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Application of SPECT Combined with CT and MRI in Malignant Tumors Clinical Value in the Diagnosis of Bone Metastasis

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Open Journal of Medical Imaging 2022年第1期12卷 9-15页

作者： Xiao li Wenda Shi Fan Xu qingshan li Xu Xiao Departments of Radiology Affiliated Hospital of Chengde Medical College Chengde China Departments of Oncology Affiliated Hospital of Chengde Medical College Chengde China Departments of Pharmacy Affiliated Hospital of Chengde Medical College Chengde China

Introduction: Bone is the most common site of hematogenous metastasis of malignant tumors. Patients with bone metastasis can have a series of bone related adverse events, which seriously affect the quality of life and survival time of patients. Imaging examination is the main means of clinical diagnosis and evaluation of bone metastasis. Aim of the Work: To evaluate the value of single-photon emission computerized tomography (SPECT) combined with CT and MRI in the diagnosis of bone metastasis of malignant tumors. Subjects and Methods: Eighty patients with bone metastasis from malignant tumors who were admitted to Affiliated Hospital of Chengde Medical College were selected from March 2019 to June 2021. They underwent bone scan with SPECT imaging, CT and MRI separately. The distribution of bone metastasis from primary tumors as well as efficacy of the above three detection methods for bone metastasis was analyzed. Results: A total of 464 lesions were detected by SPECT and CT in the same scanning field, with SPECT detection rate of 92.5% (429/464) and CT detection rate of 77.8% (361/464) (P P P P Conclusion: SPECT may be the preferred screening modality for uspected bone metastases, and when combined with CT and MRI, it can clarify the regional distribution of bone metastasis from malignant tumors and improve the sensitivity, specificity and accuracy of diagnosis with high clinical significance.

关键词： Bone Scan with SPECT Imaging Malignant Bone Metastases Computed Tomography Magnetic Resonance Imaging

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Epithelial-Mesenchymal Transition and Breast Cancer Stem Cells in Breast Cancer Progression

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Advances in Breast Cancer Research 2022年第2期11卷 141-151页

作者： Wanyue Han qingshan li Qing Zhang Fan Xu The Affiliated Hospital of Chengde Medical University Chengde China

Breast cancer stem cells (BCSCs) are a small subpopulation of cancer cells having the ability of self-renewing and multi-lineage differentiation, which have also been termed as “tumor-initiating cells”. And in recent years, the role of epithelial mesenchymal transition (EMT) in malignant tumors has been valued. This paper will briefly review and discuss the relationship between BCSCs and EMT.

关键词： Epithelial-Mesenchymal Transition Breast Cancer Stem Cells E-Cadherin Vimentin Signaling Pathway

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Expression and Clinical Significance of Ki67 in Common Gastrointestinal Tumours

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Open Journal of Gastroenterology 2021年第12期11卷 295-306页

作者： Fangyu Shi Yunnan Dai Yiying Bai qingshan li Affiliated Hospital of Chengde Medical University Chengde China

Ki67 is a marker of cell proliferation that is expressed in the S, G2 and M phases but not in the G0 phase of the cell cycle. Several recent studies showed that the expression of Ki67 is closely related to the occurrence and development of gastrointestinal tumours. The Ki67 index is closely related to the degree of differentiation, invasion, metastasis and prognosis of gastrointestinal tumours. This review describes the relationship between the Ki67 index and degree of malignancy, therapeutic effect and prognosis of gastrointestinal tumours.

关键词： Gastrointestinal Neoplasms Ki67 Pathological Features Prognosis

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IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis

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Cellular & Molecular Immunology 2015年第3期12卷 366-372页

作者： qingshan li Xin Xu Weijie Zhong Qinghua Du Bizhen Yu Huabao Xiong Department of Hematology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou China lmmunology Institute Mount SinaiSchool of Medicine New York NY USA Department of Hematology &Oncology Guangzhou First People's Hospital Guangzhou Medical UniversityGuangzhou China

p53 is a well-known tumor suppressor. However, the regulatory mechanism（s） for p53 expression in B lymphoma cells, and the possible role of p53 in the development of the radioresistance in tumor cells are largely unknown. A human B lymphoma cell line, Karpas1106 （k1106）, was used as a model of radioresistance. Apoptosis of k1106 cells was determined using flow cytometry. Expression of p53 was assessed using real time RT-PCR and western blotting. The results showed that irradiation at 8 Gy induced apoptosis in up to 40% of k1106 cells. At the same time, the irradiation markedly increased IL-6 production of the k1106 cells. When k1106 cells were cocultured with regulatory T cells （Tregs） and irradiated, the rate of apoptotic k1106 cells was significantly reduced, indicating an acquired resistance to irradiation. IL-6 derived from the irradiation-treated k1106 cells induced IL-17 expression in Tregs. The IL- 17＋Foxp3＋ T cells suppressed p53 expression in k1106 cells. Collectively, irradiated k1106 cells induce the expression of IL-17 in Tregs, which interferes with the expression of p53 protein in k1106 cells and thereby represses irradiation-triggered apoptosis in k1106 cells.

关键词： interleukin-17 irradiation lymphoma p53 protein regulatory T cells

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Heterometallic Cluster Catalyzing Coordinative Hydrogenation Promoted by Oxygen Transfer Reagent

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分子催化 1998年第1期 2-3页

作者： li qingshan DING Errun WU Shulin YIN Yuanqi 1) (Lanzhou Institute of Chemical Physics The Chinese Academy of Sciences Lanzhou 730000)

ＨｅｔｅｒｏｍｅｔａｌｉｃＣｌｕｓｔｅｒＣａｔａｌｙｚｉｎｇＣｏｏｒｄｉｎａｔｉｖｅＨｙｄｒｏｇｅｎａｔｉｏｎＰｒｏｍｏｔｅｄｂｙＯｘｙｇｅｎＴｒａｎｓｆｅｒＲｅａｇｅｎｔＬＩＱｉｎｇｓｈａｎＤＩＮＧＥｒｒｕｎＷＵＳ... 详细信息

ＨｅｔｅｒｏｍｅｔａｌｉｃＣｌｕｓｔｅｒＣａｔａｌｙｚｉｎｇＣｏｏｒｄｉｎａｔｉｖｅＨｙｄｒｏｇｅｎａｔｉｏｎＰｒｏｍｏｔｅｄｂｙＯｘｙｇｅｎＴｒａｎｓｆｅｒＲｅａｇｅｎｔＬＩＱｉｎｇｓｈａｎＤＩＮＧＥｒｒｕｎＷＵＳｈｕｌｉｎＹＩＮＹｕａｎｑｉ１）（...

关键词： Heterometallic cluster Hydrogenation Oxygen transfer reagent Homogeneous catalysis

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Investigation of the Value of Different Field Strength MRI Scans for the Diagnosis of Rotator Cuff in Juries

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Open Journal of Radiology 2022年第1期12卷 32-36页

Objective: A comparison of the difference between the two types of field MR scan in diagnosis of shoulder joint injury. Method: Randomly selected 153 patients with arthroscopic or open arthroplasty who had shoulder pain or dysfunction treated in our hospital from 2014 to 2017 were divided into 1.5 T group and 3.0 according to the field strength of MRI examination. Postoperative pathology was a gold standard. The sensitivity, specificity, consistency, and predictive value of two field-strength MRI examinations in the diagnosis of rotator cuff tears were calculated and compared. Results: The sensitivity, specificity, crude consistency, positive predictive value, and negative predictive value of the 1.5 T group were 68.75%, 82.35%, 73.47%, 88.00%, and 58.33%, respectively. The 3.0 T group was 72.22%, 89.47%, 78.18%, 92.86% and 62.96%, the differences between the above indicators were not statistically significant (P > 0.05). Conclusion: There was no difference in the authenticity and benefit index of rotator cuff injury diagnosed by 1.5 T and 3.0 T MRI.

关键词： Shoulder Joint Magnetic Resonance Imaging Field Strength Diagnostic Value

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Effect of Ganoderma lucidum Polysaccharide on Antioxidative Ability of Rats with Myocardial Injury Induced by Doxorubicin

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Journal of Biosciences and Medicines 2022年第4期10卷 14-19页

作者： Fan Xu Xiao li qingshan li Xiao Xu Wenxin li Xiaolei Yu Departments of Oncology Affiliated Hospital of Chengde Medical College Chengde China Departments of Radiology Affiliated Hospital of Chengde Medical College Chengde China Departments of Pharmacy Affiliated Hospital of Chengde Medical College Chengde China

Objective: The objective is to investigate the effect of Ganoderma lucidum polysaccharide (GLPS) on the oxidative stress induced by doxorubicin (DOX) in cardiomyocytes. Methods: SD rats were divided into control group, DOX group, GLPS low dose and high dose + DOX group. SOD and MDA levels in myocardial tissue were detected in each group. The expression of related proteins in each group was detected by Western blot. Results: GLPS can increase the SOD level and decrease MDA caused by DOX (p Conclusion: Ganoderma polysaccharide can improve the oxidative stress injury of myocardial tissue induced by doxorubicin and play a protective role in myocardial tissue.

关键词： Doxorubicin Ganoderma lucidum Polysaccharide Myocardial Tissue Antioxidant Capacity

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Effects of Different Doses of Doxorubicin on H9C2 Cells

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Journal of Biosciences and Medicines 2022年第3期10卷 136-140页

作者： Fan Xu Xiao li Xiaolei Yu qingshan li Wenxin li Xu Xiao Departments of Oncology The Affiliated Hospital of Chengde Medical College Chengde China Departments of Radiology The Affiliated Hospital of Chengde Medical College Chengde China Departments of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China

Objective: To study the effect of different doses of doxorubicin on H9C2 cells and to provide a reference for the clinical study of doxorubicin. Methods: Doxorubicin (1, 2, 4, 6, 10 ug/ml) was co-cultured with H9C2 cells for 6, 12 and 24 hours. The morphological changes of cells were observed, and the cell inhibition rates of different time and drug concentration were calculated. Results: Doxorubicin could inhibit the activity of cardiomyocytes in a dose-dependent manner from 1 to 10 ug/ml. Conclusion: A certain dose of doxorubicin has a toxic effect on cardiomyocytes and can cause cardiomyocyte necrosis and apoptosis.

关键词： H9C2 Cells Doxorubicin Cell Inhibition Rate

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Preparation and research status of healthy functional water

Preparation and research status of healthy functional water

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2012 China Functional Materials Technology and Industry Forum

作者： Longlong Guan qingshan li Bi'e Jin State Key Laboratory of Metastable Materials Science and Technology Yanshan University

Basing on the definition of the functional water,this paper analyzed its mechanism of action and the benefits to human body,and summed up four preparation methods to obtain this advanced *** were electrolysis method,magnetic field cutting method,spectrum similar method,and physical adsorption method,and then made a brief statement on the latest researches of each ***,described the viewpoint about the development tendency of healthy functional water.

关键词： functional water active water healthy water

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A Design Proposal about an Installation to Push the Sand on Railroad

A Design Proposal about an Installation to Push the Sand on ...

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2012 China Functional Materials Technology and Industry Forum

作者： Chen Mingbiao Wang Yunsi Hu Xinjun qingshan li College of Mechanical Engineering Qinghai University Key Laboratory of Metastable Materials Science and Technology College of Materials Science and EngineeringYanshan University

A kind of installation used to push the sand out of railroad consisted of railway sand pushing installation and railway turnout sand blowing *** installation can be set on the pre-panel of the rail car or patrol and check vehicle;which can be used for quick extrusion the sand on the railway and blow out the sand in the railway *** the train can run in gear when the railways are covered with a lot of *** we can solve the problem that the train is blocked by the sand on the railway.

关键词： Railway installation Railway sand pushing installation Railway turnout sand blowing installation Railway sand cleaning installation

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