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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi li li sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

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Thermodynamic modeling of gas solubility in aqueous sodium chloride solution

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Chinese Journal of Chemical Engineering 2021年第10期34卷 184-195页

作者： li sun Jierong liang College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China Department of Chemical and Biochemical Engineering Technical University of Denmark2800 Kgs.LyngbyDenmark Department of Energy Conversion and Storage Technical University of Denmark2800 Kgs.LyngbyDenmark

An electrolyte Equation of State is presented by combining the Cubic Plus Association Equation of State,Mean Spherical Approximation and the Born *** new model uses experimental relative static permittivity,intend to predict well the activity coefficients of individual ions(ACI)and liquid densities of aqueous *** new model is applied to model water+Na Cl binary system and water+gas+Na Cl ternary *** cation/anion-water interaction parameters of are obtained by fitting the experimental data of ACI,mean ionic activity coefficients(MIAC)and liquid densities of water+Na Cl binary *** cation/anion-gas interaction parameters are obtained by fitting the experimental data of gas solubilities in aqueous Na Cl *** modeling results show that this new model can correlate well with the phase equilibrium and volumetric *** gas,predictions for ACI,MIAC,and liquid densities present relative average deviations of 1.3%,3.6%and 1.4%compared to experimental reference *** most gas-containing systems,predictions for gas solubilities present relative average deviations lower than 7.0%.Further,the contributions of ACI,and salting effects of Na Cl on gases are analyzed and discussed.

关键词： Thermodynamic modeling liquid density Activity coefficients of individual ions Gas solubility

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Experimental and finite element analyses on the corrosion of underground pipelines

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Science China(Technological Sciences) 2015年第6期58卷 1015-1020页

作者： sun li CHEN Chen sun QianQian School of Civil Engineering Shenyang Jianzhu University liaoning Urban Architectural Design Institute

Underground pipelines, on which a city relies for survival and development, have become an important part of lifeline engineering. Underground pipelines are utilized for conveying liquid, gas or loose solid, pipeline leakage and damage occasionally resulting from corrosion. Corrosion monitoring of underground pipelines is aimed at ensuring their normal operation and preventing loss of life and property. In this paper, a new method to monitor corrosion of pipelines has been proposed to solve the mentioned problem. Under the influence of internal pressure and corrosion, the pipeline wall becomes thinner and the circumferential deformation increases. The method is to indirectly investigate pipeline corrosion by monitoring the circumferential deformation. Numerical simulation confirms that the circumferential strain curve of the pipeline wall measured by using the proposed method to describe the corrosion is feasible. The proposed method provides a new way for real-time and long-term monitoring and management of underground pipelines.

关键词： underground pipeline fiber bragg grating sensor corrosion monitoring

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Parallel ADR Detection Based on Spark and BCPNN

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Tsinghua Science and Technology 2019年第2期24卷 195-206页

作者： li sun Shan sun Tianlei Wang Jiyun li Jingsheng lin School of Computer Science and Technology Donghua University Ruijin Hospital Affiliated to Shanghai Jiao Tong University

Adverse Drug Reaction(ADR) is one of the major challenges to the evaluation of drug safety in the medical field. The Bayesian Confidence Propagation Neural Network(BCPNN) algorithm is the main algorithm used by the World Health Organization to monitor ADRs. Currently, ADR reports are collected through the spontaneous reporting system. However, with the continuous increase in ADR reports and possible use scenarios, the efficiency of the stand-alone ADR detection algorithm will encounter considerable challenges. Meanwhile, the BCPNN algorithm requires a certain number of disk I/O, which leads to considerable time consumption. In this study,we propose a Spark-based parallel BCPNN algorithm, which speeds up data processing and reduces the number of disk I/O in BCPNN, and two optimization strategies. Then, the ADR data collected from the FDA Adverse Event Reporting System are used to verify the performance of the proposed algorithm and its optimization *** show that the parallel BCPNN can significantly accelerate data processing and the optimized algorithm has a high acceleration rate and can effectively prevent memory overflow. Finally, we apply the proposed algorithm to a dataset provided by a real medical consortium. Experiments further prove the performance and practical value of the proposed algorithm.

关键词： Adverse Drug Reaction (ADR) Bayesian Confidence Propagation Neural Network (BCPNN) parallel Spark

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Solid-state synthesis and electrochemical properties of SmVO_4 cathode materials for low temperature SOFCs

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Rare Metals 2006年第z1期25卷 240-242页

作者： sun Xueli li Song sun Juncai Institute of Materials and Technology Dalian Maritime University Dalian 116026 China Institute of Materials and Technology Dalian Maritime University Dalian 116026 China Institute of Materials and Technology Dalian Maritime University Dalian 116026 China

A new cathode material fabricated by solid state reaction method was reported. The SmVO4 powder was obtained by firing the mixture of Sm2O3 and V2O5 powders in the temperature range of 700-1200 ℃. Its structure was identified by X-ray diffraction method and the electrochemical properties of SmVO4 as cathodes for solid oxide fuel cells (SOFCs) were investigated in single unit cell at the temperature ranged from 450-550 ℃. The results of the single fuel cell unit show that the maximum current densities are 641, 797, 688 mA·cm-2 and the maximum power output are 165, 268, 303 mW·cm-2 and the open circuit voltage are 1.04, 0.96, 0.92 V at 450, 500 and 550 ℃, respectively.

关键词： SOFC SmVO4 cathode solid-state reaction electrochemical properties

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In situ investigation of the mechanical properties of nanomaterials by transmission electron microscopy

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Acta Mechanica Sinica 2012年第6期28卷 1513-1527页

作者： Jun sun Feng Xu li-Tao sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of Education Southeast University

With the progress of modern transmission elec- tron microscopy （TEM） and development of dedicated func- tional TEM specimen holders, people can now manipulate a nano-object with nanometer-range precision and simulta- neously acquire mechanical data together with atomic-scale structural information. This advanced methodology is play- ing an increasingly important role in nanomechanics. The present review summarizes relevant studies on the in situ in- vestigation of mechanical properties of various nanomateri- als over the past decades. These works enrich our knowledge not only on nanomaterials （such as carbon nanotubes, car- bon onions, boron nitride nanotubes, silicon nanowires and graphene, etc.） but also on mechanics at the nanoscate.

关键词： Nanomaterials Transmission electron mi-croscopy In situ Nanoscale mechanics

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Machine Learning and Data-Driven Techniques for the Control of Smart Power Generation Systems:An Uncertainty Handling Perspective

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Engineering 2021年第9期7卷 1239-1247页

作者： li sun Fengqi You Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and the EnvironmentSoutheast UniversityNanjing 210096China Robert Frederick Smith School of Chemical and Biomolecular Engineering Cornell UniversityIthacaNY 14853USA

Due to growing concerns regarding climate change and environmental protection,smart power generation has become essential for the economical and safe operation of both conventional thermal power plants and sustainable *** first-principle model-based methods are becoming insufficient when faced with the ever-growing system scale and its various *** burgeoning era of machine learning(ML)and data-driven control(DDC)techniques promises an improved alternative to these outdated *** paper reviews typical applications of ML and DDC at the level of monitoring,control,optimization,and fault detection of power generation systems,with a particular focus on uncovering how these methods can function in evaluating,counteracting,or withstanding the effects of the associated uncertainties.A holistic view is provided on the control techniques of smart power generation,from the regulation level to the planning *** benefits of ML and DDC techniques are accordingly interpreted in terms of visibility,maneuverability,flexibility,profitability,and safety(abbreviated as the“5-TYs”),***,an outlook on future research and applications is presented.

关键词： Smart power generation Machine learning Data-driven control Systems engineering

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Adsorption characteristics of copper,lead,zinc and cadmium ions by tourmaline

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Journal of Environmental Sciences 2006年第6期18卷 1221-1225页

作者： JIANG Kan sun Tie-heng sun li-na li Hai-bo School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China Key Laboratory of Environmental Engineering of Shenyang University Shenyang 110041 China

The adsorption characteristics of heavy metals： Cu（Ⅱ）, Pb（Ⅱ）, Zn（Ⅱ） and Cd（Ⅱ） ions on tourmaline were studied. Adsorption equilibrium was established. The adsorption isotherms of all the four metal ions followed well Langmuir equation. Tourmaline was found to remove heavy metal ions efficiently from aqueous solution with selectivity in the order of Pb（Ⅱ）〉Cu（Ⅱ）〉Cd（Ⅱ）〉Zn（Ⅱ）. The adsorption of metal ions by tourmaline increased with the initial concentration of metal ions increasing in the medium. Tourmaline could also increase pH value of metal *** maximum heavy metal ions adsorbed by tourmaline was found to be 78.86, 154.08, 67.25, and 66.67 mg/g for Cu（Ⅱ）, Pb（U）, Zn（Ⅱ） and Cd（U）, respectively. The temperature （25-55℃） had a small effect on the adsorption capacity of tourmaline. Competitive adsorption of Cu（Ⅱ）, Pb（Ⅱ）, Zn（Ⅱ） and Cd（Ⅱ） ions was also studied. The adsorption capacity of tourmaline for single metal decreased in the order of Pb〉Cu〉Zn 〉Cd and inhibition dominance observed in two metal systems was Pb〉Cu, Pb〉Zn, Pb〉Cd, Cu〉Zn, Cu〉Cd, and Cd〉Zn.

关键词： adsorption heavy metals Langmuir isotherm tourmaline

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The Later Effects of DHA in Diet on Regulating Transcription of lipid Genes of Broiler

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Agricultural Sciences in China 2011年第4期10卷 611-618页

作者： li Yan sun Chao College of Animal Science Northwest A＆F University Yangling 712100 P.R.China

The effect of docosahexaenoic acid （DHA） on lipid metabolism in broiler were studied in order to provide test results for polyunsaturated fatty acids （PUFA） regulating fatty deposition. 1-wk-old Arbor Acres （AA） broiler were fed with DHA microalgae and slaughtered after 2 wk. The tissues were stored for isolating total RNA. RT-PCR was used to analyze the expression changes of genes. DHA microalgae significantly increased average body gain and feed conversion rates, reduced the levels of total cholesterol （TC）, total glycerin （TG）, and low-density lipoprotein cholesterol （LDL-C） in serum and increased the content of high-density lipoprotein cholesterol. 1 wk later, the effects were still remained. In liver tissue, DHA microalgae increased the expression of PPARα and carnitine palmitoyltransferase-1 （CPT-1）. 1 wk later, it was observed that DHA up-regulated the expression of fatty acid synthase （FAS）, acetyl CoA carboxylase （ACC）, lipoprotein lipase （LPL） and carnitine palmitoyltransferase-1 （CPT-1）. 2 wk later, it still increased the expressions of FAS and CPT-1, but a converse result was observed for ACC and LPL. In adipose tissue, DHA microalgae suppressed the expression of PPARα and LPL, up-regulated the expression of ACC, FAS, and CPT-1. After withdrawal, the expression of genes in test group was significantly lower than that in control group （P0.01）. In the muscle of chest, DHA microalgae significantly inhibited the gene expression （P0.01）. 1 wk later, the expressions of FAS, LPL and CPT-1 in test group were significantly higher than that in control group （P0.05）. 2 wk later, it was shown that DHA significantly inhibited fat synthesis and decomposition. In the leg, there was not any PPARα expression being detected, probably because of the less expression in muscle tissues or the regulation of PPARα had no relation to the case. DHA microalgae promote fat synthesis in the liver and inhibit in adipose and muscle tissues. It still has effects after 1 wk of withdrawa

关键词： DHA broiler adipose tissue liver lipid metabolic genes

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Physical Layer Security with Its Applications in 5GNetworks： A Review

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China Communications 2017年第12期14卷 1-14页

作者： li sun Qinghe Du Department of Information and Communications Engineering Xi'an Jiaotong University Xi'an 710049 China The State Key Laboratory of Integrated Services Networks Xidian University Xi'an 710071 China National Simulation Education Center for Communications and Information Systems Xi'an 710049 China

5G network is expected to support massive user connections and exponentially increasing wireless services,which makes network security unprecedentedly *** traditional security-guaranteeing techniques which rely heavily on cryptographic approaches at upper layers of the protocol stack,physical-layer security(PLS) solutions fully take advantages of the characteristics of wireless channels to degrade the received signal qualities at the malicious users,and realize keyless secure transmission via signal design and signal processing *** avoids the difficulties in the distribution and management of secret keys,and provides flexible security levels through adaptive transmission protocol ***,PLS techniques match the features of 5G networks ***,the application of PLS to 5G networks is a promising solution to address the security *** article presents a comprehensive review of the state-of-the-art PLS techniques,and discusses their applications in 5G *** first summarize the principle and advantages of PLS techniques,and point out the reasons why PLS is suitable for 5G ***,we review the existing PLS methods in literature,and highlight severalPLS solutions that are expected to be applied in 5G ***,we conclude this article and figure out some further research directions.

关键词： 5G physical layer security an-ti-eavesdropping signal design statistical se-curity guarantee fountain coding

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