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东北红豆杉化学成分的分离与鉴定(Ⅱ)

沈阳药科大学学报 2011年第5期28卷 355-359页

作者：郭佳音王文泽吴立军王继文李亚男高慧媛沈阳药科大学中药学院辽宁沈阳110016 沈阳天峰生物工程技术有限公司辽宁沈阳110006

目的对东北红豆杉(Taxus *** Zucc.)的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到8个化合物,分别鉴定为柳杉酚(sugiol,1)、20-羟基蜕皮酮(20-hydroxyecdysone,2)、d... 详细信息

目的对东北红豆杉(Taxus *** Zucc.)的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到8个化合物,分别鉴定为柳杉酚(sugiol,1)、20-羟基蜕皮酮(20-hydroxyecdysone,2)、davidioside B(3)、表儿茶素(epicatechin,4)、2-去乙酰氧基-7β,9α-二去乙酰基紫杉宁J(2-deacetoxy-7β,9α-dideacetyl-taxinine J,5)、2-去乙酰氧紫杉宁E(2-deacetoxytaxinine E,6)、7-表-10-去乙酰基巴卡亭III(7-epi-10-deacetyl baccatin III,7)、7-O-β-D-木糖-10-乙酰基巴卡亭III(7-O-β-D-xylose-10-deacetyl baccatin III,8)。结论化合物3为首次从红豆杉属植物中得到,化合物1、5、7、8为首次从东北红豆杉植物中分离得到,并利用二维核磁共振技术首次对化合物6的碳谱数据进行了全归属。

关键词：东北红豆杉化学成分结构鉴定

A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 500-504页

作者： Wen-jun Bai Hong-jun li Jian-jun Jin Wen-Ping Xu Sorsaburu Sebastian Xiao-Feng wang Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China Eli lilly and Company Indianapolis Indiana 46285 USA

Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction （ED）. Recent study results indicate that men with ED in China who were naive to phosphodiesterase inhibitor type 5 （PDE5） therapy prefer tadalafil 20-mg （on-demand） versus sildenafil 100-mg （on-demand）. Differences in psychosocial outcomes may help to explain treatment preference in favor of tadalafih This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with ED na＇（ve to PDE5 inhibitor therapy. Eligible patients were randomized to sequential 20-mg tadalafU/lOO-mg sildenafil （n = 190） or 100-mg sildenafil/20-mg tadalafil （n = 193） for 8 weeks each and were asked which treatment they preferred to take for the 8-week extension phase. Psychosocial outcomes were assessed using the Psychological and Interpersonal Relationship Scale （PAIRS）, Drug Attributes Questionnaire （DRAQ）, and Sexual life Quality Questionnaire （SLQQ）. When taking tadalafil versus sildenafil, men had a higher mean endpoint score on the PAIRS Spontaneity Domain （tadalafil = 2.86 vs sildenafil = 2.72; P 〈 0.001）, and a lower mean endpoint score on the Time Concerns Domain （tadalafil = 2.41 vs sildenafil = 2.55; P 〈 0.001）. A numerical increase in the Sexual Self-Confidence Domain was observed when taking tadalafil versus sildenafil （tadalafil -- 2.76 vs sildenafil = 2.72; P= 0.102）. The most frequently chosen drug attributes explaining treatment preference were able to get an erection long after having drug, and ability to get an erection every time. SLQQ results were comparable between treatment groups. These psychosocial outcomes may explain why more Chinese men preferred tadalafil versus sildenafil for the treatment of ED in this clinical trial.

关键词： drug attributes erectile dysfunction phosphodiesterase type 5 inhibitor psychological assessment of sexual dysfunction

低温来流对深水水库过饱和总溶解气体输移的影响

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长江科学院院报 2024年第9期41卷 35-43,52页

作者：周哲成石浩洋郭辉王智欣李析男杨文俊金光球长江科学院水力学研究所武汉430010 长江科学院流域水资源与生态环境科学湖北省重点实验室武汉430010 河海大学水利水电学院南京210098 河海大学环境学院南京210098 贵州省水利水电勘测设计研究院科技创新部贵阳550002

梯级深水水库产生的水温分层现象可降低下游水库来流水温,导致泄洪水体总溶解气体(TDG)的过饱和程度随库区密度分层流的输移过程产生变化。以溪洛渡—向家坝区间为研究区域,基于原位观测和数值模拟相结合的研究手段,研究低温来流对深水... 详细信息

梯级深水水库产生的水温分层现象可降低下游水库来流水温,导致泄洪水体总溶解气体(TDG)的过饱和程度随库区密度分层流的输移过程产生变化。以溪洛渡—向家坝区间为研究区域,基于原位观测和数值模拟相结合的研究手段,研究低温来流对深水水库过饱和TDG纵向和垂向输移过程的影响规律。研究表明:①来流水温降低2℃,TDG云团潜入位置提前36.4 km,峰值垂向位置下移55 m、垂向影响范围减少23%;②来流水温降低2℃,TDG饱和度110%以上云团输移至向家坝坝前阶段和后续阶段,包络面积衰减速率降幅分别为16%和44%;③从射流区到交换区过饱和TDG平均纵向迁移速度显著降低,降幅达92%;④来流水温降低2℃,向家坝表孔出流TDG饱和度峰值和均值的降低程度分别为机组出流的3.2倍和4倍;⑤水温降低对鱼类安全水深阈值的补偿效应可量化为0.20 m/℃。研究成果可为梯级深水水库汛期生态调度提供科学支撑。

关键词： TDG输移过程数学模型水库水温分层总溶解气体(TDG) 云团位置水温补偿生态调度梯级深水水库

Application of suspension magnetization roasting as technology for high-efficiency separation of valuable iron minerals from high-iron bauxite

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Transactions of Nonferrous Metals Society of China 2022年第7期32卷 2391-2402页

作者： Ruo-feng wang Shuai YUAN Peng GAO Yan-jun li School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China National-local Joint Engineering Research Center of High-efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

A technology for suspension magnetization roasting−magnetic separation was proposed to separate iron minerals for *** optimum parameters were as follows:a roasting temperature of 650℃,a roasting time of 20 min,a CO concentration of 20%,and particles with a size less than 37μm accounting for 67.14%of the roasted *** total iron content and iron recovery of the magnetic concentrate were 56.71%and 90.50%,*** phase transformation,magnetic transition,and microstructure evolution were systematically characterized through iron chemical phase analysis,X-ray diffraction,vibrating sample magnetometry,X-ray photoelectron spectroscopy,and transmission electron *** results demonstrated the transformation of hematite to magnetite,with the iron content in magnetite increasing from 0.41%in the raw ore to 91.47%in the roasted product.

关键词： high-iron bauxite suspension magnetization roasting comprehensive utilization magnetic separation phase transformation

面向手工艺类非遗的具身体验式教育游戏研究——以“布艺虎寻踪”教育游戏为例

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现代教育技术 2024年第3期34卷 89-96页

作者：朱俊洁李亚楠孙兴清华大学深圳国际研究生院广东深圳518055

数字游戏已成为非物质文化遗产展示、传播的新兴方式,但当前面向手工艺类非遗的教育游戏难以在保证乐趣性、吸引力的同时实现对非遗技艺与文化的有效学习。基于此,文章设计了面向手工艺类非遗的具身体验式教育游戏模型,并基于此模型开... 详细信息

数字游戏已成为非物质文化遗产展示、传播的新兴方式,但当前面向手工艺类非遗的教育游戏难以在保证乐趣性、吸引力的同时实现对非遗技艺与文化的有效学习。基于此,文章设计了面向手工艺类非遗的具身体验式教育游戏模型,并基于此模型开发了一款手势交互的教育游戏“布艺虎寻踪”。之后,文章采用包括调查问卷、学习效果客观测试和半结构化访谈的混合研究方法,通过对照实验,验证了具身体验式教育游戏对于提升手工艺类非遗的学习效果、学习体验和学习动机具有积极作用。文章设计的具身体验式教育游戏可以提升学习者学习手工艺类非遗的效果与意愿,促进对非遗的保护与传承,并推动了游戏学习与非遗文化的融合。

关键词：非物质文化遗产教育游戏具身认知体验式学习手势交互

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Completely thoracoscopic lobectomy for the surgical management of bronchiectasis

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Chinese Medical Journal 2013年第5期126卷 875-878页

作者： ZHOU Zu-li ZHAO Hui li Yun li Jian-feng JIANG Guan-chao wang jun Department of Thoracic Surgery Peking University People'sHospital Beijing 100044 China

Background The feasibility of completing a Iobectomy by completely video-assisted thoracoscopic surgery （cVATS） in the management of bronchiectasis is unclear. By retrospectively comparing the outcomes from the Iobectomies that used thoracotomy vs. cVATS, we determined the appropriateness of the minimally invasive cVATS approach in the management of bronchiectasis. Methods Between june 2001 and October 2010, 60 patients with bronchiectasis underwent surgery, of which 56 Iobectomies were performed. All Iobectomies were carried out by either thoracotomy or cVATS approach. Pulmonary vessels and bronchi were manipulated by ligation or stapler in the thoracotomy group, while they were dissected by endo-cutters in the cVATS group. Results There were 21 patients in the thoracotomy group and 35 patients in the cVATS group. Two cVATS patients （5.7%） converted. The difference in operation time, chest tube duration, lengths of hospitalization, and morbidity were not significantly different between the two groups （P 〉0.05）. The blood loss was less in the cVATS group （P=0.015）. A total of 52.4% and 62.9% of patients were postoperatively asymptomatic in the thoracotomy and cVATS groups respectively, and symptomatic improvement was obtained in 38.1% patients by thoracotomy vs. 31.4% patients by cVATS. Conclusion cVATS Iobectomy is safe and effective for the management of bronchiectasis, especially for the patients with localized lesions.

关键词： video-assisted thoracoscopic surgery lobectomy bronchiectasis

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抗Ku及其他高频抗原抗体的鉴定思路

中国实验血液学杂志 2024年第3期32卷 875-882页

作者：张飞飞李婧薇沈伟何屹袁红田力叶志君四川省医学科学院·四川省人民医院输血科四川成都610072 上海市血液中心上海200051 中国医学科学院输血研究所四川成都610052 四川省医学科学院·四川省人民医院营养科四川成都610072

目的:通过对一例女性高频抗原抗体(抗-Ku)病例进行血清学鉴定及血型基因测序分析,为高频抗原抗体的鉴定提供一定思路。方法:运用血型鉴定、患者红细胞抗原鉴定、抗体筛选、抗体鉴定等方式检测该患者的血型及抗体。以巯基试剂处理后的血... 详细信息

目的:通过对一例女性高频抗原抗体(抗-Ku)病例进行血清学鉴定及血型基因测序分析,为高频抗原抗体的鉴定提供一定思路。方法:运用血型鉴定、患者红细胞抗原鉴定、抗体筛选、抗体鉴定等方式检测该患者的血型及抗体。以巯基试剂处理后的血清与筛选细胞反应、患者血清与酶或巯基试剂处理的筛选细胞反应的方式来判断该抗体的类型及特点,采用基因测序的方法确定患者血型的基因型。结果:该患者血型为O型RhD^(+),其血清与抗体筛选细胞及抗体鉴定细胞在间接抗人球及盐水介质中的反应呈强反应性,且强度一致,自身阴性,直接抗人球蛋白弱阳性;其他血型为CcEe、Jk(a+b-)、P1-、Le(a-b-)、Lu(a-b+)、K-、k-、Kp(a-b-)。血清经2-ME处理后,在间接抗人球介质中仍与3组筛选细胞反应;血清与经木瓜酶、菠萝酶修饰后的筛选细胞反应强度不变,与巯基试剂DTT、2-ME处理后的筛选细胞反应为阴性。基因测序显示该患者KEL基因型为KEL*02N.24,为罕见的K0表型。结论:血清学试验和分子生物学实验鉴定出该患者为罕见的Kell-null血型(又称K0),该患者体内产生了IgG及IgM性质的高频抗原抗体抗-Ku。血清学方法及分子生物学方法在此类稀有血型及高频抗原抗体的鉴定中具有重要意义。

关键词：高频抗原抗体 K0 抗-Ku 血清学实验基因测序

Microstructure,mechanical properties and fracture behavior of a new WE43 alloy

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Rare Metals 2021年第8期40卷 2197-2205页

作者： Gui-Long Jia li-Ping wang Yi-Cheng Feng Er-jun Guo Yan-Hong Chen Chang-liang wang School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin150040China

The microstructures,mechanical properties and fracture behaviors of a new WE43 alloy(Mg-4 Y-1.6 Nd-2 Sm-0.5 Zr)were *** microstructure of the as-cast alloy includes a Mg matrix,Mg_(41)Sm_(5),Mg_(41)Nd_(5)and Mg_(24)Y_(5)eutectic phases,as well asβ-*** an optimal solution treatment,the eutectic phases are almost completely dissolved;only a few spots of blocky Mg-Y compounds remain at grain *** an aging treatment,a large amount ofβ’-phases are dispersed and precipitated at the grain interior,which provides good comprehensive mechanical properties of the alloy,particularly in the under-aged *** tensile strength is up to290 MPa,the yield strength reaches 209 MPa,and the elongation is slightly ***,the fracture behaviors of the studied alloy in different states significantly *** addition,a comparison of mechanical properties of the new WE43,traditional WE43 and other modified WE43 alloys is presented.

关键词： Mg-Y-Nd-Sm-Zr Microstructure Mechanical properties Fracture behavior Heat treatment

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基于AHP的零碳建筑技术评估与应用研究

低温建筑技术 2024年第2期46卷 44-47页

作者：王坤朋陈川李钧范陈辰山东电力工程咨询院有限公司济南250013 山东建筑大学济南250101

发展零碳建筑是我国国家战略,零碳建筑技术评估是促进规模化发展低碳建筑、零碳建筑的重要一环。文中以山东建筑大学教学实验综合楼一期为验证案例,运用AHP层次分析法构建的建筑概念设计阶段的零碳建筑技术综合评估模型,得出建筑项目的... 详细信息

发展零碳建筑是我国国家战略,零碳建筑技术评估是促进规模化发展低碳建筑、零碳建筑的重要一环。文中以山东建筑大学教学实验综合楼一期为验证案例,运用AHP层次分析法构建的建筑概念设计阶段的零碳建筑技术综合评估模型,得出建筑项目的零碳建筑技术建议方案,在此基础上设计应用于概念设计阶段零碳建筑技术综合评估软件,运用软件为例得出评估结果与实际零碳建筑技术的应用基本符合,验证了评估方法与评估软件的可行性和可操作性。研究实现了零碳建筑技术的跨学科、跨专业综合评估,可为零碳建筑提供决策支持,帮助不同建设目标的零碳建筑合理选择适宜的建筑技术。

关键词：零碳建筑零碳建筑技术评估 AHP层次分析法