检索结果-南通市图书馆

Synthesis of Analogs of phosphoamino Acids and their Biomimic reactions

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1999年第7期10卷 537-538页

作者： Yong JU Dong yan QIN Yu Fen ZHAO(bioorganic phosphorus {3. laboratory department of chemistry tsinghua university beijing 100084) Tsing Hua Univ Dept Chem Bioorgan Phosphorus Chem Lab Beijing 100084 Peoples R China

In order to further confirm the biomimic properties of N-phosphoamino acids. A series of model compounds, analogue of phosphoryl amino acids, were synthesized and their biomimic mechanism was also investigated by NMr and MS methods. The results indicated that the reactivity of phosphoryl biological small molecules was depended on the configuration, function groups and positions.

关键词： synthesis analogs of phosphoamino acid biomimic reaction

Electron Impact Mass Spectrometry of Acylaminotetraoxyphosphorane

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1997年第7期8卷 629-632页

作者： Nan Jing ZHANG Hai yan LU Xin CHEN Yu Fen ZHAO(bioorganic phosphorus {3. laboratory, department of chemistry tsinghua university, beijing 100084) TSING HUA UNIV DEPT CHEMBIOORGAN PHOSPHORUS CHEM LABBEIJING 100084PEOPLES R CHINA

The electron impact ionization mass spectral fragmentations of a series of acylaminotetraoxyphosphoranes were investigated. The results showed that EIMS of such compounds exhibited very characteristic fragmentation pa... 详细信息

关键词： Mass Electron Impact Mass Spectrometry of Acylaminotetraoxyphosphorane Chen

x-ray Crystal Structure of a Dinuclear Zinc(Ⅱ) Complex with Unusual Two Monodentate O-coordination of Carboxylate Group of Isonicotinate

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1998年第9期9卷 881-884页

作者： Feng mei NIE ru Ji WANG yan mei {3. Yu Fen ZHAO (Bio-organic phosphorus chemistry laboratory, department of chemistry,tsinghua university, beijing, 100084)Munirathinam NETHAJI Akhil r. CHAKrAVArTY (department of Inorganic and physical chemistry, Ind Bio-Organ. phosphorus Chem. Lab. Department of Chemistry Tsinghua University Beijing 100084 China department of Inorganic chemistry Indian Institute of Science Bangalore 560 012 India

reaction of Zn(ClO4)2·6H2O with septadentate 2,6-bis[bis(2-benzimidazolylme-thyl)amino methyl]-4-methylphenol (Hbbap) and sodium isonicotinate yielded a dinuclear zinc complex[Zn2(bbap) (Iso) (Hiso)] (ClO4)2·[Zn2 (bbap) (Iso) (H2O)] (ClO4)2·4H2O(1a·1b·4H2O). Hiso isisonicotinic acid and Iso is isonicotinate anion. The structure has been established by X-raycrystallography and shows that the two zinc ions are bridged by the phenoxy unit of bbap- ligand,and the presence of unusual monodentate O-coordination of carboxylate group from isonicotinicacid. The coordination geometry around the zinc ion is approximately trigonal bipyramidal.

关键词： zinc complex isonicotinate metalloenzyme crystal structure

A Theoretical research on the Intermediate in the reaction of N-phosphorylamino-acid to form peptide or ribotide

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1998年第12期9卷 0-0页

作者： ru Gang ZHONG Zhao Long li Yu Fen ZHAO Qian Huan DAI (bioorganic phosphorus {3. laboratory, tsinghua university, beijing 100084)(Center for Chem. and Bioeng. of Cancer res., beijing polytechnic university, beijing 100022) Tsing Hua Univ Bioorgan Phosphorus Chem Lab Beijing 100084 Peoples R China beijing polytech Univ Ctr Chem & Bioengn Canc Res Beijing 100022 Peoples R China

In order to explain the high activity of N-phosphoryl-α-amino acids, ab initio and MNDO calculations are performed to study the reaction pathway of the intermediate formation from N-dimethylphosphoryl-α-alanine (DMp... 详细信息

关键词： phosphoryl-α-amino acid reaction pathway quantum chemistry

同方期刊数据库

pentacoordinated Spirophosphoranes from Amino Acid Sodium Salts

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1997年第5期8卷 397-400页

作者： Hai yan LU Nan Jing ZrANG Yu Fen ZrAO(bioorganic phosphorus {3. laboratory, Dcyartinen of {3.tsinghua Uhiverslty, beijing, 100084) TSING HUA UNIV DEPT CHEMBIOORGAN PHOSPHORUS CHEM LABBEIJING 100084PEOPLES R CHINA

The reactions of 2-chloro-1,3.2-dioxaphospholane with various sodium salts of amino acids to afford the pentacoordinated spirophosphoranes containing amino acid were studied by NMr spectra techniques. The results showed that natural alpha-amino acids had greater ability than beta-amino acids to form the pentacoordinated species, which is important in the biosynthesis and prebiotic synthesis of of oligopeptides and proteins.

关键词： pentacoordinated Spirophosphoranes from Amino Acid Sodium Salts li

O-phosphorylation of Oligopeptides with phosphoramidite

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 1998年第12期9卷 0-0+0-0页

作者： yan Met li Yu Fen ZHAO (Bio-organic phosphorus {3. laboratory, department of chemistry,tsinghua university, beijing 100084)Herbert WALDMANN (Institute of Organic {3., university of Karlsruhe, 76128 Karlsfuhe, Germany) Tsing Hua Univ Dept Chem Bioorgan Phosphorus Chem Lab Beijing 100084 Peoples R China Univ Karlsruhe Inst Organ Chem D-76128 Karlsruhe Germany

phosphopeptides were synthesized with bis-alkyloxy-N,N-dialkylphosphorfollowed by oxidation. Many hydroxyl groups in oligopeptides can be O-phosphorylated in onestep.

关键词： phosphopeptide phosphoramidite

Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMr and molecular modeling

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science china chemistry 2010年第9期53卷 1987-1993页

作者： liU yan1,SHI yanHong2,liU XiaoXia1,liN MingKun1,liN DongHai1,2 & ZHAO YuFen1,3.1Key laboratory for chemical biology of Fujian province,department of chemical biology,department of chemistry,College of {13. and chemical Engineering,Xiamen university,Xiamen 3.1005,china 2Shanghai Institute of Materia Medica,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203.china 3.ey laboratory for bioorganic phosphorus {13. and chemical biology,Ministry of Education,department of chemistry,School of life Sciences and Engineering,tsinghua university,beijing 100084,china 1. Key laboratory for chemical biology of Fujian province Department of Chemical Biology Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 201203 China3. Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing 100084 China

Seryl-Histidine dipeptide(Ser-His) has been previously reported to be capable of cleaving DNAs and carboxyl esters,as well as *** protein cleavage mechanism has not been addressed *** an initial step of protein cleavage activity,the non-covalent binding affinity of Ser-His for proteins is a crucial *** this work,we took cyclophilin A(CypA) as a substrate protein,and evaluated the non-covalent interaction between CypA and Ser-His using a combination of NMr spectroscopy and molecular modeling *** independent Ser-His binding sites on CypA were detected using 15N-1H heteronuclear single-quantum coherence(HSQC) *** binding site binds one Ser-His *** constants,Kd1 and Kd2,were estimated to be 2.07 and 6.66 mmol/L,respectively,indicative of the weak non-covalent interaction between Ser-His and *** on molecular modeling results,we suggest that both the α-amino and the side chain hydroxyl group of Ser-His are crucial for the non-covalent interaction between Ser-His and *** work sheds light on the molecular mechanism of Ser-His and its analogues cleaving proteins.

关键词： Ser-His cyclophilin A HSQC non-covalent interaction binding sites

protein misfolding and inhibitor design

在线全文

学校读者我要写书评

暂无评论

Protein misfolding and inhibitor design

peptidase Mimics to Selectively Degrade β-Amyloid of Alzheimer's Disease

第六届全国化学生物学学术会议

作者： li yan-mei~* Key {3. of bioorganic phosphorus chemistry and chemical biology(Ministry of Education),department of chemistry,tsinghua university,beijing 100084,p.r.china

＜正＞Great deals of aetiologically distinct diseases have been linked by the likehood that they result from the progressive misfolding of specific proteins into aggregates that can cause cell *** are some secreted proteins that can,under abnormal circumstances,be converted in part to highly stable extracellular *** include amylin in the diabetic pancreas and proteins such as the amyloid -peptide（A） and Tau in Alzheimer’s disease.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Peptidase Mimics to Selectively Degrade β-Amyloid of Alzhei...