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Selective and asymmetric ion transport in covalent organic framework-based two-dimensional nanofluidic devices

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International Journal of Smart and Nano Materials 2024年第1期15卷 186-197页

作者： li-Qiu huang Shuang Chen Ri-jian Mo Zhong-Qiu li Xing-hua Xia State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina

Two-dimensional(2D)covalent organic framework(COF)mem-branes featuring well-aligned and programmable vertical nano-channels have emerged as a promising candidate for advanced nanofluidic devices and showcased vast potential in the fields of smart-gating,ion-separation,and ***,the transverse interlayer nanochannels with a height of sub-nanometer-scale in 2D-COF membranes have scarcely been studied in ***,we report the ion transport characteristics in 2D interlayer nanochannels of protonated CoF *** dis-tinct surface-charge-governed ionic conductance in domination of electrolyte concentration below 1o-3 M as well as the exceptional anion/cation(Cl^(-)/K^(+))selectivity is revealed due to the pronounced charge and nano-confinement ***,evident ion current rectification is witnessed when incorporating asymmetric geometry into the system,which is attributed to the dynamic process of ion enrichment and dissipation within the protonated *** work offers immense prospects for 2D-COF membranes in the fields of biomimetic nanofluidic devices and cutting-edge electronic devices.

关键词： Two-dimensional covalent organic framework interlayernanochannels ion transport characteristics nanofluidic device

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水蛭活性肽生物活性测定方法的建立

时珍国医国药 2024年第7期35卷 1648-1651页

作者：王雨晴张惠惠李华健李亚男吴冬雪李喆孙志强柏道鸣宋景李双凤王少平代龙山东中医药大学药学院山东济南250300 滨州医学院药学院山东烟台264003 山东禹泽药康产业技术研究院有限公司山东德州251200 安徽生物肽产业研究院有限公司安徽芜湖241000 山东协和学院山东济南250109 烟台食品药品检验检测中心山东烟台264035

目的在体外系统评估三种水蛭活性肽(蚂蟥、柳叶蚂蟥、日本医蛭)的抗凝血活性;并建立新的水蛭活性肽生物活性测定方法。方法采用体外生物活性测定方法APTT法、PT法、TT法、纤维蛋白原-凝血酶时间(Fibg-TT)法,对蚂蟥活性肽(APP),柳叶蚂蟥... 详细信息

目的在体外系统评估三种水蛭活性肽(蚂蟥、柳叶蚂蟥、日本医蛭)的抗凝血活性;并建立新的水蛭活性肽生物活性测定方法。方法采用体外生物活性测定方法APTT法、PT法、TT法、纤维蛋白原-凝血酶时间(Fibg-TT)法,对蚂蟥活性肽(APP),柳叶蚂蟥活性肽(APA)和日本医蛭活性肽(APH)的活性进行评估。建立新的以水蛭活性肽作为研究对象的生物活性测定体系,通过建立水蛭标准品,定义并测定效价以及考察方法学,建立适合水蛭活性肽的生物活性测定方法。结果APP,APA和APH均能够显著延长血浆-TT和Fibg-TT时间;由于Fibg-TT法采用纤维蛋白原代替动物血浆,避免了动物个体差异性引起的实验误差。因此,该研究以Fibg-TT为测定方法,通过优化实验,最终选择加入纤维蛋白原含量为0.2%的改良Fibg-TT法建立APP,APA和APH的生物活性评价方法,效价测定结果以及可靠性检验良好;方法学考察结果表明该方法可行性、重复性和准确性较好,并建立完整操作规程,可作为APP,APA和APH的生物活性评价方法。结论建立了新的水蛭活性肽生物活性测定方法—改良Fibg-TT法,其准确性、重复性和可行性良好,可作为《中国药典》对水蛭生物活性测定方法的补充,并反应水蛭活血化瘀的真正起效物质。

关键词：水蛭活性肽生物活性改良Fibg-TT法

Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy

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Nano-Micro Letters 2024年第3期16卷 303-312页

作者： Xueqiu You Dongao Zhang Xia‑Guang Zhang Xiangyu li Jing‑hua Tian Yao‑Hui Wang jian‑Feng li School of Ocean Information Engineering Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent ProcessingJimei UniversityXiamen 361021People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsCollege of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China

Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER ***,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial ***,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation *** spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively *** comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:li+

关键词： In situ Raman Interfacial water Hydrogen evolution reaction Cations

The RNA-binding domain of DCL3 is required for long-distance RNAi signaling

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aBIOTECH 2024年第1期5卷 17-28页

作者： Jie li Bo-Sen Zhang hua-Wei Wu Cheng-Lan liu Hui-Shan Guo jian-hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of the Chinese Academy of SciencesBeijing 100049China Qilu Zhongke Academy of Modern Microbiology Technology Jinan 250022China

Small RNA(sRNA)-mediated RNA silencing(also known as RNA interference,or RNAi)is a conserved mechanism in eukaryotes that includes RNA degradation,DNA methylation,heterochromatin formation and protein translation *** plants,sRNAs can move either cell-to-cell or systemically,thereby acting as mobile silencing signals to trigger noncell autonomous ***,whether and what proteins are also involved in noncell autonomous silencing have not been *** this study,we utilized a previously reported inducible RNAi plant,PDSi,which can induce systemic silencing of the endogenous PDS gene,and we demonstrated that DCL3 is involved in systemic PDS silencing through its RNA binding *** confirmed that the C-terminus of DCL3,including the predicted RNA-binding domain,is capable of binding short *** affecting RNA binding,but not processing activity,reduced systemic PDS silencing,indicating that DCL3 binding to RNAs is required for the induction of systemic *** mosaic virus infection assays showed that the RNA-binding activity of DCL3 is required for antiviral RNAi in systemically noninoculated *** findings demonstrate that DCL3 acts as a signaling agent involved in noncell autonomous silencing and an antiviral effect in addition to its previously known function in the generation of 24-nucleotide sRNAs.

关键词： RNAi signaling DCL3 RBD RNAs Cucumber mosaic virus

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi Yu Tao Yu jian-hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

Serum hyaluronan levels in oral cancer patients

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Chinese Medical Journal 2008年第4期121卷 327-330页

作者： XING Ru-dong CHANG Shi-min li jian-hua li hua HAN Zheng-xue Department of Oral and Maxillofacial Surgery Capital Medical University School of Stomatology Beijing 100050 China Department of Stomatology Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

Background Hyaluronan （HA） is most likely associated with tumor invasion and metastasis. Studies have shown that HA levels are often increased in serum of patients with various malignant tumors. The purpose of this study was to determine the levels of serum hyaluronan in patients with oral cancer and evaluate the value of serum HA in adjuvant diagnosis, staging and monitoring treatment response in these patients.Methods Eighty-four hospitalized patients with oral cancer, 65 patients with benign tumors in the oral and maxillofacial region and 67 healthy individuals were included in this investigation. Venous blood was collected from these patients and the healthy individuals before therapy. One week after therapy, venous blood was collected once again in 43 patients with oral cancer. Serum samples were obtained and serum HA levels examined.Results The serum HA concentration was significantly higher in oral cancer patients than in patients with benign tumors and in healthy controls （P〈0.05）. The serum HA level in patients with stages Ⅲ and Ⅳdisease was higher than in patients with stages Ⅰ and Ⅱ disease, but there was no significant difference in the HA level between stages Ⅰ and Ⅱnor between stages Ⅲand Ⅳ（P〉0.05）. After a complete treatment the HA levels in patients with oral cancer became lower than before treatment, but the difference was not significant （P〉0.05）.Conclusions The results of this study suggest that the determination of HA levels may provide additional information in diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging and in monitoring treatment response was limited.

关键词： hyaluronan oral cancer serum

Development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1263-1284页

作者： Tingting li jian Yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during *** chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact *** work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input *** complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF ***,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually *** alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF ***,Cr,or Al addition leads to the formation of undesirable *** reduces the high-temperature stability of the ***,V,and B can enhance HAZ ***-containing precipitates present good thermal *** or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with *** formation of the B-depleted zone around the inclusion promotes IAF *** interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be *** the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of

关键词： oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element

A Potential Degree Sequence Problem of the Loebl-Komlós-Sós Conjecture

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Acta Mathematicae Applicatae Sinica 2024年

作者： Guang-ming li jian-hua YIN School of Mathematics and Statistics Hainan University

A non-increasing sequenceπ=(d1,..., dn) of nonnegative integers is said to be a graphic sequence if it is realizable by a simple graph G on n vertices. In this case, G is referred to as a realization ofπ. In terms of graphic sequences, the Loebl-Komlós-Sós conjecture states that for any integers k and n, if π=(d1,..., dn)is a graphic sequence with d「n/2」≥k, then every realization ofπcontains all trees with k edges as *** problem can be viewed as a forcible degree sequence problem. In this paper, we consider a potential degree sequence problem of the Loebl-Komlós-Sós conjecture, that is, we prove that for any integers k and n, ifπ=(d1,..., dn) is a graphic sequence with d「n/2」≥k, then there is a realization ofπcontaining all trees with k edges as subgraphs.

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Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-hua He jian-Fei Gao ling-Bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance