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Bifurcations, Analytical and Non-Analytical Traveling Wave Solutions of (2 + 1)-Dimensional Nonlinear Dispersive Boussinesq Equation

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Applied Mathematics 2024年第8期15卷 543-567页

作者： Dahe Feng jibin li Airen Zhou School of Mathematics and Statistics Guizhou University of Finance and Economics Guiyang China School of Mathematical Sciences Huaqiao University Quanzhou China

For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits of the regular system are obtained. Under different parametric conditions, various sufficient conditions to guarantee the existence of analytical and non-analytical solutions of the singular system are given by using singular traveling wave theory. For certain special cases, some explicit and exact parametric representations of traveling wave solutions are derived such as analytical periodic waves and non-analytical periodic cusp waves. Further, two-dimensional wave plots of analytical periodic solutions and non-analytical periodic cusp wave solutions are drawn to visualize the dynamics of the equation.

关键词： (2 + 1)-Dimensional Nonlinear Dispersive Boussinesq Equation Bifurcations Phase Portrait Analytical Periodic Wave Solution Periodic Cusp Wave Solution

Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin Wang Min Yang Wei Xiong Quan Wang Bobo Zheng Yang Bai Kaiyong Zou jibin li Jiansong Ren Wanqing Chen Jingbo Zhai Jiang li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive Center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China Ambulatory Surgery Center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of Clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health ***-screening services that can reduce cancer mortality are strongly ***,the specific role of COVID-19 in cancer screening is not fully *** study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next *** searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,*** studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were *** methodological quality of the included studies was assessed using the Newcastle-Ottawa *** in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this *** screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,p<0.01),cervical cancer(Pooled IRR=0.56,95%CI:0.47 to 0.67,p<0.01),breast cancer(Pooled IRR=0.57,95%CI:0.49 to 0.66,p<0.01)and prostate cancer(Pooled IRR=0.71,95%CI:0.56 to 0.90,p<0.01)during the COVID-19 pandemic were significantly lower than those before the COVID-19 *** screening rates of lung cancer(Pooled IRR=0.77,95%CI:0.58 to 1.03,p=0.08)and colorectal cancer using noninvasive screening methods(Pooled IRR=0.74,95%CI:0.50 to 1.09,p=0.13)were reduced with no statistical *** subgroup analyses revealed that the reduction in cancer-screening rates varied across *** results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer *** innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare fo

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

Organocatalytic radical aminoacylation of alkenes forβ-aminoketone synthesis

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Science China Chemistry 2024年

作者： Ayisenbati Jialingbieke Xinying Hu Zuquan liu Xiyun lin Yiwen Yin jibin li Yatian Huang Ding Du State Key Laboratory of Natural Medicines School of Science China Pharmaceutical University

An NHC organocatalytic radical aminoacylation of alkenes has been developed by using aldehydes as the acylating reagents and activated aryloxy-amides as the N-radical precursors, providing a new platform for modular access to highly functionalized β-aminoketones. The key to the success of this reaction relies on the single electron transfer(SET) event between the enolates of Breslow intermediates and carefully screened N-radical precursors, followed by a radical addition and radical-radical coupling relay process. The protocol features simple and readily available materials(abundant and feed-stock aldehydes and alkenes),mild reaction conditions(metal-, photo-and oxidant-free, in EA at room temperature), easily removable protecting group for late-stage functionalization.

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Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping li liling Zhang Wei Xu Ru Feng Wenyu li Yin Xiao Xinxiu liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming li jibin li Suxia lin Yanxia He liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

浅水波方程模型与奇非线性行波方程解的动力学行为及精确的参数表示:动力系统方法

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四川师范大学学报（自然科学版） 2024年第4期47卷 451-468页

作者：李继彬浙江师范大学数学科学学院浙江金华321004 华侨大学数学科学学院福建泉州362021 昆明理工大学理学院云南昆明650093

首先,介绍在重力作用下,无旋、无黏性和不可压缩的流体的表面波传播的一维(或两维单向)浅水波运动的各种不同模型(PDE),这些模型对应的行波系统一般是奇平面动力系统.其次,用著名的广义Camassa-Holm方程作为例子,通过对应的行波系统的... 详细信息

首先,介绍在重力作用下,无旋、无黏性和不可压缩的流体的表面波传播的一维(或两维单向)浅水波运动的各种不同模型(PDE),这些模型对应的行波系统一般是奇平面动力系统.其次,用著名的广义Camassa-Holm方程作为例子,通过对应的行波系统的精确解来研究该方程的尖孤子、周期尖波、伪尖孤子、伪周期尖波及有界破缺波解的存在性.第三,应用动力系统分支理论和奇摄动几何理论相结合的方法,建立了奇非线性行波方程研究的理论和方法,介绍奇非线性行波动力学行为的2个主要定理,完整地解决了波的光滑性与非光滑性、完整性和破缺性的判定问题.第四,介绍当伴随正则系统直线解上的奇点是结点时,如何用相轨道识别对应的波形,并研究一个非线性水波方程,获得该系统的各型光滑的孤立波和周期波在不同参数条件下的存在性和精确的参数表示.

关键词：浅水波方程模型广义Camassa-Holm方程奇非线性行波方程分枝动力系统方法

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The Exact Traveling Wave Solutions to Two Integrable KdV6 Equations

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Chinese Annals of Mathematics,Series B 2012年第2期33卷 179-190页

作者： jibin li Yi ZHANG Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina Faculty of Science Kunming University of Science and TechnologyKunming 200062China

The exact explicit traveling solutions to the two completely integrable sixthorder nonlinear equations KdV6 are given by using the method of dynamical systems and Cosgrove's *** is proved that these traveling wave solutions correspond to some orbits in the 4-dimensional phase space of two 4-dimensional dynamical *** orbits lie in the intersection of two level sets defined by two first integrals.

关键词： KdV6 equation Exact traveling wave solution Solitary wave solution Quasi-periodic wave solution

Mechanistic insight into the biofilm formation and process performance of a passive aeration ditch(PAD)for decentralized wastewater treatment

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Frontiers of Environmental Science & Engineering 2022年第7期16卷 35-46页

作者： jibin li Jinxing Ma li Sun Xin liu Huaiyu liao Di He Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou510006China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Decentralized wastewater containing elevated salinity is an emerging threat to the local environment and sanitation in remote coastal *** the cost and treatment efficiencies,we propose a passive aeration ditch(PAD)using non-woven polyester fabric as a feasible bubbleless aerator and biofilm carrier for wastewater *** has been first given to PAD’s efficacy in treating saline decentralized wastewater,and then to the impact of chemical oxygen demand-to-nitrogen(C/N)ratio and salinity on biofilm formation.A multispecies model incorporating the salinity effect has been developed to depict the system performance and predict the microbial *** showed that the PAD system had great capacity for pollutants *** biofilm thickness increased at a higher C/N ratio because of the boost of aerobic heterotrophs and denitrifying bacteria,which consequently improved the COD and total nitrogen ***,this led to the deterioration of ammonia ***,while a higher salinity benefited the biofilm growth,the contaminant removal efficiencies decreased because the salinity inhibited the activity of aerobic heterotrophs and reduced the abundance of nitrifying bacteria inside the *** on the model simulation,feed water with salinity below 2%and C/N ratio in a range of 1 to 3 forms a biofilm that can reach relatively high organic matter and ammonia *** findings not only show the feasibility of PAD in treatment of saline decentralized wastewater,but also offer a systematic strategy to predict and optimize the process performance.

关键词： Decentralized wastewater Passive aeration ditch Biofilm formation C/N ratio Salinity Model simulation

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妊娠期膳食模式与早产风险的meta分析

现代医药卫生 2024年第11期40卷 1909-1916页

作者：刘星宇李世文林钇汐李继斌重庆医科大学公共卫生学院营养与食品卫生教研室重庆400016

目的评估妊娠期膳食模式对早产发生风险的影响,为降低早产发生率提供膳食指导依据。方法系统检索PubMed、Web of Science、知网等数据库关于妊娠期膳食模式和早产关联的相关研究,将膳食模式按照食物成分相似性,分为“健康”“不健康”... 详细信息

目的评估妊娠期膳食模式对早产发生风险的影响,为降低早产发生率提供膳食指导依据。方法系统检索PubMed、Web of Science、知网等数据库关于妊娠期膳食模式和早产关联的相关研究,将膳食模式按照食物成分相似性,分为“健康”“不健康”和“混合”3种膳食模式,运用RevMan5.4软件对纳入研究中妊娠期膳食最高和最低依从性的结局效应进行meta分析,并进行亚组分析和敏感性分析。结果最终纳入23篇文献,总样本量312892例。对其中18篇文献进行meta分析结果显示,健康膳食模式依从性高可降低早产发生风险[OR=0.82,95%CI(0.76,0.89)],进行亚组分析和敏感性分析后结局稳定。纳入文献中的健康膳食模式漏斗图不对称,存在发表偏倚。不健康膳食模式和混合膳食模式与早产发生风险之间未发现显著相关性。结论不同的膳食模式对早产的发生风险具有较大影响,妊娠期高摄入水果、蔬菜、全谷物、低脂乳制品、豆类、植物油和鱼类等健康膳食模式可降低早产发生风险。

关键词：膳食模式妊娠早产 meta分析

2020—2023年某三甲皮肤病专科医院医务人员感染性职业暴露现况调查

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皮肤性病诊疗学杂志 2024年第7期31卷 489-495页

作者：罗开元邱慧李济宾燕翼安宁波广州医科大学附属第三医院广东广州510150 南方医科大学皮肤病医院广东广州510091 中山大学肿瘤防治中心广东广州510060

目的了解皮肤病专科医院医务人员感染性职业暴露的发生特征,为防控感染性职业暴露提出可行性建议。方法回顾性收集2020年1月1日—2023年12月31日某三甲皮肤病专科医院医务人员感染性职业暴露数据,分析暴露者的人群、科室、暴露方式和... 详细信息

目的了解皮肤病专科医院医务人员感染性职业暴露的发生特征,为防控感染性职业暴露提出可行性建议。方法回顾性收集2020年1月1日—2023年12月31日某三甲皮肤病专科医院医务人员感染性职业暴露数据,分析暴露者的人群、科室、暴露方式和部位、防护情况,以及暴露场所、暴露源和暴露时间分布等特征。结果该院4年间医务人员感染性职业暴露共97例,年发生率总体呈先上升后下降趋势,不同年份发生率差异有统计学意义(χ~2=4.09,P=0.043)。暴露者以医生为主(59.79%),年龄≤35岁(85.56%)、工龄≤5年(71.13%)者发生职业暴露占比较高;暴露场所以门诊为主(59.79%);暴露发生方式多为针刺伤或锐器伤(86.60%);暴露部位以手部为主(84.54%);暴露时机以注射及穿刺(39.17%)为主;本人操作不慎/未做好个人防护是暴露发生的主要原因(92.78%);暴露源以不明病原体(27.84%)占比最高,其次是乙型肝炎病毒(13.40%)、梅毒螺旋体(8.25%)、人类免疫缺陷病毒(2.06%)。结论皮肤病专科医院医务人员感染性职业暴露的年发生率较高,尤其易发生于医生和年龄较小、工龄较短人员中,职业暴露风险较综合医院有其专科特色。建议采取加强培训、做好标准防护、完善暴露后处置流程、建立信息化上报系统、关怀医务人员心理状态等措施,以有效防控职业暴露的发生。

关键词：皮肤病专科医院感染性职业暴露医务人员乙型肝炎病毒