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World Journal of Gastroenterology 2009年第12期15卷 1528-1529页

作者： Yan Yin li-hua he Jian-Zhong Zhang Department of Diagnosis National Institute for-Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

helicobacter pylori(H pylori),a gastric pathogen,is a major cause of chronic gastritis and peptic ulcer disease,and is an important risk factor for the development of gastric *** of the bacterium from gastric biopsy is essential for the determination of drug resistance of H ***,the isolation rates of H pylori from infected individuals vary from 23.5%to 97% due to a number of factors such as biopsy preparation,cultural environment,medium and the method *** the present case,we found that a prolonged incubation period of up to 19 d allowed successful isolation of H pylori from a patient who received triple therapy that failed to eradicate the bacterium.

关键词： helicobacter pylori Isolation Eradication

Sensitivity of key factors and uncertainties in health risk assessment of benzene pollutant

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Journal of Environmental Sciences 2007年第10期19卷 1272-1280页

作者： liU Zhi-quan ZHANG Ying-hua li Guang-he ZHANG Xu Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

Predicting long-term potential human health risks from contaminants in the multimedia environment requires the use of models. However, there is uncertainty associated with these predictions of many parameters which can be represented by ranges or probability distributions rather than single value. Based on a case study with information from an actual site contaminated with benzene, this study describes the application of MMSOILS model to predict health risk and distributions of those predictions generated using Monte Carlo techniques. A sensitivity analysis was performed to evaluate which of the random variables are most important in producing the predicted distributions of health risks. The sensitivity analysis shows that the predicted distributions can be accurately reproduced using a small subset of the random variables. The practical implication of this analysis is the ability to distinguish between important versus unimportant random variables in terms of their sensitivity to selected endpoints. This directly translates into a reduction in data collection and modeling effort. It was demonstrated that how correlation coefficient could be used to evaluate contributions to overall uncertainty from each parameter. The integrated uncertainty analysis shows that although drinking groundwater risk is similar with inhalation air risk, uncertainties of total risk come dominantly from drinking groundwater route. Most percent of the variance of total risk comes from four random variables.

关键词： Monte Carlo sensitivity uncertainty MMSOILS models risk assessment

A highly stable and luminescent mononuclear Cu(Ⅰ)bis-{5-tert-butyl-3-(6-methyl-2-pyridyl)-1H-1,2,4-triazole}complex

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Chinese Chemical Letters 2017年第5期28卷 1027-1030页

作者： Yan-Sheng Luo Jing-lin Chen Xue-hua Zeng Lu Qiu li-hua he Sui-Jun liu he-Rui Wen School of Metallurgy and Chemical Engineering Jiangxi University of science and TechnologyGanzhou 341000China

A new emissive mononuclear homoleptic Cu（Ⅰ） complex of 5-rert-butyl-3-（6-methyl-2-pyridyl）-1H-1,2,4-triazole（bmptzH）,[Cu（bmptzH）2]（ClO4）（1）,has been synthesized by treatment of[Cu（PPh_3）2（CH3CN）2]（ClO4） or [Cu（CH3CN）4]（ClO4） with the bmptzH *** is revealed that complex 1 displays a distorted N4 tetrahedral arrangement formed by two bmptzH chelates,in which bmptzH adopts a neutral bidentate chelating coordination mode using the N atom of the pyridyl ring and the 4-N not 2-N atom of the 1,2,4-triazolyl *** is shown that complex 1 is highly stable and exhibits good luminescence properties in solution and solid states at room temperature due to the introduction of a methyl group at the ortho-position of the pyridyl ring.

关键词： Cu(I) complex 1 2 4-Triazole 6-Methyl-2-pyridyl Luminescence Crystal structure

Analysis of the urinary peptidome associated with helicobacter pylori infection

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World Journal of Gastroenterology 2011年第5期17卷 618-624页

作者： Di Xiao Fan-liang Meng li-hua he Yi-Xin Gu Jian-Zhong Zhang National Institute for Communicable Disease Controland Prevention Chinese Center for Disease Control and Pre-vention Beijing 102206 China

AIM： To investigate the relationship between urinary peptide changes and helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography＇and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry （MS）. ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS. RESULTS： Approximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MAL-DI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability （97%） and positive predictive value （94%）. Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYN- RGDSTF. The peptide was identified as isoform 1 of the fibrinogen a chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones. CONCLUSION： The appearance of urinary fibrinogen degradation products is caused by an active H. pyloriinduced process.

关键词： Urinary peptidome profiling MB-matrix-assisted laser desorption/ionization time-of-flight massspectrometry helicobacter pylori Fibrinogen degrada-tion products

Adherence and invasion of mouse-adapted H pylori in different epithelial cell lines

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World Journal of Gastroenterology 2007年第6期13卷 845-850页

作者： Mao-Jun Zhang Fan-liang Meng Xiao-Yun Ji li-hua he Jian-Zhong Zhang Department of Diagnostics National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Supported by the National Natural Science Foundation of China No. 30370078

AIM： To assess the adhesion and invasion abilities of different mouse adapted H py/or/strains in different cell lines in vitro and investigate their effects on the virulence factors cagA and vacA. METHODS： The adherence and invasion abilities of different N pylori strains in different epithelial cell lines were examined by the gentamycin protection assay. The null mutants of cagA and vacA were processed by direct PCR mutation method. The morphologic changes of different cell lines after N pylori attachment were examined by microscopy. RESULTS： The densities of adherence to and invasion into cells in vitro were different from those in the mouse infection experiments. 88-3887 strain could invade and adhere to cells stronger than SS1 and X47. All tested strains had better adhering and invasive abilities in SCG-7901 cell. CagA and vacA minus mutants had the same invasion and adherent abilities as their wild types. In all strains and cell lines tested, only AGS cell had the significant hummingbird phenotype after inoculation with the 88-3887 wild-type. CONCLUSION： Both the host cells and the bacteria play important parts in the invasion and adhesion abilities of Hpylori. CagA and VacA are not related to the ability of invasion and adhesion of Hpylori in different cell lines in vitro.

关键词： Hpylori Adherence Invasion Cell line

Primary antibiotic resistance of helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study

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World Journal of Gastroenterology 2015年第9期21卷 2786-2792页

作者： Yue-Xi Zhang li-Ya Zhou Zhi-Qiang Song Jian-Zhong Zhang li-hua he Yu Ding Department of Gastroenterology Beijing Sixth Hospital Department of Gastroenterology Peking University Third Hospital State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

AIM:To determine the resistance patterns of helicobacter pylori(***) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over ***:In this prospective,serial and crosssectional study,*** cultures were successfully obtained from 371 and 950 patients(never receiving eradication) during 2009-2010 and 2013-2014,*** to amoxicillin,clarithromycin,metronidazole,levofloxacin,tetracycline,and rifampicin was determined by Epsilometer ***:The resistance rates of isolates obtained during 2009-2010 were 66.8%,39.9%,34.5%,15.4%,6.7%,and 4.9% to metronidazole,clarithromycin,levofloxacin,rifampicin,amoxicillin and tetracycline,respectively; and the corresponding rates for isolates during 2013-2014 were 63.4%,52.6%,54.8%,18.2%,4.4% and 7.3%,*** resistance rates to clarithromycin and levofloxacin were significantly increased after four *** 2009-2010,14.6% of *** isolates were susceptible to all tested antibiotics,with mono(33.7%),double(28.3%),triple(16.7%),quadruple(6.2%),quintuple(0.3%) and sextuple resistance(0.3%) also being *** 2013-2014,9.4% were susceptible to all tested antibiotics,and mono(27.6%),double(28.4%),triple(24.9%),quadruple(7.3%),quintuple(2.3%) and sextuple resistance(0.1%) was also *** multiple resistant *** isolates were found during ***(to levofloxacin and metronidazole),age(to levofloxacin) and endoscopic findings(to clarithromycin) were independent factors influencing antibiotic ***:*** resistance to commonly used antibiotics in Beijing is high with increased multiple antibiotic resistance.

关键词： helicobacter pylori Antibiotic resistance Beijing

Temperature Difference Between the Air and Organs of Rice Plant and Its Relation to Spikelet Fertility

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Agricultural Sciences in China 2008年第6期7卷 678-685页

作者： YAN Chuan DING Yan-feng liU Zheng-hui WANG Qiang-sheng li Gang-hua he Ying WANGShao-hua Key Laboratory of Crop Growth Regulation Ministry of Agriculture/Hi-Tech Key Laboratory of Information Agriculture of Jiangsu Province Nanjing Agricultural University Nanjing 210095 P.R.China

Based on the experiment of measuring panicles and leaves, air temperature, and humidity above the canopy of rice cultivars after heading in 2005 and 2006, we investigated the temperature difference （TD） between the air and organs of rice plant and its relationship with spikelet fertility. The results showed that TDs between the air and organs of rice varied with air temperature, air humidity, and plant type. For similar air humidity, TDs were lower at the air temperature of 28.5℃ than at higher temperature of 35.5℃, whereas for the same air temperature, the TDs decreased as the air humidity increased. TDs were also affected by plant type of the cultivars. Erect panicle cultivars showed higher TDs than those with droopy panicles under similar climatic conditions, and cultivars with panicles above flag leaf （PAFL） had higher TDs than those with panicles below the flag leaf （PBFL）. Cultivars grown in a location with lower air humidity and higher temperature, such as Taoyuan, China, had higher spikelet fertility than those in higher humidity under the similar air temperature during the grain filling stage. This is partially attributed to the larger TDs under the lower humidity. Rowspacing and the ratio of basal-tillering to panicle-spikelet fertilizer showed a significant influence on TD and subsequently on spikelet fertility, suggesting the possibility of increasing spikelet fertility by agronomic management.

关键词： rice air temperature temperature of organs spikelet fertility

The Promoting Effect on the Activities ofFe Doped TiO_2 Photocatalysts

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Chemical Research in Chinese Universities 2001年第2期17卷 187-192页

作者： YU Xi-bin, WANG Gui-hua and li he-xing (Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China) 上海师范大学上海 200234

The particles of titanium-iron (Ti/Fe) complex with different Fe contents were prepared by means of the sol-gel method and used as a photocatalyst. The activity of the catalyst was investi- gated as a function of the Fe content during the liquid-phase oxidation of tetracycline, which showed an enhancement at the low Fe content. The XRD, Raman, XPS, and UV-Vis absorp- tion spectra indicated that the crystalline structure of the Ti/Fe complex particles changed from anatase phase to rutile phase when the Fe content increased. The isolated Fe203, Fe304, FeO species were observed and Fe3+ ions were highly dispersed in the TiO2 matrixes, then Ti-O-Fe species were formed. These species increased the surface defects of the Ti/Fe particles. Also, ac- tive hydroxyl radicals could be generated in the catalytic transformation, which led to the higher activity of the catalyst than bare Ti02 for the degradation of tetracycline.

关键词： Titanium Fe doped photocatalyst Photocatalytic activity Tetracycline

Prevention of iodinated contrast-induced nephropathy

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Chinese Medical Journal 2011年第23期124卷 4079-4082页

作者： li Jian-hua he Neng-shu College of Postgraduate Tianjin Medical University Tianjin 300070 China

Objective To lessen the occurrence of contrast-induced nephropathy （CIN）, the preventive measures of CIN were reviewed. Data sources The data used in this review were from PubMed with relevant English articles and from Chinese Knowledge Information （CNKI） published from 1989 to 2009. The search terms were ＂contrast medium＂, ＂contrast-induced nephropathy＂ and ＂prevention＂. Articles involved in prevention of CIN were selected. Study selection CIN is the third most common cause of acute kidney injury and is associated with an unfavorable prognosis. The best treatment is prophylaxis because CIN can not be reversed or ameliorated. Results Thirty articles were included. Among various preventive measures, pericatheterization hydration is almost universally accepted as an appropriate and safe measure to prevent CIN, although there is no agreement as to composition, amount, and timing of hydration. Based on the use of concomitant nephrotoxic agents or high doses of contrast medium （CM） is one of risk factors for CIN, discontinuation of potentially nephrotoxic drugs 2-3 days before and after the procedure until renal function recover, and using the lowest possible dose of CM can decrease the risk of CIN. It is promising that removing the majority of CM from the coronary sinus, before it enters the systemic circulation, during coronary angiography can reduce the risk for CIN in animal studies and in limited clinical trials. Inconsistent data exist with respect to application of some vasodilators （endothelin antagonists and adenosine antagonists） and antioxidants （N-acetylcysteine and statins） in preventing CIN in high-risk patients, and new vasodilators and antioxidants continue to be tested. Conclusions Pericatheterization hydration, discontinuation of nephrotoxic drugs, and using the lowest possible dose of CM are effective measures to lessen the risk for CIN. Other prophylactic strategies and some drugs are promising, but further confirmation is required.

关键词： contrast medium contrast-induced nephropathy prevention

Structures and luminescence properties of two copper(I) halide complexes featuring 2-(2-benzimidazolyl)-6-methylpyridine

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Chinese Chemical Letters 2012年第10期23卷 1169-1172页

作者： li hua he Jing lin Chen Jin Yun Wang Xiu Xiu Chen Xiu Zhen Tan Xing Fu Cao School of Science Jiangxi University of Science and TechnologyGanzhou 341000China School of Metallurgy and Chemical Engineering Jiangxi University of Science and TechnologyGanzhou 341000China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Two new copper（I） halide complexes bearing 2-（2-benzimidazolyl）-6-methylpyridine （Hbmp） and PPh3 ligands, Cu（Hbmp）（PPh3）X （X = Br （1）; I （2））, have been synthesized and characterized. Single-crystal X-ray structure analysis reveals that the halide ligand has a significant impact on the Cu-Npyridyl bond lengths. Complexes 1 and 2 show the solid-state emissions at ambient temperature, varying with the halide bound to the { Cu（Hbmp）（PPh3） } motif, which are perhaps best attributed to the metal-to-ligand charge-transfer （Cu（I） → Hbmp） transition mixed with some ligand-to-ligand charge-transfer （X and PPh3 → Hbmp） character.

关键词： Copper(I) complex 2-(2-Benzimidazolyl)-6-methylpyridine Crystal structure Photoluminescence