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创业型大学的转型与未来:以“奇点大学”为例

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黑龙江高教研究 2017年第2期35卷 34-36页

作者：李威李莉方复旦大学高等教育研究所上海200433

创业型大学经历三十多年的发展,其概念、内涵、形式、机制都在不断革新。2009年诞生于美国硅谷的奇点大学,致力于培养未来领军人物,在办学理念、创业环境、组织结构、师资聘用、学生来源、教学内容、教学形式、创业教育等方面都具有独... 详细信息

创业型大学经历三十多年的发展,其概念、内涵、形式、机制都在不断革新。2009年诞生于美国硅谷的奇点大学,致力于培养未来领军人物,在办学理念、创业环境、组织结构、师资聘用、学生来源、教学内容、教学形式、创业教育等方面都具有独到的创新之处,代表创业型大学的转型方向。基于奇点大学的启示,文章对创业型大学的未来发展图景进行展望:充满活力且富有创新精神的学习型机构、与内外部所有的利益相关者紧密联系、很强的地域特色、覆盖大学各个学院和部门的创新创业教学法、自下而上的创新奖励机制,从而最大限度地实现学生创业的自主授权和创新思维的自由。

关键词：创业型大学奇点大学创新精神组织变革

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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数字媒介时代中国儿童文学的游戏新质

兰州大学学报（社会科学版） 2024年第2期52卷 98-109页

作者：李利芳彭雨兰州大学文学院甘肃兰州730000

游戏精神是儿童文学的核心审美要素,反映儿童本能心理需求。从纸媒时代到数字媒介时代,儿童文学的创作和传播形式发生巨大转向,其游戏形式与游戏场域发生根本性转换。数字图书实体能够与故事分离,成为阅读游戏的新主体,读者身体亦参与... 详细信息

游戏精神是儿童文学的核心审美要素,反映儿童本能心理需求。从纸媒时代到数字媒介时代,儿童文学的创作和传播形式发生巨大转向,其游戏形式与游戏场域发生根本性转换。数字图书实体能够与故事分离,成为阅读游戏的新主体,读者身体亦参与进阅读活动,作为精神游戏的阅读活动被加入实体游戏形式。非线性叙事和自由选择模式让数字图书阅读增加了建构个性化故事的游戏形式。与此同时,传统儿童文学阅读形成的“书与人”的私密阅读空间被打破,数字图书提供了群体交互空间,数字阅读表现出群体性活动特征和社交性活动转向。文本世界与现实世界的界限因数字技术变得模糊,图书元素可通过数字技术呈现于现实世界,现实世界的不确定性经由互动进入文本世界。游戏的结构特性和数字媒介表达形式、内在符号会深刻影响儿童认知和文化生成。数字儿童文学的游戏精神由“出世”的精神幻想转为“入世”的互动乐趣,表现出与数字媒介特性相符的狂欢性、主动性、社交性特征,以及由故事幻想转向世界幻想的新特质。

关键词：儿童文学数字媒介数字儿童文学游戏精神游戏形式游戏场域

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梯形成形冲击响应函数推导、仿真和实验研究

原子能科学技术 2014年第2期48卷 341-346页

作者：胡创业康玺屈国普李方立南华大学核科学技术学院湖南衡阳421001

本文介绍了利用逆z变换方法得到梯形成形冲击响应函数的推导过程,采用软件产生的单指数信号对其正确性进行了仿真验证。在单指数信号上加载不同标准差的高斯白噪声,经梯形成形仿真得到输出信号和输入白噪声标准差的比值约为0.447。通过... 详细信息

本文介绍了利用逆z变换方法得到梯形成形冲击响应函数的推导过程,采用软件产生的单指数信号对其正确性进行了仿真验证。在单指数信号上加载不同标准差的高斯白噪声,经梯形成形仿真得到输出信号和输入白噪声标准差的比值约为0.447。通过搭建数字核信号获取平台,对实际输入核信号进行梯形成形,验证了推导过程与结果的正确性。

关键词：梯形滤波卷积冲击响应函数

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Mg-Fe-HTlc对黄原胶流变性的影响

化学学报 2011年第15期69卷 1760-1764页

作者：李丽芳王莉王建伟王冬青山东农业大学化学与材料科学学院泰安271018

研究了荷负电高分子物质黄原胶(XG)及类水滑石HTlc/XG复合悬浮体系的流体类型及触变性.结果发现,供试体系流变曲线都符合Herschel-Bulkley模型.在0.05～0.20 wt%范围内,随XG含量增加,XG溶液表现出由假塑性流体到塑性流体的转变,没有触变... 详细信息

研究了荷负电高分子物质黄原胶(XG)及类水滑石HTlc/XG复合悬浮体系的流体类型及触变性.结果发现,供试体系流变曲线都符合Herschel-Bulkley模型.在0.05～0.20 wt%范围内,随XG含量增加,XG溶液表现出由假塑性流体到塑性流体的转变,没有触变性;1.5 wt%纯HTlc悬浮体系为牛顿流体,无触变性.当HTlc/XG质量比为29.0～6.5时(复合悬浮体系固含量保持为1.5%),体系均表现为假塑性流体;除HTlc/XG质量比为29.0体系无触变性外,其它复合悬浮体系均表现为正触变性.

关键词：黄原胶类水滑石流体类型触变性

Comparative proteomics analysis of human gastric cancer

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World Journal of Gastroenterology 2008年第37期14卷 5657-5664页

作者： Wei li Jian-fang li Ying Qu Xue-Hua Chen Jian-Min Qin Qin-Long Gu Min Yan Zheng-Gang Zhu Bing-Ya liu Shanghai Key Laboratory of Diagnosis and Treatment for GastrointestinalCancer Department of Surgery Shanghai Institute of DigestiveSurgery Ruijin Hospital Shanghai Jiao Tong University Schoolof Medicine Shanghai 200025 China

AIM: To isolate and identify differentially expressed proteins between cancer and normal tissues of gastric cancer by two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). METHODS: Soluble fraction proteins of gastric cancer tissues and paired normal tissues were separated by 2-DE. The differentially expressed proteins were selected and identified by MALDI-TOF-MS and database search. RESULTS: 2-DE profiles with high resolution and reproducibility were obtained. Twenty-three protein spots were excised from sliver staining gel and digested in gel by trypsin, in which fifteen protein spots were identified successfully. Among the identified proteins, there were ten over-expressed and five under-expressed proteins in stomach cancer tissues compared with normal tissues. CONCLUSION: In this study, the well-resolved, reproducible 2-DE patterns of human gastric cancer tissue and paired normal tissue were established and optimized and certain differentially-expressed proteins were identified. The combined use of 2-DE and MS provides an effective approach to screen for potential tumor markers.

关键词： Proteome Two-dimensional polyacrylamide gel electrophoresis Mass spectrometry Gastric cancer Tumor markers

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei liu Yantong li Meng-Xiang Wu Hao Kang Xiao-li Zhao lin Xu linlin liu Xiaodong li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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Ⅰ期子宫内膜癌167例临床分析

中国妇幼保健 2008年第13期23卷 1771-1773页

作者：李莉芳南方医科大学附属南海医院妇产科广东佛山528200

目的:探讨Ⅰ期子宫内膜癌生物学行为和相关因素。方法:对该院1997年1月～2006年12月收治的167例Ⅰ期子宫内膜癌患者临床资料进行回顾性分析。结果:临床Ⅰ期盆腔淋巴结转移率为11.3%;术前分段诊刮加B超检查,对判断浸润深度有一定价值,但... 详细信息

目的:探讨Ⅰ期子宫内膜癌生物学行为和相关因素。方法:对该院1997年1月～2006年12月收治的167例Ⅰ期子宫内膜癌患者临床资料进行回顾性分析。结果:临床Ⅰ期盆腔淋巴结转移率为11.3%;术前分段诊刮加B超检查,对判断浸润深度有一定价值,但与术后病理检查相比,差别有显著性意义(P<0.01)。经单因素分析:浸润深度、病理分级和组织学类型均与盆腔淋巴结转移有关(P<0.05)。结论:分段诊刮加B超检查对判断浸润深度有一定价值,但需提高精确度。Ⅰ期子宫内膜癌盆腔淋巴结转移与子宫肌层浸润深度、组织学类型和病理分级密切相关。临床Ⅰ期低危组可仅行全子宫双附件切除,不必盆腔淋巴结清扫。

关键词： Ⅰ期子宫内膜癌相关因素临床分析