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Endovascular treatment of wide-necked intracranial aneurysms using of ＂remodeling technique＂ with the HyperForm balloon

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Chinese Medical Journal 2008年第8期121卷 725-729页

作者： MU Shi-qing YANG Xin-jian li you-xiang ZHANG you-ping LU Ming WU Zhong-xue Department of Neuroradiosugery Beijing Neurosurgical Institute Capital Medical University Beijing 100053 China

Background Aneurysms with wide-necked or a large neck/fundus ratio, especially located on an arterial bifurcation or a small artery, are challenges for interventional neuroradiologist because of the risk of coil migration or coil protrusion into the parent vessels. Our study was designed to improve the efficacy and safety of the ＂remodeling technique＂ with the HyperForm balloon for these difficult aneurysms and was confirmed by a follow-up result. Methods From June 2004 to September 2006, forty-two patients （20 men, 22 women） with wide-necked or large neck/fundus ratio aneurysms were treated by using the ＂remodeling technique＂ with the HyperForm balloon. Results Forty wide-necked aneurysms were successfully treated with the HyperForm balloon remodeling technique with only two failed cases. Final results consisted of total occlusion in 34 cases （80.9%）, subtotal in 4 （9.5%） and incomplete in 2 （4.8%）. One aneurysmal rupture occurred, but no clinical consequence was shown. No thromboembolic events were observed during treatment. Final angiographic follow-up time ranged from 3 to 18 months. Conclusions The ＂remodeling technique＂ with the HyperForm balloon is a very useful tool in the treatment of wide-necked or unfavorable neck/fundus ratio intracranial aneurysms - located on an arterial bifurcation or a small artery and, especially, located on the bifurcation of a large artery and a small one. In our experience, this technique provided a safe and efficient treatment for difficult aneurvsms when the standard remodelina techniaue miaht have failed.

关键词： aneurysms remodeling technique HyperForm balloon endovascular treatment

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Embolization of brain arteriovenous malformations with ethylene vinyl alcohol copolymer： technical aspects

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Chinese Medical Journal 2009年第16期122卷 1851-1856页

作者： GAO Kun YANG Xin-jian MU Shi-qing li you-xiang ZHANG you-ping LU Ming WU Zhong-xue Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Endovascular therapy plays an important role in the treatment of brain arteriovenous malformations （BAVMs）. Ethylene vinyl alcohol copolymer （Onyx） is a novel liquid embolic material. This study aimed to summarize our experience of using Onyx for embolization of BAVMs with the focus on embolization technique. Methods From September 2003 to November 2007, 115 patients （43 women and 72 men, with a mean age of 29 years） with BAVMs were endovascularly treated with Onyx in our department. The following features of all AVMs were evaluated prior to treatment： type of nidus and shunt, draining veins, and feeding arteries. A total of 196 endovascular procedures were performed. Results The course of endovascular treatment was completed in 88 patients. Additional sessions were planned in 27 patients. Of the 88 patients, total occlusion was obtained in 23 patients （26.1%）, near-total （〉80% of the original volume） occlusion was obtained in 35 patients （39.8%） and partial occlusion （〈80% of the original volume） was obtained in 30 patients （34.1%） using embolization as the sole therapeutic technique. Mean volume reduction was 72% （range 30%-100%） in 115 patients. Thirty four patients （38.6%, 34/88） underwent radiosurgical treatment. Additional embolization sessions were planned in 27 patients. Complications occurred in 19 patients （16.5%, 19/115）, leading to death in one patient （mortality 0.9%） and permanent disabling in 3 patients （morbidity 2.6%）. Conclusions Onyx was shown to be feasible and safe for embolization of BAVMs. Proper use of the Onyx injection technique largely improved the endovascular treatment of BAVMs. Large AVMs can be adequately reduced in size through the use of additional treatment.

关键词： brain arteriovenous malformations endovascular treatment Onyx copolymer

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Endovascular treatment of a giant internal carotid artery bifurcation aneurysm with drainage into cavernous sinus

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Chinese Medical Journal 2012年第3期125卷 539-542页

作者： Zhang Zhen-hai Yang Xin-jian Wu Zhong-xue li you-xiang Jiang Peng Capital Med Univ Beijing Neurosurg Inst Beijing 100050 Peoples R China Capital Med Univ Dept Intervent Neuroradiol Beijing Tiantan Hosp Beijing 100050 Peoples R China

This report documents the treatment of a giant aneurysm of the internal carotid artery bifurcation with a fistula to the cavernous sinus, which appeared following closed head trauma. A 39-year-old man suffered from a blunt head trauma in an automobile accident. Two weeks after the trauma, progressive chemosis of left eye was presented. Four months after the trauma, digital subtraction angiography showed an internal carotid artery bifurcation aneurysm, with drainage into the cavernous sinus. The lesion was successfully obliterated with preservation of the parent artery by using coils in conjunction with Onyx. Follow-up angiography obtained 3 months postoperatively revealed persistent obliteration of the aneurysm and fistula as well as patency of the parent artery. Endovascular treatment involving the use of coils combined with Onyx anneam to be a feasible and effective o[}tion for treatment of this hard-to-treat lesion.

关键词： traumatic aneurysm carotid-cavernous fistula endovascular coils embolization Onyx

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Tagging Salt Tolerant Gene Using PCR Markers in Soybean

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Agricultural Sciences in China 2001年第1期 30-34页

作者： GUO Bei QIU li-juan SHAO Gui-hua CHANG Ru-zhen liU li-hong XU Zhan-you li xiang-hua SUN Jian-ying Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Breeding and Cultivation Chinese Academy of Agricultural Science Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081 Institute of Crop Germplasm Resources of Chinese Academy of Agricultural Science Key Laboratory of Crop Germplasm & Biotechnology Ministry of Agriculture Beijing 100081

The purpose of this study was to screen and identify PCR markers associated with salt tolerant gene in soybean( Glycine soja L. ) so that salt tolerance can be identified efficiently and accurately. Between these tolerant and sensitivity to salt and three crosses were tested in this experiment. By BSA method, two codominant PCR markers were identified through the salt tolerant (sensitive) cuitivars bulks and the salt tolerant (sensitive) individual bulks of a F2 population. There was a 600bp band in the sensitive individuals and a 700bp band or two 700bp/600bp bands in the tolerant individuals. The markers were closely linked with salt tolerant/sensitive alleles. Moreover the markers were tested in the other two F2 populations from "salt tolerant cultivar × sensitive cuitivar" and confirmed by 12 salt tolerance cultivars and 13 salt sensitive cultivars with different genetic background. It indicated that the markers (700bp and 600bp) could be applied in salt tolerant identification of the soybean germplasm resources, and markers-assisted selection in salt tolerant breeding of soybean. The markers, its obtained method and application were patented for invention in 1998.

关键词： Salt tolerant gene Molecular marker Patent Soybean

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Transvenous embolization of cavernous dural arteriovenous fistula:report of 28 cases

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Chinese Medical Journal 2007年第24期120卷 2229-2232页

作者： HE Hong-wei JIANG Chu-han WU Zhong-xue li you-xiang WANG Zhong-cheng Department of Neuroradiosurgery Beijing Neurosurgery InstituteBeijing Tiantan Hospital Capital Medical University Beijing100050 China

Background Usually, cavernous dural arteriovenous fistula can be treated via transarterial approaches. However, in many complicated patients, transvenous approaches are superior to the transarterial ones because of the difficulties during a transarterial operation. In this study, we retrospectively analyzed the outcomes of 28 patients with cavernous dural arteriovenous fistula treated by transvenous embolization. Methods From September 2001 to December 2005, 28 patients with 31 cavernous dural arteriovenous fistulae were treated with transvenous embolization in Beijing Tiantan Hospital. The involved cavernous sinuses were catheterized via the femoral vein-inferior petrosal sinus approach or the femoral-facial-superior ophthalmic vein approach, and embolized with coils （GDC, EDC, Matrix, Orbit or free coil） or coils plus silk. The patients were followed up for 3 to 26 months. Results All the 31 cavernous sinuses in the 28 patients were successfully embolized. Complete angiographic obliteration of the fistulae was achieved immediately in 25 patients. Residual shunting was observed in the other 3, who had drainage through the pterygoid plexus （2 patients） or the inferior petrosal sinus （1） after the operation. Headache and vomiting were the most common symptoms after the embolization. In 3 patients, who achieved complete angiographic obliteration immediately, the left oculomotor nerve palsy remained unchanged after the operation. Transient abducens nerve palsy was encountered in 1. In 1 patient, the occular symptoms were improved after the operation, but recurred 4 days later, and then disappeared spontaneously after 5 days. During the follow-up, no patient had recurrence. Three months after the operation, angiography was performed on the 3 patients with residual shunting. Two of them had angiographic cure, the other had residual drainage through the pterygoid plexus. Conclusions Transvenous catheterization and embolization of the cavernous sinus is a safe and ef

关键词： transvenous cavernous sinus dural arteriovenous fistula embolization

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Transvenous embolization with a combination of detachable coils and Onyx for a complicated cavernous dural arteriovenous fistula

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Chinese Medical Journal 2008年第17期121卷 1651-1655页

作者： HE Hong-wei JIANG Chu-han WU Zhong-xue li you-xiang LU Xian-li WANG Zhong-cheng Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Treatment of cavernous dural arteriovenous fistulas （DAVF） is usually made by a transarterial approach. However, in many complicated patients, treatments via transarterial approaches can not be achieved, and only an operation via a transvenous approach is feasible. We aimed to study the feasibility of transarterial embolization of cavernous dural arteriovenous fistulas with a combination detachable coils and Onyx to embolize a complicated cavernous DAVF via a transvenous approach. Methods From August 2006 to August 2007, six cases of complicated cavernous DAVF were embolized with a combination of detachable coils and Onyx via a transvenous approach. Three cases were male and the other three were female. Their ages ranged from 36 to 69 years old. The fistula was in the right lateral cavernous sinus in one case, in the left lateral cavernous sinus in another, and in the bilateral cavernous sinus in 4 cases. One fistula was fed by the right internal carotid artery and its meningohypophyseal trunk; one was fed by the branches of the left internal carotid artery and left external carotid artery; four were fed by the branches of the bilateral internal carotid artery and/or the bilateral external carotid artery. One case was drained via one lateral inferior petrosal sinus; three were drained via bilateral inferior petrosal sinuses; one was drained via one lateral ophthalmic and facial veins; one was drained via the inferior petrosal sinus and the ophthalmic and facial veins. Four were embolized via the inferior petrosal sinus, and two were embolized via the ophthalmic and facial veins. Results Among six cases of complicated cavernous DAVF, four were fully embolized with Onyx by a single operation, and two cases were fully embolized with Onyx following two operations. Transient headache was found after operation in all patients, but was cured after several days by the symptomatic treatments. In one case, the first operation via the inferior petrosal sinus was a f

关键词： transvenous cavernous dural arteriovenous fistula embolization Onyx detachable coils

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Successful tubes treatment of esophageal fistula

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 709-714页

作者： ZHOU Ning, CHEN Wei-xing, li you-ming, xiang Zhun, GAO Ping, FANG Ying (Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China) Department of Gastroenterology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China.

Aim: To discuss the merits of "tubes treatment" for esophageal fistula (EF). Methods: A 66-year-old female who suffered from a bronchoesophageal and esophagothoratic fistula underwent a successful "three tubes treatment" (close chest drainage, negative pressure suction at the leak, and nasojejunal feeding tube), combination of antibiotics, antacid drugs and nu-tritional support. Another 55-year-old male patient developed an esophagopleural fistula (EPF) after esophageal carcinoma operation. He too was treated conservatively with the three tubes strategy as mentioned above towards a favorable outcome. Results: The two patients recovered with the tubes treatment, felt well and became able to eat and drink, presenting no complaint. Con-clusion: Tubes treatment is an effective basic way for EF. It may be an alternative treatment option.

关键词： Esophageal fistula Bronchoesophageal fistula Esophagopleural fistula Tubes treatment

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辽宁省部分普通高校女大学生体育现状的调查研究

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广州体育学院学报 2006年第3期26卷 123-125页

作者：李有香鞍山师范学院辽宁鞍山114005

运用问卷调查、数理统计、文献资料、专家访谈等方法、对辽宁部分普通高校女大学生体育现状进行调研分析,结果表明:体育需求表现出多元化的特点;关注体育的态度以及对余暇体育活动主动性不高,女大学生对体育课的满意程度呈正态分布,活... 详细信息

运用问卷调查、数理统计、文献资料、专家访谈等方法、对辽宁部分普通高校女大学生体育现状进行调研分析,结果表明:体育需求表现出多元化的特点;关注体育的态度以及对余暇体育活动主动性不高,女大学生对体育课的满意程度呈正态分布,活动场地以校内的运动场(馆)为主:大部分学生每周不同程度地参加体育活动但活动时间比较短,锻炼效果不高。

关键词：辽宁体育现状

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Endovascular treatment of cerebral arteriovenous malformations with Onyx embolization

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Chinese Medical Journal 2005年第24期118卷 2041-2045页

作者： HE Hong-wei JIANG Chu-han liU Hong-bing li you-xiang ZHANG Jing-bo WU Zhong-xue Department of Neurosurgery Qilu Hospital Shandong UniversityJinan 250012 China Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing 100050China

Background In the past 5 years, new treatment materials and techniques offering a different concept in endovascular treatment have been described for cerebral arteriovenous malformations （CAVMs）. The aim of this study was to assess the endovascular treatment of CAVMs by using a liquid embolic material, Onyx （ Micro Therapeutics. Inc. , Irvine, CA, USA）. Methods From September 2003 to September 2004, Onyx was used to treat 22 patients with CAVMs. Ten AVMS were located in functional areas, 8 in deep cerebral areas, and 4 in the cerebellar hemisphere. The size of CAVMs was about 3 cm in diameter in 5 patients, 3 -6 cm in 11, and more than 6 cm in 6. Results In the 22 patients, Onyx embolization was successful. Nidus occlusion was complete in 3 patients, 〉 90% in 8, 〉 80% and 〈 90% in 6, and 〉 50% and 〈 80% in 5. Complications included transient neurological deficits in 2 patients, and adherence of microcatheter to the site of injection in 2. Conclusions Being non-adhesiveness, Onyx is a safe and satisfactory embolic material in the treatment of CAVMs. But its long-term efficacy awaits further follow-up.

关键词： cerebral arteriovenous malformations embolization, therapeutic Onyx copolymer

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管板结构残余接触应力的数值模拟研究

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现代制造工程 2009年第6期 68-73页

作者：李又香湖南城建职业技术学院湘潭411101

利用弹塑性理论确定胀接过程所需的最大和最小胀接压力,分别建立单管胀接和多管胀接的三维非线性有限元分析模型,通过对模拟计算结果的分析得知,胀接后模型的等效应力、残余接触应力沿管子轴向分布不均匀,在管板开槽处会形成一道残余接... 详细信息

利用弹塑性理论确定胀接过程所需的最大和最小胀接压力,分别建立单管胀接和多管胀接的三维非线性有限元分析模型,通过对模拟计算结果的分析得知,胀接后模型的等效应力、残余接触应力沿管子轴向分布不均匀,在管板开槽处会形成一道残余接触应力集中圈;多管胀接相互之间产生一定的影响,使已胀管的残余接触应力分布更加趋向不均匀,其最大值处会变得更大,而在最小值处其值会下降。研究结果能够为胀接接头的结构设计和工艺参数的选择提供指导。

关键词：液压胀管胀接力残余接触应力多管胀接模型

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