检索结果-南通市图书馆

Biomedical and Environmental Sciences 2021年第12期34卷 1015-1019页

作者： DING Run Rong HUANG Guo Yu ZHANG Yu Jing SUN Hua Lei liU Yi ming XU Ze li wen Jie li Xing Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina

Diabetes mellitus(DM) is a chronic metabolic disorder characterized by a combination of hyperglycemia, reduced insulin sensitivity, and/or relative impairment of insulin secretion[1]. Renal damage, which is a major microvascular complication of DM and a progressive kidney disease, has been considered the most common cause of end-stage renal disease[2]. Renal fibrosis is a common outcome of progressive renal damage.

关键词： Renal damage impairment

Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第4期12卷 389-405页

作者： Hongbin Wei Chunlu dong Xun li The First School of Clinical Medicine Lanzhou UniversityLanzhouGansuChina The First Hospital of Lanzhou University LanzhouGansuChina Key Laboratory Biotherapy and Regenerative Medicine of Gansu Province LanzhouGansuChina Cancer Prevention and Treatment Center of Lanzhou University School of Medicine LanzhouGansuChina Hepatopancreatobiliary Surgery Institute of Gansu Province LanzhouGansuChina Clinical Research Center for General Surgery of Gansu Province LanzhouGansuChina

Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of *** suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of *** this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to *** then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other *** may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent *** also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell *** then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.

关键词： Hepatocellular carcinoma liver cancer Immunotherapy Vaccines

The relation between the radii and the densities of magnetic skyrmions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2021年第7期73卷 146-154页

作者： Yu-Jiao Bo wen-wen li Yu-Chen Guo Ji-Chong Yang Department of Physics Liaoning Normal UniversityDalian 116029China

Compared with the traditional magnetic bubble,a skyrmion has a smaller size,and better stability and therefore is considered as a very promising candidate for future memory *** skyrmions are manipulated,erased and created,the density of skyrmions can be varied,however the relationship between the radii and the densities of skyrmions needs more *** this paper,we study this problem both theoretically and by using the lattice *** average radius of skyrmions as a function of material parameters,the strength of the external magnetic field and the density of skyrmions is obtained and *** this explicit function,the skyrmion radius can be easily predicted,which is helpful for the future study of skyrmion memory devices.

关键词： radius of a skyrmion shape of a skyrmion lattice simulation

Structures,Components and Functions of Secretory Tissues in Houttuynia cordata

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2007年第12期49卷 1734-1745页

作者： Xi-Lu Ni li Peng wen-Zhe liu College of life Sciences Northwest University Xi'an 710069 China College of life Sciences Ningxia University Yinchuan 750021 China

Houttuynia cordata Thunb., traditionally used as a therapeutic plant in folk medicine, has shown antioxidant and anticancer activities. The species, as a core component of paleoherbs, is normally characterized based on the presence of different types of secretory tissue： oil cells, three types of secretory cells and glandular hairs. The aim of this work was to study the structural, componential, and the functional characteristics of the secretory tissues in both the floral and vegetative parts. The results indicate that oil cells and secretory cells are distributed in all organs of the plant, while glandular hairs are situated on the aerial stems and leaves. Both oil cells and glandular hairs initiate from the protoderm, but their developmental processes are different. Although three types of secretory cells initiate from different primary meristems, the developmental patterns of different secretory cells are the same. Also, although the origins of secretory cells are different from oil cells, their early developmental processes are the same. Histochemical results show that oil cells, secretory cells and glandular hairs produce flavonoids, phenolic compounds, tannins, lipids, aldehyde and ketone-compounds. In addition, there are terpenoids and pectic-like substances in oil cells, alkaloids in secretory cells of aerial stems, and terpenoids and alkaloids in glandular hairs. These compounds play very important roles in protecting plants from being eaten by herbivores （herbivory） and infected by microbial pathogens. The oil cell and secretory cell, as unicellular secretory tissues, are intermediates between the primitive surface glandular and secretory cavity and canal during the evolution of secretory structures.

关键词： components functions glandular hairs Houttuynia cordata oil cells secretory ceils secretory tissues structures.

A negative selection algorithm based on hierarchical clustering of self set

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2013年第8期56卷 203-215页

作者： CHEN wen li Tao liU XiaoJie ZHANG Bing College of Computer Science Sichuan University National Computer Network Emergency Response Technical Team Coordination Center of China

Negative selection algorithm(NSA) is an important method of generating artificial immune ***,the traditional NSAs aim at eliminating the self-recognized invalid detectors,by matching candidate detectors with the whole self *** matching process results in extremely low generation efficiency and significantly limits the application of *** this paper,an improved NSA called CB-RNSA,which is based on the hierarchical clustering of self set,is *** CB-RNSA,the self data is first preprocessed by hierarchical clustering,and then replaced by the self cluster centers to match with candidate detectors in order to reduce the distance calculation *** the detector generation process,the candidate detectors are restricted to the lower coverage space to reduce the detector *** the paper,probabilistic analysis is performed on non-self coverage of ***,termination condition of the detector generation procedure in CB-RNSA is *** is more reasonable than that of traditional NSAs,which are based on predefined detector *** theoretical analysis shows the time complexity of CB-RNSA is irrelevant to the self set ***,the difficult problem,in which the detector training cost is exponentially related to the size of self set in traditional NSAs,is resolved,and the efficiency of the detector generation under a big self set is also *** experimental results show that:under the same data set and expected coverage,the detection rate of CB-RNSA is higher than that of the classic RNSA and V-detector algorithms by 12.3% and 7.4% ***,the false alarm rate is lower by 8.5% and 4.9% respectively,and the time cost of CB-RNSA is lower by 67.6% and 75.7% respectively.

关键词： artificial immune system negative selection algorithm detector cluster

NUMERICAL SIMULATION OF STRESS-INDUCED SECONDARY FLOWS WITH HYBRID FINITE ANALYTIC METHOD

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2002年第4期14卷 24-30页

作者： li, Wei Chen, wen-Xue Xie, Sheng-Zong Coll. of Water Conservancy Eng. Wuhan Univ. Wuhan 430072 China China Inst. of Water Resources Beijing 100038 China

The algorithm of the Hybrid Finite Analytic Method (HFAM) was used to simulate the fully developed turbulent flows in non-circular ducts and open channels. The turbulent flow fields in a square duct and a rectangular open channels were calculated by the Naot and Rodi's model, and that in a compound channel was calculated by Speaizle's non-linear eddy-viscosity model with this algorithm. The results show that the HFAM is suitable for calculating these complicated turbulent flows.

关键词： Algorithms Computational fluid dynamics Computer simulation Finite element method

The　Electrochemistry　of　Cytochrome　c　at　a　Viologen-thiol　Self-Assembled　Monolayer

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1998年第1期14卷 17-24页

作者： li, JH Cheng, GJ dong, SJ Chinese Acad Sci Changchun Inst Appl Chem Electroanalyt Chem Lab Changchun 130022 Peoples R China

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－... 详细信息

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－ｊｕｎ（ＬａｂｏｒａｔｏｒｙｏｆＥ...

关键词： at Viologen-thiol Monolayer Self-Assembled The Cytochrome Electrochemistry

Symmetric Energy-Conserved Splitting FDTD Scheme for the Maxwell’s Equations

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2009年第9期6卷 804-825页

作者： wenbin Chen Xingjie li dong liang School of Mathematical Sciences Fudan UniversityShanghai200433China School of Mathematics University of MinnesotaMinneapolisMN 55455USA Department of Mathematics and Statistics York UniversityTorontoON M3J 1P3Canada

In this paper,a new symmetric energy-conserved splitting FDTD scheme(symmetric EC-S-FDTD)for Maxwell’s equations is *** new algorithm inherits the same properties of our previous EC-S-FDTDI and EC-S-FDTDII algorithms:energy-conservation,unconditional stability and computational *** keeps the same computational complexity as the EC-S-FDTDI scheme and is of second-order accuracy in both time and space as the EC-S-FDTDII *** convergence and error estimate of the symmetric EC-S-FDTD scheme are proved rigorously by the energy method and are confirmed by numerical experiments.

关键词： Maxwell’s equation ADI method FDTD energy-conserved second-order accuracy symmetric scheme

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 657-666页

作者： wen-jie FAN Jia-qi ZHANG Jia-qi ZHAN li HU li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

The Novel and Hybrid Detection Approaches for V-BLAST Systems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2008年第4期5卷 143-149页

作者： dong Wei li Jiandong Chen liang Xidian Univ Inst Informat Sci State Key Lab Integrated Serv Networks Broadband Wireless Communicat Lab Xian 710071 Peoples R China

Based on the new discrete particle swarm op-timization(NDPSO) and the mutation operation of the genetic algorithm,a hybrid discrete particle swarm op-timization(HDPSO) algorithm is proposed and applied to the signal detection of the Vertical Bell-Labs Layered Space-Time(V-BLAST)*** two detection ap-proaches that employ the HDPSO and parallel interfer-ence cancellation(PIC) algorithms in V-BLAST system are *** of approaches is that the HDPSO algorithm is used as the first stage of the PIC to provide a good initial point for successive stages of the PIC,the other is that PIC is embedded into the HDPSO al-gorithm to improve further the fi tness of the population at each *** a hybridization of the HDPSO with the PIC can speed up its *** addition,a better initial data estimate supplied by the HDPSO algorithm improves the performance of the PIC,and the embedded PIC improves the performance of the *** and simulation results show that the pro-posed detection approaches have lower computational complexity than the optimal ML detection approach and better detection performance than other conventional detection approaches.

关键词： Vertical Bell-Labs Layered Space-Time system Discrete particle swarm optimization Parallel inference cancellation