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Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine- 2,5-dicarboxamide Derivatives as MMP 13 Inhibitors

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Chemical Research in Chinese Universities 2013年第1期29卷 67-70页

作者： LU Hai-bin WANG Shi-han li qing-min WANG Yong-sheng College of Pharmacy Jilin University Changchun 130021 P. R. China Changchun University of Chinese Medicine Changchun 130021 P. R. China

We designed and synthsized a series of novel 6-oxo-l,6-dihydropyrimidine-2,5-dicarboxamide derivatives and evaluated their inhibition effects on MMP 3, MMP 12 and MMP 13. The pharmacological results show that they hav... 详细信息

关键词： Matrix metalloproteinase 13(MMP 13) Matrix metalloproteinase(MMP) Inhibition

血清Hcy与NT-proBNP和hs-CRP水平与急性心肌梗死患者心功能及预后的相关性

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医药论坛杂志 2024年第14期45卷 1562-1565页

作者：李庆敏董凤芝王哲新马利亚赵贺红开封市人民医院检验科河南开封475000

目的探讨血清同型半胱氨酸(HCY)、N末端B型脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)水平与急性心肌梗死患者心功能及预后的相关性,以期为临床早期制定干预方案提供参考。方法选取86例开封市人民医院2021年4月—2023年4月就诊的急... 详细信息

目的探讨血清同型半胱氨酸(HCY)、N末端B型脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)水平与急性心肌梗死患者心功能及预后的相关性,以期为临床早期制定干预方案提供参考。方法选取86例开封市人民医院2021年4月—2023年4月就诊的急性心肌梗死患者,比较不同心功能分级患者血清Hcy、NT-proBNP、hs-CRP水平及心功能指标[左心室舒张末内径(LVDD)、左室射血分数(LVEF)],分析血清Hcy、NT-proBNP、hs-CRP水平与急性心肌梗死患者心功能的相关性,并比较不同预后患者血清Hcy、NT-proBNP、hs-CRP水平,并分析其与急性心肌梗死患者预后的关系。结果不同心功能分级患者入院时血清Hcy、NT-proBNP、hs-CRP水平及LVDD比较:Ⅳ级>Ⅲ级>Ⅱ级,LVEF比较:Ⅳ级<Ⅲ级<Ⅱ级(P<0.05);血清Hcy、NT-proBNP、hs-CRP与心功能分级、LVDD呈正相关,与LVEF呈负相关(P<0.05);与预后良好患者比较,预后不良患者入院时血清Hcy、NT-proBNP、hs-CRP水平较高(P<0.05);经logistic回归方程分析结果显示,血清Hcy、NT-proBNP、hs-CRP为急性心肌梗死患者预后的影响因素(P<0.05)。结论血清Hcy、NT-proBNP、hs-CRP水平与急性心肌梗死患者心功能及预后具有显著相关性,为临床早期评估患者预后,针对性制定干预方案提供参考。

关键词：急性心肌梗死心功能同型半胱氨酸 N末端B型脑钠肽前体超敏C反应蛋白

Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang qing-lin Cheng Wei Sun Yi Zhao Zhi-min li Key Lab of ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

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软土地区地铁基坑工程施工预警研究

价值工程 2024年第7期43卷 4-6页

作者：李清民中铁十四局集团有限公司济南250000

软黏土地层分布广泛,因软黏土强度低、高触变性、高压缩性、低渗透性与结构性不良等性质,深基坑工程针对自身及周边环境变形安全管控,必须制定有效的监控制实施方案,对施工过程各阶段变形进行监控,监测数据科学指导施工,及时控制施工进... 详细信息

软黏土地层分布广泛,因软黏土强度低、高触变性、高压缩性、低渗透性与结构性不良等性质,深基坑工程针对自身及周边环境变形安全管控,必须制定有效的监控制实施方案,对施工过程各阶段变形进行监控,监测数据科学指导施工,及时控制施工进度及施工工法的运用,确保施工全过程安全。结合软黏土地区基坑工程监测及施工组织实践,分析软黏土基坑工程变形规律。

关键词：深基坑监控量测施工管控预警分析

Efficient and accurate worm grinding of spur face gears according to an advanced geometrical analysis and a closed-loop manufacturing process

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Journal of Central South University 2022年第1期29卷 1-13页

作者： ZHOU Yuan-sheng TANG Zhong-wei SHI Xian-lin TANG Jin-yuan li Zheng-min-qing State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Worm grinding has been applied to manufacture gears to pursue high accuracy and fine surface *** the worm used to grind face gears is manufactured with multi-axis computer numerical control(CNC)machining,the machining accuracy is usually improved by increasing the number of tool paths with more time ***,this work proposes a generated method to improve the efficiency by dressing the worm surface with only one path,and a closed-loop manufacturing process is applied to ensure the machining *** to an advanced geometric analysis,the worm surface is practically approximated as a swept surface generated by a planar ***,this curve is applied as the profile of a dressing wheel,which is used to dress the worm *** practical machining is carried out in a CNC machine tool,which was originally used to grind helical ***,a closed-loop manufacturing process including machining,measurement,and modification is proposed to compensate the machining *** proposed method is validated with simulations and practical experiments.

关键词： face gears worm grinding worm dressing geometrical analysis closed-loop manufacturing

Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

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World Journal of Clinical Cases 2024年第2期12卷 249-255页

作者： li-min Wen Ran li Yan-ling Wang qing-Xia Kong min Xia Clinical Medicine College Jining Medical UniversityJining 272067Shandong ProvinceChina School of Basic Medical Sciences Shandong UniversityJinan 250012Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Jining Medical UniversityJining 272007Shandong ProvinceChina

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular ***-term seizures can seriously affect the prognosis and quality of life of ***(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding *** To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform *** From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were *** clinical,imaging,and EEG characteristics were *** stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively *** In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the *** In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

关键词： Post-stroke epilepsy Electroencephalogram Seizure Stroke Slow wave

Joint training with local soft attention and dual cross-neighbor label smoothing for unsupervised person re-identification

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Computational Visual Media 2024年第3期10卷 543-558页

作者： qing Han Longfei li Weidong min Qi Wang qingpeng Zeng Shimiao Cui Jiongjin Chen School of Mathematics and Computer Sciences Nanchang UniversityNanchang 330031China Institute of Metaverse Nanchang UniversityNanchang 330031China Jiangxi Key Laboratory of Smart City Nanchang 330031China

Existing unsupervised person re-identification approaches fail to fully capture thefine-grained features of local regions,which can result in people with similar appearances and different identities being assigned the same label after *** identity-independent information contained in different local regions leads to different levels of local *** address these challenges,joint training with local soft attention and dual cross-neighbor label smoothing(DCLS)is proposed in this ***,the joint training is divided into global and local parts,whereby a soft attention mechanism is proposed for the local branch to accurately capture the subtle differences in local regions,which improves the ability of the re-identification model in identifying a person’s local significant ***,DCLS is designed to progressively mitigate label noise in different local *** DCLS uses global and local similarity metrics to semantically align the global and local regions of the person and further determines the proximity association between local regions through the cross information of neighboring regions,thereby achieving label smoothing of the global and local regions throughout the training *** extensive experiments,the proposed method outperformed existing methods under unsupervised settings on several standard person re-identification datasets.

关键词： person re-identification(Re-ID) unsupervised learning(USL) local soft attention joint training dual cross-neighbor label smoothing(DCLS)

Effects of Adalimumab Entering National Reimbursement on Medical Costs for Patients With Psoriasis:A 4-Year Single-Center Retrospective Study in China

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International Journal of Dermatology and Venereology 2024年第2期7卷 84-88页

作者： Yu li Bo-Kun Zhu qing-Sheng min Mei Ju min li Department of Medical Affairs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Hospital Network Information Center Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Physiotherapy Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Adalimumab(ADA)is expensive and rarely used among ***,its cost for moderate to severe chronic plaque psoriasis can now be reimbursed since its addition to the National Reimbursement Drug list(NRDL)in January ***,we conducted this study to estimate the medical cost of ADA and its influencing factors in patients with psoriasis using ADA and thus gain a better understanding of the effect of the NRDL adjustment in ***:This retrospective study evaluated the medical cost of ADA before and after the addition of ADA to the NRDL(2018—2022)among 320 patients in a large professional dermatology specialty *** analysis,Welch’s analysis of variance,and multiple regression analysis were used to evaluate the medical cost and influencing ***:Before ADA was added to the NRDL,patients’mean total cost and ADA cost were¥24,243.56±16,346.53 and¥20,391.11±14,440.69,*** ADA became covered by the NRDL,the above 2 expenses decreased to¥10,461.19±7,554.66 and¥8,775.27±7,092.16,*** significant decrease in the cost of ADA resulted in a significant 110.5-times increase in ADA *** significant differences were found in the total cost,patient type(outpatient/inpatient),insurance status(yes/no),reimbursement status(before/after),and *** insurance reimbursement(Plity of ADA,and stimulating the need for treatment.

关键词： adalimumab biological agent psoriasis medical cost medical insurance

Construction of daily precipitation series and the observational characteristics of extreme precipitation in Tianjin,China during 1888-2022

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Advances in Climate Change Research 2024年第1期15卷 52-61页

作者： Peng SI qing-Xiang li Xiao-Yang CHEN min WANG Chuan-Jun LUO Tianjin Meteorological Information Center Tianjin Meteorological BureauTianjin 300074China Research Centerfor Ecology and Environment of Central Asia Chinese Academy of SciencesWulumuqi 830011China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 528478China Key Laboratory of Tropical Amosphere-Ocean System Ministry of EducationZhuhai 528478China Shaoguan Meteorological Service Shaoguan 512028China

Given the difficulties in rescuing and ensuring the quality of long-term climate data,current studies on century-scale climate change are usually limited to annual and monthly data,resulting in the poor detection of extreme climate events and their changes before *** this study,we reconstructed a daily precipitation series for Tianjin from 15 September 1887 to 31 December 2022 on the basis of the most comprehensive daily precipitation records collected from the Tianjin Meteorological Archive,China,and in reference to the precipitation analysis results based on the datasets developed by the Climatic Research Unit Time-Series version 4.06,Global Precipitation Climatology Centre and University of Delaware along with the application of various homogenisation methods for climate *** approach provides a complete and reliable century-long daily precipitation series for the study of regional or local extreme weather and climate *** reconstructed daily dataset reveals that the annual precipitation amount and R95 intensity in Tianjin during 1888-2022 lack significant trends and have values of 0.74±6.99 and-1.84±3.22 mm per decade,*** the annual and seasonal scales,the precipitation amount and R95 intensity,particularly those in autumn,have increased since the latter half of the 20th century relative to those in ***,the increase in precipitation amount and R95 intensity is relatively limited compared with that in atmospheric water vapour content due to surface warming,indicating the highly sensitive response of extreme precipitation events to *** addition,the estimates for the return periods of 5,10,20,50 and 100 years covering 1888-2022,1888-1950 and 1951-2022 depict that the intensity of heavy rain and above magnitude was highest in 1888-1950 and decreased in 1951-2022.

关键词： Over a century-long timescale Daily precipitation series Extreme precipitation Return period