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Effect of Silicon Content on Thermodynamics of Austenite Decomposition in C-Si-Mn TRIP Steels

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Journal of Iron and Steel Research International 2006年第3期13卷 57-60,73页

作者： ZHU li-juan WU Di zhao Xian-ming State Key Lab of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Some numerical models such as central atoms model （CAM） and superelement model were used to simulate the thermodynamics of austenite decomposition in the Fe-C-Mn-Si TRIP （transformation induced plasticity） steels. Thermodynamic calculations were carried out under a para-equilibrium （PE） condition. The results show that certain silicon content can accelerate the polygonal ferritic transformation and increase the volume fraction and stability of retained austenite by retarding the precipitation of carbides during the bainitic transformation.

关键词： central atoms model superelement model para-equilibrium austenite decomposition TRIP steel

Brominated Butyl Rubber Anticorrosive Coating and its Self-healing Behaviors

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Chinese Journal of Polymer Science 2023年第2期41卷 297-305页

作者： Guang-Bing Luo Bo Pang Xing-Qi Luo Yi Wang Hong Zhou li-juan zhao College of Chemistry and Materials Science Sichuan Normal UniversityChengdu610066China The Second Research Institute of Civil Aviation Administration of China(CAAC) Chengdu610041China

Self-healing anticorrosive coatings in extreme environment have attracted considerable interest from *** this work,4-tert-butylpyridine(TBP)was incorporated into brominated butyl rubber(BIIR)polymer networks to form a reversible ionic bond with the highly reactive bromine *** on the low glass transition temperature of the BIIR polymer and the electrostatic effects,a robust self-healing anticorrosive coating of TBP-BIIR was ***-BIIR coating showed a maximum protection efficiency(PE)of more than 94%(TBP-BIIR-acid,94.37%;TBP-BIIR-alkali,94.95%;TBP-BIIR-salt,95.49%)when treated with a strong acid(HNO_(3),pH=2),strong base(NaOH,pH=12)and high salt solution(3.5 wt%NaCl).In addition,the PE of coating repaired exceed 89%,and the maximum PE value was approximately 95%in different solutions,which demonstrated its extinguished self-healing *** results indicated that the TBP-BIIR anticorrosive coating could provide excellent safety and durability in special environment,which would be extremely beneficial to improve the working life of metal parts used in aviation and shipping,oil and gas and related industries.

关键词： Brominated butyl rubber Self-healing Anticorrosive Coating

;~lasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth

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Asian Journal of Andrology 2012年第4期14卷 536-545页

作者： Yan-Bo liu ling Zhang Ya-Xiong Guo li-Fang Gao Xi-Chun liu li-juan zhao Bao-Feng Guo li-Jing zhao Xue-Jian zhao De-Qi Xu Prostate Diseases Prevention and Treatment Research Centre and Department of Pathophysiology Norman Bethune Medical SchoolJilin UniversityChangchun 130021 China Department of Pathophysiology School of Bacic MedicineBeihua UniversityJilin132013China Urology center The First Hospital of Jilin University Changchun 130021China New Vaccine National Engineering Research Center Beijing 100176China

Persistent activation of Survivin and its overexpression contribute to the formation, progression and metastasis of several different tumor types. Therefore, Survivin is an ideal target for RNA interference mediated-growth inhibition. Blockade of Survivin using specific short hairpin RNAs （shRNA） can significantly reduce prostate tumor growth. RNA interference does not fully ablate target gene expression, owing to the idiosyncrasies associated with shRNAs and their targets. To enhance the therapeutic efficacy of Survivin-specific shRNA, we employed a combinatorial expression of Survivin-specific shRNA and gene associated with retinoid-interferon-induced mortality-19 （GRIM-19）. Then, the GRIM-19 coding sequences and Survivin-specific shRNAs were used to create a dual expression plasmid vector and were carried by an attenuated strain of Salmonella enteric serovar typhimurium （S. typhimurium） to treat prostate cancer in vitro and in vivo. We found that the co-expressed Survivin-specific shRNA and GRIM-19 synergistically and more effectively inhibited prostate tumor proliferation and survival, when compared with treatment with either single agent alone in vitroand in vivo. This study has provided a novel cancer gene therapeutic approach for prostate cancer.

关键词： GRIM-19 prostate cancer RNAi Salmonella enterica serovar typhimurium Survivin tumor cell growth

High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis

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Neural Regeneration Research 2015年第5期10卷 814-818页

作者： Hong-xia Xue Wen-yi Fu Hua-dong Cui li-li Yang Ning Zhang li-juan zhao Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Department of Rheumatology and Immunology the First Affiliated Hospital of China Medical University

Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among an- kylosing spondylitis patients for 1 year after treatment. In this study, 207 ankylosing spondylitis cases received thalidomide treatment, while 116 ankylosing spondylitis cases received other treat- ments. Results showed that the incidence of thalidomide-induced peripheral neuropathy in the thalidomide group was higher than that in the non-thalidomide group. There was no significant difference in the incidence of neuropathy between the 〈 6 months medication and 〉 6 months medication groups. There were no differences in the mean age, gender, or daily dose between the two groups. The incidence of peripheral neuropathy among patients receiving 25, 50, 75, or 100 mg thalidomide per day was 4.6%, 8.5%, 17.1%, 21.7%, respectively. The incidence was significantly different between the groups receiving 25 mg and 100 mg thalidomide. In conclu- sion, thalidomide can induce peripheral neuropathy within 1 year after treatment of ankylosing spondylitis; however, age and gender have no obvious impact on the incidence of peripheral neuropathy. The incidence of peripheral neuropathy is associated with increasing daily doses of thalidomide.

关键词： nerve regeneration peripheral nerve injury thalidomide ankylosing spondflitis adversereactions peripheral neuropathy prospective study treatment dose treatment time age sex neuralregeneration

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

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World Journal of Gastroenterology 2016年第44期22卷 9718-9726页

作者： Yu-li Chen Xiao-Qiang Mo Gan-Rong Huang Yan-Qiang Huang juan Xiao li-juan zhao Hong-Yu Wei Qian liang Department of Medical Microbiology and Immunology Youjiang Medical University for Nationalities

Helicobacter pylori(H. pylori) is a kind of chronic infectious pathogen which can cause chronic gastritis, peptic ulcer, gastric cancer and other diseases. The genetic structure of the pathogenic genes of H. pylori varies largely, which contributes to the differences in virulence among various strains, and in clinical symptoms. Virulence genes of H. pylori can be categorized into three main classes: those related to adhesion and colonization, those related to gastric mucosal injury, and others. This review focuses on the relationship between genetic polymorphisms of the three classes of virulence genes of H. pylori and diseases. Most of the genetic polymorphisms of the main virulence factors of H. pylori are summarized in this paper.

关键词： Helicobacter pylori Pathogenic gene Polymorphism Gastrointestinal disease

linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation

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World Journal of Gastroenterology 2023年第32期29卷 4860-4872页

作者： Wen-Ting Zhou Yuan-Yuan Dai li-juan liao Shi-Xian Yang Hao Chen liang Huang juan-li zhao Yan-Qiang Huang School of Basic Medicine Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Youjiang Medical University for NationalitiesAffiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Laboratory Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Department of PathologyWannan Medical CollegeWuhu 533000Anhui ProvinceChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Sciences Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Resistance to antibiotics is one the main factors constraining the treatment and control of Helicobacter pylori(***)***,there is an urgent need to develop new antimicrobial agents to replace *** previous study found that linolenic acid-metronidazole(Lla-Met)has a good antibacterial effect against ***,both antibiotic-resistant and sensitive ***,*** does not develop resistance to ***,it could be used for preparing broad-spectrum antibacterial ***,since the antibacterial mechanism of Lla-Met is not well understood,we explored this phenomenon in the present *** To understand the antimicrobial effect of Lla-Met and how this could be applied in treating corresponding *** *** cells were treated with the Lla-Met compound,and the effect of the compound on the cell morphology,cell membrane permeability,and oxidation of the bacteria cell was ***,the differently expressed genes in *** in response to Lla-Met treatment were *** Lla-Met treatment induced several changes in *** cells,including roughening and *** vivo experiments revealed that Lla-Met induced oxidation,DNA fragmentation,and phosphatidylserine ectropionation in *** *** Lla-Met with L-cysteine abrogated the above *** analysis revealed that Lla-Met treatment up-regulated the expression of superoxide dismutase SodB and MdaB genes,both anti-oxidation-related *** Lla-Met kills *** mainly by inducing oxidative stress,DNA damage,phosphatidylserine ectropionation,and changes on cell morphology.

关键词： Helicobacter pylori Oxidation Superoxide dismutase SodB genes MdaB genes

Flame-retardant and Self-healing Biomass Aerogels Based on Electrostatic Assembly

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Chinese Journal of Polymer Science 2020年第12期38卷 1294-1304页

作者： Ji-Yu Yang Yu Xia Jin zhao Long-Fei Yi Yong-Jiao Song Hong Wu Shao-Yun Guo li-juan zhao Jin-Rong Wu College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China State Key Laboratory ofPolymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065China State Key Laboratory ofPolymer Materials Engineering Collegeof Polymer Science and EngineeringSichuan UniversityChengdu 610065China

It remains a significant challenge to fabricate self-healing aerogels with excellent flame ***,we develop a class of biomass aerogels by electrostatically assembling chitosan(CS),phytic acid(PA),and itaconic acid(IA).The electrostatic interaction between CS and IA is weak and dynamic,so freeze-drying the solution of CS and IA enables the formation of continuous aerogel skeleton with self-healing ability and re-programmability;in comparison,the electrostatic interaction between CS and PA is strong and less dynamic,and thus mixing PA with CS in aqueous solution leads to fine precipitates of high flame retardancy due to the synergistic phosphorus-nitrogen *** the continuous skeleton and the fine precipitates results in self-healing aerogles with UL-4 V-0 rating of flame retardancy aerogels and autoextinguishable ***,the aerogels after burning in flame for 30 s form a skin-core structure,and the carbonized skin protects the integrity of the aerogels and the self-healing ability of the internal ***,this work provides a facile strategy to develop multifunctional aerogels which hold great promise for advanced applications.

关键词： Chitosan Flame retardancy Electrostatic interactions Biomass aerogel Self-healing

Ice Crystal Growth Mechanism and Structure-activity Relationships of Graphene Oxide/Poly(vinyl alcohol)Aerogels

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Chinese Journal of Polymer Science 2022年第7期40卷 772-780页

作者： Xiao-Tian Xi Xing-Qi Luo Yu Xia Long-Fei Yi Yi Wang Da-Yu Song Yong-Jiao Song Jin-Rong Wu li-juan zhao College of Chemistry and Materials Science Sichuan Normal UniversityChengdu610068China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China

Aerogels are special porous materials with low thermal conductivity,light weight,high energy absorption rate and large surface area,which have been applied in many ***,controlling the aerogel microstructure remains an academic ***,by employing graphene oxide(GO)as the aerogel skeleton and utilizing poly(vinyl alcohol)(PVA)to regulate the ice crystal growth,we elucidate the relationships between the physicochemical properties of GO/PVA aerogel precursors and the nucleation and growth of ice crystals by using an ice-templating *** demonstrate that due to the hydrogen bond formed between PVA and water molecules,resulting in the initial crystallization temperature being reduced from-12.60℃(GO/PVA-0.01)to-16.21℃(GO/PVA-0.1).Meanwhile,the strong hydrogen bond between PVA and GO limits the diffusion of water molecules,thereby inhibiting the growth of ice crystals,decreasing the pore size of the GO/PVA aerogel from 9.96 nm(GO/PVA-0.01)to 7.19 nm(GO/PVA-0.3),and thus the compressive strength of the aerogel increases from 0.045 MPa to ***,the finding of this study can be extended to other aerogel precursors,and exhibit important scientific value and practical significance for the preparation of aerogel materials with highly controllable structures and performances.

关键词： Aerogel GO/PVA Ice crystal growth Structure-activity relationships

Recurrent hemoptysis in pediatric bronchial Dieulafoy’s disease with inferior phrenic artery supply:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6268-6273页

作者： Fang Wang Jiao Tang Mou Peng Pu-Jue Huang li-juan zhao Yin-Yue Zhang Tao Wang Department of Pediatric Cardiology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pediatrics The First People's Hospital of Longquanyi DistrictChengdu 610041Sichuan ProvinceChina Department of Pediatrics Western Theater General HospitalChengdu 610041Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina Key Laboratory of Development and Diseases of Women and Children of Sichuan Province Chengdu 610041Sichuan ProvinceChina

BACKGROUND Bronchial Dieulafoy’s disease(BDD)is characterized by the erosion of an anomalous artery in the submucosa of the *** etiology of pediatric BDD is mainly congenital dysplasia of bronchus and pulmonary arteries,which is different from chronic inflammatory injury of the airway in adult *** internal thoracic artery,subclavian artery,and intercostal artery are known to be involved in the blood supply to the BDD lesion in *** SUMMARY We report a case of BDD in a 4-year-old boy with recurrent hemoptysis for one *** angiography showed a dilated right bronchial artery,and anastomosis of its branches with the right lower pulmonary vascular *** showed nodular protrusion of the bronchial mucosa with a local *** embolization of the bronchial artery was performed to stop *** month after the first intervention,the symptoms of hemoptysis recurred.A computed tomography angiogram(CTA)showed another tortuous and dilated feeding artery in the right lower lung,which was an abnormal ascending branch of the inferior phrenic artery(IPA).The results of angiography were consistent with the CTA *** IPA was found to be another main supplying artery,which was not considered during the first ***,the IPA was also treated by microsphere embolization combined with coil interventional *** the one-year follow-up,the patient never experienced *** The supplying arteries of the bleeding lesion in children with BDD may originate from multiple different aortopulmonary collateral arteries,and the IPA should be considered to reduce missed *** is a noninvasive radiological examination for the screening of suspected vessels,which shows a high coincidence with angiography,and can serve as the first choice for the diagnosis of BDD.

关键词： Hemoptysis Child Bronchial Dieulafoy’s disease Inferior phrenic artery Interventional treatment Case report