卷 56-64页

作者： jun-li zhang Hai-Ting Zhu Xin-Ning zhang Si-Yuan Ma Yu-Feng Hu Jing-Qiu zhang Ming-Rui Jiang Hui-Nan Wang Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China.

Background:To optimize the steaming processing technology of Polygonatum cyrtonema Hua(PC)decoction ***:The softening method and drying method of PC decoction pieces were studied with Polygonatum Polysaccharide(PCP),diosgenin combined extract as quantitative *** process parameters such as softening time,drying temperature and drying time were determined,and the best processing technology of PC decoction pieces was ***:Among the three softening methods of PC,the infiltration method had the highest ranking,with an average comprehensive index of 0.9496,and the softening effect was the *** the three drying methods,the drying effect of the hot air drying method was the best,and the average comprehensive index was ***:The infiltration method is the best softening method for PC decoction pieces,and the hot air drying method is the best drying method for PC decoction pieces.

关键词： Polygonatum cyrtonema Hua assaying preparative technics

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Study on the regulatory effect of liver X receptor in HEK293 cells by six main diterpene esters in Semen Euphorbiae

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TMR Modern Herbal Medicine 2024年第2期7卷 35-40页

作者： Si-Yuan Ma Fan-Miao Kong Xiao-Tong Wei jun-li zhang Hai-Ting Zhu Xin-Ning zhang Yu-Feng Hu Ming-Rui Jiang Hui-Nan Wang Yi-Cen Xu Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Background:To study the effects of the main diterpene esters in Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)on the transcriptional activity and protein expression of liver X receptor(LXR).Methods:The effect of the main diterpene ester components in Semen Euphorbiae on the viability of HEK293 cells were studied by MTT *** LXR-Luc plasmid vector was transfected into HEK293 cells and treated with Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)for 24 *** effect of the main diterpene ester components of Semen Euphorbiae on LXR-Luc luciferase activity was investigated by dual luciferase reporter gene system,and the expression of LXRαprotein was detected by Western ***:Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)could significantly reduce the relative luciferase activity(RLU)of LXRα,and the expression level of LXRαprotein was significantly ***:Euphorbia factor L_(1),L_(2),L_(3),L_(7a),L_(7b)and L_(8)can inhibit the expression of LXR protein level,which may be achieved by inhibiting the transcriptional activity of LXR.

关键词： Semen Euphorbiae diterpene esters HEK293 LXR dual luciferase reporter gene system

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Effects of different processing methods on the quality of Polygonatum cyrtonema Hua

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TMR Modern Herbal Medicine 2024年第2期7卷 28-34页

作者： Xin-Ning zhang Shuang-Hui Shi jun-li zhang Fan-Miao Kong Hai-Ting Zhu Si-Yuan Ma Yu-Feng Hu Ming-Rui Jiang Hui-Nan Wang Meng-lin Wang Xiao-Tong Wei Jing-Qiu zhang Nan Sun Meng-Yu Chen Qian-Qian liu Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Background:In this study,we explored the effects of different processing methods on the quality of Polygonatum cyrtonema Hua(PC),and the role of Huangjiu in the processing ***:The sensory characteristics of the crude product,steamed product,and wine-processed product of PC were *** colorimeter was used to analyze the chromatic values of three different processed products on *** the same time,the contents of the water extract and alcohol extract were measured *** content of three different processing Polygonatum Polysaccharide(PCP)was determined using 0.2%anthrone-sulfuric *** correlation difference between the chromatic values and chemical composition of different PC products was analyzed using various analytical ***:The surface colors gradually deepened,the sweetness increased,the viscosity strengthened,and the tongue-numbing sensation disappeared after PC *** contents of extract and L^(*) gradually decreased from the crude to the steamed to the wine-processed product,consistent with the pattern of surface color ***,E^(*)ab gradually *** content of PCP was crude product>wine-processed product>steamed *** results of multivariate statistical analysis showed that the samples processed for crude,steamed,and wine-processed product were clustered into three *** correlation analysis showed that L^(*)and E^(*)ab were highly significant positively correlated with the content of PCP,and a*was significantly negatively correlated with the content of ***:The results showed that the wine-processed product had the best *** internal quality of the PC was correlated with its characteristics and chromatic *** this study,we investigated the internal and external quality of three different products of PC in order to provide a reference for further research on the impact of different processing methods on PC quality,the standardization of PC processing,and the

关键词： Polygonatum cyrtonema Hua different products chemical composition chromatic value characteristics

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Microstructure and properties of in situ synthesized TiB_2+WC reinforced composite coatings

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Rare Metals 2008年第5期27卷 451-456页

作者： li jun zhang Huiying li Wenge zhang Guangjun School of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China

Nickel-based composite coatings reinforced by in situ synthesized TiB2 and WC particles were deposited on stainless steel by laser cladding, and their microstmcture and mechanical properties were investigated. The results show that the coatings are mainly composed of 7-Ni cellular dendrites and dispersed spherical/strip/network shaped TiB2 and equiaxial WC particles. The initial WC particles are dissolved to become fine and mostly dispersed within Y-Ni cellular dendrites. The coating prepared at a special laser energy of 0.225 kJ@mm^-2 is uniform, continuous, and free of pores and cracks. With the decrease in special energy density, TiB2 phase changes from fine spherical particles which cluster together to strip shape with different morphologies and further crystallizes to form network structure, and the dispersion zone also gradually changes from intragranular to intergranular phase. The coating possesses a higher microhardness compared with the substrate, and it has a good metallurgical bond with the substrate and excellent cracking resistance.

关键词： laser cladding in situ synthesis composite coating microstructure

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Integral Self-affine Tiles of Bandt's Model

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Acta Mathematicae Applicatae Sinica 2010年第1期26卷 169-176页

作者： Hui Rao li-jun zhang Department of Mathematics and Statistics Central China Normal University Wuhan 430079 China Department of Mathematics Tsinghua University Beijing 100084 China

Integral self-affine tiling of Bandt＇s model is a generalization of the integral self-affine tiling. Using ergodic theory, we show that the Lebesgue measure of the tile is a rational number where the denominator equa... 详细信息

关键词： IFS self-affine tiling invariant measure _

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Oxidative stress in leukemia and antioxidant treatment

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Chinese Medical Journal 2021年第16期134卷 1897-1907页

作者： Chao Dong Nai-Jin zhang li-jun zhang Department of Hematology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Cardiology The First Hospital of China Medical UniversityShenyangLiaoning 110001China.

Oxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species(ROS)and the antioxidant defense systems,which can activate various transcription factors and affect their transcriptional *** stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of *** standard chemotherapy strategies for the pre-treatment of leukemia have many ***,the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily *** article reviews the research progress of oxidative stress and *** addition,the application of antioxidants treatment in leukemia has been summarized.

关键词： Reactive oxygen species Oxidative stress Leukemia Antioxidant treatment

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Adaptive Iterative Learning Control for Nonlinear Time-delay Systems with Periodic Disturbances Using FSE-neural Network

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International Journal of Automation and computing 2011年第4期8卷 403-410页

作者： Chun-li zhang jun-Min li Department of Applied Mathematics Xidian University Xi＇an 710071 PRC

An adaptive iterative learning control scheme is presented for a class of strict-feedback nonlinear time-delay systems, with unknown nonlinearly parameterised and time-varying disturbed functions of known periods. Radial basis function neural network and Fourier series expansion （FSE） are combined into a new function approximator to model each suitable disturbed function in systems. The requirement of the traditional iterative learning control algorithm on the nonlinear functions （such as global lipschitz condition） is relaxed. Furthermore, by using appropriate Lyapunov-Krasovskii functionals, all signs in the closed loop system are guaranteed to be semiglobally uniformly ultimately bounded, and the output of the system is proved to converge to the desired trajectory. A simulation example is provided to illustrate the effectiveness of the control scheme.

关键词： Adaptive control iterative learning control (ILC) time-delay systems Fourier series expansion-neural network periodic disturbances.

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