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Synergistic Effects of Activin A and Fibroblast Growth Factor 2 in the Modulation of Insulin Expression

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Chemical Research in Chinese Universities 2006年第2期22卷 229-232页

作者： BAO Yong-li JIANG Hong-yu Ji Shou-xian WU Yin MENG Xiang-ying li yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China The First Affiliated Hospital Jilin University Changchun 130021 P. R. China The Second Affiliated Hospital Jilin University Changchun 130041 P. R. China

Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients worldwide is increasing. The reduction of insulin biosynthes is in pancreatic E-cells is closely associated with the onset and progression of diabetes, therefore, it is important to search for ways to induce insulin-producing cells in non-E-cells. In the present study, it has been reported that activin A and a basic fibroblast growth factor 2 （ FGF2）, can synergistically increase the insulin mRNA level, in both mouse El4 striatal primary cell cultures and the hippocampal neuronal cell line HT22. Activin A and FGF2 can jointly stimulate the nuclear translocation of Smad3 and specifically activate ERK1/2. It is interesting to note that a specific inhibitor for MEK, U0126, can efficiently block the induction of an insulin promoter activity by activin A and FGF2. This indicates that activin A collaborates with FGF2, giving a signal to induce the insulin gene through selective activation of the ERK-type MAP kinase and Smad3 in mouse striatal and HT22 cells. These data suggest that activin A may act in concert with FGF2 for the development of insulin -positive neurons

关键词： Activin A Fibroblast growth factor 2 (FGF2) Insulin

Asymmetric association of rainfall and atmospheric circulation over East Asia with anomalous rainfall in the tropical western North Pacific in summer

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Atmospheric and Oceanic Science Letters 2016年第3期9卷 185-190页

作者： LU Ri-yu HONG Xiao-Wei li xin-yu State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences College of Earth Science University of the Chinese Academy of Sciences

It is well known that precipitation anomalies in the tropical western North Pacific （WNP） significantly affect circulation and rainfall in East Asia during summer. In this study, the authors further investigated this relationship, by examining the anomalies associated with positive and negative precipitation anomalies in the tropical WNP. The results suggest these anomalies are asymmetric between the enhanced and suppressed WNP rainfall. Positive precipitation anomalies over the WNP, in comparison with their negative counterparts, are more closely related to the meridional teleconnection pattern and rainfall anomalies along the East Asian rain belt. The implications of the results are discussed.

关键词： Teleconnection East Asianrain fall western NorthPacific East Asian jet asymmetry

Dissolved organic nitrogen (DON) in the processes of polluted source water treatment

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Chinese Science Bulletin 2010年第27期55卷 3098-3101页

作者： GU li liU Bing yu xin Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China

Dissolved organic nitrogen (DON) is currently considered to be one of the most important issues in drinking water field due to its formation of nitrogenous disinfection *** paper deals with DON concentrations in typical processes of a water treatment *** results show that very little DON is removed by these ***,biological activity in some processes can even increase DON concentration and decrease the ratio of dissolved organic carbon/DON,which may pose a risk to drinking water safety.

关键词：溶解有机碳有机氮水处理过程污染水源消毒副产物污水处理厂生物活性安全风险

Description of the Superdeformed Bands of the Odd-Odd Nuclei in A ～ 150 Region

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Communications in Theoretical Physics 2002年第8期38卷 200-204页

作者： ZHANG Da-li liU yu-xin Department of Physics Huzhou Teacher''s College Huzhou 313000 Zhejiang Province China Department of Physics Peking University Beijing 100871 China Institute of Theoretical Physics Academia Sinica P.O. Box 2735 Beijing 100080 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China

With the supersymmetry scheme including many-body interactions, the global property and the △I ＝ 4bifurcation in the superdeformed (SD) bands of odd-odd nuclei in A ～ 150 mass region are investigated *** results for the γ-ray energies, the dynamical moments of inertia, and energy differences △ Eγ - △ Erefγ are *** shows that this approach is quite powerful in describing not only the SD bands in even-even and odd-A nuclei butalso those in odd-odd nuclei in the mass region.

关键词： superdeformed band, dynamical moment of inertia, △I = 4 bifurcation, odd-odd nuclei

Effect of wastewater treatment processes on the pyrolysis properties of the pyrolysis tars from sewage sludges

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Journal of Thermal Science 2011年第2期20卷 167-172页

作者： Wu Xia Xie li-ping li xin-yu Dai Xiao-hong Fei Xue-ning yuan-guangt School of Environment ＆ Chemical Engineering Tianjin Polytechnic University Tianjin 300160 China Department of Environmental and Municipal Engineering Tianjin Institute of Urban Construction Tianjin 300384 China

The pyrolysis properties of five different pyrolysis tars, which the tars from 1# to 5# are obtained by pyrolyzing the sewage sludges of anaerobic digestion and indigestion from the A2/O wastewater treatment process, those from the activated sludge process and the indigested sludge from the continuous SBR process respectively, were studied by thermal gravimetric analysis at a heating rate of 10 ℃/min in the nitrogen atmosphere. The results show that the pyrolysis processes of the pyrolysis tars of 1#, 2#, 3# and 5# all can be divided into four stages: the stages of light organic compounds releasing, heavy polar organic compounds decomposition, heavy organic compounds decomposition and the residual organic compounds decomposition. However, the process of 4# pyrolysis tar is only divided into three stages: the stages of light organic compounds releasing, decomposition of heavy polar organic compounds and the residual heavy organic compounds respectively. Both the sludge anaerobic digestion and the "anaerobic" process in wastewater treatment processes make the content of light organic compounds in tars decrease, but make that of heavy organic compounds with complex structure increase. Besides, both make the pyrolysis properties of the tars become worse. The pyrolysis reaction mechanisms of the five pyrolysis tars have been studied with Coats-Redfern equation. It shows that there are the same mechanism functions in the first stage for the five tars and in the second and third stage for the tars of 1#, 2#, 3# and 5#, which is different with the function in the second stage for 4# tar. The five tars are easy to volatile.

关键词： sewage sludge pyrolysis tar pyrolysis wastewater treatment process anaerobic digestion

Mutation Analysis of AVPR2 and AQP2 Gene in Chinese Patients with Congenital Nephrogenic Diabetes Insipidus

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Chemical Research in Chinese Universities 2008年第3期24卷 312-315页

作者： WANG Ying li Hong-jun yu Zhen-xiang BAO Yong-li WU Yin yu Chun-lei MENG Xiang-ying li yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China Out-patient Department China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China Department of Respiratory Medicine First Hospital of Jilin University Changchun 130021 P. R. China Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education Northeast Normal University Changchun 130024 P. R. China

To detect mutations of the aquaporin 2 gene（AQP2） and the arginine vasopressin V2 receptor gene（AVPR2） of Chinese congenital nephrogenic diabetes insipidus, and to establish the foundation for further studying the emergence mechanism of the disease and clinical diagnosis, all the exons and part of introns of AQP2 and AVPR2 genes were amplified with intronic primers, using genomic DNA extracted from three patients with congenital nephrogenic diabetes insipidus and two mothers as template, PCR product was ligated into a T-vector and then sequenced. The result was compared with the database sequence to identify the mutable sites via a BLAST search, the incidence of every mutation was analyzed, and the putative transcription factor binding sites that maybe disturbed were analyzed by MAPPER. Mutation g.1394A〉G in exon 3 of AVPR2 was detected in all the subjects, g.861C〉T（S167L） in exon 2 of AVPR2 and IVS1＋3G〉A in intron of AQP2 were detected, respectively, in two patients, and c.836A〉C in 3′ untranslated region of AQP2 was detected in two patients and one mother. Four mutations were identified. g.1394A〉G of AVPR2 and c.836A〉C of AQP2 have high incidence in patients with nephrogenic diabetes insipidus. Detection on the two sites may become auxiliary diagnosis index of congenital nephrogenic diabetes insipidus.

关键词： Nephrogenic diabetes insipidus Gene mutation AQP2 A VPR2

Antibody Phage library Screening Efficiency Measured by KD Values

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Chemical Research in Chinese Universities 2005年第6期21卷 677-679页

作者： WANG Hui-tang SHAN. Ya-ming TANG li-li GAO li-zeng WANG li-ping li Wei li yu-xin College of life Science Jilin University Changchun 130023 P. R. China Institute of Genetics and Cytology Northeast Normal University Changchun 130021 P. R. China

An antibody phage library was screened with two target molecules, IFNα-2a and FGFR-GST, and the KD value of each round of panning was measured. It was found that the apparent KD values decreased along with each additional panning round, which indicates the increase of the binding affinity between the phage and the target molecules. This result shows that the KD value is a reliable intrinsic parameter and a new method for screening efficiency detection is thus provided.

关键词： KD value Antibody phage library Screening efficiency Target

Toxic effects of acetochlor, methamidophos and their combination on nifH gene in soil

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Journal of Environmental Sciences 2007年第7期19卷 864-873页

作者： SU Zhen-cheng ZHANG Hui-wen li xin-yu ZHANG Qin ZHANG Cheng-gang Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China. Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Toxic effects of two agrochemicals on nifH gene in agricultural black soil were investigated using denaturing gradient gel electrophoresis （DGGE） and sequencing approaches in a microcosm experiment. Changes of soil nifH gene diversity and composition were examined following the application of acetochlor, methamidophos and their combination. Acetochlor reduced the nifH gene diversity （both in gene richness and diversity index values） and caused changes in the nifH gene composition. The effects of acetochlor on nifH gene were strengthened as the concentration of acetochlor increased. Cluster analysis of DGGE banding patterns showed that nifH gene composition which had been affected by low concentration of acetochlor （50 mg/kg） recovered firstly. Methamidophos reduced nifH gene richness that except at 4 weeks. The medium concentration of methamidophos （150 mg/kg） caused the most apparent changes in nifH gene diversity at the first week while the high concentration of methamidophos （250 mg/kg） produced prominent effects on nifH gene diversity in the following weeks. Cluster analysis showed that minimal changes of nifH gene composition were found at 1 week and maximal changes at 4 weeks. Toxic effects of acetochlor and methamidophos combination on nifH gene were also apparent. Different nifH genes （bands） responded differently to the impact of agrochemicals： four individual bands were eliminated by the application of the agrochemicals, five bands became predominant by the stimulation of the agrochemicals, and four bands showed strong resistance to the influence of the agrochemicals. Fifteen prominent bands were partially sequenced, yielding 15 different nifH sequences, which were used for phylogenetic reconstructions. All sequences were affiliated with the alpha- and beta-proteobacteria, showing higher similarity to eight different diazotrophic genera.

关键词： agrochemicals acetochlor methamidophos toxic effects nifH gene PCR-DGGE

Analysis of Essential Oils from Flower-buds, Leaves and Stems of Filipendula palmata(Pall.) Maxim.

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Chemical Research in Chinese Universities 2005年第6期21卷 658-662页

作者： WU Yin MENG Xiang-ying liU Xiao-hua BAO Yong-li WANG Shu-ping li yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China

The essential oils of the flower-buds, leaves and stems of Filipendula palmata（ Pall. ） Maxim. were analyzed by GC and GC-MS. Thirty-three, forty-seven and forty-seven compounds in the flower-buds, leaves and stems were identified, respectively. Methyl salicylate exists in a great amount which is up to 70. 10% in the flower-buds. Its amount is also high in other two parts. The data obtained show that it may be one of the main natural mosquito-expelling and pain-alleviating components in the three parts. The flower-buds are the main active part with the mosquito-expelling function.

关键词： Filipendula palmata( Pall. ) Maxim. Essential oil GC-MS