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A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy

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Rare Metals 2023年第5期42卷 1483-1493页

作者： Zi-Yao Wang Jie mei Dong-Qi Ni Sheng-mei li Jin-Min Ye Shi-lin li Ya-ling Wang Ying liu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing100190China University of Chinese Academy of Sciences Beijing100049China GBA National Institute for Nanotechnology Innovation Guangzhou510700China

The high incidence and mortality of lung cancer have present threaten in front of people all over the *** in clinical trials find that mutations of some genes influence progress of lung cancer directly or indirectly,therefore,some kinds of molecular inhibitors benefit patients in clinical therapy,which helpfully prolong survival time of patients and show great potential in lung cancer *** is a kind of nucleic acid molecules which can silence targeted gene translation through binding to mRNA completely to cure *** delivery of siRNA for cancer therapy mostly can be classified into loading through electrostatic interaction,physical surrounding,and chemically *** delivering siRNA by coordination has not been *** study unprecedently utilizes the coordination between siRNA and Fe^(2+)to form a self-assembly structure in which doxorobicin(DOX) and human serum albumin(HSA) were used to stabilize the whole nanoplatform followed polyethylenimine(PEI) *** the heat incubation strategy,highly loading efficiency for siRNA and DOX was *** nanoplatform with stability and sustain release of drugs exhibited good lysosome escape,gene silencing effect and cytotoxicity which provided new horizon for co-deli very of siRNA and other molecular or protein drugs.

关键词： Lung cancer siRNA Coordination Nanoparticles Drug delivery

Fabrication and characterization of anodic oxide films on a Ti-10V-2Fe-3Al titanium alloy

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 96-100页

作者： Jian-hua liu Jun-lan Yi Song-mei li mei Yu Yong-zhen Xu School of Materials Science and Engineering Beihang University Beijing 100191 China

Anodic oxide films of the titanium alloy Ti-10V-2Fe-3Al in ammonium tartrate electrolyte without hydrofluoric acid or fluoride were fabricated. The morphology, components, and microstructure of the films were characterized by scanning electron microscopy （SEM）, X-ray photoelectron spectroscopy （XPS）, X-ray diffraction （XRD）, and Raman spectroscopy. The results showed that the films were thick, uniform, and nontransparent. Such films exhibited sedimentary morphology, with a thickness of about 3 μm, and the pore diameters of the deposits ranged from several hundred nanometers to 1.5 μm. The films were mainly titanium dioxide. Some coke-like deposits, which may contain or be changed by OH, NH, C-C, C-O, and C=O groups, were doped in the films. The films were mainly amorphous with a small amount of anatase and rutile phase.

关键词： titanium alloys anodic oxide films titanium dioxide pulse current method

Absorption interferometer of two-sided cavity

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Chinese Physics B 2021年第5期30卷 373-377页

作者： Miao-Di Guo Hong-mei li School of Sciences Xi'an Technological UniversityXi'an 710021China College of Electronic Science and Engineering Jilin UniversityChangchun 130012China

We propose a scheme in which an arbitrary incidence can be made perfectly reflected/transmitted with a phase *** analyze the variation of intracavity field as well as output field with closed-loop phaseφ_(1) of the control fields and relative phaseφ_(2)of the probe *** two phases,medium absorption and light interference can be controlled so that photon escape from the cavity can be manipulated,thus an intensity switching based on phase modulation can be *** the condition for perfect transmitter or reflector is *** based on the transmission/reflection analysis,the total absorption of this system can be *** our scheme can be used as an absorption interferometer to explore the optical absorption in some complicated *** state delay of the output light intensity,which is dependent onφ1 orφ2,can be applied in the realization of quantum phase gate and subtle wave *** based on this scheme,we implement the state transfer between perfect transmitter/reflector and non-perfect coherent photon absorber via relative-phase modulation.

关键词： cavity quantum electrodynamics(QED) optical switching quantum interference

Experimental study on the size effect on the equation of state of concretes under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 160-167页

作者： mei li Jian Cui Yanchao Shi Baijian Tang Xin Chen Key Laboratory of Coast Civil Structural Safety of the Ministry of Education Tianjin UniversityTianjin 300072China School of Civil Engineering Suzhou University of Science and Technology1701 Binhe RoadSuzhou 215011JiangsuChina School of Civil Engineering Tianjin UniversityTianjin 300072China

Adopting the classical theory of hydrocodes,the constitutive relations of concretes are separated into an equation of state(EoS)which describes the volumetric behavior of concrete material and a strength model which depicts the shear properties of *** experiments on the EoS of concrete is always challenging due to the technical difficulties and equipment limitations,especially for the specimen size effect on the *** some researchers investigate the shock properties of concretes by fly-plate impact tests,the specimens used in their tests are usually in one *** this paper,the fly-plate impact tests on concrete specimens with different sizes are performed to investigate the size effect on the shock properties of concrete *** mechanical background of the size effect on the shock properties are revealed,which is related to the lateral rarefaction effect and the deviatoric stress produced in the *** to the tests results,the modified EoS considering the size effect on the shock properties of concrete are proposed,which the bulk modulus of concrete is unpredicted by up to 20% if size effects are not accounted for.

关键词： Concrete Equation of state Size effect Shock wave Fly-plate impact test

lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups

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Biomedical and Environmental Sciences 2009年第5期22卷 423-429页

作者： Yu-mei ZHANG XUE-ZHONG liU HAO LU li mei ZONG-PING liU College of Veterinary Medicine Yangzhou University Yangzhou 225009 Jiangsu China College of Veterinary Medicine Northwest Sci-Tech University of Agriculture and Forestry Yangling 712100 Shaanxi China

Objective To assess lipid peroxidation and ultrastructural modifications in rat brains following perinatal exposure to lead （Pb） and/or cadmium （Cd）. Methods Female rats were divided into four groups： control group, Pb （300 mg/L） group, Cd group （10 mg/L） and Pb＋Cd （300 mg/L, 10 mg/L） group. The compounds were delivered in the drinking water throughout pregnancy and lactation. Results The levels of compounds in blood and brain of the Pb＋Cd group were similar to those of other groups, but the effects of Pb＋Cd on pups＇ body and brain weights were higher than on other compounds. Electron microscopy revealed that Pb and Cd had effects on mitochondrial swelling, disruption and cristae loss, Nissl body dissolution, degenerated organelles and vacuoles, cytomembrane disappearance, and nuclear chromoplasm concentration. The activity of glutathione peroxidase （GSH-Px）, superoxide dismutase （SOD）, catalase （CAT）, acetylcholinesterase （ACHE） was decreased, whereas the activity of maleic dialdehyde （MDA） was increased. Conclusion Perinatal exposure to low doses of Pb and Cd can produce alterations in lipid peroxidation and ultrastructural modifications in rat brains, and exposure to both metals can result in greater damages.

关键词： Lead Cadmium lipid peroxidation Ultrastructure Brain Rat

Cobalt and manganese stress in the microalga Pavlova viridis (Prymnesiophyceae):Effects on lipid peroxidation and antioxidant enzymes

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Journal of Environmental Sciences 2007年第11期19卷 1330-1335页

作者： li mei ZHU Qin HU Chang-wei CHEN li liU Zhi-li KONG Zhi-ming National Key Laboratory of Pollution Control and Resource Reuse of China School of the Environment Nanjing University Nanjing 210093 China School of life Science Nanjing University Nanjing 210093 China

Pollution of marine environment has become an issue of major concern in recent years. Serious environmental pollution by heavy metals results from their increasing utilization in industrial processes and because most heavy metals are transported into the marine environment and accumulated without decomposition. The aim of the present study is to investigate the effects on growth, pigments, lipid peroxidation, and some antioxidant enzyme activities of marine microalga Pavlova viridis, in response to elevated concentrations of cobalt （Co） and manganese （Mn）, especially with regard to the involvement of antioxidative defences against heavy metal-induced oxidative stress. In response to Co^2＋, lipid peroxidation was enhanced compared to the control, as an indication of the oxidative damage caused by metal concentration assayed in the microalgal cells but not Mn^2＋. Exposure of Pavlova viridis to the two metals caused changes in enzyme activities in a different manner, depending on the metal assayed： after Co^2＋ treatments, total superoxide dismutase （SOD） activity was irregular, although it was not significantly affected by Mn^2＋ exposure. Co^2＋ and Mn^2＋ stimulated the activities of catalase （CAT） and glutathione （GSH）, whereas, glutathione peroxidase （GPX） showed a remarkable increase in activity in response to Co^2＋ treatments and decreased gradually with Mn^2＋ concentration, up to 50 μmol/L, and then rose very rapidly, reaching to about 38.98% at 200 μmol/L Mn^2＋. These results suggest that an activation of some antioxidant enzymes was enhanced, to counteract the oxidative stress induced by the two metals at higher concentration.

关键词： antioxidant enzymes cobalt manganese malondialdehyde (MDA) Pavlova viridis

Enhanced Ultraviolet Resistance of Polypropylene Random Copolymer Filled by ZnO-supported Mesoporous Zeolite

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Chinese Journal of Polymer Science 2015年第7期33卷 976-987页

作者： mei li Gu li Zi-shou Zhang Xin Dai Yue-wen Yang 麦堪成 Materials Science Institute School of Chemistry and Chemical Engineering Sun Yat-sen University Key Laboratory for Polymeric Composite and Functional Materials Ministry of Education Guangdong Provincial Key Laboratory for High Performance Polymer-based Composites

To enhance the ultraviolet resistance of ZnO based polymer materials, ZnO-supported mesoporous zeolite（M-ZnO） was prepared and characterized by atomic absorption spectroscopy and scanning electron microscopy. The ultraviolet resistance, crystallization behavior and melting characteristics of ZnO and M-ZnO filled PPR composites were compared by FTIR spectra and differential scanning calorimetry. The ultraviolet resistance of M-ZnO filled PPR composites is higher than that of ZnO filled PPR composites, indicating higher ultraviolet resistance of M-ZnO than that of ZnO. The crystallization temperatures of mesoporous zeolite filled PPR were higher than those of M-ZnO and decreased with increasing UV-irradiation time. But the crystallization temperatures of M-ZnO filled PPR composites were not influenced by UV-irradiation time. The ZnO supported on the surface of zeolite is effective in enhancing the ultraviolet resistance of ZnO based polymer materials.

关键词： Polypropylene random copolymer(PPR) ZnO Mesoporous zeolite Photo-oxidation degradation

Numerical investigations on cluster characteristics in the supercritical water circulating fluidized bed riser

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Particuology 2024年第11期94卷 281-293页

作者： Kenan Xi Runqing li Xiazhi li mei li Xiudong Xu Yu Zhang Hao Wang Youjun Lu Northwest Institute of Nuclear Technology Xi'an710024China State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an710049China Xi'an Institute of Applied Optics Xi'an710065China

There are currently no reports about clusters in the supercritical water circulating fluidized bed(SCWCFB).Simulations were conducted to investigate the numbers,diameters,aspect ratios,circularity,and orientation angles of cluster in the riser of SCWCFB via two-fluid model across different flow velocities,solid circulation rates,pressures,and *** results show that cluster numbers are mainly between 10 and 80 per *** are more at the bottom but less at the top,and more near the wall but less at the *** diameters are mainly between 0.2 and 0.5 times the bed *** are large at the bottom but small at the top,and large at the center but small near the *** aspect ratios are mainly between 0 and 1,indicating that most clusters have shorter width than their ***-like clusters are more likely to appear near the walls,and clusters at the center of the riser are more likely to be *** circularity is mainly between 0.2 and 0.4,suggesting that the shapes of clusters are far from the *** absolute values of cluster orientation angles are mainly between 75°and 90°,indicating that most clusters move in the vertical *** fluid velocities may facilitate cluster coalescence.

关键词： Supercritical water Circulating fluidized bed Cluster Two-fluid model Riser

Characteristics of karst groundwater system in the northern basin of Laiyuan Spring area

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Journal of Groundwater Science and Engineering 2018年第4期6卷 261-269页

作者： li Bo li Xue-mei Hebei Geological Survey Institute Shijiazhuang 050000China Hebei Hydrogeology and Engineering Geology Exploration Institute Shijiazhuang 050000China

Guided by the theory of groundwater system, based on the groundwater level data from the northern basin of Laiyuan Spring area, the authors took into account factors such as the lithology, geological structure and topography to study the relationship between groundwater recharge, runoff and drainage in this area. It was concluded that the infiltration of atmospheric precipitation is the main source of groundwater supply in this area; the upper layer of the Spring area is distributed with the Cambrian-Lower Ordovician karst water, and the lower layer is filled with the Jixian system karst water. The upper layer of karst water supplies to the lower layer of karst water or the pore water in loose strata through the fault while the lower layer of karst water runs to the three strong runoff belts from the east and west sides of the watershed, southwards into the basin, partially replenishing the pore water in loose strata, or forming fault Springs(e.g. Nanguan Spring, Beihai Spring) when dolomite movement encounters faults. Replenished by atmospheric precipitation and the upper and lower layers of karst waters, the pore water in loose strata joins the groundwater in the southern basin and then flows eastwards, in the end it flows out of the system in Shangfanpu. Through the analyses of groundwater level data and hydrogeological drilling data, based on groundwater D and ^(18) O isotope test results, the karst groundwater circulation system in the northern basin of Laiyuan Spring area is further verified, which provides hydrogeological basis for water resources development and utilization as well as protection in this area.

关键词： Laiyuan Spring area Groundwater Relationship between groundwater recharge Runoff and drainage Upper and lower layers of groundwater Three strong runoff belts