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Gastric metastasis of small cell lung carcinoma:Three case reports and review of literature

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World Journal of Gastroenterology 2024年第31期30卷 3717-3725页

作者： Shan Yang Qing-Yun He Qing-Jing Zhao Han-Tao Yang Zheng-Yi Yang Wen-Yi Che Hua-mei li Hui-Chao Wu Department of Gastroenterology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of The First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Zhejiang Provincial People's Hospital Bijie HospitalBijie 551700Guizhou ProvinceChina Department of Gastroenterology Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Small cell lung carcinoma(SCLC)is highly susceptible to metastasis in the early stages of the ***,the stomach is an uncommon site of metastasis in SCLC,and only a few cases of this type of metastasis have been ***,SCLC gastric metastases have not been systematically characterized and are easily missed and *** SUMMARY We report three cases of gastric metastasis from SCLC in this *** first patient presented primarily with cough,hemoptysis,and epigastric *** other two patients presented primarily with abdominal discomfort,epigastric distension,and *** patients underwent gastroscopy and imaging ***,the immunohistochemical results of the lesions in three patients were suggestive of small cell ***,the three patients were diagnosed with gastric metastasis of SCLC through a comprehensive *** three patients did not receive appropriate treatment and died within a short *** Here,we focused on summarizing the characteristics of gastric metastasis of SCLC to enhance clinicians'understanding of this disease.

关键词： Small cell lung cancer Gastric neoplasms Neoplasm metastasis Diagnosis Case report

Effect of exogenous free N^(ε)-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction:neuroinflammation,and metabolic disorders

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Food Science and Human Wellness 2024年第5期13卷 2970-2981页

作者： Huang Zhang Lan Mo Xi Chen mei li Maiquan li Yang Xu Maomao Zeng Zhiyong He Qingwu Shen Jie Chen Wei Quan College of Food Science and Technology Hunan Agricultural UniversityChangsha 410128China Henan University of Animal Husbandry and Economy Zhengzhou 450046China College of Food Science and Engineering Northwest A&F UniversityYangling 712100China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

Diabetes-associated cognitive dysfunction has already been attracted considerable *** glycation end products(AGEs)from daily diets are thought to be a vital contributor to the development of this ***,the effect of one of the best-characterized exogenous AGEs N^(ε)-(carboxymethyl)lysine(CML)on cognitive function is not fully *** the present study,diabetical Goto-Kakizaki(GK)rats were treated with free CML for *** was found that oral consumption of exogenous CML significantly aggravated diabetes-associated cognitive dysfunction in behavioral *** details,exogenous CML increased levels of oxidative stress,promoted the activation of glial cells in the brain,up-regulated the release of inflammatory cytokines interleukin-6,inhibited the protein expression of the brain-derived neurotrophic factor and thus led to ***,exogenous CML promoted the amyloidogenesis in the brain of GK rats,and inhibited the expression of ***,several tricarboxylic acid cycle and glutamate-glutamine/γ-aminobutyric acid cycle intermediates including pyruvate,succinic acid,glutamine,glutamate were significantly changed in brain of GK rats treated with exogenous free *** conclusion,exogenous free CML is a potentially noxious compounds led to aggravated diabetes-associated cognitive dysfunction which could be possibly explained by its effects on neuroinflammation,energy and neurotransmitter amino acid homeostasis.

关键词： Diabetes Cognitive dysfunction N^(ε)-(carboxymethyl)lysine Neuroinflammation Metabolomic

Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： Xiao-li mei Shu-Yi Wu Si-Lan Wu Xiao-lin Luo Si-Xing Huang Rui liu Zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified Xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

靶向Nrf2-铁死亡通路与缺血性脑卒中后脑损伤治疗研究进展

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中国临床药理学与治疗学 2024年第2期29卷 188-197页

作者：李梅李强赤峰学院附属医院神经内科内蒙古赤峰024000

铁死亡在缺血性脑卒中后脑损伤的病理生理过程中起着至关重要的作用。通过激活核因子-红细胞系2相关因子2(Nrf2)在转录上控制铁死亡途径的许多关键成分进而抑制铁死亡,将其作为缺血性脑卒中后脑损伤的治疗靶点。本文简要描述了铁死亡过... 详细信息

铁死亡在缺血性脑卒中后脑损伤的病理生理过程中起着至关重要的作用。通过激活核因子-红细胞系2相关因子2(Nrf2)在转录上控制铁死亡途径的许多关键成分进而抑制铁死亡,将其作为缺血性脑卒中后脑损伤的治疗靶点。本文简要描述了铁死亡过程及其在缺血性脑卒中后脑损伤中的作用。同时对Nrf2与铁死亡之间的关系进行重要的概述,重点综述药物靶向激活Nrf2通路抑制铁死亡对缺血性脑卒中后脑损伤的治疗作用。

关键词：铁死亡 Nrf2 缺血性脑卒中缺血性脑卒中后脑损伤

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong liANG Qi mei li-yan liANG You-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

Research Progress on Combined Chinese and Western Medicine Treatment of Mycoplasma pneumoniae Pneumonia in Children

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Journal of Clinical and Nursing Research 2024年第6期8卷 117-122页

作者： Wenping Yang Le Wang Sha Wang Nannan Ma li mei Shaanxi Provincial People's Hospital Children's Hospital Xi'an 710000Shaanxi ProvinceChina

With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research *** a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and *** article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in *** article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in *** article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.

关键词： Children Mycoplasma pneumoniae pneumonia Combined Chinese and Western medicine Research progress

司各特历史小说在近代中国的经典化与意识形态形塑

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河北学刊 2024年第1期44卷 134-140页

作者：栾丽梅中央民族大学河北工业职业技术大学

晚清到民国,司各特历史小说在中国的经典化历程与意识形态的变迁密切相关,二者在特定的多元文化背景下相得益彰。司各特历史小说在中国的传播既是近代文学通往现代文学的一座“桥梁”,也是社会进步的“催化剂”。但意识形态的差异成为... 详细信息

晚清到民国,司各特历史小说在中国的经典化历程与意识形态的变迁密切相关,二者在特定的多元文化背景下相得益彰。司各特历史小说在中国的传播既是近代文学通往现代文学的一座“桥梁”,也是社会进步的“催化剂”。但意识形态的差异成为横亘在中西文化之间的“藩篱”,对司各特所描绘的共同体文化记忆形成了遮蔽和重构。司各特历史小说的汉译若要保持活力,急需积极调整翻译策略,突破意识形态的藩篱,再现文化记忆。目前,迫切需要在建立文化认同与文化自信的基础上求同存异、文明互鉴,因此探讨司各特历史小说在中国的经典化历程对于当今时代具有借鉴和启发意义。

关键词：司各特历史小说意识形态文明互鉴

可溶性CD40配体通过长链非编码RNA linc00239对THP-1细胞生物学行为的影响

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吉林大学学报（医学版） 2024年第1期50卷 88-96页

作者：封忠昕李梅贵州医科大学附属医院血液科贵州贵阳550004

目的:探讨CD40配体(CD40L)通过长链非编码RNA(lncRNA)linc00239对人单核细胞白血病THP-1细胞生物学行为的影响,阐明其可能的作用机制。方法:构建linc00239过表达载体(pcDNA-linc00239)和干扰载体(sh-linc00239),转染至THP-1细胞,采用实时荧光定量PCR(RT-qPCR)法检测转染效率。THP-1细胞分为对照组、空载体(vector)组、pcDNA-linc00239组、sh-linc00239组、vector+CD40L组、pcDNA-linc00239+CD40L组和sh-linc00239+CD40L组。RT-qPCR法检测各组细胞中linc00239表达水平,CCK-8法检测各组细胞增殖活性,流式细胞术检测各组不同细胞周期细胞百分率和细胞凋亡率,RT-qPCR法和Western blotting法检测各组细胞中B细胞淋巴瘤2(Bcl-2)和Bcl-2关联X蛋白(Bax)mRNA和蛋白表达水平,Western blotting法检测各组细胞中蛋白激酶B(AKT)和磷酸化AKT(p-AKT)蛋白表达水平并计算p-AKT/AKT比值。结果:与vector组比较,pcDNA-linc00239组细胞增殖活性和G_(2)期细胞百分率明显升高(Plinc00239、Bcl-2 mRNA及蛋白表达水平和p-AKT/AKT比值明显升高(Plinc00239组和vector+CD40L组细胞增殖活性和G_(2)期细胞百分率明显降低(Plinc00239、Bcl-2 mRNA和蛋白表达水平及p-AKT/AKT比值明显降低(Plinc00239组比较,pcDNA-linc00239+CD40L组细胞增殖活性和G_(2)期细胞百分率明显降低(Plinc00239、Bcl-2 mRNA和蛋白表达水平及p-AKT/AKT比值明显降低(Plinc00239组比较,sh-linc00239+CD40L组细胞增殖活性和G_(2)期细胞百分率明显降低(Plinc00239、Bcl-2 mRNA和蛋白表达水平及p-AKT/AKT比值明显降低(Plinc00239抑制THP-1细胞增殖和细胞周期进展,并诱导细胞凋亡。

关键词： CD40配体长链非编码RNA linc00239 急性髓系白血病细胞周期细胞凋亡

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Research Progress in Integrated Chinese and Western Medicine Health Management for School-Age Children with Asthma

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Journal of Clinical and Nursing Research 2024年第7期8卷 85-90页

作者： Hanlu Zhang Le Wang Sha Wang Nannan Ma li mei Shaanxi Provincial People’s Hospital Children’s Hospital Xi’an 710000Shaanxi ProvinceChina

Objective:The purpose of this study is to investigate the application of Chinese and Western medicine in the health management of school-age children with asthma and its research progress,with a view to providing a more comprehensive and effective management strategy for the ***:Using the method of literature review,this study systematically searched and analyzed the relevant studies on the combination of Chinese and Western medicine in the health management of school-aged children with asthma in recent years,focusing on Chinese medicine treatment,Western medicine treatment,and the combined health management of Chinese and Western ***:Chinese medicine treatment,Western medicine treatment,and the health management mode of combining Chinese and Western medicine showed unique advantages in school-age asthmatic *** the comprehensive use of Chinese medicine’s diagnosis and treatment,Chinese medicine conditioning,Chinese medicine characteristic therapy,and Western medicine’s modern medical methods,it not only effectively relieved asthma symptoms but also significantly improved the quality of life of the *** the same time,this management mode also focuses on the psychological guidance and family care of the children,forming an all-round and multi-level health management ***:The health management strategy of combining Chinese and Western medicine has a broad application prospect in school-age asthmatic children,and its specific interventions and mechanisms of action should be further studied to provide more scientific and systematic guidance for clinical practice.

关键词： School-age children with asthma Chinese medicine treatment Western medicine treatment Health management