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Graphdiyne scaffold anchored highly dispersed ruthenium nanoparticles as an efficient cathode catalyst for rechargeable li-CO_(2) battery

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Chinese Chemical Letters 2024年第1期35卷 552-557页

作者： Yiru Ma Huiqi Qu Wenna wang Ziyang Guo Yueqin Yu Feng liu Bin Yu Minge Tian Zhenjiang li Bin li Lei wang College of Chemistry and Molecular Engineering State Key Laboratory Base of Eco-Chemical EngineeringInternational Science and Technology Cooperation Base of Eco-Chemical Engineering and Green ManufacturingQingdao University of Science and TechnologyQingdao 266042China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China Biomedical Sensing Engineering Technology Research Center Shandong UniversityJi'nan 250100China Scientific Green(Shandong)Environmental Technology Co. Ltd.Jining Economic Development ZoneJining 272499China

lithium (li)-CO_(2) battery is rising as an attractive energy-storage system with the competence of CO_(2) conversion/fixation. However, its practical development is seriously hindered by the high overpotential. Herein, a rational design on a highly catalytic li-CO_(2) battery electrode built by graphdiyne powder as a multi-functional laminar scaffold with anchored highly dispersed Ru nanoparticles is explored. The strong interaction between the abundant acetylenic bond sites of graphdiyne scaffold and Ru nanoparticles can effectively promote the electrochemical progress and reduce the voltage polarization. The unique channels architecture of the cathodic catalyst with enough space not only accelerates CO_(2) diffusion and electrons/li+ transport, but also allows a large amount of accommodation for discharged product (li2CO3) to assure an advanced capacity. The corresponding li-CO_(2) battery displays an advanced discharged capacity of 15,030 mAh/g at 500 mA/g, great capacity retention of 8873 mAh/g at 2 A/g, high coulombic efficiency of 97.6% at 500 mA/g and superior life span for 120 cycles with voltage gap of 1.67 V under a restricted capacity of 1000 mAh/g at 500 mA/g. Ex/in-situ studies prove that synergy between Ru nanoparticles and acetylene bonds of GDY can boost the round-trip CO_(2)RR and CO_(2)ER kinetics.

关键词： Nanopores li-CO_(2)battery Anchored Ru nanoparticles Graphdiyne Synergistic effect

Single-base editing in IGF2 improves meat production and intramuscular fat deposition in liang Guang Small Spotted pigs

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Journal of Animal Science and Biotechnology 2024年第1期15卷 108-126页

作者： Tianqi Duo Xiaohong liu Delin Mo Yu Bian Shufang Cai Min wang Ruiqiang li Qi Zhu Xian Tong Ziyun liang Weilun Jiang Shiyi Chen Yaosheng Chen Zuyong He State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275GuangdongChina Department of Pharmacology(the State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China

Background Chinese indigenous pigs are popular with consumers for their juiciness,flavour and meat quality,but they have lower meat ***-like growth factor 2(IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation.A single nucleotide polymorphism(SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor,zinc finger BED-type containing 6(ZBED6),leading to up-regulation of IGF2 and causing major effects on muscle growth,heart size,and backfat *** favorable mutation is common in Western commercial pig populations,but absent in most Chinese indigenous pig *** improve meat production of Chinese indigenous pigs,we used cytosine base editor 3(CBE3)to introduce IGF2 intron3-C3071T mutation into porcine embryonic fibroblasts(PEFs) isolated from a male liang Guang Small Spotted pig(LGSS),and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer(SCNT) to generate the founder line of IGF2^(T/T) *** We found the heterozygous progeny IGF2^(C/T) pigs exhibited enhanced expression of IGF2,increased lean meat by 18%-36%,enlarged loin muscle area by 3%-17%,improved intramuscular fat(IMF) content by 18%-39%,marbling score by 0.75-1,meat color score by 0.53-1.25,and reduced backfat thickness by 5%-16%.The enhanced accumulation of intramuscular fat in IGF2^(C/T) pigs was identified to be regulated by the PI3K-AKT/AMPK pathway,which activated SREBP1 to promote *** We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality,and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3KAKT/AMPK signaling *** study provides a further understanding of the biological functions of IGF2and an example for improving porcine economic traits through precise base editing.

关键词： CBE3 IGF2 Intramuscular fat Meat production PI3K-AKT/AMPK ZBED6

Hypermethylation of GSTM5 and its effect on oxidation in myelodysplastic syndrome

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iLABMED 2024年第2期2卷 108-124页

作者： Chi wang Yafei Yu Qing Chang Tengteng Dong liye wang Mianyang li Department of Clinical Laboratory Medicine The First Medical CenterChinese PLA General HospitalBeijingChina

Background:Hypermethylation of glutathione-S-transferase 5(GSTM5)and its effect on oxidation in the pathogenesis of myelodysplastic syndrome(MDS)were ***:GSTM5 methylation was detected in bone marrow(BM)samples from MDS patients,acute myeloid leukemia(AML)patients,and control in-dividuals using methylation-specific PCR and MassARRAY *** sequencing PCR was performed to verify methylation levels,while mRNA levels were determined using reverse transcription polymerase chain *** between GSTM5 methylation and clinical parameters were *** MDS cell line,SKM-1,was treated with decitabine,buthionine sulfoximine,or overexpression of GSTM5,and the glutathione level and cell viability were ***:The MassARRAY analysis revealed significant differences in GSTM5 methylation levels between the MDS and control ***5 methylation levels were significantly increased in the high-risk subgroup and showed a significant association with MDS progression to AML(hazard ratio=3.6).Levels of GSTM5 mRNA were significantly decreased in the MDS group,exhibiting a negative correlation with the GSTM5 gene methylation *** BM HS-5 cells exhibited significantly lower levels of GSTM5 methylation than SKM-1 *** of GSTM5 in SKM-1 cells or treatment with buthionine sulfoximine or decitabine resul-ted in inhibition of proliferation and significantly decreased glutathione ***:GSTM5 plays an anti-oxidative role in MDS and the tumor suppressor effect of GSTM5 may be mediated by reducing glutathione ***5 hypermethylation and low levels of GSTM5 expression may be prog-nostic markers for MDS.

关键词： glutathione GSTM5 methylation myelodysplastic syndrome prognosis

Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet

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life Metabolism 2024年第2期3卷 55-69页

作者： Tongxing Song Ming Qi Yucheng Zhu Nan wang Zhibo liu Na li Jiacheng Yang Yanxu Han Jing wang Shiyu Tao Zhuqing Ren Yulong Yin Jinshui Zheng Bie Tan College of Animal Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410000China Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhanHubei 430070China

Postnatal growth retardation(PGR)frequently occurs during early postnatal development of piglets and induces high *** date,the mechanism of PGR remains poorly *** tissue-derived microbes have been documented to be associated with several disorders of metabolism and body ***,the connection between microbial disturbance of adipose tissue and pig PGR remains ***,we investigated piglets with PGR and found that the adipose tissue of PGR piglets was charac-terized by metabolism impairment,adipose abnormality,and specific enrichment of culturable bacteria from *** of Sphingomonas paucimobilis,a species of Sphingomonas genus from the alphaproteobacteria,induced PGR in ***,this bacterium could also lead to metabolic disorders and susceptibility to acute stress,resulting in weight loss in ***,multi-omics analysis indicated the changes in lipid metabolism as a response of adipose tissue to abnormal microbial *** experimental tests proved that one of the altered lipids phosphatidylethanolamines could rescue the metabolism disorder and growth retardation,thereby suppressing the amount of Sphingomonas in the adipose ***,these results highlight that the microbe–host crosstalk may regulate the metabolic function of adipose tissue in response to PGR.

关键词： adipose tissue microbe metabolic disorder postnatal growth retardation piglet

Metal organic frameworks-based cathode materials for advanced li-S batteries: A comprehensive review

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Nano Research 2024年第4期17卷 2592-2618页

作者： Zhengkun Xie Boyong Cao Xiyan Yue Ruixue wang Ziqian Xue Jiajia wang Guoqing Guan Weihua Chen College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China Laboratory of Energy Conversion Engineering Institute of Regional InnovationHirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan Institute for Integrated Cell-Material Sciences(iCeMS) Kyoto UniversitySakyo-kuKyoto 606-8501Japan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

li-S batteries(LSBs)have been considering as new and promising energy storage systems because of the high theoretical energy density and low ***,their practical application is inhibited by several factors,including poor electrical conductivity of electrode materials,greatly volumetric variation,as well as the polysulfide formation upon the *** address these problems,it is imperative to develop and design effective and suitable sulfur host anode *** organic frameworks(MOFs)-based cathode materials,possessing their good conductivity and easy morphology design,have been extensively studied and exhibited enormously potential in *** this review,a comprehensive overview of MOFs-based sulfur host materials is provided,including their electrochemical reaction mechanisms,related evaluation parameters,and their performances used in LSBs in the past few *** particular,the recent advances using in-situ characterization technologies for investigating the electrochemical reaction mechanism in LSBs are presented and ***,the challenges and prospects associated with future research on MOF-related sulfur host materials are *** is anticipated to offer the guidance for the identification of suitable MOFs-based sulfur cathode materials for high-performance LSBs,thereby contributing for the achievement of a sustainable and renewable society.

关键词： lithium metal anode sulfur cathode metal organic frameworks host energy density in-situ characterization

锂金属负极固体电解质界面膜的理解与改性策略

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科学通报 2024年第10期69卷 1298-1314页

作者：李宛峡李新鹏陈亚威揭育林曹瑞国焦淑红中国科学技术大学化学与材料科学学院材料科学与工程系合肥230026

锂金属负极因具有较高的比容量和较低的电极电势,被认为是最有发展前景的电池负极材料之一.然而,不稳定的锂金属负极固体电解质界面膜和严重的锂枝晶生长问题限制了锂金属负极的实际应用.认识和理解锂金属负极固体电解质界面膜的组成与... 详细信息

锂金属负极因具有较高的比容量和较低的电极电势,被认为是最有发展前景的电池负极材料之一.然而,不稳定的锂金属负极固体电解质界面膜和严重的锂枝晶生长问题限制了锂金属负极的实际应用.认识和理解锂金属负极固体电解质界面膜的组成与结构,并将其与锂金属生长行为建立有效的关联,是解决锂金属负极不稳定问题的关键.本文综述了近年来有关锂金属负极固体电解质界面膜的表征技术和调控策略,并介绍了锂金属软包电池的界面研究现状.本文对锂金属负极的实际应用具有一定的指导意义.

关键词：锂金属负极固体电解质界面膜锂金属枝晶锂金属电池

Automatic bug assignments without texts: a study

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Frontiers of Computer Science 2024年第4期18卷 211-213页

作者： Zexuan li Kaixin HUANG Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

1 Introduction Automatic bug assignment has been well-studied in the past *** textual bug reports usually describe the buggy phenomena and potential causes,engineers highly depend on these reports to fix ***,researchers spend much effort on processing bug reports,aiming for obtaining key information and/or clues for reproducing bugs,analyzing their root causes,assigning them to developers/maintainers,and fixing these ***,our previous research[1]reveals that noises in texts bring adverse impacts to automatic bug assignments unexpectedly,mainly due to insufficiency of classical Natural Language Processing(NLP)techniques.

关键词： bug assignment maintain

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代谢重编程对腹主动脉瘤的影响

生理学报 2024年第3期76卷 457-474页

作者：王歌王美丽首都医科大学基础医学院生理学与病理生理学系北京100069

腹主动脉瘤(abdominal aortic aneurysm,AAA)早期起病隐匿,急性破裂时常危及患者生命。目前,AAA缺乏有效的药物治疗手段,深入探索其发病机制成为解决问题的关键。代谢重编程是细胞为满足自身物质和能量需要而改变代谢模式的过程,主要包... 详细信息

腹主动脉瘤(abdominal aortic aneurysm,AAA)早期起病隐匿,急性破裂时常危及患者生命。目前,AAA缺乏有效的药物治疗手段,深入探索其发病机制成为解决问题的关键。代谢重编程是细胞为满足自身物质和能量需要而改变代谢模式的过程,主要包括糖代谢、脂质代谢和氨基酸代谢三个方面,其在心血管疾病尤其是AAA中的调节作用近年来备受关注。本文聚焦近年血管平滑肌细胞(vascular smooth muscle cells,VSMCs)和巨噬细胞的代谢重编程对AAA发生、发展的影响的研究进展,特别是其在VSMCs凋亡和表型转化、细胞外基质重塑、氧化应激和炎症反应等主要病理过程中的作用,以期从代谢角度为AAA的机制研究和临床治疗提供新思路。

关键词：腹主动脉瘤代谢重编程血管平滑肌细胞巨噬细胞

跨文化视角下中国地域武术文化内容的国际传播策略

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当代体育科技 2024年第27期14卷 125-128页

作者：李娇王美红吉林师范大学吉林四平136000

在全球化背景下,该文聚焦跨文化视角下中国地域武术文化内容的国际传播。先阐述了中国地域武术文化的丰富内涵与独特价值。接着分析了当前国际传播的现状及面临的问题。基于此,提出了策略,旨在为中国地域武术文化的国际传播提供经验借鉴... 详细信息

在全球化背景下,该文聚焦跨文化视角下中国地域武术文化内容的国际传播。先阐述了中国地域武术文化的丰富内涵与独特价值。接着分析了当前国际传播的现状及面临的问题。基于此,提出了策略,旨在为中国地域武术文化的国际传播提供经验借鉴,从而提升中国地域武术文化在国际上的影响力和认知度,弘扬中华优秀传统文化,为国际文化交流与合作开辟新途径。

关键词：跨文化视角中国地域武术文化国际传播策略构建文化价值