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室旁核VGlut2神经元投射通路

中国兽医学报 2024年第7期44卷 1514-1520页

作者：王星刘昊东李鹏辉李嘉成樊奇闫睿贺炀张明周鑫杜晨光内蒙古农业大学兽医学院内蒙古呼和浩特010018 内蒙古自治区基础兽医学重点实验室内蒙古呼和浩特010018 内蒙古农业大学职业技术学院内蒙古包头014109

囊泡型谷氨酸转运蛋白2(VGlut2)作为兴奋性神经递质表达于下丘脑室旁核(PVNVGlut2),调节摄食和能量代谢,对维持机体稳态具有重要作用。但尚不清楚PVNVGlut2神经元上、下游投射网络,阻碍了解析谷氨酸能神经元环路功能。因此,本研究采用... 详细信息

囊泡型谷氨酸转运蛋白2(VGlut2)作为兴奋性神经递质表达于下丘脑室旁核(PVNVGlut2),调节摄食和能量代谢,对维持机体稳态具有重要作用。但尚不清楚PVNVGlut2神经元上、下游投射网络,阻碍了解析谷氨酸能神经元环路功能。因此,本研究采用脑立体定位注射技术,将顺行和逆行示踪病毒注射到VGlut2小鼠的PVN,寻找PVNVGlut2神经元的输入和输出核团。顺行示踪结果表明,PVNVGlut2神经元投射到下游内侧杏仁核(MeAD)和弓状核(ARC)。逆行示踪结果表明,PVNVGlut2接受前置核(Pr)、桥脑网状被盖核(RtTg)、舌下神经核(12N)输入。此外,在PVN发现VGlut2与神经元型一氧化氮合酶(nNOS)神经元共表达。通过病毒追踪工具解析PVNVGlut2神经元的解剖学网络,为后续研究剖析PVNVGlut2功能调控奠定基础。

关键词：下丘脑室旁核谷氨酸能神经元神经投射能量代谢脑立体定位注射小鼠

岩心-测井-地震信息二步匹配预测页岩储层层理缝

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新疆石油天然气 2024年第1期20卷 21-30页

作者：李嘉成田刚王俊超张腾佟亮新疆油田公司工程技术研究院(监理公司) 新疆克拉玛依834000 北京远望景盛科技发展有限公司北京海淀100083

页岩油勘探开发突破的关键在于储层层理缝的表征及预测,其成因机制的复杂性和影响因素的多样性致使预测技术遭遇瓶颈。在岩心和薄片尺度(mm级)层理缝识别、电阻率成像和常规测井尺度(m级)层理缝评价的基础上,发现吉木萨尔凹陷芦草沟组... 详细信息

页岩油勘探开发突破的关键在于储层层理缝的表征及预测,其成因机制的复杂性和影响因素的多样性致使预测技术遭遇瓶颈。在岩心和薄片尺度(mm级)层理缝识别、电阻率成像和常规测井尺度(m级)层理缝评价的基础上,发现吉木萨尔凹陷芦草沟组上甜点段层理缝在白云岩储层中最发育,其次为白云质粉砂岩、泥质粉砂岩,且多发在致密储层分布区,与储层基质孔隙度具有负相关性。结合三维地震数据预测的岩性分布及反演的孔隙度分布,利用井-震信息尺度匹配技术,探索了岩心“点”、测井“线”、地震“面”递次推进的页岩储层层理缝预测技术,融合了岩心识别准确、测井曲线纵向分辨率高、三维地震数据横向连续性强的显著优势。在吉木萨尔凹陷芦草沟组27口井上甜点段进行验证,预测平均相对误差为8%,应用效果良好。该技术的应用可为吉木萨尔凹陷芦草沟组页岩油勘探开发提供有力支撑,对其他盆地页岩油储层评价亦具有重要的借鉴意义。

关键词：吉木萨尔凹陷页岩油层理缝主控因素信息融合定量预测

盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响

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中南医学科学杂志 2024年第3期52卷 396-399页

作者：唐雷周铁李嘉诚陆晓俊同济大学附属上海市第四人民医院泌尿外科上海200434

目的探究盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响。方法选取ⅢB型慢性前列腺炎患者120例,随机均分为对照组(盐酸坦索罗辛+前列倍喜)及三联组(盐酸坦索罗辛+前列倍喜+针灸)。比较两组临... 详细信息

目的探究盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响。方法选取ⅢB型慢性前列腺炎患者120例,随机均分为对照组(盐酸坦索罗辛+前列倍喜)及三联组(盐酸坦索罗辛+前列倍喜+针灸)。比较两组临床疗效、治疗前后中医证候评分、美国国立卫生研究院慢性前列腺炎症指数(NIH-CPSI)评分、血清免疫指标[免疫球蛋白(Ig)A、IgM、IgG]和炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2、IL-8、IL-10]水平。结果治疗后,三联组治疗总有效率高于对照组(P0.05)。结论盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者临床疗效显著,可明显改善其血清免疫和炎症指标。

关键词：慢性前列腺炎盐酸坦索罗辛前列倍喜针灸免疫炎症

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蓝斑核谷氨酸能神经元参与调节小鼠体重

畜牧兽医学报 2024年第6期55卷 2672-2679页

作者：李国俊曹晓娟刘昊东李鹏辉李嘉成樊奇王星陈玉洁海日汗张小宇杜晨光内蒙古农业大学职业技术学院包头014109 内蒙古自治区草食家畜兽医基础与疫病防控重点实验室呼和浩特010018 动物胚胎与发育工程自治区高等学校重点实验室呼和浩特010018 内蒙古农业大学兽医学院呼和浩特010018

下丘脑是参与进食调控的重要脑区,具有复杂的环路调控机制。然而,是否存在下丘脑以外同样发挥体重调节功能的神经核团尚不清楚。本试验利用神经环路示踪技术,鉴定向背肩胛棕色脂肪组织(interscapular brown adipose tissue, IBAT)发送... 详细信息

下丘脑是参与进食调控的重要脑区,具有复杂的环路调控机制。然而,是否存在下丘脑以外同样发挥体重调节功能的神经核团尚不清楚。本试验利用神经环路示踪技术,鉴定向背肩胛棕色脂肪组织(interscapular brown adipose tissue, IBAT)发送神经元投射的神经元类型和分布,探究中枢神经元及神经环路调节能量稳态的形态学基础。首先通过报告基因和逆行示踪识别囊泡型谷氨酸转运体2(vesicular glutamate transporter 2, VGlut2)和细胞外调节蛋白激酶(extracellular regulated protein kinase, ERK)神经元,顺行示踪试验拓展VGlut2神经元发送神经支配的大脑区域。化学遗传技术验证VGlut2免疫阳性神经元的体重和采食调控作用。结果显示:LC^(VGlut2::ERK)神经元向IBAT发送密集的神经支配信号。ERK免疫阳性神经元富集表达在LC,可作为LC特异性标记物。LC^(VGlut2)神经元向纹状体(neurons project to the striatum, CPu)、第二运动皮层(secondary motor cortex, M2)、下丘脑腹内侧核(ventromedial hypothalamic nucleus, VMH)和迷走神经背核(dorsal motor nucleus of the vagus, DMV)发送神经元投射。化学遗传激活LC^(VGlut2)神经元显著降低小鼠体重(P=0.016 5)和采食(P=0.029 0)。综上,LC^(VGlut2)神经元参与小鼠的体重调节过程。鉴定除下丘脑室旁核(paraventricular nucleus of hypothalamus, PVN)以外的谷氨酸能神经元及调节体重的下游神经环路,将进一步加深对于摄食行为和摄食过程中神经调控机制的了解,为研究和干预肥胖相关的疾病提供新思路。

关键词：下丘脑谷氨酸能神经元蓝斑核体重

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基于串级线性自抗扰的四旋翼姿态控制方法

遥测遥控 2024年第1期45卷 38-46页

作者：常哲陈鹏云李佳成石上瑶中北大学航空宇航学院太原030051 中北大学软件学院太原030051

针对四旋翼无人机姿态调整过程中,由于参数不确定性及外界环境干扰,往往给姿态控制带来一定困难。本文研究提出一种基于串级线性自抗扰的四旋翼姿态控制方法。首先建立四旋翼无人机的动力学姿态模型,提出采用串级PID双环路控制架构,将... 详细信息

针对四旋翼无人机姿态调整过程中,由于参数不确定性及外界环境干扰,往往给姿态控制带来一定困难。本文研究提出一种基于串级线性自抗扰的四旋翼姿态控制方法。首先建立四旋翼无人机的动力学姿态模型,提出采用串级PID双环路控制架构,将姿态控制任务分解为内外两个环路。采用Levant微分器提取控制参量,以强化跟踪能力。此外,对原线性自抗扰控制器进行优化,旨在更好地消除外界随机扰动对系统的影响。利用MATLAB Simulink环境对提出的控制方法进行模拟,结果表明相比传统方法,该方法能更好地抑制系统受扰动引起的影响,增强系统对期望信号的跟踪能力,从而明显提高了四旋翼无人机姿态调整的精度与稳定性,以及四旋翼无人机姿态控制的精度和鲁棒性。

关键词：四旋翼无人机线性自抗扰控制串级PID控制 Levant微分器

Enhancing soil aggregation and acetamiprid adsorption by ecofriendly polysaccharides hydrogel based on Ca^(2+)-amphiphilic sodium alginate

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Journal of Environmental Sciences 2022年第3期34卷 55-63页

作者： Siqi Zhang Furui He Xiuqin Fang Xinyu Zhao Yuanyuan liu Gaobo Yu Yang Zhou Yuhong Feng jiacheng li Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology Hainan UniversityHainan 570228China

Soil aggregation plays an important role in agricultural production ***,the structure of soil aggregation is destroyed by the natural environment and unreasonable farming management,resulting in the loss of water,fertilizers and pesticides in *** present,hydrogels have been widely reported to promote the formation of soil *** this paper,amphiphilic calcium alginate(ASA/Ca^(2+))was applied to promote the formation of soil aggregation and enhance pesticide ***,an ASA was obtained through the one-pot Ugi condensation(a four-component green chemical reaction).Then,ASA/Ca^(2+) hydrogel is prepared by Ca^(2+) *** formation of soil aggregation was determined through the Turbiscan Lab Expert stability analyzer,Confocal Laser Scanning Microscope(CLSM),and Transmission Electron Microscope(TEM).And the effect of soil aggregation on acetamiprid environmental behavior was investigated by adsorption kinetics,adsorption isotherms,and *** results shown that the three-dimensional network structure of ASA/Ca^(2+) hydrogel can promote the formation of soil *** durability index(ADI)was 0.55 in the presence of ASA/Ca^(2+) hydrogel,indicating that amphiphilic hydrogel can enhance the stability of soil *** adsorbing capacity of acetamiprid was 1.58 times higher than pure soil,and the release of acetamiprid only about 20%in the presence of ASA/Ca^(2+) *** results would be helpful for the formation of soil aggregation and pesticides adsorption on soil ***,ASA/Ca^(2+) hydrogel is likely to improve soil quality,simultaneously it can minimize the mobility of pesticides in the agricultural system.

关键词： Soil aggregation Amphiphilic Hydrogel network Pesticides migration

Effect of an eco-friendly o/w emulsion stabilized with amphiphilic sodium alginate derivatives on lambda-cyhalothrin adsorption-desorption on natural soil minerals

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Journal of Environmental Sciences 2019年第4期31卷 230-238页

作者： Yang Peng Dunchao Xiao Gaobo Yu Yuhong Feng jiacheng li Xinyu Zhao Yiyuan Tang Longzheng Wang Quan Zhang Hainan University Key Laboratory of Advanced Materials of Tropical Island Resources Ministry of EducationCollege of Materials and Chemical EngineeringHainan University

The effects of amphiphilic O/W emulsions,stabilized by the alkyl polyglycoside(APG)or cholesterol-grafted sodium alginate(CSAD)/APG systems,on lambda-cyhalothrin adsorption/desorption mechanisms on natural soil minerals(i.e.,illite and kaolinite)were *** and desorption of lambda-cyhalothrin onto soil minerals was studied via batch equilibration to give insight into the adsorption equilibrium,kinetics,and thermodynamics of lambda-cyhalothrin adsorption onto *** results indicate the following:(i)The adsorption processes for the APG system and CSAD/APG system include:rapid adsorption,slow adsorption,and adsorption *** adsorption kinetics of pesticide on illite and kaolinite are in accordance with the Ho and McKay model,and the adsorption isotherm conforms to the Freundlich *** addition,the adsorption processes of pesticide for the two systems on minerals were spontaneous and feasible(ΔG^00),and mainly involved chemical bonding(ΔH^0>60).(ii)The equilibrium adsorption percentages of the pesticide on illite for the APG system and CSAD/APG system were 42.4%and 64.8%,and the corresponding equilibrium adsorption percentages on kaolinite were 40.8%and 61.8%,***,the pesticide adsorption rate K_(2-CSAD/APG)was faster than K_(2-APG),and its adsorption capacity K_(f-CSAD/APG )was greater than K_(f-APG).Meanwhile,the pesticide desorption K_(fd)in the CSAD/APG system was smaller than that in the APG *** a result,this eco-friendly O/W emulsion based on amphiphilic sodium alginate derivatives might provide a green pesticide formulation,since it could reduce the amount of lambda-cyhalothrin entering aquatic systems to threaten non-target fish and invertebrate species.

关键词： Sodium alginate derivatives Alkyl polyglycoside Synergetic effect Green pesticide Water pollution remediation Lambda-cyhalothrin

DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug

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Genes & Diseases 2023年第6期10卷 2557-2571页

作者： Bingxue Yang Xinran Xie Zhaoyu Wu Dazhao Lv Jiajun Hu Yuyun Chen Jiaxing li Shuyue Luo jiacheng li Jie Luo Shiyi Zhang School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Hand-foot syndrome(HFS)is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment *** though the cause and pathophysiology of HFS are relatively widely reported,how the toxicity of fluoropyrimidine translates into persistent inflammation has not been ***,prevention and treatment strategies for HFS based on its mechanistic occurrence and development are *** our study,we demonstrated that cGAS-STING signaling pathway-mediated cellular senescence played a critical role in the inflammatory reaction and provided a therapeutic solution for ***,DNA damage,as the primary cytotoxic cause,in keratinocytes induces cell cycle arrest,activates the cGAS-STING signaling pathway,and subsequently mediates cellular senescence,ultimately fueling a robust secondary inflammatory response that results in *** importantly,the thymidine prodrug thymidine diacetate was proven to be effective in preventing HFS by compensating for thymidylate deficiency to facilitate the replication and repair of DNA and thus causing the escape from cellular *** data highlight the importance of DNA damage-mediated cellular senescence in the etiology of HFS and provide a potential therapeutic anchor point for fluoropyrimidine-induced HFS.

关键词： Cellular senescence cGAS-STING Cutaneous toxicity DNA damage Fluoropyrimidine Hand-foot syndrome Keratinocytes Thymidine prodrug

基于小波包去噪与LSTM的超声飞渡时间测量方法

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现代计算机 2024年第9期30卷 39-42页

作者：李嘉成汪达陈立玮戴静周新志四川大学电子信息学院成都610065 中核核电运行管理有限公司嘉兴314000 北京康安森仪表技术有限公司北京100107

超声流量计通常采用时差法进行流量测量,但面对锅炉等环境噪声较强的复杂环境,传统的阈值法和互相关法等方法的流量测量精度会受到极大影响。提出一种基于小波包去噪与LSTM的超声飞渡时间测量方法,利用实际锅炉换热管道中采集到的超声... 详细信息

超声流量计通常采用时差法进行流量测量,但面对锅炉等环境噪声较强的复杂环境,传统的阈值法和互相关法等方法的流量测量精度会受到极大影响。提出一种基于小波包去噪与LSTM的超声飞渡时间测量方法,利用实际锅炉换热管道中采集到的超声信号数据开展实验,结果表明文章所提测量模型相较于传统的GCC、QCC等算法,在超声飞渡时间测量准确率方面提高了20.03%以上,平均绝对误差方面至少降低了0.1860,均方根误差方面至少降低了0.2829,提高了锅炉管道流量的测量精度。

关键词：超声流量计时差法小波包去噪 LSTM