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World Journal of Gastroenterology 2018年第21期24卷 2236-2246页

作者： Ting-Ting li Hao liu Jiang Yu Guang-Yao Shi li-Ying Zhao Guo-xin li Department of General Surgery Nanfang HospitalSouthern Medical University Division of Cardiology Third Affiliated HospitalSun Yat-sen University

Gastric cancer(GC), with its high incidence and mortality rates, is a highly fatal cancer that is common in East Asia particularly in China. Its recurrence and metastasis are the main causes of its poor prognosis. Circulating tumor cells(CTCs) or other blood biomarkers that are released into the circulating blood stream by tumors are thought to play a crucial role in the recurrence and metastasis of gastric cancer. Therefore, the detection of CTCs and other blood biomarkers has an important clinical significance; in fact, they can help predict the prognosis, assess the staging, monitor the therapeutic effects and determine the drug susceptibility. Recent research has identified many blood biomarkers in GC, such as various serum proteins, autoantibodies against tumor associated antigens, and cell-free DNAs. The analysis of CTCs and circulating cell-free tumor DNA(ctDNA) in the peripheral blood of patients with gastric cancer is called as liquid biopsy. These blood biomarkers provide the disease status for individuals and have clinical meaning. In this review, we focus on the recent scientific advances regarding CTCs and other blood biomarkers, and discuss their origins and clinical meaning.

关键词： Gastric cancer Biomarker Circulating tumor cells Autoantibodies Cell-free DNA

Synthesis and electrochemical properties of li[Ni_xCo_yMn_(1-x-y)]O_2 (x, y = 2/8, 3/8) cathode materials for lithium ion batteries

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Rare Metals 2009年第1期28卷 43-48页

作者： HU Chuanyue li Zheng GUO Jun DU Yong WANG xingyan liU xin YI Tao State key Laboratory of Powder Metallurgy Central South University Changsha 410083 China Department of Chemistry and Material Science Hunan Institute of Humanities Science and Technology Loudi 410007 China

The tmiform layered li（Ni2/8Co3/8Mn3/8）O2, li（Ni3/8Co2/8Mn3/8）O2, and li（Ni3/8Co3/8Mn2/8）O2 cathode materials for lithium ion batteries were prepared using the hydroxide co-precipitation method. The effects of calcination temperature and transition metal contents on the structure and electrochemical properties of the li-Ni-Co-Mn-O were systemically studied. The results of XRD and electrochemical performance measurement show that the ideal preparation conditions were to prepare the li（Ni3/8Co3/8Mn2/8）O2 cathode material calcined at 900℃ for 10 h. The well-ordered li（Ni3/8Co3/8Mn2/8）O2 synthesized under the optimal conditions has the I003/I104 ratio of 1.25 and the R value of 0.48 and delivers the initial discharge capacity of 172.9 mA·h·g^-1, the discharge capacity of 166.2 mA·h·g^-1 after 20 cycles at 0.2C rate, and the impedance of 558 Ω after the first cycle. The decrease of Ni content results in the decrease of discharge capacity and the bad cycling performance of the li-Ni-Co-Mn-O cathode materials, but the decreases of Mn content and Co content to a certain extent can improve the electrochemical properties of the li-Ni-Co-Mn-O cathode materials.

关键词： lithium ion batteries cathode material electrochemical properties hydroxide co-precipitation method

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Discriminative Histogram Intersection Metric Learning and Its Applications

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Journal of Computer Science & Technology 2017年第3期32卷 507-519页

作者： Peng-Yi Hao Yang Xia Xiao-xin li Sei-ichiro Kamata Sheng-Yong Chen College of Computer Science and Technology Zhejiang University of Technology Hangzhou 310023 China Graduate School of Information Production and Systems Waseda University Kitakyushu 808-0135 Japan

In this paper, a novel method called discriminative histogram intersection metric learning （DHIML） is proposed for pair matching and classification. Specifically, we introduce a discrimination term for learning a metric from binary infor-mation such as same/not-same or similar/dissimilar, and then combine it with the classification error for the discrimination in classifier construction. Compared with conventional approaches, the proposed method has several advantages. 1） The histogram intersection strategy is adopted into metric learning to deal with the widely used histogram features effectively. 2） By introducing discriminative term and classification error term into metric learning, a more discriminative distance metric and a classifier can be learned together. 3） The objective function is robust to outliers and noises for both features and labels in the training. The performance of the proposed method is tested on four applications： face verification, face-track identification, face-track clustering, and image classification. Evaluations on the challenging restricted protocol of Labeled Faces in the Wild （LFW） benchmark, a dataset with more than 7000 face-tracks, and Caltech-101 dataset validate the robustness and discriminability of the proposed metric learning, compared with the recent state-of-the-art approaches.

关键词： metric learning pair matching image classification face verification

CPicker： Leveraging Performance-Equivalent Configurations to Improve Data Center Energy Efficiency

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Journal of Computer Science & Technology 2018年第1期33卷 131-144页

作者： Fa-Qiang Sun Gui-Hai Yan xin He Hua-Wei li Yin-He Han State key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China National Computer Network Emergency Response Technical Team of China Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China

The poor energy proportionality of server is seen as the principal source for low energy efficiency of modern data centers. We find that different resource configurations of an application lead to similar performance, but have distinct energy consumption. We call this phenomenon as ＂performance-equivalent resource configurations （PERC）＂, and its performance range is called equivalent region （ER）. Based on PERC, one basic idea for improving energy efficiency is to select the most efficient configuration from PERC for each application. However, it cannot support every application to obtain optimal solution when thousands of applications are run simultaneously on resource-bounded servers. Here we propose a heuristic scheme, CPicker, based on genetic programming to improve energy efficiency of servers. To speed up convergence, CPicker initializes a high quality population by first choosing configurations from regions that have high energy variation. Experiments show that CPicker obtains above 17% energy efficiency improvement compared with the greedy approach, and less than 4% efficiency loss compared with the oracle case.

关键词： performance equivalence energy efficiency data center power management dynamic voltage and frequencyscaling (DVFS)

Regioregular Asymmetric Diketopyrrolopyrrole Copolymers with Good Molecular Ordered Assembly Ability for High-performance Polymer Transistors

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Chinese Journal of Polymer Science 2023年第8期41卷 1215-1222,I0006页

作者： Qing-Qing liu Jia-xin Yang Man Zhao Can Gao Bo Guan Huan-li Dong Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Introduction of asymmetric units into conjugated polymers is an important strategy to regulate the photophysical and electronic properties of polymers,as asymmetric units can not only regulate solubility and energy levels,but also molecular stacking and orientation,thus giving much higher optoelectronic ***,very few studies have been reported in this *** semiconducting properties of conjugated polymers could be regulated through regioregularity ***,we took the asymmetric thiophene/pyridine side group DPP as core and developed the regioregular monomer T-Py-DPP through three steps:alkyl chain introduction,tin monomer coupling and NBS double *** T-Py-DPP monomer was polymerized into reg-PPy TDPP-2FBT with a head-to-head *** regioregularity of T-Py-DPP unit endowed reg-PPy TDPP-2FBT with backbone planarity,self-assembly orientation,network-like morphology and high crystallinity in films,thus the superior bipolar transport *** highest hole and electron mobilities of reg-PPy TDPP-2FBT were 0.93 and 0.57 cm^(2)·V^(-1)·s^(-1),respectively,with 40%improvement relative to the regiorandom polymer.

关键词： Asymmetric copolymers Regioregularity Good orientation Organic field-effect transistor Enhanced performance

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Role of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 782-790页

作者： Tian-Yu Xie Di Wu Shuo li Zhao-Yan Qiu Qi-Ying Song Da Guan li-Peng Wang Xiong-Guang li Feng Duan xin-xin Wang School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery Chinese PLA General HospitalBeijing 100853China

BACKGROUND Gastric cancer is the second most common malignant tumor in China,ranking third among all malignant tumor mortality *** intraperitoneal chemotherapy(HIPEC)has been shown to increase significantly the effectiveness of intraperitoneal chemotherapeutic drugs,prolong the action time of these drugs on intraperitoneal tumor cells,and enhance their diffusion in tumor *** may be one of the best choices for the eradication of residual cancer cells in the abdominal *** The aim of this study was to study the role of preventive HIPEC after radical *** A prospective analysis was performed with patients with c T4 N0-3 M0 gastric cancer to compare the effects of postoperative prophylactic HIPEC plus intravenous chemotherapy with those of routine adjuvant ***’medical records were analyzed,and differences in the peritoneal recurrence rate,diseasefree survival time,and total survival time between groups were *** The first site of tumor recurrence was the peritoneum in 11 cases in the conventional adjuvant chemotherapy group and in 2 cases in the HIPEC group(P=0.020).The 1-year and 3-year disease-free survival rates were 91.9%and 60.4%,respectively,in the conventional adjuvant chemotherapy group and 92.1%and 63.0%,respectively,in the HIPEC *** 1-year and 3-year overall survival rates were 95.2%and 66.3%,respectively,in the conventional adjuvant chemotherapy group and 96.1%and 68.6%,respectively,in the HIPEC *** significant difference in postoperative or chemotherapy complications was observed between *** In patients with c T4 N0-3 M0 gastric cancer,prophylactic HIPEC after radical tumor surgery is beneficial to reduce peritoneal tumor recurrence and prolong survival.

关键词： Hyperthermic intraperitoneal chemotherapy Gastric cancer Prognosis Locally advanced Overall survival Disease-free survival

基于正交试验的纱线断裂时间与强力的回归分析

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合成纤维 2025年第1期54卷 29-33页

作者：穆奎唐孔科程杰马艳丽山东省产品质量检验研究院山东济南250102

通过三因素三水平的正交试验,利用极差法和显著性水平分析法得出:隔距、拉伸速度、预加张力这三个因素对单纱断裂强力、断裂伸长率、断裂时间的影响不明显;隔距、预加张力对单纱断裂强力、断裂伸长率、断裂时间的影响为不显著;拉伸速度... 详细信息

通过三因素三水平的正交试验,利用极差法和显著性水平分析法得出:隔距、拉伸速度、预加张力这三个因素对单纱断裂强力、断裂伸长率、断裂时间的影响不明显;隔距、预加张力对单纱断裂强力、断裂伸长率、断裂时间的影响为不显著;拉伸速度对单纱断裂强力、断裂伸长率的影响为不显著,对断裂时间的影响为显著。通过回归分析,断裂时间与断裂强力两者之间存在明显的函数关系,建立断裂时间与断裂强力的回归方程,R2值接近1,该方程可以准确有效地模拟断裂时间与断裂强力的函数关系。断裂时间是单纱断裂强力的一个重要表征值,建议在以后的标准更新中将其纳为考核指标,为纱线的使用者提供参考依据。

关键词：断裂强力断裂时间断裂伸长率正交试验回归分析

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Coupling the k-nearest neighbor procedure with the Kalman filter for real-time updating of the hydraulic model in flood forecasting

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International Journal of Sediment Research 2016年第2期31卷 149-158页

作者： Kailei liu Zhijia li Cheng Yao Ji Chen ke Zhang Muhammad Saifullah College of Hydrology and Water Resources Hohai University National Cooperative Innovation Center for Water Safety & Hydro-Science of Hohai University Department of Civil Engineering The University of Hong Kong The Cooperative Institute for Mesoscale Meteorological Studies University of Oklahoma Hydrometeorology & Remote Sensing (HyDROS) Laboratory and School of Civil Engineering and Environmental Sciences University of Oklahoma

The Kalman filter(KF) updating method has been widely used as an efficient measure to assimilate realtime hydrological variables for reducing forecast uncertainty and providing improved ***,the accuracy of the KF relies much on the estimates of the state transition matrix and is limited due to the errors inherit from parameters and variables of the flood forecasting models.A new real-time updating approach(named KN2K) is produced by coupling the k-nearest neighbor(KNN) procedure with the KF for flood forecasting *** nonparametric KNN algorithm,which can be utilized to predict the response of a system on the basis of the k most representative predictors,is still efficient when the descriptions for input-output mapping are *** this study,the KNN procedure is used to provide more accurate estimates of the state transition matrix to extend the applicability of the *** updating performance of KN2K is investigated in the middle reach of the Huai River based on a onedimensional hydraulic model with the lead times ranging from 2 to 12 *** forecasts from the KN2Kliffe efficiency larger than 0.85 in the 12-h-ahead forecasts,has a significant advantage in accuracy and robustness compared to the KF *** is demonstrated that improved updating results can be obtained through the use of KNN *** tests show that the KN2K method can be used as an effective tool for real-time flood forecasting.

关键词： Kalman filter K-nearest neighbor Coupling method State-transition matrix Real-time updating

Array of single crystalline anatase TiO2 nanotubes with significant enhancement of photoresponse

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Progress in Natural Science:Materials International 2021年第4期31卷 536-540页

作者： Lvchao Qiu ke Fang Yubo li Shutao Huang Guanxing li Songda li Hu He Wentao Yuan Hangsheng Yang Wei Tian Yong Wang State key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Center of Electron Microscopy School of Materials Science and Engineering Zhejiang University key Laboratory of Micro-Nano Electronic Device and Smart System of Zhejiang Province College of Information Science & Electronic Engineering Zhejiang University School of Physical Science and Technology Soochow University

Anatase TiO2nanotubes array（ATONA） has attracted tremendous attention owing to its promising applications in solar cells, water splitting and organic pollutants photocatalytic degradation. However, the activity of ATONAs was greatly suppressed by the grain boundaries existed in the tube walls, which acted as carrier scattering and recombination centers. Herein, we report a novel strategy to prepare array of single crystalline anatase TiO2nanotubes（SC-ATONAs） with significant enhancement of the photocatalytic activity and UV photo response performance compared to the polycrystalline counterparts. The growth of SC-ATONAs was achieved by establishing a crystallization temperature gradient along the tube wall, which ensured the crystallization started from the nucleation of a single nucleus at the bottom of amorphous TiO2nanotubes prepared by Ti anodization. These findings pave the way to prepare single-crystalline nanotubes with superior performance for other materials.

关键词： Single crystalline TiO 2 nanotube Crystallization temperature gradient Photo response Photocatalysis

Full robot-assisted gastrectomy with intracorporeal robot-sewn anastomosis produces satisfying outcomes

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World Journal of Gastroenterology 2013年第38期19卷 6427-6437页

作者： xin-xin liu Zhi-Wei Jiang Ping Chen Yan Zhao Hua-Feng Pan Jie-Shou li Department of Gastrointestinal Surgery Subei People’s Hospital of Jiangsu Province Post-doctoral Mobile Stations of Nanjing University Clinical Medical College of Yangzhou University Department of General Surgery Jinling HospitalSchool of MedicineNanjing University

AIM:To evaluate the feasibility and safety of full robotassisted gastrectomy with intracorporeal robot handsewn anastomosis in the treatment of gastric ***:From September 2011 to March 2013,110consecutive patients with gastric cancer at the authors’institution were enrolled for robotic *** to tumor location,total gastrectomy,distal or proximal subtotal gastrectomy with D2 lymphadenectomy was fully performed by the da Vinci Robotic Surgical *** construction,including Roux-en-Y jejunal limb,esophagojejunal,gastroduodenal and gastrojejunal anastomoses were fully carried out by the intracorporeal robot-sewn *** the end of surgery,the specimen was removed through a 3-4 cm incision at the umbilicus trocar *** details of the surgical technique are well *** benefits in terms of surgical and oncologic outcomes are well documented,as well as the failure rate and postoperative ***:From a total of 110 enrolled patients,radical gastrectomy could not be performed in 2 patients due to late stage disease;1 patient was converted to laparotomy because of uncontrollable hemorrhage,and1 obese patient was converted due to difficult exposure;2 patients underwent extra-corporeal anastomosis by minilaparotomy to ensure adequate tumor ***-sewn anastomoses were successfully performed for 12 proximal,38 distal and 54 total *** average surgical time was 272.52±53.91 min and the average amount of bleeding was 80.78±32.37 *** average number of harvested lymph nodes was 23.1±*** specimens showed adequate surgical *** regard to tumor staging,26,32 and 46 patients were staged asⅠ,ⅡandⅢ,*** average hospitalization time after surgery was 6.2 *** patient experienced a duodenal stump anastomotic leak,which was mild and treated *** patient was readmitted for intra-abdominal infection and was treated *** afferent loop obstruction occurred i

关键词： Robotic surgery Gastric cancer Total gastrectomy Esophagojejunal anastomosis