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Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang Yan li li-chao sun Xiao-yu liu Nan Gao Sheng-tao Yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its ***:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ *** was intraperitoneally injected 2 h before *** data(blood pressure and heart rate) were *** intestinal microcirculation data of the rats were analyzed via microcirculation ***-linked immunosorbent assay(EliSA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the *** analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in *** expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western ***:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory ***,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small ***:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

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Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2074-2078页

作者： Wan-ling Xu Wen-Jing Tang Wei-Ying Yang li-chao sun Ze-Qun Zhang Wei li Xiu-Xian Zang Department of Emergency Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Chinese Traditional Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying *** SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed *** patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital *** poisoning can cause lifethreatening MODS and is rare *** case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt *** This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

关键词： Cantharidin Poisoning Multiorgan dysfunction syndrome Clinical treatment and management Case report

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The Later Effects of DHA in Diet on Regulating Transcription of lipid Genes of Broiler

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Agricultural Sciences in China 2011年第4期10卷 611-618页

作者： li Yan sun chao College of Animal Science Northwest A＆F University Yangling 712100 P.R.China

The effect of docosahexaenoic acid （DHA） on lipid metabolism in broiler were studied in order to provide test results for polyunsaturated fatty acids （PUFA） regulating fatty deposition. 1-wk-old Arbor Acres （AA） broiler were fed with DHA microalgae and slaughtered after 2 wk. The tissues were stored for isolating total RNA. RT-PCR was used to analyze the expression changes of genes. DHA microalgae significantly increased average body gain and feed conversion rates, reduced the levels of total cholesterol （TC）, total glycerin （TG）, and low-density lipoprotein cholesterol （LDL-C） in serum and increased the content of high-density lipoprotein cholesterol. 1 wk later, the effects were still remained. In liver tissue, DHA microalgae increased the expression of PPARα and carnitine palmitoyltransferase-1 （CPT-1）. 1 wk later, it was observed that DHA up-regulated the expression of fatty acid synthase （FAS）, acetyl CoA carboxylase （ACC）, lipoprotein lipase （LPL） and carnitine palmitoyltransferase-1 （CPT-1）. 2 wk later, it still increased the expressions of FAS and CPT-1, but a converse result was observed for ACC and LPL. In adipose tissue, DHA microalgae suppressed the expression of PPARα and LPL, up-regulated the expression of ACC, FAS, and CPT-1. After withdrawal, the expression of genes in test group was significantly lower than that in control group （P0.01）. In the muscle of chest, DHA microalgae significantly inhibited the gene expression （P0.01）. 1 wk later, the expressions of FAS, LPL and CPT-1 in test group were significantly higher than that in control group （P0.05）. 2 wk later, it was shown that DHA significantly inhibited fat synthesis and decomposition. In the leg, there was not any PPARα expression being detected, probably because of the less expression in muscle tissues or the regulation of PPARα had no relation to the case. DHA microalgae promote fat synthesis in the liver and inhibit in adipose and muscle tissues. It still has effects after 1 wk of withdrawa

关键词： DHA broiler adipose tissue liver lipid metabolic genes

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OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He li chao li Di sun Zhi Min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted *** study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and *** results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice *** increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation

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Characteristics of Bi-2223 HTS Tapes Under Short-Circuit Current Impacts in Hybrid Energy Transmission Pipelines

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 736-745页

作者： Yuguang sun chao Yin Weizhen li Xinyang li Xiaohua Jiang Department of Electric Engineering Tsinghua UniversityBeijing 100084China

A hybrid energy transmission pipeline is proposed with the aim of long-distance cooperative transmission of electricity and chemical fuels, which is composed of an inner high-temperature superconducting (HTS) power cable and outer liquefied natural gas (LNG) pipeline. The flowing LNG could maintain the operating temperature of the inner HTS power cable within the range of 85 K-90 K, thus the Bi-2223 superconductors in the HTS power cable produce little Joule loss with the transmission current below the critical current. Owing to the advantages of high power density, low transmission losses and economical manufacturing costs, the hybrid energy transmission pipeline is expected to be widely utilized in the near future. In order to ensure the safety of the HTS power cable and explosive LNG in case of short-circuit faults, this paper tests and analyzes the characteristics of Bi-2223 HTS tapes of the Type HT-CA, Type HT-SS and Type H models under short-circuit current impacts at the LNG cooling temperature (85 K-90 K). An experimental platform is designed and established for the ampacity tests of HTS tapes above LN2 cooling temperature (77 K). The AC over-current impact tests at 85 K-90 K are carried out on each sample of Bi-2223 tapes respectively, and the experimental results are analyzed and compared to evaluate their performances under different operating conditions. The results indicate that the Type HT-CA tape can withstand 50 Hz short-circuit current impact with the amplitude of 1108 A (10 times of critical current Ic ) for 100 ms at 90 K, and its resistance is the smallest of the three tested samples under similar current impacts. Therefore, the Type HT-CA Bi-2223 tape is the optimal superconductor of the HTS power cable in the hybrid energy transmission pipeline.

关键词： Bi-2223 high-temperature superconducting(HTS)tape critical current hybrid energy transmission pipeline liquefied natural gas(LNG)cooling temperature short-circuit current impact characteristics

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Spontaneous pneumomediastinum in diabetic ketoacidosis:A case series of 10 patients

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World Journal of Emergency Medicine 2022年第2期13卷 141-143页

作者： Wan-ling Xu li-chao sun Xiu-xian Zang Hong Wang Wei li Department of Emergency Medicine the First Hospital of Jilin UniversityChangchun 130021China

Dear editor,Spontaneous pneumomediastinum(SPM,also known as Hamman’s syndrome)is an uncommon *** is induced without any comorbidities and is secondary to underlying factors,such as smoke,asthma,esophageal rupture,or labor and delivery.[1,2]The frequency of idiopathic pneumomediastinum is 1 of 32,000 hospitalized persons.[3]Awareness of SPM and appropriate examination play a key role in the early diagnosis and intervention for SPM to avoid potentially serious *** in diabetic ketoacidosis(DKA)has been described in several case reports.[4-6]However,most data are described from isolated cases,and these cases have varying clinical *** study presents a case series of ten patients diagnosed with SPM complicating DKA to assess their characteristics,treatment,and prognosis.

关键词： patients diagnosis diabetic

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： chao-Yue sun Wen li Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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Trichostatin A improves the inflammatory response and liver injury in septic mice through the FoxO3a/autophagy signaling pathway

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World Journal of Emergency Medicine 2022年第3期13卷 182-188页

作者： Mei-jia Shen li-chao sun Xiao-yu liu Meng-chen Xiong Shan li A-ling Tang Guo-qiang Zhang Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100193China Emergency Department China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND:Sepsis-induced liver injury is a fatal complication of *** A(TSA)regulates inflammation and autophagy in some human diseases,and forkhead box O3a(FoxO3a)has been shown to regulate *** present study aims to investigate whether TSA exerts its effects on septic liver injury through the FoxO3a/autophagy signaling ***:A sepsis mouse model was constructed by the cecal ligation and puncture(CLP)method,and AML12 cells were pretreated with lipopolysaccharide(LPS)(1μg/mL)to establish a sepsis cell *** mice were divided into four groups,namely control group,TSA group,CLP group,and CLP+TSA group,with 10 mice in each *** were divided into control group,TSA group,LPS group,and LPS+TSA ***-eosin(H&E)staining and biochemical methods were used to evaluate liver tissue ***-linked immunosorbent assay(EliSA)was applied to detect the expression of proinflammatory cytokines,and Western blotting and immunofluorescence were used to measure autophagy-related protein ***:Compared with the CLP group(mice),the proinflammatory cytokines(interleukin-β[IL-β]2,665.27±324.90 pg/mL to 2,080.26±373.66 pg/mL;interleukin-6[IL-6]399.01±60.98 pg/mL to 221.90±46.89 pg/mL)and the hepatocyte injury markers(aspartate transaminase[AST]from 198.18±27.07 U/L to 128.42±20.55 U/L;alanine aminotransferase[ALT]from 634.98±74.10 U/L to 478.60±32.56 U/L)were notably decreased after TSA ***,LC3 II and FoxO3a showed an obvious increase and P62 showed an obvious decrease in the CLP+TSA *** experiment results showed the similar *** Fox O3a gene was knocked down in AML12 cells,the promotion of autophagy and the improvement of liver enzyme index and inflammation by TSA were ***:TSA may improve the inflammatory response and liver injury in septic mice through Fox O3a/autophagy.

关键词： Sepsis liver injury Trichostatin A Autophagy Inflammation

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Sepsis caused by Eggerthelle lenta: a case report

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World Journal of Emergency Medicine 2022年第5期13卷 415-417页

作者： li-chao sun Wan-ling Xu Jian-nan Chai li Pang Xiu-xian Zang Wei li Ji-hong Xing Department of Emergency Medicine the First Hospital of Jilin UniversityChangchun 130021China Department of Clinical Laboratory the First Hospital of Jilin UniversityChangchun 130021China

Dear editor,Eggerthelle lenta(***)is a gram-positive non-spore-bearing anaerobic bacilli that was first isolated from human feces by Arnold Eggerth in 1935.[1]It is classified as an anaerobic eubacterium that cannot decompose glucose and tryptophan[2]but can synthesize diff erent kinds of steroid metabolism enzymes.[3]On the basis of the high content of guanine+cytosine detected by 16S ribosomal RNA gene sequencing,its original name Eubacterium lentum was changed to *** and concurrently transferred to its own distinct genus Eggerthella.[4]*** often exists in the gastrointestinal tract.[5]Previous reports on ***-induced sepsis were ***,we present a case of ***-induced sepsis with abdominal pain as the main symptom.

关键词： 16S editor metabolism

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River width and depth as key factors of diurnal activity energy expenditure allocation for wintering Spot-billed Ducks in the Xin'an River Basin

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Avian Research 2024年第1期15卷 116-122页

作者： chao Yu Xuying Lu Deli sun Mengnan Chu Xueyun li Qun li College of life and Environmental Sciences Huangshan UniversityHuangshan245021China Environment Conservation Research Centre of Xin’an River Basin Huangshan UniversityHuangshan 245021China Department of Resources Conservation Southern Anhui National Wildlife Rescue CenterXiuning 245400China

Rivers are important habitats for wintering ***,they are easily influenced by natural and human *** important approach for waterbirds to adapt to habitats is adjusting the activity time and energy expenditure allocation of diurnal *** compensatory foraging hypothesis predicts that increased energy expenditure leads to longer foraging time,which in turn increases food intake and helps maintain a constant energy ***,it is unclear whether human-disturbed habitats result in increased energy expenditure related to safety or *** this study,the scan sample method was used to observe the diurnal behavior of the wintering Spot-billed Duck(Anas poecilorhyncha) in two rivers in the Xin’an River Basin from October 2021 to March *** allocation of time and energy expenditure for activity in both normal and disturbed environments was *** results showed that foraging accounted for the highest percentage of time and energy ***,foraging decreased in the disturbed environment than that in the normal *** behavior showed the opposite trend,while other behaviors were similar in both *** total diurnal energy expenditure of ducks in the disturbed environment was greater than that in the normal environment,with decreased foraging and resting time percentage and increased behaviors related to immediate safety(swimming and alert) and *** results oppose the compensatory foraging hypothesis in favor of increased *** optimal diurnal energy expenditure model included river width and water depth,which had a positive relationship;an increase in either of these two factors resulted in an increase in energy *** study provides a better understanding of energy allocation strategies underlying the superficial time allocation of wintering waterbirds according to environmental *** these changes can help understand the maximum fitness of wi

关键词： Diurnal behavior activities River factors Time and energy expenditure allocation Wintering Spot-billed Duck Xin’an River Basin

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