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A hybrid physics-informed data-driven neural network for CO_(2) storage in depleted shale reservoirs

Petroleum Science 2024年第1期21卷 286-301页

作者： Yan-Wei Wang Zhen-Xue Dai Gui-Sheng Wang li Chen Yu-zhou Xia Yu-Hao zhou College of Construction Engineering Jilin UniversityChangchun130026JilinChina Institute of Intelligent Simulation and Early Warning for Subsurface Environment Jilin UniversityChangchun130026JilinChina School of Energy Resources China University of GeosciencesBeijing100083China Department of Safety Environmental Protection and Quality ManagementShengli OilfieldSinopecDongying257000ShandongChina Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiChina College of Computer Science and Technology China University of Petroleum(East China)Qingdao266580ShandongChina Department of Physics University of FribourgFribourg1700Switzerland

To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport ***,most current CO_(2) sequestration models do not adequately consider multiple transport ***,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and *** this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training *** this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and *** incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion ***,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated *** validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise *** study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.

关键词： Deep learning Physics-informed data-driven neural network Depleted shale reservoirs CO_(2)storage Transport mechanisms

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Hollow-structured all-silicon terahertz metasurface supporting quasi-bound states in the continuum for refractive index based Auramine O concentration sensing

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Photonics Research 2024年第7期12卷 1574-1582页

作者： XIN TANG HAODUO JIA LANBIN li MING li DAI WU KUI zhou PENG li WEIJUN WANG JITAO li DINGYU YANG College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang 621000China School of Precision Instruments and Opto-Electronics Engineering Tianjin UniversityTianjin 300072China Guizhou Zhenhua Fengguang Semiconductor Co. Ltd.Guiyang 550000China Chengdu Huanyuxin Technology Co. Ltd.Chengdu 610095China

Quasi-bound states in the continuum (QBIC),with exceptionally high-Q factors and the local field enhancement effect,have found potential applications in matter *** the QBIC mechanism into terahertz(THz) metasurfaces can significantly enhance the interaction between incident THz waves and matter,providing a feasible platform for the detection of biochemical ***,most experimental studies on terahertz QBIC metasurfaces utilize metallic *** contrast,research on terahertz all-dielectric QBIC metasurfaces generally remains at the simulation stage due to the high fabrication process requirements,and transitioning to the experimental stage still poses many *** this paper,a hollow-structured all-silicon metasurface supporting THz QBIC is *** resonance of THz QBIC is excited via a simple hollow structure and observed in *** and experimental results demonstrated that the designed THz QBIC metasurface can achieve sensing of Auramine ***,it is the first study,to our knowledge,to employ a metasurface to sense Auramine ***,the sensing performance maintains good stability under different humidity and temperature *** study provides new references and insights for the design and implementation of THz QBIC,and also opens a new pathway for the detection of Auramine O.

关键词： supporting continuum refractive

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Iridoids modulate inflammation in diabetic kidney disease: A review

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Journal of Integrative Medicine 2024年第3期22卷 210-222页

作者： Tong-yi zhou Na Tian liu li Rong Yu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng Changsha 410208Hunan ProvinceChina

In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical *** has become a pervasive complication of type 2 *** the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic ***,primarily derived from the potent components of traditional herbs,have been the subject of long-standing *** data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of *** article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this ***,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic *** review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

关键词： Diabetic kidney disease Iridoids Gut-kidney axis Traditional Chinese medicine monomer Inflammation

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Design of advanced porous silver powder with high-sintering activity to improve silicon solar cells

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Nano Research 2024年第4期17卷 3189-3197页

作者： Yongsheng li Ziwei Chen Rui zhou Wenguang Zhao Mu li Jun Chen Zhongyuan Huang Jian liu Yuhang li Maolin Yang Minghan Yu Dong zhou Yuan lin Feng Pan School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055China Institute of Advanced Science Facilities Shenzhen 518107China Institute of Zhejiang University-Quzhou Quzhou 324000China Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China Institute of Materials Research(IMR) Tsinghua UniversityTsinghua Shenzhen International Graduate SchoolShenzhen 518055China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Silver(Ag)paste is widely used in semiconductor metallization,especially in silicon solar *** powder is the material with the highest proportion in Ag *** morphology and structure of Ag powder are crucial which determine its characteristics,especially for the sintering *** this work,a simple method was developed to synthesize a type of microcrystalline spherical Ag particles(SP-A)with internal pores and the structural changes and sintering behavior were thoroughly studied by combining ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),in-situ heating X-ray diffraction(XRD),focused ion beam(FIB),and thermal analysis *** to the unique internal pores,the grain size of SP-A is smaller,and the coefficient of thermal expansion(CTE)is higher than that of traditional solid Ag *** a result,the sintering activity of SP-A is excellent,which can form a denser sintered body and form silver nanoparticles at the Ag–Si interface to improve silver silicon *** silicon solar cell built with SP-A obtained a low series resistance(Rs)and a high photoelectric conversion efficiency(PCE)of 19.26%.These fill a gap in Ag particle structure research,which is significant for the development of high-performance electronic Ag particles and efficient semiconductor devices.

关键词： silver particles small angle X-ray scattering(SAXS) pore size distribution in-situ heating X-ray diffraction(XRD) sintering silicon solar cells

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A review of MXene-derived quantum dots:Synthesis,characterization,properties,and applications

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Particuology 2024年第8期91卷 50-71页

作者： Chunhe zhou Kar Ban Tan Wenjuan Han li Wang Ming Lu The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchunJilin 130103China Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdangSelangor 43400Malaysia

Cutting MXene to a minimum size and forming the derived two-dimensional MXene quantum dots(MQDs),which possess a unique intrinsic layered geometry structure,restricts exciton due to their novel spatial *** gives rise to a broad spectrum of fascinating properties,rendering them for various ***,the correlation between composition,structure,and processing control of MQDs is investigated systematically,giving further insight into the intrinsic and extrinsic *** review also provides an opportunity to explore new compositions,modify the properties,and tailor MQDs into the guided architectural design before any prospective applications.

关键词： MXene Quantum dots Characterization Properties Applications

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Effect of solvent on the initiation mechanism of living anionic polymerization of styrene:A computational study

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Chinese Journal of Chemical Engineering 2024年第5期69卷 135-142页

作者： Shen li Yin-Ning zhou Zhong-Xin liu Zheng-Hong Luo School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China Department of Chemical Engineering School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

For living anionic polymerization(LAP),solvent has a great influence on both reaction mechanism and *** this work,by using the classical butyl lithium-styrene polymerization as a model system,the effect of solvent on the mechanism and kinetics of LAP was revealed through a strategy combining density functional theory(DFT)calculations and kinetic *** terms of mechanism,it is found that the stronger the solvent polarity,the more electrons transfer from initiator to solvent through detailed energy decomposition analysis of electrostatic interactions between initiator and solvent ***,we also found that the stronger the solvent polarity,the higher the monomer initiation energy barrier and the smaller the initiation rate ***,initiation is more favorable at lower temperatures based on the calculated results ofΔG_(TS).Finally,the kinetic characteristics in different solvents were further examined by kinetic *** is found that in benzene and n-pentane,the polymerization rate exhibits first-order ***,slow initiation and fast propagation were observed in tetrahydrofuran(THF)due to the slow free ion formation rate,leading to a deviation from first-order kinetics.

关键词： living anionic polymerization Solvent effect Reaction kinetics Computational chemistry Mathematical modeling Kinetic modeling

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Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants

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China CDC weekly 2024年第23期6卷 542-546,I0008-I0011页

作者： Meiyu zhou Huilin Zhang Qi Xiao Kexin li Xiaoting li Haiyan Chu Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter of Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Nutrition and Food Safety School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina

What is already known about this topic?Chlorinated organophosphate flame retardants(Cl-OPFRs)are frequently detected chemicals in the environment and biological samples,yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of *** is added by this report?This study utilizes the adverse outcome pathway(AOP)framework to assess the health implications and mechanisms of Cl-OPFRs,identifying multi-system toxicity,with a particular emphasis on reproductive issues and the possible toxic *** are the implications for public health practice?These results enhance knowledge of the health hazards linked to Cl-OPFRs,supporting the creation of focused risk evaluations and suitable regulatory actions.

关键词： utilize supporting Chlorin

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Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit

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Science China(life Sciences) 2024年第10期67卷 2198-2212页

作者： Zhen li Xuefei li Jingxia lin Yangming Wang Huiqing Cao Jiajian zhou Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Dermatology Hospital Southern Medical UniversityGuangzhou 510091China Beijing Advanced Center of RNA Biology(BEACON) Peking UniversityBeijing 100871China

Many long noncoding RNAs(lncRNAs)have been identified through siRNA-based screening as essential regulators of embryonic stem cell(ESC)***,the biological and molecular functions of most lncRNAs remain ***,we employed CRISPR/Cas9-mediated knockout technology to explore the functions of 8 lncRNAs previously reported to promote pluripotency in mouse ***,all of these lncRNAs were dispensable for pluripotency maintenance and proliferation in mouse ESCs when disrupted individually or in ***-cell transcriptomic analysis also showed that the knockout of these lncRNAs has a minimal impact on pluripotency gene expression and cell *** further showed that several small hairpin RNAs(shRNAs)previously used to knock down lncRNAs caused the downregulation of pluripotency genes in the corresponding lncRNA-knockout ESCs,indicating that off-target effects likely responsible for the pluripotency defects caused by these ***,linc1343-knockout and linc1343-knockdown ESCs failed to form cystic structures and exhibited high expression of pluripotency genes during embryoid body(EB)*** reintroducing RNA products generated from the linc1343 locus,we found that two snoRNAs,Snora73a and Snora73b,but not lncRNAs,could rescue pluripotency silencing defects during EB differentiation of linc1343 knockout *** results suggest that the 8 previously annotated pluripotency-regulating lncRNAs have no overt functions in conventional ESC culture;however,we identified snoRNA products derived from an annotated lncRNA locus as essential regulators for silencing pluripotency genes.

关键词： long noncoding RNAs embryonic stem cells CRISPR/Cas9 snoRNAs stem cell differentiation

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun li Fang-zhou Sun Chun-Xiao li Hong-Nan Mo Yan-Tong zhou Dan Lv Jing-Tong Zhai Hai-li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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Long-term complete response to anti-programmed-death-1 monotherapy in a patient with relapsed and refractory ovarian adenocarcinoma: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1967-1973页

作者： Guang-Di zhou Qin li Affiliated to Shanghai Jiao Tong University School of Medicine Xinhua HospitalShanghai 200092China Department of Obstetrics and Gynecology Shanghai Changhai HospitalShanghai 200433China

BACKGROUND Ovarian cancer is the most common malignant tumor of the female reproductive system,and the survival rate of patients with relapsed and refractory ovarian cancer is very *** SUMMARY Here,we report a case of high-grade serous papillary adenocarcinoma of the ovary that was successfully treated with *** surgery and adjuvant chemotherapy for the 56-year-old patient were successful;however,her tumor *** second-line chemotherapy,targeted agents,and other treatments were ineffective,as the tumor continued to recur and ***-programmed cell death-1(PD-1)monotherapy(tislelizumab)completely alleviated the tumor,and the multiple metastatic tumors *** date,the patient has used anti-PD-1 for 32 months,experiencing no disease progression and maintaining good health without additional *** This case suggests that anti-PD-1 immunotherapy may have long-term positive effects on outcomes in some refractory recurrent solid *** research is needed to identify patients most likely to respond to anti-PD-1 therapy.

关键词： Anti-programmed cell death-1 Tislelizumab Ovarian cancer Relapsed cancer treatment Immunotherapy Case report

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