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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang {1. Yong-{1. Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun {1. Yun-Dan {1.ao Zhe-Wei Kang {1.-Fang Wang Yue {1. Ming {1. Bing {1.u Hai-liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(201.RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA department of Medicine Harvard Medical SchoolBostonMA 02115USA department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1.79),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(liNC01.95,DDHD2,SBNO1.KCNG2,SEMA7A,and RUFY1.involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Effect of opioid receptor antagonist naltrindole on transplantation rejection

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Acta Pharmacologica Sinica 1999年第5期 81-82页

作者： li Yi-Fan, XU Xiao-Nan, MEI lin, liang Ying, DING Gui-{1., FAN shao-Guang( department of Physiology, department of Immunology, beijing Medical University, beijing 1.0083 . china)

In our previous work, naltrexone, a common opioid receptor antagonist was found to be able to inhibit transplantation rejection. The purpose of present study is to investigate the subtype of the opioid receptors involved in transplantation *** in vivo experiment:Cardiac tissue of the newborn C57 mice was transplanted into the ear of Balb/c *** survival of the transplanted tissue was tested with the ECG of transplanted tissue. Naltrexone or naltrindole (a selective opioid receptor antagonist) 5 mg-kg-1.as injected ip twice per day for 1. d, *** in vitro experiment: Lymphocytes from two different strain mice were mixed and cultured together. Naltrexone, naltrindole or enkephalin (a selective opioid receptor agonist) was added into the culture fluid, respectively.~3H-TdR uptake (cpm) was measured to show the mixed lymphocyte *** mean

关键词： test show Effect of opioid receptor antagonist naltrindole on transplantation rejection

Ethnic Differences in Preterm Birth Risks for Pregnant Women with Thyroid Dysfunction or Autoimmunity:A Meta-analysis

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Biomedical and Environmental Sciences 2016年第10期29卷 724-733页

作者： li Min WANG {1. Wei WU {1. li SHI Jin YU Pu lin PENG Xiu ling SUN liang department of Gynecology and Obstetrics Beijing HospitalNational Center of Gerontology Institute of Geriatrics Beijing HospitalNational Center of Gerontology department of Gynecology and Obstetrics Morin Dawa Daur Autonomous Banner Hospital

Objective Abnormal maternal thyroid function is associated with preterm ***,this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting *** study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic *** Relevant studies were identified through searches of MEDliNE,Excerpta Medica,Wan Fang,{1. Biological Medicine disc,and{1. National Knowledge Infrastructure from inception to June 1.,*** articles in which an incidence or prevalence of thyroid dysfunction or autoimmunity before second trimester of pregnancy could be extracted were *** Thirty-two unique studies were included for the final *** involved were divided into two groups：Group 1.G1. and Group 2（G2） comprising of Asian and Caucasian populations,*** thyroid antibodies were associated with the occurrence of preterm birth in both G1.[odds ratio（OR）：3.62,95% confidence interval（CI）：2.83-4.65] and G2（OR：1.35,95% CI：1.1.-1.56）;hypothyroidism,only in G2（OR：1.20,CI：1.09-1.33）;and subclinical hypothyroidism or hypothyroxinemia,in neither *** Thyroid autoimmunity may be a more favorable factor leading to preterm birth among pregnant women of different ethnicities,compared with thyroid dysfunction.

关键词： Thyroid Hypothyroidism Autoimmunity Preterm birth Ethnicity

The effects of biodiversity gradient on plant mass and metabolism of individual submerged macrophytes

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Ecological Processes 2021年第1期10卷 500-509页

作者： liang-Yu Qi Hong-Yuan Zeng Zhong-Xi Bai Yan-Hong Wang {1. {1.u Wen Zhong Shi-Yun Ye Hui Fu {1. {1. Chang-liang shao Ai-Ping Wu Ecology department College of Resources&EnvironmentHunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake AreaHunan Agricultural UniversityChangsha 410128China. School of Forestry and Bio-technology Zhejiang Agriculture and Forestry UniversityHangzhou 311300China. CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChangsha 410128China. National Hulunber Grassland Ecosystem Observation and Research Station&Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China.

Background:The effects of biodiversity on community function and services are frequently studied in the history of ecology,while the response of individual species to biodiversity remains great *** this study,we determined the biodiversity effects on community productivity as well as species level plant mass and carbon(C)and nitrogen(N)metabolism of eight submerged *** macrophytes in Lake Erhai were selected and planted in a water depth of one meter along a diversity gradient of 1.2,4 or 8 ***,the community productivity or species level plant mass,soluble protein,free amino acid and soluble carbohydrate were correlated to species richness to determine the biodiversity effects on community and single ***:The results showed that the community level biomass was positively correlated to plant species richness although the species level plant mass of individual species responded differently to the overall plant species ***,only one plant mass positively correlated to species richness and the others decreased or showed no significant correlation with the increase of species *** soluble proteins of most macrophytes were positively correlated to species richness;however,both the free amino acid and soluble carbohydrate of the plants were negatively or not significantly correlated to species ***:These results indicated that the selection effects might dominate in our aquatic communities and the negative impacts of biodiversity on C and N metabolism of the macrophytes increased with the increase of species richness,which might result from the strong competition among the studied *** biodiversity effects on the plant mass,and C and N metabolism of individual submerged species were first reported in this study,while more such field and control experiments deserve further research.

关键词： Species richness Productivity Competition Submerged macrophyte Metabolism Biodiversity

Preparation of li+-doped TiO2 Films by Sol-gel Process

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Preparation of Li+-doped TiO2 Films by Sol-gel Process

CEPC Technical Design Report

The 3～〔rd〕International Conference on High-Performance Ceramics(CICC-3)（1.

作者： feng Zhou Kaiming {1. Hua shao and Anmin Hu department of Materials Science and Engineering of Tsinghua University beijing 1.0084 china

＜正＞ liNO3-doped TiO2 thin films on glass-ceramics were prepared by sol-gel dip coating. The influence of liNO3 addition on the phase transformation temperature was studied. The transformation temperatures of non-crystalline to anatase and anatase to rutile are originally 520℃and 880℃without the addition of liNO3. By adding 5%liNO3 the two transformation temperatures decrease to 440℃and 580℃, respectively. The average size of the particles was found to be around 40nm for the liNO3- doped TiO2 film annealed at 600℃.

关键词： Sol-Gel. TiO2 Thin Film liNO3

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen shao-Long Chen shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics {1. Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1. University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by{1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2)s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,201.)and the Conceptual Design Report(CDR,201.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Comparison of the safety and efficacy of two types of drug-eluting balloons （RESTORE DEB and SeQuent Please） in the treatment of coronary in-stent restenosis： study protocol for a randomized controlled trial （RESTORE ISR china）

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Journal of Geriatric Cardiology 2018年第2期15卷 117-122页

作者： Lei GAO Qin QIN shao-{1. CHEN Hui CHEN Le-feng WANG Ze-Ning JIN Hui li Jun ZHANG Jian-An WANG Yang ZHENG Guo-Sheng FU Yun-Dai CHEN department of Cardiology Chinese PLA General Hospital Beijing China department of Cardiology Tianjin Chest Hospital Tianjin China department of Cardiology Nanjing First Hospital Nanjing China department of Cardiology Beijing Friendship Hospital Capital Medical University Beijing China department of Cardiology Beijing Chao-yang Hospital Capital Medical University Beijing China department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China department of Cardiology Daqing Oilfield General Hospital Daqing China department of Cardiology Cangzhou Central Hospital Cangzhou China department of Cardiology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China department of Cardiology the First Hospital of Jilin University Changchun China department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China

1.Introduction In-stent restenosis （ISR）, characterized by neointimal proliferation and/or neoatherosclerosis in the vessel of the stent, can cause a reduction in lumen diameter after stent implantation, which can directly induce the recurrence of angina symptoms or an acute coronary syndrome in patients and is usually life-threatening.

关键词： Drug-eluting balloons In-stent restenosis Percutaneous coronary interventions

Simple and validated HPLC-UV methods to determine dl-PHPB and dl-NBP in plasma:application to the conversion studies of novel drug Potassium 2-(1.Hydroxypentyl)-benzoate(dl-PHPB),a pro-drug of 3-n-butylphthalide (dl-NBP) in vitro and in vivo

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Simple and validated HPLC-UV methods to determine dl-PHPB an...

Wafer-Scale Gigahertz Graphene Field Effect Transistors on SiC Substrates

全国生化与分子药理学药物靶点研讨会

作者： Jiang li {1.-{1. Xu ling Wang Nan {1. Shi-ping Ma Xiao-liang Wang (department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,beijing 1.0050,china)

To investigate the conversion of dl-PHPB to dl-NBP,two HPLC-UV methods were developed and validated for determination of dl-PHPB and *** quantification of dl-PHPB and dl-NBP,4- biphenylacetic acid and diazepam were used as the internal standard(IS),*** methanol deproteiniation,samples were separated on an Aichrom Bond-1.C1. column using methanol and

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Chinese Physics Letters 2011年第12期28卷 231-234页

作者： PAN Hong-liang JIN Zhi MA Peng GUO Jian-Nan {1.U Xin-Yu YE Tian-Chun {1. Jia DUN {1.-Bo feng Zhi-Hong department of Microwave IC Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029 Science and Technology on ASIC Lab Hebei Semiconductor Research InstituteShijiazhuang 050051

Wafer-scale graphene field-effect transistors are fabricated using benzocyclobutene and atomic layer deposition Al_(2)O_(3) as the top−gate *** epitaxial-graphene layer is formed by graphitization of a 2-inch-diameter Si-face semi-insulating 6H-SiC *** graphene on the silicon carbide substrate is heavily n-doped and current saturation is not *** the intrinsic characteristic of this particular channel material,the devices cannot be switched *** cut-off frequencies of these graphene field-effect transistors,which have a gate length of 1.m,are larger than 800 *** largest one can reach 1.24 *** are greater than 95% active devices that can be successfully *** thus succeed in fabricating wafer-scale gigahertz graphene field-effect transistors,which paves the way for high-performance graphene devices and circuits.

关键词： switched effect carbide