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A large deviation for occupation time of critical branching α-stable process

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Science China Mathematics 2011年第7期54卷 1445-1456页

作者： li qiuyue REN YanXia College of Science China Agricultural University Beijing 100083 China LMAM School of Mathematical Sciences Center for Statistical Science Peking University Beijing 100871 China

In this paper we establish a large deviation principle for the occupation times of critical branching α-stable processes for large dimensions d > 2α, by investigating two related nonlinear differential equations. Ou... 详细信息

关键词： large deviation critical branching α-stable process occupation time

Manganese toxicity-induced chlorosis in sugarcane seedlings involves inhibition of chlorophyll biosynthesis

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The Crop Journal 2022年第6期10卷 1674-1682页

作者： Shu Yang Guizhi ling qiuyue li Ke Yi Xinlian Tang Muqing Zhang Xiaofeng li State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangxi Key Laboratory for Sugarcane Biology College of AgricultureGuangxi UniversityNanning 530004GuangxiChina Institute for New Rural Development Guangxi UniversityNanning 530004GuangxiChina

Manganese(Mn)toxicity-induced leaf chlorosis limits crop production in acidic soils,but its underlying mechanisms remain *** effects of excessive Mn on chlorophyll(Chl)biosynthesis in sugarcane(Saccharum officinarum L.)leaves were *** Mn treatment,Chl concentration decreased with Mn accumulation and chlorosis appeared in expanding *** that,levels of the initial Chl precursor 5-aminolevulinic acid(ALA)and its downstream intermediates decreased,whereas magnesium-protoporphyrin IX monomethyl ester(MgPME)*** of Mn in leaves downregulated the ALA biosynthetic gene GluTR(encoding glutamyl-tRNA reductase)and MgPME conversion gene MgPMEC(encoding MgPME cyclase),upregulated the ALA biosynthesis inhibitor FLU(encoding FLUORESCENT),but had no significant effect on the expression of other Chl biosynthetic *** above Mn-induced changes of Chl precursors and expression of corresponding genes commenced before the Chl decline and leaf chlorosis,and were reversed by ALA ***,excessive Mn-induced chlorosis in sugarcane is mediated by a Chl-biosynthesis disorder resulting from the inhibition of ALA synthesis and MgPME conversion.

关键词： Sugarcane Manganese toxicity Chlorosis Chlorophyll biosynthesis Gene expression

CuO/Co_(3)O_(4)Bifunctional Catalysts for Electrocatalytic 5-Hydroxymethylfurfural Oxidation Coupled Cathodic Ammonia Production

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Energy & Environmental Materials 2024年第5期7卷 255-262页

作者： li Zhang Peiyue Jin Ze Wu Bo Zhou Junchang Jiang Aomeng Deng qiuyue li Tanveer Hussain Yiqiong Zhang Hanwen liu Shuangyin Wang College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410114China School of Chemical Engineering Xiangtan UniversityXiangtan 411105China State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China School of Science and Technology University of New EnglandArmidaleNSW 2351Australia WA School of Mines MineralsEnergy and Chemical Engineering(WASM-MECE)Curtin UniversityPerthWA 6102Australia

The electrochemical coupling of biomass oxidation and nitrogen conversion presents a potential strategy for high value-added chemicals and nitrogen ***,in this work,CuO/Co_(3)O_(4)with heterogeneous interface is successfully constructed as a bifunctional catalyst for the electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid and the electroreduction of nitrate to ammonia(NH_(3)).The open-circuit potential spontaneous experiment shows that more 5-hydroxymethylfurfural molecules are adsorbed in the Helmholtz layer of the CuO/Co_(3)O_(4)composite,which certifies that the CuO/Co_(3)O_(4)heterostructure is conducive to the kinetic adsorption of *** situ electrochemical impedance spectroscopy further shows that CuO/Co_(3)O_(4)has faster reaction kinetics and lower reaction potential in oxygen evolution reaction and 5-hydroxymethylfurfural electrocatalytic ***,CuO/Co_(3)O_(4)also has a good reduction effect on NO_(3)^(-).The ex-situ Raman spectroscopy shows that under the reduction potential,the metal oxide is reduced,and the generated Cu_(2)O can be used as a new active site for the reaction to promote the electrocatalytic conversion of NO_(3)^(-)to NH_(3) *** work provides valuable guidance for the synthesis of value-added chemicals by 5-hydroxymethylfurfural electrocatalytic oxidation coupled with NO_(3)^(-)while efficiently producing NH_(3).

关键词： 5-hydroxymethylfurfural oxidation ammonia production bifunctional catalyst CuO/Co_(3)O_(4) electrocatalyst

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中国组织工程研究 2025年第2期29卷 279-285页

作者：侯成志韩佳童魏光成卓泽川李秋月赵勇俞张镜泽中国中医科学院望京医院北京市100102

背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质... 详细信息

背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质疏松症的机制。方法:取8周龄雌性SD大鼠24只,采用随机数字表法分为4组(n=6),3个实验组分别灌胃给予1,2,4 g/kg的骨疏康药液(2次/d),对照组灌胃给予等量蒸馏水(2次/d),连续灌胃7 d后抽取大鼠主动脉血,离心收集血清,同组血清合并,获得低、中、高浓度的骨疏康含药血清及正常血清,进行后续实验。①将RAW 264.7细胞分6组培养:对照组加入正常血清,低、中、高浓度组分别加入低、中、高浓度的骨疏康含药血清,Nrf2抑制剂组加入核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)抑制剂ML385,Nrf2激活剂组加入Nrf2激活剂t-BHQ,采用CCK8法检测细胞相对活性。②将第3代RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL),低、中、高浓度组在加入RANKL的基础上分别加入低、中、高浓度的骨疏康含药血清,培养5 d后进行抗酒石酸酸性磷酸染色。③将RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入正常血清与RANKL,高浓度+破骨组加入RANKL+高浓度骨疏康含药血清,破骨+Nrf2激动剂组加入RANKL+t-BHQ,高浓度+破骨+Nrf2抑制剂组加入RANKL+高浓度骨疏康含药血清+ML385,培养5 d后进行Western Blot与活性氧含量检测。结果与结论:①CCK8检测结果显示,骨疏康含药血清及Nrf2抑制剂、激动剂对RAW 264.7细胞活力无明显影响;②抗酒石酸酸性磷酸染色结果显示,骨疏康含药血清呈浓度依赖性抑制破骨细胞的分化;③Western Blot与活性氧含量检测结果显示,与空白对照组比较,破骨组Nrf2蛋白表达降低(P<0.05),c-Fos、NFATc1蛋白表达与活性氧含量升高(P<0.05);与破骨组比较,高浓度+破骨组、破骨+Nrf2激动剂组、高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达升高、活性氧含量降低(P<0.05),高浓度+破骨组、破骨+Nrf2激动剂组c-Fos、NFATc1蛋白表达降低(P<0.05);与高浓度+破骨组比较,高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达降低(P<0.05),活性氧含量升高(P<0.05);④结果表明,骨疏康通过激活Nrf2减少活性氧生成,进而抑制下游c-Fos/NFATc1通路表达和破骨细胞分化。

关键词：骨质疏松症骨疏康含药血清破骨细胞 Nrf2 c-Fos/NFATc1通路 RAW 264.7细胞

Inhibition of lipid oxidation in foods and feeds and hydroxyl radical-treated fish erythrocytes:A comparative study of Ginkgo biloba leaves extracts and synthetic antioxidants

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Animal Nutrition 2016年第3期2卷 234-241页

作者： Huatao li Xiaoqiu Zhou Ping Gao qiuyue li Hansi li Rong Huang Min Wu College of life Sciences Neijiang Normal University Conservation and Utilization of Fishes Resources in the Upper Reaches of the Yangtze River Key Laboratory of Sichuan Province Neijiang Normal University Animal Nutrition Institute Sichuan Agricultural University College of life Sciences Sichuan University Archives Neijiang Normal University

This study explored the effects of butylated hydroxytoluene(BHT) and ethoxyquin(EQ) and ethyl ether extracts, ethyl acetate extracts(EAE), acetone extracts, ethanol extracts and aqueous extracts of Ginkgo biloba leaves(EGbs) on lipid oxidation in a linoleic acid emulsion, fish flesh and fish feed and in hydroxyl radical(·OH)-treated carp erythrocytes. The linoleic acid, fish flesh and fish feed were incubated with BHT,EQ and EGbs at 45℃ for 8 d, respectively, except for the control group. The lipid oxidation in the linoleic acid emulsion, fish flesh and fish feed was then measured by the ferric thiocyanate method or thiobarbituric acid method. The carp erythrocytes were treated with BHT, EQ. or EGbs in the presence of40 μmol/L FeSO_4 and 20 μmol/L H_2 O_2 at 37℃ for 6 h,except for the control group. Oxidative stress and apoptosis parameters in carp erythrocytes were then evaluated by the commercial kit. The results showed that BHT, EQ and EGbs inhibited lipid oxidation in the linoleic acid emulsion, fish flesh and fish feed and·OH-induced phosphatidylserine exposure and DNA fragmentation(the biomarkers of apoptosis) in carp erythrocytes. Furthermore, BHT, EQ and EGbs decreased the generation of reactive oxygen species(ROS),inhibited the oxidation of cellular components and restored the activities of enzymatic antioxidants in·OH-treated carp erythrocytes. Of all examined EGbs, EAE showed the strongest effects. The effects of EAE on lipid oxidation in the linoleic acid emulsion and on superoxide anion and malonaldehyde levels,catalase activity and apoptosis in. OH-treated carp erythrocytes were equivalent to or stronger than those of BHT. Moreover, these results indicated that the inhibition order of EGbs on the generation of ROS and oxidation of cellular components in fish erythrocytes approximately agreed with that for the food and feed materials tested above. And, the antioxidative and anti-apoptotic effects of EGbs were positively correlated with their flavonoid c

关键词： Ginkgo biloba lipid oxidation Apoptosis Fish erythrocyte Flavonoids

Exosomal lncRNA liNC01268 promotes pancreatic cancer progression via the miR-217-KIF2A-PI3K/AKT axis

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Genes & Diseases 2023年第5期10卷 1799-1801页

作者： Shanshan liu Yang Di qiuyue li litian Chen Yan Ma Xiaomeng He Christopher Corpe Xiaoyan Zhang Jianqing Xu Jin Wang Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Department of Pancreatic Surgery Huashan HospitalFudan UniversityShanghai 201508China Department of Hepatobiliary Surgery Shanghai Jiaotong University School of Medicine Xinhua HospitalShanghai 200025China King's College London LondonNutritional Science DepartmentWaterlooLondon SE19NHUnited Kingdom

Pancreatic cancer(PaCa)is one of the most aggressive and lethal malignancies with rapid progression and poor prognosis with the 5-year survival rate remaining less than 5%because approximately 80%of PaCa patients are diagnosed at an advanced stage and lose the chance of curative resection.1 Accumulated evidence has revealed that noncoding RNAs(ncRNAs)are involved in the pathogenesis of PaCa and serve as potential biomarkers for PaCa.2,3 Exosomal lncRNAs also play a vital role in tumorigenesis and some exosomal lncRNAs have been reported to accelerate tumor progression.4 In this study,we first employed RNA-seq of PaCa plasma samples to identify significantly differentially expressed lncRNAs in PaCa patients and revealed that liNC01268 was up-regulated in PaCa tumor tissues and ***01268 is an emerging lncRNA associated with glioma malignancy grade.5 *** further analyzed the malignant biological behaviors of this lncRNA in PaCa and found that liNC01268 promoted cell proliferation,migration,and invasion as an oncogene,which promoted epithelial–mesenchymal transition(EMT)in PaCa via the miR-217-KIF2A-PI3K/AKT axis.

关键词： PI3K/AKT cancer invasion

中国典型草原植被高度组合的普适性规律与区域差异

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Journal of Plant Ecology 2023年第1期16卷 203-213页

作者： Jihua Hou qiuyue li Pu Yan li Xu Mingxu li Nianpeng He School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Vegetation Ecology Ministry of EducationNortheast Normal UniversityChangchun 130024China

详细测定每株植物高度是精细评估草地生态系统中植物群落高度结构的重要方法,并经常用来分析草地植被生长与环境因子关系的普适性和区域差异。本研究在我国青藏高原、内蒙古高原和黄土高原,分别沿降水梯度布设了3条从草甸-草原-荒漠的... 详细信息

详细测定每株植物高度是精细评估草地生态系统中植物群落高度结构的重要方法,并经常用来分析草地植被生长与环境因子关系的普适性和区域差异。本研究在我国青藏高原、内蒙古高原和黄土高原,分别沿降水梯度布设了3条从草甸-草原-荒漠的典型草地生态系统样带。研究结果发现,我国3大高原的草地生态系统植被平均高度为30.38±22.44 cm,其中黄土高原最高,内蒙古高原次之,青藏高原最低。这3个高原草地生态系统的植被聚合高度分布都呈现偏正态分布(0.91,3.60),而且从青藏、内蒙古到黄土高原,该分布逐渐趋于正态(0,3)。然而,在青藏高原的草甸和荒漠生态系统中分别呈现出指数分布和均匀分布。在3大高原中,气候和土壤营养对植被平均高度解释率超过70%,然而对植被聚合高度的解释率最高仅为29%(青藏高原)。从青藏高原、内蒙古高原至黄土高原,植被平均高度对环境综合响应强度逐渐增强,具体表现为气温、降水的影响逐渐增强,而辐射、风速和营养物浓度影响逐渐减弱。我们的研究表明,正态分布是草地植被高度构建的普适性原则,而环境因素的协同作用在不同区域存在差异。

关键词：草地植被高度群落结构环境变化样带

Research on Electromagnetic Acoustic Emission Signal Recognition Based on Local Mean Decomposition and Least Squares Support Vector Machine

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Journal of Computer and Communications 2023年第5期11卷 70-83页

作者： Chenglong Yang Yushu Lai qiuyue li School of Electronic and Information Engineering Chongqing Three Gorges University Chongqing China Chongqing Engineering Technology Research Center for light Alloy and Processing Chongqing China

Electromagnetic acoustic emission technology is one of nondestructive testing, which can be used for defect detection of metal specimens. In this study, round and cracked metal specimens, round metal specimens, and intact metal specimens were prepared. And the electromagnetic acoustic emission signals of the three specimens were collected. In addition, the local mean decomposition(LMD), Autoregressive model(AR model) and least squares support vector machine (LSSVM) algorithms were combined to identify the eletromagnetic acoustic emission signals of round and cracked, round, and intact specimens. According to the algorithm recognition results, the recognition accuracy of can reach above 97.5%, which has a higher recognition rate compared with SVM and BP neural network. The results of the study show that the algorithm is able to identify quickly and accurately crack defect in metal specimens.

关键词： Electromagnetic Acoustic Emission Technology LMD LSSVM Defect Detection of Metal Crack

Interface of 3D Micro-cellular Structural AlMnCe/Al_2O_3 Composite

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稀有金属材料与工程 2011年第S3期40卷 128-131页

作者： Wang Shuxia, li Shaolong, Jiang qiuyue, Shi Lei, Wang Minggang, Jia Suqiu, Zhao Zhankui Key Laboratory of Advanced Structural Materials, Ministry of Education, Changchun University of Technology, Changchun 130012, China Changchun Univ Technol Key Lab Adv Struct Mat Minist Educ Changchun 130012 Peoples R China

The AlMnCe/Al2O3 metal/ceramic composite with 3D micro-cellular structure is prepared by spark plasma sintering (SPS) at 520 ℃. It consists of consecutive nano-Al2O3 sintering body phase and AlMnCe alloy discrete phase. The microstructure of sample, characteristic of the micro-cellular structure and microstructure of the interface are investigated via scanning electron microscope (SEM) and transmission electron microscope (TEM) method. The results indicate that two kinds of interfaces are formed in the sample during SPS process, one is the micro-nano type metal/ceramic interface between the metal cellular body and the nano-ceramic cellular wall, the other is the nano-nano type ceramic/ceramic interface in the nano-ceramic cellular wall. The fusion transition area with a width 200-300 nm at interface of the AlMnCe alloy and nano-Al2O3 sintering body is formed. The AlMnCe alloy has a sufficient immersional wetting for the Al2O3 cellular wall. The bonding of interface between the nano-Al2O3 sintering body and the AlMnCe alloy particle is powerful, and new phase and crack is not found.

关键词： spark plasma sintering composite microcellular structure interface