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Principles and methods of rock support for rockburst control

Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 46-59页

作者： Charlie Chunlin li Norwegian University of Science and Technology(NTNU) TrondheimNorway

This paper presents the principles of rock support for rockburst control and three rockburst support systems used in deep metal *** the principles of rock support are presented,rock fracture related to strain burst is first discussed with the help of photos taken on site,and the energy sources and transformations during bursting are illustrated through conceptual *** parallel extension fracture usually occurs in the ejected and surrounding rocks in a strain burst event,while the ejected rock in a fault-slip rockburst is often already pre-fractured before the *** must be excessive release energy available for rock *** excessive release energy comes from both the ejected rock itself and the surrounding *** prevent rock ejection in a rockburst,the support system must be able to dissipate the excessive release *** support devices in a support system for rockburst control must be able to dissipate energy,be firmly linked,and be compatible in deformability.A support system for rockburst control comprises surface-retaining devices and yield rockbolts as well as yield cablebolts when *** mesh on the top of shotcrete liner is a good practice to enhance the surfaceretaining capacity of the support ***-absorbing yield rockbolts dissipate energy either by stretching of the bolt shank or by sliding of the inner anchor in the ***,mesh strap and shotcrete are the surface-retaining devices widely used in the current rock support *** three types of rock support used for rockburst control at present are soft support system using Split Set bolts,hybrid support system using rebar and two-point anchored yield bolts,and entirely yieldable support system using strong yield bolts.

关键词： Rock support Rockburst Rockbolt Yield rockbolt Mesh Shotcrete

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Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2533-2549页

作者： Qiuyi li Cheng Chen Jinxia Kong lian li Junlin li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Induction of immunogenic cell death promotes antitumor immunity against cancer. However, majority of clinically-approved drugs are unable to elicit sufficient ICD. Here, our study revealed that mitochondria-targeted delivery of doxorubicin(DOX) massively amplified ICD via substantial generation of reactive oxygen species(ROS) after mitochondrial damage. The underlying mechanism behind increased ICD was further demonstrated to be ascribed to two pathways:(1) ROS elevated endoplasmic reticulum(ER) stress, leading to surface exposure of calreticulin;(2) ROS promoted release of various mitochondriaassociated damage molecules including mitochondrial transcription factor A. Nevertheless, adaptive upregulation of PD-L1 was found after such ICD-inducing treatment. To overcome such immunosuppressive feedback,we developed a tumor stimuli-responsive nano vehicle to simultaneously exert mitochondrial targeted ICD induction and PD-L1 blockade. The nano vehicle was self-assembled from ICD-inducing copolymer and PD-L1 blocking copolymer, and possessed long-circulating property which contributed to better tumor accumulation and mitochondrial targeting. As a result, the nano vehicle remarkably activated antitumor immune responses and exhibited robust antitumor efficacy in both immunogenic and non-immunogenic tumor mouse models.

关键词： Immunogenic cell death Mitochondrial targeting PD-L1 blockade Endoplasmic reticulum stress Mitochondria-associated damage molecules Stimuli-responsive Antitumor immune responses Antitumor efficacy

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Statistics matters in interpretations of non-traditional stable isotopic data

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Acta Geochimica 2020年第2期39卷 271-279页

作者： Chun-Hui li CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026AnhuiChina CAS Center for Excellence in Comparative Planetology Hefei 230026AnhuiChina

Increasing volumes of of non-traditional stable isotope data have brought new opportunities to gain important insights into geochemical and planetary ***,there is a worrysome trend that the isotopic data are interpreted in a fashion that its statistical approaches are chosen *** communication summarizes the rules regarding calculating the mean,standard deviation and relative standard deviation of a population,as well as error propagation and significant *** rules should be used when reporting geochemical data,especially for isotope *** two examples,I show that statistics matters in isotopic data interpretation.

关键词： Isotopic data processing Error propagation Significant digits Difference between means with uncertainties

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Improving hydrogen storage performance of li–Mg–N–H system by adding niobium hydride

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Rare Metals 2014年第1期33卷 86-90页

作者： Xi-lin Zhu Shu-Min Han Xin Zhao Yuan li Bao-Zhong liu College of Environmental and Chemical Engineering Yanshan University State Key Laboratory of Metastable Materials Science and Technology Yanshan University School of Materials Science and Engineering Henan Polytechnic University

Hydrogen storage MgH2-xNbH （x = 0 and 0.05） properties of 2liNH2- composites and the catalysis of NbH on hydrogen sorption reaction of the li-Mg- N-H system were investigated. Hydrogen sorption properties of 2liNH2-MgH2 system are effectively improved by adding NbH. Temperature programmed desorption results show the addition of NbH reduces the dehydriding onset temperature of 2liNH2-MgH2 system by 21 K. Approximate 3.62 wt% hydrogen in 2liNH2-MgHz- 0.05NbH composite is released following a 500 min at 433 K, whereas the amount of hydrogen desorption is only -3.16 wt% for the pristine system under the same condition. The sample with NbH exhibits higher dehydriding rate compared with the pristine one. Moreover, hydrogen absorption rate increases by adding NbH into the 2liNH2- MgH2 system. Hydrogen absorption capacity of the samples with NbH is 3.23 wt% within 400 rain, which is higher than that of pristine sample. Fine NbH particles homogeneously distribute in the 2liNH2-MgH2-0.05NbH composite, and catalyze the hydrogen sorption reaction rather than reacts as a reactant into new compound.

关键词： Hydrogen storage performances li-Mg-N-H system Niobium hydride Kinetics

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Conformation Analysis and Comparison of Epristeride(17β-N-t-Butylcarboxamide-androst-3,5-diene-3-carboxylic Acid) and Its Analogs

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Chemical Research in Chinese Universities 2005年第5期21卷 525-527页

作者： YAO li-xin Lab of Molecular Drug Design Key Laboratory of Controlled Release of Guangdong ProvinceInstitute of Materia Medica Guangdong College of Pharmacy Guangzhou 510240 P. R. China

Conformations of Epristeride（ 17-β-N-t-butylcarboxamide-androst-3,5-diene-3-carboxylic acid） and its analogs were analyzed with the random search method and compared by means of the methods for steroid conformers, Connolly surfaces, dihedral angles, and molecular accessibility probes with protons, hydroxyl and methyl groups contained simultaneously. Analog d is different from others, which is in accordance with the preliminary clinical trial results under double blind conditions.

关键词： Epristeride Conformation analysis Molecular accessibility Analog

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The Sufficient and Necessary Conditions of the Strong Law of Large Numbers under Sub-linear Expectations

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Acta Mathematica Sinica,English Series 2023年第12期39卷 2283-2315页

作者： li Xin ZHANG School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018P.R.China School of Mathematical Sciences Zhejiang UniversityHangzhou 310027P.R.China

In this paper, by establishing a Borel–Cantelli lemma for a capacity which is not necessarily continuous, and a link between a sequence of independent random variables under the sub-linear expectation and a sequence of independent random variables on R^(∞) under a probability, we give the sufficient and necessary conditions of the strong law of large numbers for independent and identically distributed random variables under the sub-linear expectation, and the sufficient and necessary conditions for the convergence of an infinite series of independent random variables, without the assumption on the continuity of the capacities. A purely probabilistic proof of a weak law of large numbers is also given.

关键词： Sub-linear expectation capacity strong convergence law of large numbers

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Negative self-feedback induced enhancement and transition of spiking activity for class-3 excitability

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Chinese Physics B 2022年第7期31卷 203-213页

作者： li li Zhiguo Zhao Huaguang Gu Guangdong Key Laboratory of Modern Control Technology Institute of Intelligent ManufacturingGuangdong Academy of SciencesGuangzhou 510070China School of Science Henan Institute of TechnologyXinxiang 453003China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Post-inhibitory rebound(PIR)spike,which has been widely observed in diverse nervous systems with different physiological functions and simulated in theoretical models with class-2 excitability,presents a counterintuitive nonlinear phenomenon in that the inhibitory effect can facilitate neural firing *** this study,a PIR spike induced by inhibitory stimulation from the resting state corresponding to class-3 excitability that is not related to bifurcation is simulated in the Morris–Lecar ***,the inhibitory self-feedback mediated by an autapse with time delay can evoke tonic/repetitive spiking from phasic/transient *** dynamical mechanism for the PIR spike and the tonic/repetitive spiking is acquired with the phase plane analysis and the shape of the quasi-separatrix *** result extends the counterintuitive phenomenon induced by inhibition to class-3 excitability,which presents a potential function of inhibitory autapse and class-3 neuron in many neuronal systems such as the auditory system.

关键词： post-inhibitory rebound spike class 3 excitability inhibitory autapse neuronal firing

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开孔泡沫金属传热和流动特性

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兵工学报 2024年第1期45卷 122-130页

作者：李婧孙晓霞马兴龙朱文祥北京理工大学机械与车辆学院北京100081 中国北方车辆研究所北京100072

近年来开孔泡沫金属运用于散热设备逐渐成为研究的热点。由于开孔泡沫金属结构复杂无序,数值模拟时大都将其结构进行化简,目前已有种类繁多的简化模型,然而适用于其传热与流动特性模拟研究的简化模型尚不明确;另外,适用于散热领域的泡... 详细信息

近年来开孔泡沫金属运用于散热设备逐渐成为研究的热点。由于开孔泡沫金属结构复杂无序,数值模拟时大都将其结构进行化简,目前已有种类繁多的简化模型,然而适用于其传热与流动特性模拟研究的简化模型尚不明确;另外,适用于散热领域的泡沫金属结构参数有待详细研究。为此,建立开孔泡沫金属的5种简化三维模型,并进行传热和流动特性的对比研究,认为Gibson-Ashby模型更能准确描述实际开孔泡沫金属的传热和流动性能。在此基础上,采用Gibson-Ashby模型对开孔泡沫金属的关键结构参数进行传热和流动综合性能分析,发现孔隙率90%、孔密度30PPI开孔泡沫金属翅片的综合性能j/f^(1/3)(j为换热因子,f为阻力因子)最优;将孔隙率90%、孔密度30PPI开孔泡沫金属翅片与平直翅片进行对比,发现开孔泡沫金属翅片换热效果是平直翅片的2倍以上,综合性能也优于平直翅片。所得研究成果可为开孔泡沫金属在换热领域的应用和设计提供参考。

关键词：开孔泡沫金属简化三维模型平直翅片数值模拟传热阻力

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Characteristics of a radio-frequency cold atmospheric plasma jet produced with a hybrid cross-linear-field electrode configuration

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Plasma Science and Technology 2019年第5期21卷 102-112页

作者： Jing li Heping li Department of Engineering Physics Tsinghua University

Cold atmospheric plasma(CAP)jet has wide applications in various fields including advanced materials synthesis and modifications,biomedicine,environmental protection and energy saving,*** control on the volume,temperature and chemically reactive species concentratio ns of the CAP jet is of great importance in actual *** this paper,an radio-frequency atmospheric-pressure glow discharge(RF-APGD)plasma generator with a hybrid cross-linear-field electrode configuration is *** experimental results show that,with the aid of the copper mesh located at the downstream of the traditional co-axial-type plasma generator with a cross-field electrode configuration,a linear field between the inner powered electrode of the traditional plasma generator and the copper mesh can be *** linerfield can,to some extent,enhance the discharges at the upstream of the copper mesh,resulting in small increments(all less than 12.5%)of the species emission intensities,electron excitation temperatures and gas temperatures by keeping other parameters being *** due to the intrinsic transparent and conducting features of the grounded copper mesh to the gas flowing,electric current and heat flux of the plasma plumes,a plasma region with higher concentrations of chemically reactive species and larger plasma plume diameters is obtained at the downstream of the grounded copper mesh on the same level of the gas temperature and electron excitation temperature compared to those of the plasma free *** addition,the charged particle number densities at the same downstream axial location of the grounded copper mesh decrease significantly compared to those of the plasma free *** means that the copper mesh is also,to some extent,helpful for separating the chemically reactive neutral species from the charged particles in side a plasma *** preceding results indicate that the cross-linear-field electrode configuration of the plasma generator

关键词： cold atmospheric plasma hybrid-cross-linear-field electrode configuration grounded copper mesh plasma jet characteristics modulation

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Synthesis characterization and improved electrochemical performance of li2FeSiO4/C as cathode for lithium-ion battery by metal doping

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Progress in Natural Science:Materials International 2019年第2期29卷 111-118页

作者： ling li Enshan Han Shunpan Qiao Hui liu Yake Shi Weiliang Yuan School of Chemical Engineering and Technology Hebei University of Technology

In this paper, li2FeSi0.98M0.02O4/C（M = Mg, Zn, Co, Mn, Ni） was synthesized as cathode material for lithium ion battery by solid-state method. The results show that the materials doped with Mg and Zn at the Si-sites have good initial discharge capacity. Then li2FeSi1-xMxO4/C（M = Mg, Zn; x = 0.01, 0.02, 0.03, 0.05） were also synthesized via solid-state method. It is concluded that li2FeSi0.99Mg0.01O4/C and li2FeSi0.98Zn0.02O4/C have better initial discharge capacity which is 125 mAh/g and 166.2 mAh/g, respectively. The capacity of li2Fe0.98Zn0.02SiO4/C is 157.3 m Ah/g after 10 cycles at 0.1 C, and the capacity retention rate is 94.6%. The li+diffusion coefficient of li2FeSi0.98Zn0.02O4/C is higher than that of pure phase materials by one order of magnitude. The li2FeSi0.99Mg0.01O4/C and li2FeSi0.98Zn0.02O4/C were tested by XRD and SEM. XRD patterns indicate that the crystal structure of li2FeSiO4is not changed after being doped with metal ion at the Si-site. The SEM image indicates that no obvious agglomeration is detected in these materials. li2FeSi0.98Zn0.02O4/C processes better electrochemical performance analyzed by EDS、XPS and FT-IR spectra. The data prove that Si4+is successfully replaced by Zn2+in the crystal structure of li2FeSiO4.

关键词： li2FeSiO4 Mg Zn doping Solid-state method li-ion battery Electrochemical performance

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