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Blockage of the Deep-Sea Mining Pump Transporting Large Particles with Different Sphericity

China Ocean Engineering 2023年第2期37卷 343-352页

作者： TENG Shuang KANG Can li ming-hui QIAO Jin-yu DING Ke-jin School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Zibo Product Quality Testing Research Institute Zibo 255063China Shanghai Marine Equipment Research Institute Shanghai 200031China

The present study aims to plumb blockage of the deep-sea mining pump transporting large particles with different shapes. A numerical work was performed through combining the computational fluid dynamics(CFD) technique and the discrete element method(DEM). Six particle shapes with sphericity ranging from 0.67 to 1.0 were selected. A velocity triangle is built with the absolute, relative, and circumferential velocities of particles. Velocity triangles with absolute velocity angles ranging from 90° to 180° prevail in the first-stage impeller. With declining sphericity, more particles follow the velocity triangle with absolute velocity angles ranging from 0° to 90°, which weakens the ability of particles to pass through the flow passage. Furthermore, the forces acting on the particles traveling in the impeller passage are analyzed. Large particles, especially non-spherical ones, suffer from high centrifugal force and therefore move along the suction surface of the impeller blades. Non-spherical particles undergo great drag force as a result of large surface area. The distribution of drag force angles is featured by two peaks, and one vanishes due to *** particle sphericity declines, both magnitude and angle of the pressure gradient force decrease. Variation of the drag force and the pressure gradient force causes clockwise deflection of the centripetal force, resulting in deflection and elongation of particle trajectory, which increases the possibility of blockage.

关键词： deep-sea mining pump particle sphericity velocity triangle force angle particle trajectory blockage

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Leaching behavior of Pb and Zn in air pollution control residues and their modeling prediction

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Journal of Environmental Sciences 2006年第3期18卷 583-586页

作者： ZHANG Hua HE Pin-jing SHAO li-ming FENG Jun-hui CAO Qun-ke State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 China

Increasing attention has been paid to air pollution control （APC） residues in China recently due to the rising proportion of waste incineration and the hazardous characteristics of the residues, among which heavy metal leaching toxicity plays an important role. Leaching behavior and potential risk of Pb and Zn in the APC residues from a Shanghai municipal solid waste （MSW） incinerator was studied, based on the leaching tests under different conditions and theoretical calculation using a geochemical thermodynamic equilibrium model MINTEQA2. Results showed that, extractant species and liquid to solid （L/S） ratio predominantly controlled the leaching toxicity of Pb and Zn, while ionic strength, vibration method and leaching time had less effect on the metals release. Leachate/final pH determined the metal leaching behavior, which changed the speciation of heavy metals in the extraction system. The equilibrium aqueous speciation, precipitation-dissolution of Pb and Zn was investigated according to the model computation, which was well in agreement with the experimental results.

关键词： leaching behavior air pollution control residues MINTEQA2 incineration plant heavy metals

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Changes in the Cytokine Profiles of Patients with Chronic Hepatitis B during Antiviral Therapy

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Biomedical and Environmental Sciences 2021年第6期34卷 443-453页

作者： li ming hui LU hui hui CHEN Qi Qi liN Yan Jie ZENG Zhan LU Yao ZHANG Lu DONG Jian Ping YI Wei XIE Yao Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Infectious Diseases Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To investigate the changes in the cytokine profiles of chronic hepatitis B(CHB)patients undergoing antiviral *** Hepatitis B e antigen(HBeAg)-positive patients were treated with Pegylated interferon(PEGIFN)and entecavir(ETV).Clinical biochemistry and cytokines were detected at baseline and every 3 *** In all,200 patients completed 48 weeks of treatment,100 in the PEG-IFN group and 100 in the ETV *** 3–6 months of treatment,compared with baseline,the PEG-IFN group showed a significant decrease in interferon-gamma(IFN-γ),interleukin-17 A(IL-17 A),interleukin-6(IL-6),interleukin-10(IL-10),and transforming growth factor beta(TGF-β)(P<0.001)and a significant increase in interferon-alpha 2(IFN-α2)(P<0.001).In the ETV group,IL-10 and TGF-β1 decreased significantly(P<0.001).After 3 months,the levels of IFN-α2,IL-17 A,and tumor necrosis factor-alpha(TNF-α)in the PEGIFN group were significantly higher than those in the ETV group(P<0.01).The levels of IL-6 and TGF-β3 were significantly lower than those in the ETV group(P<0.01).After 6 months,the levels of IFN-α2,IFN-γ,and TNF-αin the PEG-IFN group were significantly higher than those in the ETV group(P<0.01),while the levels of IL-6 and TGF-β3 were significantly lower than those in the ETV group(P<0.01).Compared with ETV,PEG-IFN had higher HBeAg and HBsAg disappearance *** During antiviral therapy,a change in the cytokine profile occurred;in the aspect of immune control and functional cure,PEG-IFN was significantly better than ETV.

关键词： Chronic hepatitis B Cytokine Interferon Nucleoside(nucleotide)analog

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OSTEOCLASTIC RESORPTION OF CANCELLOUS BONE TISSUES OF FEMORAL NECK IN HIP FRACTURE PATIENTS (A SCANNING ELECTRON MICROSCOPIC STUDY)

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中华创伤杂志 1997年第2期 71-76页

作者： CHAI Ben fu, TANG Xue ming, li hui Shanghai Institute of Traumatology and Orthopaedics Shanghai Second Medical University, Shanghai 200025

ＯＳＴＥＯＣＬＡＳＴＩＣＲＥＳＯＲＰＴＩＯＮＯＦＣＡＮＣＥＬＬＯＵＳＢＯＮＥＴＩＳＳＵＥＳＯＦＦＥＭＯＲＡＬＮＥＣＫＩＮＨＩＰＦＲＡＣＴＵＲＥＰＡＴＩＥＮＴＳ（ＡＳＣＡＮＮＩＮＧＥＬＥＣＴＲＯＮＭＩＣＲＯＳＣＯＰＩＣ... 详细信息

ＯＳＴＥＯＣＬＡＳＴＩＣＲＥＳＯＲＰＴＩＯＮＯＦＣＡＮＣＥＬＬＯＵＳＢＯＮＥＴＩＳＳＵＥＳＯＦＦＥＭＯＲＡＬＮＥＣＫＩＮＨＩＰＦＲＡＣＴＵＲＥＰＡＴＩＥＮＴＳ（ＡＳＣＡＮＮＩＮＧＥＬＥＣＴＲＯＮＭＩＣＲＯＳＣＯＰＩＣＳＴＵＤＹ）ＣＨＡＩＢｅｎ－ｆｕ（...

关键词： HIP FRACTURE NECK FEMORAL PATIENTS CANCELLOUS BONE

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Expression patterns of the retinal development-related genes in the fetal and adult retina

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Chinese Medical Journal 2007年第19期120卷 1716-1719页

作者： li hui-ming WANG Feng QIU Wei liU Yan HUANG Qian Central Laboratory Shanghai Jiao Tong University Shanghai 200080 China Department of Ophthalmology First People＇s Hospital Shanghai Jiao Tong University Shanghai 200080 China

Background Retina is important in converting light into neural signals, but little is known about the regulatory genes essential for the retinal morphological formation, development and functional differentiation. This study aimed to investigate the mRNA expression patterns and cellular or subcellular distribution of 33 differentially expressed genes in the retina belonging to the early and middle-late embryogenesis stages as well as the early adult stage during human development. Methods In situ hybridization and real-time fluorescent quantitative reverse transcription polymerase chain reaction （FQ-RT-PCR） were used to assay 33 differentially expressed genes which were screened out using microarray analysis and were not present in the retinal cDNA or the Expressed Sequence Tags （EST） database of the National Eye Institute （NEI） Genebank. Results Nine of the 33 genes belonged to EST or the unknown cDNA fragments, and the remaining belonged to the novel genes in the retina. During the human retinal development 17 genes were down-regulated, 6 were up-regulated and the remaining 10 were relatively unchanged. Most of the genes expressed in all layers of the retina at the gestation stage, and in the fully developed retina some genes examined did show higher expression level in certain specific cells and structures such as retinal ganglion cells or the outer segment of photoreceptor cells. Conclusion The gene expression profile during retinal development possesses temporal and spatial distribution features, which can provide experimental evidence for further research of the functions of those genes.

关键词： retina human development gene expression in situ hybridization gene expression profiling

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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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Fcγ receptor IIIA polymorphisms and efficacy of rituximab therapy on Chinese diffuse large B-cell lymphoma

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Chinese Medical Journal 2010年第2期123卷 198-202页

作者： ZHANG Wei WANG Xuan li Jian DUAN ming-hui ZHOU Dao-bin Department of Hematology Peking Union Medical College Hospital Beijing 100730 China

Background Rituximab is used extensively in combination with chemotherapy to cure non-Hodgkin＇s lymphoma （NHL）, and not only accelerates short-term improvement, but also prolongs patient survival and decreases relapse. The aim of this study was to evaluate the impact of Fcγ receptor IliA （FcyRIIIA） gene polymorphisms on the response to rituximab therapy for newly diagnosed B-cell lymphomas. Methods Patients with newly diagnosed histologically-proven CD20-positive B-cell lymphoma were eligible for the study. All of the patients received rituximab combined with chemotherapy （CHOP）. The FcyRIIIA type was analyzed by PCR. The initial efficacy was assessed after 6 cycles and the long-term survival was determined. Results Thirty-four patients were recruited between October 2005 and April 2006. The FcyRIIIA distribution was as follows： 11 patients were VV, 5 were FF, and 18 were VE After a median of 6 cycles （range 4-8） of rituximab combined chemotherapy, the overall response rate was 79% （82% in the VV group, 83% in the VF group, and 60% in the FF group; P=0.04）. After a median follow-up time of 37 months （range 34-41）, there were 12 relapses among 27 responders （44%）; 5 of 9 patients （5/9） in the VV group, 5 of 15 patients （33%） in the VF group, and 2 of 3 patients （2/3） in the FF group （P=0.21）. The 1-year overall survival in the VV, FF, and VF groups was 80%, 60%, and 80%, respectively, and the 3-year overall survival was 58%, 40%, and 69%, respectively （P=0.08）. After analysis by COX regression, only the international prognosis index and response to initial treatment were significantly related to overall survival. Conclusions The distribution of FcyRIIIA polymorphisms in this B-cell lymphoma population shows that VF is most frequently expressed, followed by VV and FE Patients with the FcyRIIIA VV and VF types are more sensitive to the initial treatment of rituximab combined with chemotherapy and have superior long-term survival compared with those with FF. Nevertheles

关键词： B-cell lymphoma rituximab Fcγ receptor IliA prognosis

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Effects of pre-pregnancy body mass index on pregnancy outcomes

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Chinese Medical Journal 2013年第23期126卷 4585-4587页

作者： li Chun-ming li Guang-hui CHEN Yi RUAN Yan WANG Xin ZHANG Wei-yuan Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Prevalence of overweight and obesity has continued to increase among women of child bearing age all over the world in recent decades. Its impact on short-term and long-term maternal and fetal outcomes continued to grow, such as increased risk of gestational diabetes mellitus, gestational hypertension, preeclampsia, fetal macrosomia, perinatal mortality and chance for cesarean deliveries） What＇s more, underweight before pregnancy also has some hazardous effects on pregnant women and fetus, such as increased risk of delivering infants small for gestational age and preterm delivery.2 The present study determined the prevalence of each body mass index （BMI） group of an obstetric population of the mainland of China, and effects of the maternal pre-pregnancy BMI on multiple antepartum, intrapartum and neonatal outcomes.

关键词： body mass index obesity gestational diabetes mellitus preeclampsia fetal macrosomia

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Cytokine Profiles and Virological Marker Monitoring during 48 Weeks Peginterferon Alfa Treatment for HBeAg-Positive Chronic Hepatitis B

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Biomedical and Environmental Sciences 2022年第4期35卷 312-321页

作者： li ming hui SUN Fang Fang CHEN Feng Xin ZENG Zhan liN Yan Jie BI Xiao Yue YANG liu DENG Wen JIANG Ting Ting HUANG Rong Hai YI Wei XIE Yao Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Capital Medical University Beijing 100069China Department of Infectious Diseases Capital Medical UniversityBeijing 100015China Department of General Surgery Capital Medical UniversityBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective This study aimed to investigate whether cytokine profiles and virological markers might add value in monitoring the effects of peginterferon(PEG-IFN)therapy for hepatitis B e-antigen(HBeAg)positive chronic hepatitis B(CHB).Methods HBeAg positive patients with CHB were treated with PEG-IFN for 48 *** biochemical,and HBV serological indexes,as well as cytokines,were detected at baseline and every12 *** A total of 116 patients with CHB were enrolled in this study;100 patients completed the 48-week treatment and follow-up,of whom 38 achieved serum HBeAg disappearance,25 achieved HBeAg seroconversion,37 showed HBsAg decreases≥1 log10 IU/mL,9 showed HBsAg disappearance,and 8became HBsAb *** cytokine levels at baseline and during treatment were similar between the HBeAg disappearance group and non-disappearance *** disappearance of HBeAg was independently associated with HBeAg levels at weeks 12 and 24,and with the HBeAg decline at week 24(Pline,HBeAg,the HBeAg decline at week 12,and HBsAg at week 24(P<0.05).Conclusion There was no significant correlation between the response to interferon(IFN)and cytokines during PEG-IFN *** changes in virological markers predicted the response to IFN after 48 weeks.

关键词： Chronic hepatitis B Cytokine Peginterferon HBsAg HBeAg

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BP Neural Network Based On Genetic Algorithm Applied In Text Classification

BP Neural Network Based On Genetic Algorithm Applied In Text...

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2011 International Conference on Information Management and Engineering(ICIME 2011)

作者： SUN Ai-xiang li ming-hui Management institute Shandong University of Technology

ISBN: (纸本)9781612842387

The The BP neural network is one of the most commonly used methods in the field of text classification. BP learning algorithm gained success to some degree, but there are still some drawbacks: the error decreasing slowly, adjusting for a long time, more iterations lead to slow convergence, and training often fall into a local minimum and can not converge to a given *** order to overcome the shortcomings of the BP neural network, this paper constructed an excellent BP neural network combined with genetic *** the learning process, the weights are described as chromosomes, then compute the fitness of the chromosomes, and then go on the genetic iteration until the convergence. And in this paper, this algorithm is applied to text *** experimental results show that: with the measurement of The BP neural network is one of the most commonly used methods in the field of text classification. BP learning algorithm gained success to some degree, but there are still some drawbacks: the error decreasing slowly, adjusting for a long time, more iterations lead to slow convergence, and training often fall into a local minimum and can not converge to a given *** order to overcome the shortcomings of the BP neural network, this paper constructed an excellent BP neural network combined with genetic *** the learning process, the weights are described as chromosomes, then compute the fitness of the chromosomes, and then go on the genetic iteration until the convergence. And in this paper, this algorithm is applied to text *** experimental results show that: with the measurement of F1-measure the accuracy of the text classification has been greatly improved.

关键词： text classification bp genetic algorithm f1-measure

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