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Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate

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Chemical Research in Chinese Universities 2014年第2期30卷 284-288页

作者： GUAN Ruqi CHAO Guoku YE Caiping WANG Yuxiang liU yanmei li Haihua ZHAO Yajuan TAI Yulei College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325027 P.R.China

Ru-B/γ-Al2O3 catalyst was prepared by reductant impregnation method,which was applied in the selective hydrogenation of ethyl 1H-indole-2-carboxylate for producing ethyl 2,3,3a,7a-tetrahydro-1H-indole-2-carboxylate with hydrogen as ***,we discussed the influences of substrate concentration,reaction solvent,hydrogenation temperature,initial hydrogen pressure and reaction time on the catalytic performance of the as-prepared *** obtained Ru-B/γ-Al2O3 catalyst showed a high-efficiency for the selective hydrogenation of ethyl 1H-indole-2-carboxylate（＞99％ conversion and selectivity） in i-propanol used as solvent at a concentration of 10％（mass fraction） of ethyl 1H-indole-2-carboxylate,a pressure of hydrogen of 6 MPa and a reaction temperature of 373 K.

关键词： Selective hydrogenation Supported amorphous catalyst Ru-B/γ-Al2O3 Indole derivative

Orientation of the peptide formation of N-phosphoryl amino acids in solution

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Chinese Science Bulletin 2002年第22期47卷 1866-1870页

作者： CHEN Zhongzhou TONG Yufeng CHEN Shuibing li yanmei CHEN YI ZHAO Yufen WANG Jinfeng Bioorganic Phosphorus Chemistry Laboratory Department of ChemistrySchool of Life Science and EngineeringTsinghua UniversityBeijing 100084China National Laboratory of Biomacromolecules Center for Molecular BiologyInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

The peptide formation of N-phosphoryl aminoacids with amino acids proceeds in aqueous solution withoutany coupling reagents. After being separated in sephadex gelcolumn, the phosphoryl dipeptides were analyzed by theelectrospray ionization tandem mass spectrometry (ESIMS/MS). The result demonstrates that phosphoryl dipeptideswere datected in all the reaction systems. It is found tkat theformation of N-phosphoryl dipeptides is oriented: theN-terminal amino acid residues of the N-phosphoryl dipep-tides are from N-phosphoryl amino acids, and the peptideelongation happened at the C-terminal. Only adipeptide, noβ-dipeptide, is formed in the N-phosphoryl dipeptides,showing that α-carboxylic group is activated selectively byN-pbosphorylation. Theoretical calculation shows that thepeptide formation of N-phosphoryl amino acids might hap-pen through a pentu-coordinate carboxylic-phosphoric in-termediate in solution. These results might give some clues tothe stlidy on the origin of proteins and protein

关键词： N-phosphoryl amino acids orientation of peptide formation solution N-phosphoryl dipeptides.

Approaching high-performance electrode materials of ZnCo2S4 nanoparticle wrapped carbon nanotubes for supercapacitors

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Journal of Materiomics 2021年第3期7卷 563-576页

作者： Ting-Feng Yi Hui Chang Ting-Ting Wei Si-Yu Qi yanmei li Yan-Rong Zhu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province QinhuangdaoChina School of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshanAnhui243002China

In this work,CNTs-wrapped ZnCo2S4 nanoparticle composites were constructed by a simple hydrothermal *** process allows to wrap ZnCo2S4 nanoparticle in an interconnected CNT matrix that combines excellent electronic conductivity with good mechanical *** CNTs wrapping suppresses the aggregation of ZnCo2S4 nanoparticle,and assures an effective contact between electrolyte and ZnCo2S4 particles,then promotes rapid ion ***,ZnCo2S4@CNTs(5 wt%)composite shows the highest specific surface area,lowest polarization and the highest reversibility during cycling among all ***2S4@CNTs(0,2.5,5 and 10 wt%)electrodes deliver specific capacitances of 360.4,1012.8,1190.4 and 1015.6 F g^(-1) with capacitance retentions of 32.9%,81.3%,84.2%and 79.3%at 10 Ag^(-1) after 10,000 *** at higher current density of 30 A g^(-1),ZnCo2S4@CNTs(5 wt%)composite also delivers a specific capacitance of about 880 F g^(-1) with a capacitance retention of 93%after 30,000 cycles,revealing outstanding cycling *** above results exhibit that ZnCo2S4@CNTs composites can be promising candidates as electrode materials for pseudocapacitors with excellent electrochemical property in future applications.

关键词： Supercapacitor Carbon nanotubes ZnCo2S4 Cycling stability

Phosphorylation induces β-Amyloid and α-Synuclein strain formation

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Phosphorylation induces β-Amyloid and α-Synuclein strain f...

Human Body Information Database and Method of Application

第十届全国化学生物学学术会议

作者： li yanmei Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University

Over twenty diseases are associated with amyloid deposits,such as Alzheimer’s disease,Parkinson′s disease and Huntington’s disease,*** of amyloid proteins would lead to the formation of toxic aggregates,including different oligomeric species and fibrils in vivo,which is one of the pathological hallmarks of these severe neurodegenerativeRecently,the demonstration that injection of‘strains’with different structural features into the brain of mice could cause different phenotypes,which is a typical characteristic of prions,strongly supported the prion-like mechanism of amyloidprevious studies usually generate different strains through the regulation of pH,salt concentration or temperature in *** our study,we synthesized?-amyloid（A?）phosphorylated at Ser 84 and?-Synuclein（?-Syn）phosphorylated at Ser 1295,showing that the phosphorylation can induce the formation of different strains ***,we designed and synthesized a series of inhibitors to regulate and induce degradation of A?and?-Syn.

关键词： neurodegenerative disease Aβ α-Syn strain

来源： cnki会议评论

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International English Education Research 2016年第7期 112-114页

作者： ZHANG li li yanmei Shanghai University of Engineering Science Shanghai China 201620

This paper elaborate the emergence of human information database and the important role it plays in the various industries of economic development. It also interpret the primary human information database of current domestic and abroad and analysis it＇s classification characteristic, Besides, this papers further explains how to make use of human information database and how to make the database to play its due value. In the end, the prospect of our country＇s body information database has been set forth, using relatively mature foreign database to improve Chinese body information database.

关键词： database human body information data mining knowledge discovery in database

Rearrangement mechanism of the sodium adducts of Fmoc protected amino acids

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Chinese Science Bulletin 2003年第21期48卷 2317-2319页

作者： DU Jintang, li yanmei, ZHU Zhentai, CHEN Yi & ZHAO Yufen Laboratory of Bioorganic Phosphorus Chemistry, Department of Chem-istry, Tsinghua University, Beijing 100084, China Correspondence should be addressed to li yanmei (e-mail: liym@mail. ***) Laboratory for Bioorganic Phosphorus Chemistry Department of Chemistry Tsinghua University China

The cationized 9-fluorenylmethoxycarbonyl (Fmoc) protected amino acids were analyzed by the electros-pray ionization tandem mass spectrometry (ESI-MS/MS). A rearrangement reaction leading to the C-terminal hydroxyl group transfer was observed. The sodium adducts of Fmoc-OH was formed. A possible rearrangement mechanism was proposed. The rearrangement reaction depended on the Fmoc group, metal ions and metal ion radius. It was shown that the Fmoc group has a strong affinity to the hydroxyl group in the gas phase.

关键词：氨基酸钠羟基重组机制金属离子

Methanol Distillation System: Process Analysis and Column Design

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化工进展 2005年第Z1期24卷 40-51页

作者： Sun Jinsheng Tian Yufeng Xu Shimin Ding Hui Wang Tao li Xingang Zheng yanmei Shool of Chemical Engineering and Technology Tianjin University Tianjin 300072 National Engineering Research Center for Distillation Technology Tianjin 300072 　　　　　

Base on industrial research and experience, the process of methanol distillation is analyzed,and above all, a new concept of high pressure flowsheet and low pressure flowsheet is defined. The new configuration helps to handle problems encountered in many factories in China. The inter influence between process and column internal pattern is also pointed out. Recommendation of new column internal designs is given. Finally, industrial examples tell the how the new concept works and the possibility of combining process to give more opens to solve engineering problems.

关键词： methanol distillation, two - effect distillation, high pressure flowsheet and low pressure flowsheet, flowsheet analysis, simulation with hydraulic, column internal design

Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis

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Food Science and Human Wellness 2024年第4期13卷 2048-2059页

作者： Xueyan Mo Mengcheng Zhou yanmei li lili Yu Huashang Bai Peihong Shen Xing Zhou Haojun Zhu Huijie Sun Ru Bu Chengjian Jiang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Science and TechnologyGuangxi UniversityNanning 530004China National Engineering Research Center for Non-Food Biorefinery State Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Research Center for Biological Science and TechnologyGuangxi Academy of SciencesNanning 530007China Guangxi Key Laboratory for Green Processing of Sugar Resources College of Biological and Chemical EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China

The application of microorganisms as probiotics is limited due to lack of safety ***,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove *** safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing *** showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely *** morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were *** hyphae and phospholipase were *** one retroelement(Tad1-65_BG)was *** biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined ***6 had no resistance to common antifungal *** enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were *** toxicity test with mice demonstrated that GXDK6 is ***6 has a good reproduction ability in the simulation gastrointestinal ***6 also has a strong antioxidant ability,β-glucosidase,and inulinase *** sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.

关键词： Meyerozyma guilliermondii Safety assessment Probiotics Marine mangrove microorganisms Whole-genome sequencing analysis

HMG-3 contributes to meiotic chromosome maintenance and inhibits reproductive aging in C. elegans

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Journal of Genetics and Genomics 2024年第12期51卷 1509-1512页

作者： Fengguo Zhang Yuanyuan liu yanmei li Xiuxiu liu Yingchun Zhang Guohai Su Department of Reproductive Medicine Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China Research Center of Translational Medicine Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China Center for Cell Structure and Function College of Life SciencesShandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongShandong Normal UniversityJinanShandong 250300China Department of Operations Jinan Blood CentreJinanShandong 250001China Department of Cardiovascular Medicine Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China

Reproductive aging involves a progressive decline in fertility,particularly in females(Duncan et al.,2018;Gruhn et al.,2019),which is characterized by the decline in the number of follicles and the deterioration of oocyte quality with age(Broekmans et al.,2004).It occurs in mammals and other organisms,including mice,flies,and worms(Tasnin et al.,2021;Toraason et al.,2022;Isola et al.,2024).Multiple factors contribute to reproductive aging,with chromosomal segregation errors among the most important *** chromosome segregation requires the completion of chromatin remodeling events during meiotic prophase(Yang et al.,2024).

关键词： aging segregation completion