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乳腺癌疫苗的临床研究现状

结直肠肛门外科 2024年第1期30卷 12-17页

作者：楚治良姚玉波王小明李淑华葛雪燕中国人民解放军联勤保障部队第九八九医院肛肠外科研究所河南洛阳471000 中国人民解放军联勤保障部队第九八九医院神经内科河南洛阳471000 宜阳县香鹿山镇卫生院肛肠外科河南宜阳471611 中国人民解放军联勤保障部队第九八九医院泌尿外科河南洛阳471000 河南科技大学第七附属医院护理部河南洛阳471000

乳腺癌疫苗主要通过激活患者自身免疫系统发挥治疗作用。随着免疫学的不断发展,乳腺癌疫苗的研究取得了很大的进步,但目前仍处于临床试验研究阶段,尚无相应疫苗上市。乳腺癌疫苗的主要类型包括:多肽疫苗、蛋白质疫苗、核酸疫苗、树突状... 详细信息

乳腺癌疫苗主要通过激活患者自身免疫系统发挥治疗作用。随着免疫学的不断发展,乳腺癌疫苗的研究取得了很大的进步,但目前仍处于临床试验研究阶段,尚无相应疫苗上市。乳腺癌疫苗的主要类型包括:多肽疫苗、蛋白质疫苗、核酸疫苗、树突状细胞疫苗、肿瘤细胞疫苗和病毒载体疫苗。本文就乳腺癌疫苗的研究现状、主要类型、相关临床研究结果、面临的挑战和发展前景进行述评,旨在为开发安全性好且临床疗效优的乳腺癌疫苗提供参考。

关键词：乳腺癌乳腺癌疫苗主要类型

Orientational Chirality,Its Asymmetric Control,and Computational Study

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Research 2023年第1期2022卷 545-552页

作者： Shengzhou Jin Yu Wang Yao Tang Jia-Yin Wang Ting Xu Junyi Pan Sai Zhang Qiankai Yuan Anis Ur Rahman James D.McDonald Guo-Qiang Wang shuhua li Guigen li School of Chemistry and Chemical Engineering Nanjing UniversityNanjing210093China Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79409-1061USA Continuous Flow Engineering Laboratory of National Petroleum and Chemical Industry Changzhou UniversityChangzhouJiangsu 213164China

Orientational chirality was discovered and characterized by a C(sp)-C(sp3)axis-anchored chiral center and a remotely anchored blocker.X-ray structural analysis proved that orientatiomers are stabilized by through-space functional groups,making it possible for 1 R-or S-chiral center to exhibit 3 orientational isomers simply by rotating operations.A new model system was proposed,fundamentally different from the traditional Felkin-Ahn-type or Cram-type *** these traditional models,chiral C(sp^(3))center and blocking C(sp^(3))carbons are connected adjacently,and there exist 6 energy barriers during rotating along the C(sp^(2))-C(sp^(3))*** comparison,the present orientational chirality model shows that a chiral C(sp)-C(sp^(3))carbon is remotely located from a blocking ***,it is focused on the steric dialog between a chiral C(sp^(3))center and a remotely anchored functional *** exist 3 energy barriers for either(R)-or(S)-C(sp)-C(sp^(3))stereogenicity in the new *** amide auxiliary was proven to be an excellent chiral auxiliary in controlling rotations of orientatiomers to give complete *** asymmetric synthesis of individual orientatiomers was conducted via multistep synthesis by taking advantage of the Suzuki-Miyaura cross-coupling and Sonogashira coupling *** functional theory computational study presented optimized conformers and relative energies for individual *** discovery would be anticipated to result in a new stereochemistry topic and have a broad impact on chemical,biomedical,and material sciences in the future.

关键词： chiral Chiral rotating

成都市龙泉驿区老年人血小板相关参数参考区间的建立

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华西医学 2024年第4期39卷 599-603页

作者：李淑华廖红艳马莉赵国江何冬梅康昕阳丽熙代琴四川大学华西医院实验医学科成都610041 成都市龙泉驿区第一人民医院检验科成都610100 四川大学华西护理学院/医院管理研究所/门诊部成都610041 成都市龙泉驿区第一人民医院急诊科成都610100 成都市龙泉驿区第一人民医院产科成都610100 成都市龙泉驿区第一人民医院眼科成都610100

目的建立成都市龙泉驿区老年人群血小板相关参数参考区间。方法选取2021年11月1日—12月31日四川大学华西医院自然人群队列研究项目龙泉驿分中心60~80周岁的研究个体,对纳入人群进行全血细胞分析,得到血小板相关参数;利用IBM SPSS Stati... 详细信息

目的建立成都市龙泉驿区老年人群血小板相关参数参考区间。方法选取2021年11月1日—12月31日四川大学华西医院自然人群队列研究项目龙泉驿分中心60~80周岁的研究个体,对纳入人群进行全血细胞分析,得到血小板相关参数;利用IBM SPSS Statistics 25软件对参考数据进行处理,获得老年人血小板相关参数参考区间。结果通过纳入排除标准筛选出参考个体1938人,检测数据排除离群值后得到参考个体1669人,其中男665人,女1004人。血小板计数参考区间:老年男性为(95.03~301.32)×10^(9)/L,老年女性为(112.13~320.75)×10^(9)/L;平均血小板体积参考区间:老年男性为8.97~13.80 fL,老年女性为9.10~13.90 fL;血小板压积参考区间:老年男性为0.13%~0.30%,老年女性为0.14%~0.32%;血小板体积分布宽度参考区间:老年男性为15.80~16.90,老年女性为15.70~16.90。结论建立本区域老年人血小板相关参数具有一定的实际意义。

关键词：老年人血小板相关参数参考区间

Structural Preferences of Two Unnatural Hybrid Octapeptides with and without the Crystal Environment:A Computational Study

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Structural Preferences of Two Unnatural Hybrid Octapeptides ...

Phosphorylation of ZmAL14 by ZmSnRK2.2 regulates drought resistance through derepressing ZmROP8 expression

中国化学会第十二届全国量子化学会议

作者： Junjian Miao shuhua li School of Chemistry and Chemical Engineering Key Laboratory of Mesoscopic Chemistry of MOEInstitute of Theoretical and Computational ChemistryNanjing University

A computational study by combining molecular dynamics simulations with density functional theory calculations has been conducted on two unnatural octapeptides,Boc-[Aib-β3（R）Val]4-OMe and Boc-[Aib-α（S）Val]4-OMe[1],and the corresponding infinite one-dimensional chains to understand their inherent structural preferences and the effect of the crystal environment on their structures.[2]For both systems,we have determined their gas-phase lowest-energy conformers,which possess hybrid helical structures（not pureα-helix-like or 310-helix-like）.For Boc-[Aib-β3（R）Val]4-OMe,our calculations show that the corresponding infinite polypeptide has anα-helix-like structure as the most stable *** result is in accord with the experimental crystal *** Boc-[Aib-α（S）Val]4-OMe,our calculations show that the infinite polypeptide will exist in 310-helix-like structure,which is also consistent with the observed crystal *** present study demonstrates that the peptide conformer in the crystal environment does not necessarily correspond to the most stable structure in vacuum.

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Journal of Integrative Plant Biology 2024年第7期66卷 1334-1350页

作者： Yalin Wang Jinkui Cheng Yazhen Guo Zhen li shuhua Yang Yu Wang Zhizhong Gong State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China College of life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China

Drought stress has negative effects on crop growth and *** of transcription factors that regulate the expression of drought-responsive genes is critical for understanding the transcriptional regulatory networks in response to drought,which facilitates the improvement of crop drought ***,we identified an Alfin-like(AL)family gene ZmAL14 that negatively regulates drought *** of ZmAL14 exhibits susceptibility to drought while mutation of ZmAL14 enhances drought *** abscisic acid(ABA)-activated protein kinase ZmSnRK2.2 interacts and phosphorylates ZmAL14 at T38 *** of ZmSnRK2.2 gene decreases drought resistance of maize.A dehydration-induced Rho-like small guanosine triphosphatase gene ZmROP8 is directly targeted and repressed by *** of ZmAL14 by ZmSnRK2.2 prevents its binding to the ZmROP8 promoter,thereby releasing the repression of ZmROP8 *** of ZmROP8 stimulates peroxidase activity and reduces hydrogen peroxide accumulation after drought ***,our study indicates that ZmAL14 is a negative regulator of drought resistance,which can be phosphorylated by ZmSnRK2.2 through the ABA signaling pathway,thus preventing its suppression on ZmROP8 transcription during drought stress response.

关键词： ZmAL14 drought tolerance transcription factor maize

Epigenetics:Mechanisms,potential roles,and therapeutic strategies in cancer progression

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Genes & Diseases 2024年第5期11卷 300-314页

作者： Dong Wang Yan Zhang Qingbo li Yu li Wen li Ao Zhang Jingxuan Xu Jingyan Meng lin Tang shuhua Lyu Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pathology Tianjin Union Medical CenterTianjin 300121China

Mutations or abnormal expression of oncogenes and tumor suppressor genes are known to cause *** studies have shown that epigenetic modifications are key drivers of cancer development and ***,the mechanistic role of epigenetic dysregulation in the tumor microenvironment is not fully ***,we reviewed the role of epigenetic modifications of cancer cells and non-cancer cells in the tumor microenvironment and recent research advances in cancer epigenetic *** addition,we discussed the great potential of epigenetic combination therapies in the clinical treatment of ***,there are still some challenges in the field of cancer epigenetics,such as epigenetic tumor heterogeneity,epigenetic drug heterogeneity,and crosstalk between epigenetics,proteomics,metabolomics,and other omics,which may be the focus and difficulty of cancer treatment in the *** conclusion,epigenetic modifications in the tumor microenvironment are essential for future epigenetic drug development and the comprehensive treatment of *** combination therapy may be a novel strategy for the future clinical treatment of cancer.

关键词： Cancer Epigenetics Gene expression Heterogeneity Tumor microenvironment

天津市五大道历史文化街区绿色空间空气质量和温湿度调查研究

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景观设计 2024年第3期22卷 22-25页

作者：刘庭风刘滨谊李树华高天李晓甜孟继森陈小奎天津大学建筑学院苏州大学金螳螂建筑学院清华大学建筑学院西北农林科技大学风景园林艺术学院天津大学建筑学院风景园林系海南大学热带农林学院天津市规划和自然资源局林业事务中心中国市政工程华北设计研究总院有限公司

绿色空间是历史文化街区的重要生态保障。为探究历史文化街区中绿色空间的生态价值,以天津市五大道历史文化街区为研究对象,针对绿色空间的类型及绿化指数、悬浮颗粒及负氧离子浓度、温湿度进行实地调研和数据分析。结果表明:良好的植... 详细信息

绿色空间是历史文化街区的重要生态保障。为探究历史文化街区中绿色空间的生态价值,以天津市五大道历史文化街区为研究对象,针对绿色空间的类型及绿化指数、悬浮颗粒及负氧离子浓度、温湿度进行实地调研和数据分析。结果表明:良好的植被覆盖和复层植被结构对净化空气、增加负氧离子浓度、降低空气温度、提高相对湿度等具有积极影响。研究旨在为历史文化街区中绿色空间的规划与设计提供科学参考与指导。

关键词：五大道历史文化街区绿色空间空气质量微气候

呼吸机相关性肺炎病原菌分布特点及发病影响因素分析

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结核与肺部疾病杂志 2024年第4期5卷 305-310页

作者：赵瑞娜李淑花崔晓红弓巧巧裴俊丽袁丽荣山西医科大学第一医院呼吸与危重症医学科太原030001

目的:分析呼吸机相关性肺炎(ventilator associated pneumonia,VAP)患者的肺部病原菌分布情况,并探讨VAP发病的影响因素。方法:采用回顾性研究方法,选取2018年1月至2021年12月在山西医科大学第一医院及阳泉市第一人民医院接受机械通气... 详细信息

目的:分析呼吸机相关性肺炎(ventilator associated pneumonia,VAP)患者的肺部病原菌分布情况,并探讨VAP发病的影响因素。方法:采用回顾性研究方法,选取2018年1月至2021年12月在山西医科大学第一医院及阳泉市第一人民医院接受机械通气治疗的1164例患者作为研究对象,均留取痰标本进行病原菌检测。收集研究对象一般资料(年龄、性别、住院时间、手术情况)、机械通气时长及次数、尿管和中心静脉导管留置时长及次数、抗菌药物使用时长及次数、痰标本的病原菌情况等信息。分析VAP患者肺部病原菌分布特点,并应用多因素logistic回归模型探究研究对象发生VAP的影响因素。结果:1164例研究对象中,171例(14.69%)发生VAP。171例VAP患者下呼吸道分泌物或气管插管终端分泌物中共检出378株病原菌,其中,革兰阴性菌298株(78.84%),革兰阳性菌66株(17.46%),真菌14株(3.70%);肺炎克雷伯菌、鲍曼不动杆菌是主要病原菌,分别占23.81%(90/378)、14.81%(56/378)。多因素logistic回归分析显示,手术[OR(95%CI)=2.506(1.640~3.828)]、住院时间≥14 d[OR(95%CI)=2.749(8.424~28.968)],以及留置尿管[OR(95%CI)=14.208(5.285~38.192)]均是接受通气治疗患者发生VAP的独立影响因素。结论:条件致病菌是造成机械通气治疗患者呼吸道感染的主要致病菌;对于实施手术、住院时间较长,以及留置尿管的患者,要警惕其发生VAP的风险。

关键词：通气机,机械感染肺炎,呼吸机相关性因素分析,统计学

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Branch-Chain-Rich Diisopropyl Ether with Steric Hindrance Facilitates Stable Cycling of lithium Batteries at-20℃

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Nano-Micro Letters 2024年第10期16卷 121-135页

作者： Houzhen li Yongchao Kang Wangran Wei Chuncheng Yan Xinrui Ma Hao Chen Yuanhua Sang Hong liu shuhua Wang State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100People's Republic of China

li metal batteries(LMBs)offer signifi-cant potential as high energy density alternatives;nev-ertheless,their performance is hindered by the slow desolvation process of electrolytes,particularly at low temperatures(LT),leading to low coulombic efficiency and limited cycle ***,it is essential to opti-mize the solvation structure thereby achieving a rapid desolvation process in LMBs at ***,we introduce branch chain-rich diisopropyl ether(DIPE)into a 2.5 M li bis(fluorosulfonyl)imide dipropyl ether(DPE)elec-trolyte as a co-solvent for high-performance LMBs at-20℃.The incorporation of DIPE not only enhances the disorder within the electrolyte,but also induces a steric hindrance effect form DIPE’s branch chain,excluding other solvent molecules from li+solvation *** of these factors contribute to the weak interactions between li^(+)and solvent molecules,effectively reducing the desolvation energy of the ***,li(50μm)||LFP(mass loading~10 mg cm^(-2))cells in DPE/DIPE based electrolyte demonstrate stable performance over 650 cycles at-20℃,delivering 87.2 mAh g^(-1),and over 255 cycles at 25℃ with 124.8 mAh g^(-1).DIPE broadens the electrolyte design from molecular structure considera-tions,offering a promising avenue for highly stable LMBs at LT.

关键词： Solvation structure li metal battery Low temperature Steric hindrance Disorder