检索结果-南通市图书馆

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

引用

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

婴儿迟发型氨甲酰磷酸合成酶Ⅰ缺乏症1例并文献分析

引用

医学新知 2020年第4期30卷 302-307页

作者：黄莎王寿懿廖立红赵东赤武汉大学中南医院儿科武汉430071 武汉大学儿童健康大数据研究中心武汉430071

目的探讨婴儿迟发型氨甲酰磷酸合成酶I缺乏症(CPSID)的临床特征及基因突变情况。方法总结1例婴儿迟发型CPSID患儿的临床资料,回顾分析其临床特点、头颅磁共振成像及基因检测等结果,并分析相关文献。结果患儿,男,1月29天,以吐奶、烦躁及... 详细信息

目的探讨婴儿迟发型氨甲酰磷酸合成酶I缺乏症(CPSID)的临床特征及基因突变情况。方法总结1例婴儿迟发型CPSID患儿的临床资料,回顾分析其临床特点、头颅磁共振成像及基因检测等结果,并分析相关文献。结果患儿,男,1月29天,以吐奶、烦躁及精神反应差等非特异性表现起病,后病情迅速进展,出现抽搐、昏迷及呼吸暂停等症状。先后两次查血氨值分别为:518.6μmol/L、952.8μmol/L,头颅磁共振提示双侧大脑半球白质区异常信号,基因检测发现CPSI致病基因存在第15号外显子c.1676delA(p.E559fs)及第20号外显子c.2407C>G(p.R803G)两处杂合突变。结合以上最终确诊为迟发型CPSID。结论对于婴幼儿建立喂养后出现不明原因吐奶、喂养困难及意识障碍等症状,应尽快完善血氨等代谢指标检测,若血氨水平明显增高,应考虑先天性尿素循环障碍,并行头部MRI检查以评价脑损伤程度。本例患儿基因检测结果发现了一个新的突变位点c.1676delA(p.E559fs),这在一定程度上扩展了CPSID的基因谱。

关键词：氨甲酰磷酸合成酶Ⅰ缺乏症迟发型婴儿 CPSI基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development and validation of a new oxide fuel rod performance analysis code for the liquid metal fast reactor

引用

Nuclear Science and Techniques 2022年第5期33卷 167-177页

作者： Guang-liang Yang Hai-Long liao Tao Ding hong-li Chen School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230026China

The integrity and reliability of fuel rods under both normal and accidental operating conditions are of great importance for nuclear *** this study,considering various irradiation behaviors,a fuel rod performance analysis code,named KMC-Fueltra,was developed to evaluate the thermal–mechanical performance of oxide fuel rods under both normal and transient conditions in the *** accuracy and reliability of the KMC-Fueltra were validated by analytical solutions,as well as the results obtained from codes and *** results indicated that KMC-Fueltra can predict the performance of oxide fuel rods under both normal and transient conditions in the LMFR.

关键词： Fuel rod analysis code Thermal-mechanical performance Irradiation behaviors Pellet-cladding mechanical interaction liquid metal fast reactor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杏李树干液流变化与环境因子的关系研究

引用

新疆农业科学 2016年第12期53卷 2194-2202页

作者：李雯雯魏雅君冯贝贝牛莹莹徐业勇王明杨红丽廖康新疆农业大学特色果树研究中心乌鲁木齐830052 新疆林科院佳木试验站新疆温宿843100

【目的】研究杏李树干液流变化与环境因子的关系,了解树体蒸腾耗水规律,为杏李水分管理提供理论依据。【方法】采用PS-TDP8型热耗散式树干液流测定系统连续监测,分析环境因子对液流速率的影响。【结果】杏李在不同生长阶段液流日变化均... 详细信息

【目的】研究杏李树干液流变化与环境因子的关系,了解树体蒸腾耗水规律,为杏李水分管理提供理论依据。【方法】采用PS-TDP8型热耗散式树干液流测定系统连续监测,分析环境因子对液流速率的影响。【结果】杏李在不同生长阶段液流日变化均呈昼高夜低的单峰曲线,晴天液流速率高于阴天。各月液流速率均不相同,4月液流速率最低,月液流量为232.31 L,6月液流速率最高,月液流量为533.81 L。4、6和8月,杏李液流速率均与空气温度相关性最大,相关系数分别为0.831、0.806、0.846。5、7月,液流速率与光照强度的相关性最大,相关系数分别为0.860、0.863。4~8月回归方程决定系数R2均在0.8左右。【结论】在生长期,杏李树干液流速率日变化均呈现昼高夜低规律,晴天液流速率高于阴天。在整个生长阶段,6月液流量达到最大。杏李树干液流与环境因子显著相关,受光照强度和空气温度的影响最大。

关键词：杏李树干液流量环境因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Excitation of Annual Polar Motion by the Pacific,Atlantic and Indian Oceans

引用

Chinese Journal of Astronomy and Astrophysics 2007年第6期7卷 831-838页

作者： JinMa Yong-hong Zhou De-Chun liao Jian-li Chen Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 Graduate School of Chinese Academy of Sciences Beijing 100049 Center for Space Research University of Texas at Austin Austin TX 78712 USA

The global oceans play important roles in exciting the annual polar motion besides the atmosphere. However, it is still unclear about how large the regional oceans contribute to the annual polar motion. We investigate systemically the contributions of the Pacific, Atlantic and Indian Oceans to the excitation of the annual polar motion, based on the output data of ocean current velocity field and ocean bottom pressure field from ＂Estimating the Circulation and Climate of the Ocean （ECCO）＂ ocean circulation model over the period 1993-2005. The result shows that due to its particular location and shape, the Atlantic Ocean makes a less significant contribution to the x-component of the annual polar motion excitation than the Pacific and Indian Oceans, while all these three oceans contribute to the y-component of the annual polar motion excitation to some extent.

关键词： annual polar motion excitation oceanic angular momentum function(OAMF) -- atmospheric angular momentum function (AAMF)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cytokinesis and cancer:Polo loves ROCK'n' Rho(A)

引用

Journal of Genetics and Genomics 2010年第3期37卷 159-172页

作者： Jing li Jue Wang hong Jiao Ji liao Xingzhi Xu Laboratory of Cancer Biology College of Life Science Capital Normal University Beijing 100048 China

Cytokinesis is the last step of the M （mitosis） phase, yet it is crucial for the faithful division of one cell into two. Cytokinesis failure is often associated with cancer. Cytoldnesis can be morphologically divided into four steps： cleavage furrow initiation, cleavage furrow ingression, midbody formation and abscission. Molecular studies have revealed that RhoA as well as its regulators and effectors are im- portant players to ensure a successful cytokinesis. At the same time, Polo-like kinase 1 （Plkl） is an important kinase that can target many substrates and carry out different functions during mitosis, including cytokinesis. Recent studies are beginning to unveil a closer tie be- tween Plkl and RhoA networks. More specifically, Plkl phosphorylates the centralspindlin complex Cyk4 and MKLPI/CHO1, thus re- cruiting RhoA guanine nucleotide-exchange factor （GEF） Ect2 through its phosphopeptide-binding BRCT domains. Ect2 itself can be phosphorylated by Plkl in vitro. Plkl can also phosphorylate another GEF MyoGEF to regulate RhoA activity. Once activated, RhoA-GTP will activate downstream effectors, including ROCK1 and ROCK2. ROCK2 is among the proteins that associate with Plkl Polo-binding domain （PBD） in a large proteomic screen, and Plkl can phosphorylate ROCK2 in vitro. We review current understandings of the interplay between Plkl, RhoA proteins and other proteins （e.g., NudC, MKLP2, PRC 1, CEP55） involved in cytokinesis, with particular emphasis of its clinical implications in cancer.

关键词： Polo-like kinase 1 RhoA GTPase Rho kinase cytokinesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiplicity of solutions for the semilinear subelliptic Dirichlet problem

引用

Science China Mathematics 2024年第3期67卷 475-504页

作者： Hua Chen hong-Ge Chen Jin-Ning li Xin liao School of Mathematics and Statistics Wuhan UniversityWuhan 430072China Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

In this paper,we study the semilinear subelliptic equation{−△Xu=f(x,u)+g(x,u)inΩ,u=0 on∂Ω,where△X=−∑m i=1 Xi∗Xi is the self-adjoint Hormander operator associated with the vector fields X=(X_(1),X_(2),...,X_(m))satisfying the Hormander's condition,f(x,u)∈C(Ω×R),g(x,u)is a Carathéodory function onΩ×R,andΩis an open bounded domain in R~n with smooth *** the perturbation from the symmetry method with the approaches involving the eigenvalue estimate and the Morse index in estimating the minimax values,we obtain two kinds of existence results for multiple weak solutions to the problem ***,we discuss the difference between the eigenvalue estimate approach and the Morse index approach in degenerate *** with the classical elliptic cases,both approaches here have their own strengths in the degenerate *** new phenomenon implies that the results in general degenerate cases would be quite different from the situations in classical elliptic cases.

关键词： degenerate elliptic equations Hormander operators perturbation method Morse index

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure evolution and diffusion mechanism of Nb/TiAl alloy diffusion-bonded joints

引用

Rare Metals 2023年第5期42卷 1686-1694页

作者： Kun Huang hong-liang Sun Ze-Wen Huang Mo-Yu liao Yang li School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu610031China Key Laboratory of Advanced Technologies of Materials Ministry of EducationChengdu610031China

The interdiffusion behavior in Nb/TiAl alloy diffusion couples was *** process was carried out in the temperature range of 950-1400℃for 8 h in the vacuum hot-pressure sintering *** microstructural evolution was observed by optical microscopy(OM),electron backscattered diffraction(EBSD),X-ray diffraction(XRD)technique and transmission electron microscopy(TEM).The element concentration distribution at the bonded interface was obtained by scanning electron microscopy with an energy-dispersive X-ray spectroscopy(EDS)*** thickness of reaction interface increases with bonding temperature *** formed phases in diffusion interface are found to be O-Ti_(2)AlNb,σ-Nb_(2)Al,δ-Nb_(3)Al and Nb solid solution(Nbss)at 1350℃.The average interdiffusion coefficient of the interface elements was calculated by the theory of *** results indicate that Al diffuses faster than Nb and Nb diffuses faster than Ti in the Ti-Al-Nb ***,it is found that Ti promotes the diffusion of Al and Nb and Nb inhibits the diffusion of Ti and Al in the process of diffusion.

关键词： Diffusion bonding TiAl alloys Nb Interface microstructure Interdiffusion coefficient

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

引用

Nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

深圳市社区居民心理卫生需求调查与分析

引用

实用预防医学 2009年第6期16卷 1948-1949页

作者：王凯李丽红廖万威宋平赵蓉深圳市福田区慢性病防治院广东深圳518048

目的调查深圳市社区居民的心理卫生需求,为深入开展心理卫生进社区提供依据和指导。方法设计封闭式调查问卷,对深圳市福田区的社区居民心理卫生需求进行抽样调查。结果对于心理卫生服务,社区居民首选的心理服务方式是社区(占47.5%),其... 详细信息

目的调查深圳市社区居民的心理卫生需求,为深入开展心理卫生进社区提供依据和指导。方法设计封闭式调查问卷,对深圳市福田区的社区居民心理卫生需求进行抽样调查。结果对于心理卫生服务,社区居民首选的心理服务方式是社区(占47.5%),其次是电话(占41.3%),然后是综合医院心理门诊(占27.5%),最不愿意的选择是精神病医院(占1.8%)。结论社区居民心理卫生需求较大,对社区居民提供心理卫生服务很有必要性。

关键词：心理卫生服务社区居民

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：