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World Journal of Clinical Cases 2021年第14期9卷 3365-3371页

作者： li-juan sun Ying li Wei Qiao Jia-Hui Yu Wei-Dong Ren Department of Ultrasound Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Ultrasound The First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina

BACKGROUND Endocardial fibroelastosis(EFE)is a rare heart disease characterized by thickening of the endocardium caused by massive proliferation of collagenous and elastic tissue,usually leading to impaired cardiac *** cardiovascular imaging for the evaluation of EFE with thrombi is even *** SUMMARY We report a rare case of EFE associated with multiple cardiovascular ***-dimensional(3D)and contrast echocardiography(CE)were used to assess ventricular *** therapy was administered to eliminate the *** peripheral contrast-enhanced thrombi with the highest risk were dissolved with anticoagulant therapy at the time of reexamination,which was consistent with the presumption of fresh loose *** This new echocardiography technique has a great advantage in the diagnosis and treatment of *** the basis of conventional echocardiography,3D echocardiography is used to display the position,shape,and narrow base of the *** does not only help to confirm the diagnosis of thrombus,but also determines its risk.

关键词： Endocardial fibroelastosis Three-dimensional echocardiography Contrast echocardiography Thrombosis Left ventricle Case report

A review on photocatalytic systems capable of synchronously utilizing photogenerated electrons and holes

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Rare Metals 2022年第7期41卷 2387-2404页

作者： li-juan sun Hai-Wei Su Qin-Qin liu Jie Hu Le-Le Wang Hua Tang School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350108China School of Environmental Science and Engineering Qingdao UniversityQingdao 266071China

With the continuous progress and development of current industrial civilization,energy crisis and envi-ronmental pollution are serious problems that threaten human beings need to be *** technolo-gies that can use clean solar light energy to manufacture clean H2 fuel and high value chemicals provide a feasibility to solve the above ***,traditional photo-catalytic water splitting mainly focused on the utilization of photogenerated electrons to produce H_(2) which leads to the waste of the *** is vital to develop photocatalysts capable of synchronously utilizing photogenerated elec-trons and holes for the future practical *** this paper,the latest progress of photocatalytic system with collaborative photooxidation-reduction application has been summarized,and water splitting for H_(2) production combining different organic synchronous reaction process has been ***,the prospect of photocatalysts capable of synchronously utilizing photogenerated elec-trons and holes are proposed.

关键词： Photocatalysis Hydrogen generation Synchronous reaction Organic synthesis

Fractal and microscopic quantitative characterization of unclassified tailings flocs

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International Journal of Minerals,Metallurgy and Materials 2021年第9期28卷 1429-1439页

作者： Di Zheng Wei-dong Song Yu-ye Tan Shuai Cao Zi-long Yang li-juan sun State Key Laboratory of High-Efficient Mining and Safety of Metal Mines of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory for Nonlinear Mechanics(LNM) Institute of Mechanics Chinese Academy of ScienceBeijing 100190China

A series of laboratory investigations are conducted to analyze the effect of flocculant type on the spatial morphology and microstructural characteristics of flocs during the flocculation and settling of *** flocculant types(i.e.,ZYZ,JYC-2,ZYD,and JYC-1)are considered in this *** fractal characteristics and internal structures of tailings flocs with different flocculant types and settlement heights are analyzed by conducting scanning electron microscopy and X-ray micro-computed tomography scanning experiments based on the fractal *** show that unclassified tailings flocs are irregular clusters with fractal characteristics,and the flocculation effect of the four flocculant types has the following trend:ZYZ>JYC-2>ZYD>*** size and average grayscale value of tailings flocs decrease with the increase in settlement *** average grayscale values at the top and bottom are 144 and 103,*** settlement height remarkably affects the pore distribution pattern,as reflected in the constructed three-dimensional pore model of tailings *** top part of flocs has relatively good penetration,whereas the bottom part of flocs has mostly dispersed *** number of pores increases exponentially with the increase in settlement *** contrast,the size of pores initially increases and subsequently decreases with the increase in settlement height.

关键词： tailings flocs fractal dimension settlement height grayscale value three-dimensional pore model

Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

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Neural Regeneration Research 2023年第7期18卷 1607-1612页

作者： Feng Pan Dan Hu li-juan sun Qian Bai Yu-Sheng Wang Xu Hou Eye Institute of Chinese PLA and Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after *** is a histone deacetylase inhibitor and multitarget drug,which has been demonstrated to protect retinal *** this study,we established rat models of optic nerve-crush injury and injected valproate into the vitreous cavity immediately after *** evaluated changes in the ultrastructure morphology of the endoplasmic reticulum of retinal ganglion cells over time via transmission electron *** and western blot assay revealed that valproate upregulated the expression of the endoplasmic reticulum stress marker glucose-regulated protein 78 and downregulated the expression of transcription factor C/EBP homologous protein,phosphorylated eukaryotic translation initiation factor 2α,and caspase-12 in the endoplasmic reticulum of retinal ganglion *** findings suggest that valproate reduces apoptosis of retinal ganglion cells in the rat after optic nerve-crush injury by attenuating phosphorylated eukaryotic translation initiation factor 2α-C/EBP homologous protein signaling and caspase-12 activation during endoplasmic reticulum *** findings represent a newly discovered mechanism that regulates how valproate protects neurons.

关键词： apoptosis C/EBP homologous protein caspase-12 endoplasmic reticulum glucose-regulated protein 78 optic nerve crush phosphorylated eukaryotic translation initiation factor 2α retinal ganglion cells unfolded protein response valproate

Carbon hollow spheres as cocatalyst of Cu-doped TiO_(2)nanoparticles for improved photocatalytic H_(2)generation

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Rare Metals 2022年第6期41卷 2063-2073页

作者： li-juan sun Hai-Wei Su Di-Fa Xu Le-Le Wang Hua Tang Qin-Qin liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha 410022China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350108China School of Environmental Science and Engineering Qingdao UniversityQingdao 266071China

The reasonable employment of cocatalyst in photocatalysis can effectively promote the photocatalytic H_(2)production *** this study,carbon hollow spheres(C),as a good conductive nonmetallic material,have been utilized as a novel cocatalyst and a matrix for loading the Cu-doped-TiO_(2)nanoparticles by a successive hydrother-mal method and metal molten salt *** Cu-doped-TiO_(2)nanoparticles were tightly anchored on the surface of carbon hollow sphere to form a zero-dimensional/three dimensional(0D/3D)Cu-doped-TiO2/C *** optimal Cu-doped-TiO_(2)/C heterojunction demon-strated greatly enhanced photocatalytic H_(2) generation activity(14.4 mmol·g^(-1)·h^(-1))compared with TiO_(2)(0.33 mmol·g^(-1)·h^(-1))and TiO_(2)/C(0.7 mmol·g^(-1)·h^(-1)).The performance improvement was mainly due to the syner-gistic effect of carbon hollow sphere cocatalyst and Cu-doping,the Cu-doping in TiO_(2)nanoparticles can minimize charge recombination and enhance the available photoex-cited electrons,while the 3D carbon hollow spheres can act as electron traps to accelerate the charge separation and offer abundant active sites for solar water splitting reaction.

关键词： Cartbon hollow sphere Cu-doped TiO_(2) Photocatalytic H_(2)generation

Stabilization technology and corrosion mechanism of rust layer on Q370 weathering steel surface

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Journal of Iron and Steel Research International 2022年第10期29卷 1694-1709页

作者： Shao-zheng Ma li-juan sun Hu-yuan sun Hong-bin sun Jin-feng Jiang Yi-xin Yin Shu-feng Qu Zhen-hua liu Shao-xia Xu Key Laboratory of Marine Environmental Corrosion and Bio-Fouling Institute of OceanologyChinese Academy of SciencesQingdao266071ShandongChina University of Chinese Academy of Sciences Beijing100049China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266237ShandongChina Shandong Weilai High Speed Railway Co. Ltd.Jinan250102ShandongChina School of Civil Engineering Shandong UniversityJinan250061ShandongChina China Railway No.10 Engineering Group Co. Ltd.Qingdao266034ShandongChina

A newly developed rust layer on Q370qENH weathering steel(sample C)was studied under dry–wet cycle test of 3.5 wt.%NaCl solution and salt spray test,compared with the bare weathering steel(sample A)and the weathering steel with additive contents(CuSO_(4)0.2,FeSO_(4)0.1,NaHSO_(3)0.02,NaCl 0.02,Na_(2)HPO_(4)0.01,and water balance,in mass%,termed as sample B).Corrosion mechanism of Q370qENH weathering steel after different surface treatments was investigated by means of surface potential scanning,mass change,polarization curve,and X-ray *** results of X-ray diffraction indicate that rust of bare weathering steel has rare Fe_(3)O_(4),and a dense oxide layer mainly composed of Fe_(3)O_(4) is formed on rust of both sample B and sample *** surface potential of sample A gradually increases to−0.2 V in the dry–wet cycle test,while the surface potential of sample A maintains at about−0.6 V in the salt spray *** surface potential of sample B and sample C is higher than that of sample A in the early stage and remains stable during the short-term accelerated corrosion ***,the mass change of sample C gradually stabilizes with time in the dry–wet cycle and salt spray *** corrosion current of the sample A is lower than that of sample C in the initial stage of short-term accelerated corrosion ***,the corrosion current of sample C is smaller than that of the sample A in the *** main components of the deep rust of sample A areγ-FeOOH andα-FeOOH,while those of the deep rust of sample B and sample C are Fe_(3)O_(4).

关键词： Weathering steel Rust layer stabilization Surface treatment Corrosion Surface potential scanning Rust layer analysis

A Rare Novel Copy Number Variation of Xp22.33-p11.22 Duplication is Associated with Congenital Heart Defects

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Chinese Medical Journal 2015年第20期128卷 2829-2830页

作者： juan Zhang Qing-Qing Wu li Wang li-juan sun Department of Ultrasound Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Congenital heart defect （CHD） is the most common fetal defects. Copy nmnber variations （CNVs） were demonstrated to be involved in the etiology of CHDs. We report three cases from a family diagnosed as CHDs with a rare novel duplication ofXp22.33-p I 1.22. A 30-year-old woman, gmvida 2 para 0. Her first pregnancy at 2012 was diagnosed to be dichorionic twin pregnancy and her second pregnancy at 2014 was a singleton pregnancy. After a routine ultrasound scan at 22 week＇s gestation, all the fetuses were diagnosed with critical CHDs. The first fetus （male） exhibited tetralogy of Fallot, atrial septal defect, persistent left superior vena cava, and coronary sinus dilatation while the examination of the second fetus （male） revealed atrioventricular septal detect and hypoplastic left heart syndrome. The third fetus （t^male） was also diagnosed with an atrioventricular septaI defect and hypoplastic left heart syndrome. The parents decided to terminate the wegnancy.

关键词： Congenital Heart Defects Copy Number Variations Chromosomal Duplication Prenatal Ultrasonic Diagnosis

A novel histone methyltransferase gene Cg SDG40 positively regulates carotenoid biosynthesis during citrus fruit ripening

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Journal of Integrative Agriculture 2024年第8期23卷 2633-2648页

作者： Jialing Fu Qingjiang Wu Xia Wang juan sun li liao li li Qiang Xu National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture&Forestry ScienceHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Institute of Horticultural Sciences Jiangxi Academy of Agricultural SciencesNanchang 330200China Plant Breeding and Genetics Section School of Integrative Plant ScienceCornell UniversityNew York 14853USA Robert W.Holley Center for Agriculture and Health USDA-Agricultural Research ServiceCornell UniversityNew York 14853USA

The flesh color of pummelo(Citrus maxima)fruits is highly diverse and largely depends on the level of carotenoids,which are beneficial to human *** is vital to investigate the regulatory network of carotenoid biosynthesis to improve the carotenoid content in ***,the molecular mechanism underlying carotenoid accumulation in pummelo is not fully *** this study,we identified a novel histone methyltransferase gene,CgSDG40,involved in carotenoid regulation by analyzing the flesh transcriptome of typical white-fleshed pummelo,red-fleshed pummelo and extreme-colored F1 hybrids from a segregated pummelo *** of CgSDG40 corresponded to flesh color change and was highly coexpressed with ***,CgSDG40 and CgPSY1 are located physically adjacent to each other on the chromosome in opposite directions,sharing a partially overlapping promoter *** localization analysis indicated that CgSDG40 localizes to the *** of CgSDG40 significantly increased the total carotenoid content in citrus calli relative to that in wild *** addition,expression of CgPSY1 was significantly activated in overexpression lines relative to wild *** together,our findings reveal a novel histone methyltransferase regulator,CgSDG40,involved in the regulation of carotenoid biosynthesis in citrus and provide new strategies for molecular design breeding and genetic improvement of fruit color and nutritional quality.

关键词： pummelo SET domain protein epigenetic regulation PSY1 lycopene fruit quality fruit color

Effect of integrin α5β1 inhibition on SDF-l/CXCR4-mediated choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 726-735页

作者： Yang Lyu Wen-Qin Xu li-juan sun Xiao-Yan Pan Jian Zhang Yu-Sheng Wang Department of Ophthalmology Eye Institute of China PLAXijing Hospitalthe Fourth Military Medical University Department of Ophthalmology General Hospital of Lanzhou Military Command Department of Biochemistry and Molecular Biology the Fourth Military Medical University

AIM：To investigate the roles of integrins in choroidal neovascularization（CNV） and their associations with the stromal cell-derived factor-1（SDF-1）/CXCR4 ***：CNV lesions were induced in mice using laser *** CNV induction,all animals were randomly assigned to：control,SDF-1,SDF-1＋age-related macular degeneration（AMD） 3100（CXCR4 inhibitor）,and SDF-1＋ATN161（integrin α5β1 inhibitor） groups;their effects on CNV progression were observed using hematoxylin eosin（HE） staining,fundus fluorescein angiography（FFA） grading and optical coherence tomography（OCT）,and their effects on CXCR4/integrin α5 expression were evaluated using Western blot and double immunofluorescence ***-exposed endothelial cells（ECs） were used to simulate CNV in vitro,they were treated with SDF-1,combined with CXCR4 siRNA/AMD3100 or ATN161,and expression of integrin α5,cell migration and tube formation were ***：Integrin subunit α5 increased at 3^ rd and 7^ th day and decreased at 14 ^th day in CNV mice,with no significant change of β***4 expression in CNV mice had persistent increase within 14 d after ***-1 treatment significantly promoted the CNV progression during 3-14 *** mean CNV length in AMD3100 andATN161 group at day 7 was 270.13 and 264.23 μm in HE images,significantly lower than the mean length in SDF-1（345.70 μm） ***3100 and ATN161 also significantly reduced thickness and leakage of CNV induced by *** integrin α5 positive area in SDF-1 group reached 2.31×104 μm^2,significantly higher than control（1.25×104 μm^2）,which decreased to 1.78×104 μm^2 after AMD3100 *** 61.36% of ECs in CNV lesions expressed α5 in SDF-1 group,which significantly decreased to 43.12% after AMD3100 *** vitro,integrin α5 peaked by 6 folds after 6 h of hypoxia exposure and CXCR4 gradually increased by up to 2.3 folds after 24 h of *** 25.12% of ECs expressed integrin α5 after SDF-1 stimulation,which

关键词： choroidal neovascularization endothelial cells stromal cell-derived factor-1 CXCR4 integrin α5β1 hypoxia

Gut hormones in microbiota-gut-brain cross-talk

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Chinese Medical Journal 2020年第7期133卷 826-833页

作者： li-juan sun Jing-Nan li Yong-Zhan Nie State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Clinical Nutrition Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Gastroenterology Chinese Academy of Medical SciencesPeking Union Medical College HospitalBeijing 100730China

The homeostasis of the gut-brain axis has been shown to exert several effects on physiological and psychological *** gut hormones released by enteroendocrine cells scattered throughout the gastrointestinal tract are important signaling molecules within the gut-brain *** interaction between gut microbiota and gut hormones has been greatly appreciated in gut-brain *** microbiota plays an essential role in modulating many gut-brain axis-related diseases,ranging from gastrointestinal disorders to psychiatric ***,gut hormones also play pleiotropic and important roles in maintaining health,and are key signals involved in gut-brain *** importantly,gut microbiota can affect the release and functions of gut *** review highlights the role of gut microbiota in the gut-brain axis and focuses on how microbiota-related gut hormones modulate various physiological *** studies could target the microbiota-hormones-gut brain axis to develop novel therapeutics for different psychiatric and gastrointestinal disorders,such as obesity,anxiety,and depression.

关键词： Microbiota Gut hormones Gut-brain axis Appetite Anxiety Depression