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Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 412-424,I0003-I0010页

作者： Shi-Chuan Tang Yong-Kang Diao Kong-Ying lin Chao li Xiao Xu Lei liang Jie Kong Qing-jing Chen xian-Ming Wang Fu-Bao liu Wei-Min Gu Ya-Hao Zhou Ying-Jian liang Hong-Zhi liu Ming-Da Wang Lan-Qing Yao Timothy M.Pawlik Feng Shen Wan Yee Lau Tian Yang Yong-Yi Zeng department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNavy Medical University(Second Military Medical University)ShanghaiChina department of Hepatobiliary Surgery Affiliated Hospital of Nantong UniversityNantongChina department of Hepatobiliary Surgery People’s Hospital of Zhejiang ProvincialPeople’s Hospital of Hangzhou Medical CollegeHangzhouChina department of Hepatobiliary Heze Municiple HospitalHezeChina department of General Surgery First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanChina department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina The First department of General Surgery Fourth Hospital of HarbinHarbinChina department of Hepatobiliary Surgery Pu’er People’s HospitalPu’erChina department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine The Chinese University of Hong KongHong KongChina department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Fujian Medical UniversityFuzhouChina The liver Disease Research Center of Fujian Province FuzhouChina

Background:The application of Pringle maneuver(PM)during hepatectomy reduces intraoperative blood loss and the need for perioperative transfusion,but its effect on long-term recurrence and survival for patients with hepatocellular carcinoma(HCC)remains *** sought to determine the association between the application of PM and post-hepatectomy oncologic outcomes for patients with ***:Patients who underwent curative hepatectomy for HCC at 9 Chinese hospitals from January 2010 to December 2018 were *** two propensity score methods[propensity score matching(PSM)and inverse probability of treatment weight(IPTW)],cumulative recurrence rate and cancer-specific mortality(CSM)were compared between the patients in the PM and non-PM *** competing-risks regression models were performed to adjust for the effect of non-cancer-specific mortality and other prognostic risk ***:Of the 2,798 included patients,2,404 and 394 did and did not adopt PM(the PM and non-PM groups),*** rates of intraoperative blood transfusion,postoperative 30-day mortality and morbidity were comparable between the two groups(all P>0.05).In the PSM cohort by the 1:3 ratio,compared to 382 patients in the non-PM group,1,146 patients in the PM group also had the higher cumulative 5-year recurrence rate and CSM(63.9%and 39.1%vs.55.3%and 31.6%,both Plication of the PM was independently associated with lower recurrence rate and CSM based on various analytical cohorts[hazard ratio(HR),0.82 and 0.77 in the adjusted entire cohort,HR 0.80 and 0.73 in the PSM cohort,and HR 0.80 and 0.76 in the IPTW cohort,respectively].Conclusions:The findings suggested that no application of PM during hepatectomy for patients with HCC reduced the risk of postoperative recurrence and cancer-specific death by appr

关键词： Hepatocellular carcinoma(HCC) Pringle maneuver(PM) recurrence survival hepatectomy

Interfacial properties and micellization of triblock poly(ethylene glycol)-poly(ε-caprolactone)-polyethyleneimine copolymers

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1122-1133页

作者： Ji li Yitian Du Haitao Su Shixuan Cheng Yanxia Zhou Yiguang jin xian-Rong Qi Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China

This study aimed to explore the link between block copolymers’interfacial properties and nanoscale carrier formation and found out the influence of length ratio on these characters to optimize drug delivery system.A library of diblock copolymers of PEG-PCL and triblock copolymers with additional PEI(PEG-PCL-PEI)were ***,a systematic isothermal investigation was performed to explore molecular arrangements of copolymers at air/water ***,structural properties and drug encapsulation in self-assembly were investigated with DLS,SLS and *** found the additional hydrogen bond in the PEG-PCL-PEI contributes to film stability upon the hydrophobic interaction compared with ***-PCL-PEI assemble into smaller micelle-like(such as PEGPCL4006-PEI)or particle-like structure(such as PEG-PCL8636-PEI)determined by their hydrophilic and hydrophobic block *** distinct structural architectures of copolymer are consistent between interface and *** the disparity of constituent ratio,we discovered the arrangement of both chains guarantees balanced hydrophilic-hydrophobic ratio in self-assembly to form stable ***,the structural differences were found to have significant influence on model drugs incorporation including docetaxel and *** together,these findings indicate the correlation between molecular arrangement and self-assembly and inspire us to tune block compositions to achieve desired nanostructure and drug loading.

关键词： Block copolymers Langmuir films Molecular arrangement Self-assembly Nanostructure

Study on the adsorption of Cr( Ⅵ) onto landfill liners containing granular activated carbon or bentonite activated by acid

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Journal of China university of Mining and Technology 2008年第1期18卷 125-130页

作者： LU Hai-jun LUAN Mao-tian ZHANG jin-li YU Yong-xian State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian Liaoning 116024 China Institute of Geotechnical Engineering School of Civil and Hydraulic Engineering Dalian University of Technology Dalian Liaoning 116024 China department of Chemistry School of Chemical Engineering Dalian University of Technology Dalian Liaoning 116024 China

The adsorption capacity of landfill liners containing granular activated carbon (GAC), or bentonite activated by acid, for Cr(VI) was investigated by batch testing. The results show that both GAC and activated bentonite could be used as sorptive amendments for trapping Cr(VI) in landfill liners. The Cr(VI) sorption to GAC and activated bentonite is much greater than Cr(VI) sorption to natural clay. The adsorption capacity of Cr(VI) onto all the soils increases with increasing temperature; adsorption capacity is also significantly influenced by soil-solid concentration. As the soil-solid concentration increases the adsorption capacity first decreases logarithmically, but then stabilizes when the soil-solid concentration exceeds a critical value (e.g. 400 g/L). Permeability tests were conducted in the laboratory. The results indicate that the hydraulic conductivity of landfill liners containing GAC or activated bentonite can meet the engineering requirement of 1 nm/s. One-dimensional transport simulations for Cr(VI) were performed to evaluate the effect of GAC and activated bentonite on landfill liners. The results of the simulations indicate that landfill liners containing GAC, or activated bentonite, significantly retard the transport of Cr(VI) relative to a conventional clay liner.

关键词： adsorption capacity soil-solid concentration landfill liners transport simulation

Effect of proximal femoral osteoporosis on cementless hip arthroplasty: A short-term clinical analysis

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2007年第1期8卷 76-80页

作者： LOU xian-feng li Yu-hong liN xiang-jin department of Orthopedics the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： The aim of this retrospective investigation was to explore the influence of femoral osteoporosis on short-term curative effects ofcementless hip arthroplasty and to evaluate the femoral metaphyseal bone mineral density （BMD） for femoral osteoporosis in order to guide prosthesis choice and rehabilitation. Methods： We performed 127 total arthroplasty operations between June 1999 to February 2003 and investigated 49 cementless hip replacements with the Metalcancellous cementless Lubeck Ⅱ system being used in all hips. There were twenty men and twenty-nine women whose mean age at the time of the operation was 60 years （range, 52-81 years）. The patients were divided into osteoporosis or normal groups according to the femoral metaphyseal BMD measured preoperatively. The average duration of follow-up was 30 months （range, 8-52 months）. We evaluated all of the patients from a clinical standpoint with use of a standard-terminology questionnaire with respect to the short-term curative effects and patients＇ satisfaction. Hip pain status and functional ability were important indicators of treatment efficacy. Results： Harris hip score and patients＇ satisfaction in femoral osteoporosis patients who underwent noncemented hip arthroplasty were lower （P=0.004, P=0.03） while the incidence of thigh pain was higher （P=0.03） than the patients with non-osteoporosis. Conclusion： The higher incidence of pain, as well as the decrease in function experienced by the patients in osteoporosis group, supports the case that cementless arthroplasty is not a better choice for those patients and that we had better select prosthesis based on the femoral metaphyseal BMD.

关键词： Cementless hip arthroplasty Osteoporosis Bone mineral density (BMD) Curative effect

信息化管理系统应用对医院医疗设备管理水平及医护人员设备使用体验的影响

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中国医疗器械信息 2024年第2期30卷 167-170页

作者：郑立彭震崔先晃张慧敏凃巧先李文兵李进东武汉经济技术开发区(汉南区)人民医院湖北武汉430090

目的:探讨信息化管理系统对医院医疗设备管理水平及医护人员设备使用体验的影响。方法:选取2021年1月~2021年6月本院75台医疗设备、5名设备科医护人员及122名医院设备使用医护人员作为对照组,行常规医疗设备管理;以2021年7月~2021年12... 详细信息

目的:探讨信息化管理系统对医院医疗设备管理水平及医护人员设备使用体验的影响。方法:选取2021年1月~2021年6月本院75台医疗设备、5名设备科医护人员及122名医院设备使用医护人员作为对照组,行常规医疗设备管理;以2021年7月~2021年12月本院75台医疗设备、5名设备科医护人员及128名医院设备使用医护人员作为试验组,应用信息化管理系统实施医疗设备管理。比较信息化管理实施前后医疗设备检查合格率、设备管理质量评分、设备维护管理情况、医护人员设备使用体验及设备经济效益。结果:试验组设备检查合格率、设备管理质量各项评分、设备预防性维修率及维修后管理率高于对照组,差异有统计学意义(P<0.05);试验组故障处理率低于对照组,差异显著(P<0.05);试验组设备经济效益优于对照组,差异有统计学意义(P<0.05);试验组设备使用医护人员总满意率高于对照组,差异有统计学意义(P<0.05)。结论:信息化管理系统能够促进医院医疗设备管理水平提高,并可改善医护人员设备使用体验及设备经济效益。

关键词：信息化管理系统医疗设备医护人员设备使用体验

Relationship between pancreaticobiliary maljunction and gallbladder carcinoma: a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 570-580页

作者： Yi-Lei Deng, Nan-Sheng Cheng, Yi-Xin lin, Rong-Xing Zhou, Chen Yang, Yan-Wen jin and xian-Ze Xiong department of Biliary Surgery, West China Hospital, Sichuan university, Chengdu 610041, China department of Biliary Surgery West China Hospital Sichuan University Chengdu 610041 China

BACKGROUND: Reports on the relationship between pancreaticobiliary maljunction (PBM) and gallbladder carcinoma (GBC) are conflicting. The frequency of PBM in GBC patients and the clinical features of GBC patients with PBM vary in different studies. DATA SOURCES: English-language articles describing the association between PBM and GBC were searched in the PubMed and Web of Science databases. Nine case-control studies fulfilled the inclusion criteria and addressed the relevant clinical questions of this analysis. Data were extracted independently by two reviewers using a predefined spreadsheet. RESULTS: The incidence of PBM was higher in GBC patients than in controls (10.60% vs 1.76%, OR: 7.41, 95% CI: 5.03 to 10.87, Pyounger than those without PBM (SMD: -9.90, 95% CI: -11.70 to -8.10, Plication bias was ***: PBM is a high-risk factor for developing GBC, especially the P-C type of PBM without congenital dilatation of the common bile duct. To prevent GBC, laparoscopic cholecystectomy is highly recommended for PBM patients without congenital dilatation of the common bile duct, especially relatively young female patients without gallstones.

关键词： pancreaticobiliary maljunction gallbladder carcinoma congenital dilatation of the common bile duct meta-analysis

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兰州市住宅室内颗粒物水平及影响因素研究

环境与健康杂志 2024年第1期41卷 1-4页

作者：李盛李普王先良赵贵雪王金玉兰州市肺科医院公共卫生科甘肃兰州730046 白银市第二人民医院公共卫生科中国疾病预防控制中心环境与健康相关产品安全所兰州市第一人民医院公共卫生科兰州大学基础医学院人体解剖教研室

目的了解兰州市典型功能区住宅室内空气颗粒物水平及影响因素,为改善室内空气质量提供依据。方法于2020年采暖期和非采暖期,选择兰州市商业区和工业区各30户住宅进行PM_(2.5)、PM_(10)、温度和相对湿度检测,同时采用问卷调查了解住宅特... 详细信息

目的了解兰州市典型功能区住宅室内空气颗粒物水平及影响因素,为改善室内空气质量提供依据。方法于2020年采暖期和非采暖期,选择兰州市商业区和工业区各30户住宅进行PM_(2.5)、PM_(10)、温度和相对湿度检测,同时采用问卷调查了解住宅特征。结果商业区住宅室内空气PM_(2.5)、PM_(10)、温度和相对湿度中位数分别为128.9μg/m^(3)、155.4μg/m^(3)、22℃和43%,工业区分别为141.1μg/m^(3)、160.4μg/m^(3)、21℃和51%,不同功能区住宅室内空气PM_(2.5)、PM_(10)、温度和相对湿度中位数差异均无统计学意义(P>0.05)。与非采暖期比较,商业区、工业区采暖期的室内PM_(2.5)、PM_(10)均较高(Z值分别为-6.716,-6.550,-6.430,-6.462,均P<0.05),温度、相对湿度均较低(Z值分别为-2.691,-7.577,-5.831,-8.603,均P<0.05)。logistic回归分析结果显示,非采暖期时,拖地或吸尘频率<1次/d、开窗通风频率<2次/d是影响PM_(2.5)、PM_(10)水平的危险因素。Spearman相关分析结果显示,非采暖期的室内温度、相对湿度与PM_(2.5)、PM_(10)浓度均呈负相关(P<0.05)。结论本次调查的典型功能区住宅室内存在颗粒物污染,以采暖期相对严重。温度、相对湿度、吸尘和开窗通风频率对室内颗粒物水平有影响。

关键词：室内空气质量颗粒物住宅特征温度相对湿度功能区

HPLC-MS/MS法测定人血浆中奈玛特韦和利托那韦浓度

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中国新药与临床杂志 2024年第1期43卷 57-61页

作者：徐宗良李盛建钱跹段虎周瑾张倩倩董昕赵亮上海大学医学院上海200444 上海市宝山区罗店医院药剂科上海201908

目的建立高效液相色谱质谱联用(HPLC-MS/MS)法测定人血浆奈玛特韦和利托那韦的血药浓度,并应用于治疗药物监测。方法血浆样品经蛋白沉淀后测定,流动相为0.1%甲酸水溶液(A相)、乙腈(B相),采用等度洗脱,流速为0.3 m L·min^(-1),柱温为40... 详细信息

目的建立高效液相色谱质谱联用(HPLC-MS/MS)法测定人血浆奈玛特韦和利托那韦的血药浓度,并应用于治疗药物监测。方法血浆样品经蛋白沉淀后测定,流动相为0.1%甲酸水溶液(A相)、乙腈(B相),采用等度洗脱,流速为0.3 m L·min^(-1),柱温为40℃,使用EC-C18色谱柱,正离子模式下进行多反应监测。结果用于定量分析的离子通道分别为m/z 500→110(奈玛特韦),m/z721.2→296.3(利托那韦),m/z 614.4→421(内标瑞德西韦)。人血浆中奈玛特韦在0.01~10μg·mL^(-1)、利托那韦在0.01~2.0μg·mL^(-1)浓度范围内线性关系良好,提取回收率分别为79.56%~89.91%、82.03%~89.56%,日间及日内的RSD均小于15%,并且稳定性良好。采用该方法检测了34例新型冠状病毒肺炎(COVID-19)患者口服Paxlovid后的血药浓度,血药浓度范围在1.04~18.0μg·mL^(-1)之间。结论本研究建立的HPLC-MS/MS方法检测快速,灵敏度高,准确性好,能应用于COVID-19患者服用Paxlovid后的血药浓度监测。

关键词：色谱法高压液相串联质谱法奈玛特韦利托那韦血药浓度

Understanding synergistic catalysis on Pt–Cu diatomic sites via operando X-ray absorption spectroscopy in sulfur redox reactions

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eScience 2024年第5期4卷 110-119页

作者： Shuai Xie Xingjia Chen Leilei Wang Guikai Zhang Haifeng Lv Guolei Cai Ying-Rui Lu Ting-Shan Chan e jing Zhang Juncai Dong Hongchang jin xianghua Kong Junling Lu Song jin Xiaojun Wu Hengxing Ji Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China School of Chemistry and Material Sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in Nanoscience and Synergetic Innovation of Quantum Information and Quantum TechnologyUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical PhysicsSchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Beijing Synchrotron Radiation Laboratory Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China National Synchrotron Radiation Research Center Hsinchu 300092China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

Sulfur redox reactions render lithium–sulfur(li–S)batteries with an energy density of>500Whkg−1 but suffer a low practical capacity and fast capacity fade due to sluggish sulfur redox reaction(SRR)kinetics,which lies in the complex reaction process that involves a series of reaction intermediates and proceeds via a cascade ***,we present a Pt–Cu dual-atom catalyst(Pt/Cu-NG)as an electrocatalyst for sulfur redox ***/Cu-NG enabled the rapid conversion of soluble polysulfide intermediates into insoluble li2S2/li2S,and consequently,it prevented the accumulation and shuttling of lithium polysulfides,thus outperforming the corresponding single-atom catalysts(SACs)with individual Pt or Cu *** X-ray absorption spectroscopy and density functional theory calculations revealed that a synergistic effect between the paired Pt and Cu atoms modifies the electronic structure of the Pt site through d-orbital interactions,resulting in an optimal moderate interaction of the metal atom with the different sulfide *** optimal interaction enhanced charge transfer kinetics and promoted sulfur redox *** work thus provides important insights on the atomic scale into the synergistic effects operative in dual-atom catalysts and will thus pave the way to electrocatalysts with enhanced efficiency for high-performance li–S batteries.

关键词： Dual-atom catalysts Sulfur redox reaction lithium-sulfur batteries Synergistic interaction X-ray absorption spectroscopy