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Application of G-quadruplex targets in gastrointestinal cancers:Advancements,challenges and prospects

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1149-1173页

作者： Zong-Qiang Han li-Na wen Department of Laboratory Medicine Beijing Xiaotangshan HospitalBeijing 102211China Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Genomic instability and inflammation are considered to be two enabling characteristics that support cancer development and progression.G-quadruplex structure is a key element that contributes to genomic instability and inflammation.G-quadruplexes were once regarded as simply an obstacle that can block the transcription of oncogenes.A ligand targeting G-quadruplexes was found to have anticancer activity,making G-quadruplexes potential anticancer ***,further investigation has revealed that G-quadruplexes are widely distributed throughout the human genome and have many functions,such as regulating DNA replication,DNA repair,transcription,translation,epigenetics,and inflammatory response.G-quadruplexes play double regulatory roles in transcription and *** this review,we focus on G-quadruplexes as novel targets for the treatment of gastrointestinal *** summarize the application basis of G-quadruplexes in gastrointestinal cancers,including their distribution sites,structural characteristics,and physiological *** describe the current status of applications for the treatment of esophageal cancer,pancreatic cancer,hepatocellular carcinoma,gastric cancer,colorectal cancer,and gastrointestinal stromal tumors,as well as the associated ***,we review the prospective clinical applications of G-quadruplex targets,providing references for targeted treatment strategies in gastrointestinal cancers.

关键词： G-quadruplex Pancreatic cancer liver cancer Gastric cancer Colorectal cancer Gastrointestinal stromal tumor

Exponential stability analysis for neutral BAM neural networks with time-varying delays and stochastic disturbances

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控制理论与应用（英文版） 2012年第1期10卷 92-99页

作者： Bo CHEN li YU wen＇ an ZHANG College of Information Engineering Zhejiang University of Technology Hangzhou Zhejiang 310023 China Zhejiang Provincial United Key Laboratory of Embedded Systems Hangzhou Zhejiang 310032 China

This paper is concerned with the global exponential stability analysis problem for a class of neutral bidi- rectional associative memory （BAM） neural networks with time-varying delays and stochastic disturbances. The stochastic disturbances are described by state-dependent stochastic processes. By utilizing an appropriately constructed Lyapunov- Krasovskii functional （LKF） and some stochastic analysis approaches, novel delay-dependent conditions are established in terms of linear matrix inequalities （LMIs）, which can be easily solved by existing convex optimization techniques. Further- more, the exponential convergence rate can be estimated based on the obtained results. An illustrate example is given to demonstrate the effectiveness of the proposed methods.

关键词： Neutral stochastic BAM neural networks Exponential stability Time-varying delays linear matrix inequalities (LMIs)

Stocking density affects the growth performance and metabolism of Amur sturgeon by regulating expression of genes in the GH/IGF axis

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Journal of Oceanology and limnology 2018年第3期36卷 956-972页

作者： REN Yuanyuan wen Haishen li Yun li Jifang Key Laboratory of Mariculture（Ocean University of China） Ministry of EducationQingdao 266003China

The effects of stocking density on the growth and metabolism of Amur sturgeon were assessed. Amur sturgeon were grown for 70 days at three dif ferent stocking densities(low stocking density, LSD: 5.5 kg/m^3; medium stocking density, MSD: 8.0 kg/m^3; and high stocking density, HSD: 11.0 kg/m^3), and the biometric index, muscle composition, and serum biochemical parameters were evaluated. In addition, pituitary, liver, and muscle samples were collected for gene cloning and expression analyses. After 70 days of growth, the fish maintained at HSD had significantly lower fi nal body weight and specifi c growth rate, and a higher feed conversion ratio than those of the fish in the MSD and LSD groups. The HSD group had the lowest lipid and protein concentrations in serum and muscle. The serum cortisol concentration increased significantly in the HSD group, indicating that the stress-response system was activated in these fish. There was no change in the concentration of serum insulin-like growth factor 2(IGF-2), while the concentrations of serum growth hormone(GH) and insulin-like growth factor 1(IGF-1) decreased in the HSD group. The full-length cDNAs of G H and IGF-2 genes(995-bp and 1 207-bp long, respectively), were cloned and analyzed. In the HSD group, the expressions of GH in the pituitary and growth hormone receptor( GHR) and IGF-1 in the liver were down-regulated at the end of the 70-day experiment. In the HSD group, the transcript level of IGF-2 significantly decreased in the liver, but did not change in muscle. Overall, our results indicated that a HSD negatively af fects the growth performance and leads to changes in lipid and protein metabolism in Amur sturgeon. The down-regulated expression of genes related to the GH/IGF axis may be responsible for the poor growth performance of Amur sturgeon under crowding stress.

关键词： Amur sturgeon stocking density growth metabolism growth hormone (GH) insulin-like growth factor(IGF) axis

Structural evolution of mesoporous graphene/liNi_(1/3)Co_(1/3)Mn_(1/3)O_(2) composite cathode for li-ion battery

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Rare Metals 2021年第3期40卷 521-528页

作者： wen-Jie liu Xian-Zhong Sun Xiong Zhang Chen li Kai Wang wen wen Yan-Wei Ma Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Layered liMO_(2)(M=Ni,Co,and Mn) is a type of promising cathode materials for high energy density and high work voltage lithium-ion ***,the poor rate performance and low power density hinder its further *** capacity fade is related to the structural transformation in the layered liMO_(2).In this work,the structural changes of bi-material cathode composed of mesoporous graphene and layered liNi_(1/3)Co_(1/3)Mn_(1/3)O_(2)(NCM) were studied via in situ X-ray diffraction(XRD).During different C-rate charge-discharge test at the voltage range of 2.5-4.1 V,the composite cathode of NCM-graphene(NCM-G) reveals better rate performances than pure NCM *** NCM-G composite electrode displays a higher rate capability of 76.7 mAh·g^(-1) at 5 C rate,compared to the pure NCM cathode of 69.8 mAh·g^(-1)discharge *** in situ XRD results indicate that a reversible phase transition from hexagonal H1 to hexagonal H2 occurs in layered NCM material during 1 C chargedischarge *** the current increasing to 2 C/5 C,the structure of layered NCM material for both electrodes reveals few changes during charge and discharge processes,which indicates the less utilization of NCM component at high ***,the improved rate performance for bi-material electrode is attributed to the highly conductive mesoporous graphene and the synergistic effect of mesoporous graphene and NCM material.

关键词： liNi_(1/3)Co_(1/3)Mn_(1/3)O_(2)(NCM) Mesoporous graphene Bi-material In situ X-ray diffraction(XRD) Structural evolution

Mechanism study on the reactions between biphenyl and HNO_2 initiated by 355 nm irradiation in aqueous phase

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Science China Chemistry 2007年第5期50卷 700-706页

作者： HUANG li ZHANG RenXi GU DingHong li Ping dong wenBo HOU HuiQi Institute of Environmental Science Fudan University Shanghai 200433 China Institute of Environmental Science Fudan University Shanghai 200433 China Institute of Environmental Science Fudan University Shanghai 200433 China Institute of Environmental Science Fudan University Shanghai 200433 China Institute of Environmental Science Fudan University Shanghai 200433 China Institute of Environmental Science Fudan University Shanghai 200433 China

The reactions taking place in the mixed solution of biphenyl and nitrous acidafter it was exposed to UV irradiation were studied in this research *** transient specieswere identified with the nanosecond transient spectroscopic technique,and the final products wereascertained by GC-MS *** was shown that the OH radical,generated by the direct photolysis ofnitrous acid,would attack biphenyl molecule to form Bp-OH adduct with a rate constant of 9.5x10^9 Lcentre dot mol^(-1) centre dot s^(-1).The Bp-OH adduct could either react with H+ or be oxidized bynitrous acid to form *** reactions between biphenyl and nitrous acid under UVirradiation in atmospheric aqueous phase were therefore suggested to be one promising source ofnitrocompounds in the environment.

关键词： biphenyl, nitrous acid, laser flash photolysis, Bp-OH adduct, nitrosobiphenol

Recent advances on the nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials

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Defence Technology（防务技术） 2022年第3期18卷 344-367页

作者： wen-li Cao Qamar-un-Nisa Tariq Zhi-Min li Jun-Qing Yang Jian-Guo Zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081 PR China CAS Key Laboratory of Energy Regulation Materials Shanghai200032China

This review covers recent advances in the synthesis and energetic performance of nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic *** materials comprise of 1,2,4-oxadiazole subunit as a key structural motif linked to different nitrogen-rich or nitrogen-oxygen azoles:tetrazole,furazan,furoxan,1,3,4-oxadiazole,pyrazole,and *** attention is devoted to the introduction of various energetic groups including nitro,nitramino,azo,azoxy,dinitromethyl,trinitroethyl moieties,and their *** physicochemical and available performance parameters including density,decomposition temperature,heat of formation,detonation pressure,detonation velocity,impact sensitivity,and friction sensitivity of typical energetic compounds are also provided and ***,it was obtained that several screened compounds exhibit superior detonation properties and outstanding insensitivities,which can be classified as a new family of high-performance energetic ***,1,2,4-oxadiazole-azoles-based energetic materials still have many thorough works to further exploited and studied,expecting to get very promising insensitive high explosives for practical application and industrialization.

关键词： 1,2,4-Oxadiazole-azoles Triazole Tetrazole Furazan Energetic materials Furoxan

Three novel dendritic chitosan derivatives for inhibiting acid corrosion of petroleum pipelines

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Petroleum Science 2023年第6期20卷 3918-3930页

作者： Guo-dong Cui Yan-ming Chen Qi-ming Zhang Zheng Wang Tian Tang Qing Zhao Yu Zhang li-Feng Zhang Yuan-Qi Gu Yang-Sheng liu College of Environmental Sciences and Engineering Peking UniversityBeijing Key Laboratory for Solid Waste Utilization and ManagementBeijing100871China University of Houston HoustonTX77204United States State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing102249China CenerTech Tianjin Chemical Research and Design Institute Co. LtdChina National Offshore Oil Corp(CNOOC)Tianjin300131China Faculty of Environment and life Beijing University of TechnologyBeijing100124China Shanxi International Energy Group Co. LtdTaiyuan030002ShanxiChina

In the process of exploration and development of oil and gas fields, the acidic environment of oil reservoir, production and transport processes cause corrosion of pipelines and equipment, resulting in huge economic losses and production safety risks. Corrosion inhibitors were widely used in oil industry because of simple operation process and economical. In this study, three environmentally friendly corrosion inhibitors were synthesized based on the natural polysaccharide chitosan. Corrosion inhibition of three dendritic chitosan derivatives (We name them BH, CH and DH) on mild steel in 1 mol/L HCl solution with natural ventilation system was evaluated by weight loss experiment, electrochemical analysis and surface morphology characterization. The experimental results showed that when the three dendritic chitosan derivatives added in the corrosive medium were 500 mg L^(−1), the corrosion inhibition efficiencies were all more than 80%. Based on quantum chemical calculation, inhibition mechanisms of three dendritic chitosan derivatives were investigated according to molecular structures. The results showed that the benzene ring, Schiff base and N atom contained in the molecule were the active centers of electron exchange, which were more likely to form a film on the carbon steel surface, thereby slowing or inhibiting corrosion. The results also predicted the corrosion inhibition effect BH > DH > CH, which was consistent with the experimental conclusion.

关键词： Chitosan derivatives Corrosion inhibitors Carbon steel Acid inhibition Efficient and environmental

Endpoint Estimates for Commutators of Fractional Integrals Associated to Operators with Heat Kernel Bounds

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Communications in Mathematical Research 2017年第1期33卷 73-84页

作者： liu Xian-jun li wen-ming Yan Xue-fang College of Mathematics and Information Science Hebei Normal UniversityShijiazhuang 050024

Let L be the infinitesimal generator of an analytic semigroup on L;（R;）with pointwise upper bounds on heat kernel,and denote by L;the fractional integrals of *** a BMO function b（x）,we show a weak type Llog L estimate of the commutators [b,L;]（f）(x) = b（x）L;（f）(x)-L;（bf）(x).We give applications to large classes of differential operators such as the Schr¨odinger operators and second-order elliptic operators of divergence form.

关键词： fractional integral commutator Llog L estimate semigroup sharp maximal function

Effi cacy and safety of low-dose corticosteroids for acute respiratory distress syndrome:A systematic review and meta-analysis

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World Journal of Emergency Medicine 2021年第3期12卷 207-213页

作者： Yu-qing Cui Xian-fei Ding Huo-yan liang dong Wang Xiao-juan Zhang li-feng li Quan-cheng Kan Le-xin Wang Tong-wen Sun General ICU the First Affi liated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou Key Laboratory of SepsisHenan Engineering Research Center for Critical Care MedicineZhengzhou 450052China Biotherapy Center the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Pharmacy the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China School of Biomedical Sciences Charles Sturt UniversityWagga Wagga 2650Australia

BACKGROUND:There are confl icting results regarding whether corticosteroids have better effi cacy than placebo in acute respiratory distress syndrome(ARDS)***,we aim to further evaluate the effi cacy and safety of corticosteroids in adult ARDS ***:The databases,including Medline,EMBASE,and Cochrane Central Register of Controlled Trials(CENTRAL)in the Cochrane library,were searched from their inception to May 2,*** controlled trials(RCTs)and observational cohort studies were selected to assess the use of corticosteroids in adult ARDS *** quality of the results was judged by the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)*** inverse-variance method with random or fixed effects modeling was used to compute pooled odds ratio(OR),standardized mean diff erence(SMD),and their 95%confi dence interval(CI).RESULTS:Eight eligible RCTs and six cohort studies were *** use of corticosteroids was associated with reduced mortality(OR 0.57,95%CI 0.43-0.76,I2=35.1%,P=0.148)in ARDS patients,and the result was confirmed in the included cohort studies(OR 0.51,95%CI 0.27-0.95,I2=66.7%,P=0.010).The subgroup analysis stratified by the initiation time and duration of corticosteroid use showed that early ARDS and prolonged corticosteroid use had signifi cant survival benefits in the *** low-dose corticosteroid use was also associated with significantly more ventilator-free days and a reduced rate of new infections in ARDS ***:The low-dose corticosteroid therapy may be safe and reduce mortality,especially in patients with prolonged treatment and early ARDS.

关键词： Low-dose Corticosteroid Acute respiratory distress syndrome Mortality Systematic review Meta-analysis