检索结果-南通市图书馆

Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： Shi li Didi Sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

猪戊型肝炎病毒ORF3蛋白影响HepG2细胞核黄素代谢的lncRNA-mRNA调控网络的鉴定

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国畜牧兽医 2021年第12期48卷 4618-4627页

作者：焦寒伟周志雄李梦娟肖玉李博文郭晓奕曾慧顾国婧帅学宏西南大学动物医学院重庆402460 西南大学医学研究院免疫学研究中心重庆402460 兽医科学工程研究中心重庆402460

为初步鉴定并挖掘出猪戊型肝炎病毒(Hepatitis E virus,HEV)ORF3蛋白影响HepG2细胞核黄素代谢信号通路的lncRNA-mRNA调控网络,本试验通过构建腺病毒过表达载体,制备高滴度过表达腺病毒,介导猪HEV-ORF3在HepG2细胞中实现过表达。Western ... 详细信息

为初步鉴定并挖掘出猪戊型肝炎病毒(Hepatitis E virus,HEV)ORF3蛋白影响HepG2细胞核黄素代谢信号通路的lncRNA-mRNA调控网络,本试验通过构建腺病毒过表达载体,制备高滴度过表达腺病毒,介导猪HEV-ORF3在HepG2细胞中实现过表达。Western blotting检测ORF3蛋白过表达成功后,运用lncRNA高通量组学测序,筛选出差异表达的lncRNA并进行靶向差异基因预测,对lncRNA靶向差异基因进行GO功能和KEGG通路富集分析,初步鉴定出与核黄素代谢信号通路相关的lncRNA-mRNA调控网络。Western blotting结果显示,在约为12 ku处出现目的条带,说明成功实现腺病毒介导猪HEV-ORF3在HepG2细胞中过表达。lncRNA高通量组学测序结果显示,共发现102个显著差异表达lncRNAs表达量上调,80个显著差异表达lncRNAs表达量下调。GO功能和KEGG通路富集分析显示,初步挖掘出lncRNA(MSTRG.13995.2)和lncRNA(MSTRG.1960.1)可能是与核黄素代谢信号通路相关的显著差异表达lncRNA,分别通过顺式调控其靶向基因APC-5和FLAD1来影响核黄素代谢信号通路。本试验初步鉴定出lncRNA(MSTRG.13995.2)-APC5和lncRNA(MSTRG.1960.1)-FLAD1可能是影响HepG2细胞核黄素代谢信号通路的lncRNA-mRNA调控网络。

关键词：猪戊型肝炎病毒(HEV) ORF3蛋白 HepG2细胞核黄素代谢 lncRNA-mRNA调控网络

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

云南8个辣椒品种品质性状分析

辣椒杂志 2023年第2期21卷 13-20,26页

作者：吴睿陈丹李孟娟杨雁邓明华云南农业大学园林园艺学院/云南省高校蔬菜种业工程研究中心昆明650000

以8个辣椒品种为试验材料,对果实色价参数(a^(*)、b^(*)、L^(*)、C、H)、品质指标(可溶性糖、可溶性固形物、总蛋白质、辣椒素、降二氢辣椒素、二氢辣椒素、Vc等)以及果形特征(单果质量、果纵径、果横径等)进行测量,通过方差分析、聚类... 详细信息

以8个辣椒品种为试验材料,对果实色价参数(a^(*)、b^(*)、L^(*)、C、H)、品质指标(可溶性糖、可溶性固形物、总蛋白质、辣椒素、降二氢辣椒素、二氢辣椒素、Vc等)以及果形特征(单果质量、果纵径、果横径等)进行测量,通过方差分析、聚类分析和主成分分析等方法进行分析,旨在为筛选云南适宜栽培辣椒品种提供参考。结果表明:(1)基于聚类分析结果,依照谱系图在欧氏距离D=4.5处,将这8个辣椒品种分为5类。(2)可溶性固形物、辣椒素和Vc含量品种间差异显著,分布范围分别为9.13~33.1 mg/g、128.9~2364μg/g、9.29~386μg/g;其他指标的变异系数均在9%以上;表明这8个品种在遗传上差异较大。(3)在主成分分析中,4个主成分因子代表了辣椒的绝大部分信息。通过评分函数F,发现‘椒中玉’和‘辣多多’品种的综合评分最高,有3个品种的综合评分达不到平均水平但某项指标突出。综上所述,8个品种的遗传差异较大,‘椒中玉’和‘辣多多’营养价值较高。

关键词：营养性状果形指数色价聚类分析主成分分析

维普期刊数据库博看期刊

Impact of Bubbles on Mechanical Performances in a Borosilicate Glass

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 25-29页

作者： li Chengxing li Dongfeng MA Shilong QIAO Ang ZHENG Qingshuang China Helicopter Research and Development Institute Jingdezhen 333001China State Key Laboratory of Silicate Materials for Ar-chitectures Wuhan University of TechnologyWuhan 430070China

To analyze the impact of bubbles on the mechanical behavior of glasses,by controlling the refining time,we prepared three borosilicate glasses with the same composition and different *** the analysis software integrated within the optical microscope,the diameter and number of the bubbles on the surface of three borosilicate glasses were *** the hardness and crack initiation resistance(CR),we built the relationship between the porosity and the mechanical performance of these borosilicate glasses.

关键词： bubbles oxide glass hardness creak initiation resistance

低剂量地西他滨皮下注射联合砷剂治疗中高危骨髓增生异常综合征效果及安全性观察

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

白血病．淋巴瘤 2019年第7期28卷 396-400页

作者：米瑞华陈琳陈玲尹青松袁芳芳李梦娟魏旭东郑州大学附属肿瘤医院血液科 450008 河南省平顶山市新华区医院血液科 467000

目的探讨低剂量地西他滨皮下注射联合砷剂治疗中高危骨髓增生异常综合征(MDS)患者的临床效果及安全性.方法回顾性分析2015年1月至2018年8月在郑州大学附属肿瘤医院、平顶山市新华区医院住院的未能行异基因造血干细胞移植术的8例中高危MD... 详细信息

目的探讨低剂量地西他滨皮下注射联合砷剂治疗中高危骨髓增生异常综合征(MDS)患者的临床效果及安全性.方法回顾性分析2015年1月至2018年8月在郑州大学附属肿瘤医院、平顶山市新华区医院住院的未能行异基因造血干细胞移植术的8例中高危MDS患者,给予低剂量地西他滨皮下注射联合砷剂治疗:地西他滨0.1~0.2mg/kg,皮下注射,2次/周,共4周;亚砷酸注射液10mg/次或0.16mg/kg,静脉给药,1次/d,共4周;复方黄黛片每天60mg/kg,分3次口服.观察疗效及不良反应.结果8例患者中男性5例,女性3例,平均年龄61.4岁,年龄范围44~80岁;难治性贫血伴原始细胞增多1(RAEB﹣1)患者1例,RAEB﹣2患者6例,难治性血细胞减少伴多系发育异常(RCMD)伴骨髓纤维化(MF)患者1例.其中3例患者既往曾接受过含地西他滨方案治疗,所有患者均顺利完成治疗,未发生治疗相关死亡.至随访结束,2例完全缓解,4例骨髓完全缓解伴血液学改善,1例疾病稳定,1例疾病进展;2例既往经含地西他滨方案治疗的患者再次给予地西他滨联合砷剂的方案治疗仍然有效.8例患者均出现2级以上骨髓抑制,除1例患者因不洁饮食出现肠道感染及1例患者出现轻度肺部感染外,其余6例患者无相关感染及心、肝、肾等不良反应的发生.结论低剂量地西他滨皮下注射联合砷剂治疗中高危MDS是安全的,可能成为中高危MDS患者的一种新治疗手段.

关键词：骨髓增生异常综合征地西他滨注射,皮下亚砷酸治疗结果不良反应

艾曲泊帕、重组人血小板生成素联合标准免疫抑制治疗重型再生障碍性贫血16例疗效及安全性分析

在线全文

学校读者我要写书评

暂无评论

中华血液学杂志 2021年第12期42卷 1021-1024页

作者：袁芳芳张青兰张丽娜熊媛媛李梦娟周虎魏旭东刘新建宋永平郑州大学附属肿瘤医院河南省肿瘤医院河南省血液病研究所450008

目的评价艾曲泊帕、重组人血小板生成素(Recombinant human thrombopoietin,rhTPO)联合标准免疫抑制治疗(Immunosuppressive therapy,IST)对重型再生障碍性贫血(Severe aplastic anemia,SAA)的疗效及安全性。方法回顾性分析2017年1月1日至2020年6月30日河南省肿瘤医院16例接受IST联合艾曲泊帕、rhTPO治疗的SAA患者,评价其疗效及安全性。结果艾曲泊帕、rhTPO联合标准IST治疗后3个月血液学反应率为81.3%,完全血液学缓解率为37.5%,6个月血液学反应率为87.5%,完全血液学缓解率为50.0%,脱离血小板输注中位时间为35(16~78)d,脱离红细胞输注中位时间为47.5(15~105)d,血小板输注中位量为5.5(3~20)U,红细胞输注中位量为6.5(2~16)U。结论艾曲泊帕联合rhTPO可提高SAA的IST血液学反应率,改善血液学缓解质量,且不良反应轻微。

关键词：贫血,再生障碍性艾曲泊帕重组人促血小板生成素免疫抑制治疗

辣椒雄性不育系线粒体基因CaORF240和CaORF301的生物信息学与表达差异分析

在线全文

学校读者我要写书评

暂无评论

辣椒杂志 2023年第3期21卷 10-19页

作者：李孟娟王姣吴睿程宏邓明华云南农业大学园林园艺学院云南省高校蔬菜种业工程研究中心昆明650000

为深入了解辣椒细胞质雄性不育与线粒体编码基因表达之间的关系,本研究以辣椒细胞质雄性不育系9704A和同型保持系9704B为试验材料,克隆了2个线粒体编码基因CaORF240和CaORF301,利用实时荧光定量PCR技术分析了这2个基因在保持系9704B不... 详细信息

为深入了解辣椒细胞质雄性不育与线粒体编码基因表达之间的关系,本研究以辣椒细胞质雄性不育系9704A和同型保持系9704B为试验材料,克隆了2个线粒体编码基因CaORF240和CaORF301,利用实时荧光定量PCR技术分析了这2个基因在保持系9704B不同组织间的表达量,以及在同型保持系9704B和细胞质雄性不育系9704A花蕾四个不同发育时期的表达差异。结果发现,CaORF240基因编码序列长度为723 bp,编码240个氨基酸,CaORF301基因编码序列长度为906 bp,编码301个氨基酸,两个基因在不育系9704A和保持系9704B中的扩增序列一致。CaORF240和CaORF301基因在保持系9704B各组织中的表达量存在差异。CaORF240和CaORF301基因在不育系与保持系花蕾不同发育阶段中的表达量存在明显差异。结果表明,CaORF240和CaORF301在9704A和9704B中存在时空表达差异,可能造成能量代谢紊乱,影响小孢子发育,从而导致辣椒雄性不育。

关键词：辣椒雄性不育线粒体基因 CaORF240 CaORF301 生物信息分析

Targets capture by distributed active swarms via bio-inspired reinforcement learning

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu Yue li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

Quantum public-key crypto via EPR pairs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs