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Integration of genomic selection with doubled-haploid evaluation in hybrid breeding: From GS 1.0 to GS 4.0 and beyond

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Molecular Plant 2022年第4期15卷 577-580页

作者： Junjie Fu Yangfan Hao huihui li Jochen C.Reif Shaojiang Chen Changling Huang Guoying Wang Xinhai li Yunbi Xu liang li Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Leibniz Institute of Plant Genetics and Crop Plant Research(IPK) 06466 Stadt SeelandGermany College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China International Maize and Wheat Improvement Center(CIMMYT) El BatanTexcoco 56130Mexico

DOUBLED-HAPLOID TECHNOLOGY FACES A GREAT CHALLENGE FOR HYBRID BREEDING,Ensuring food security for the ever-growing population is a common mission and a great challenge for agricultural scientists ***,advances in crop breeding and management practices have contributed substantially to crop ***,the substantial increase in global grain yields over the last eight decades is largely due to the adoption of ***,the rate of increase of hybrid yields began to slow down in the early 2000s,and since then,it has reached a plateau for many crops and regions(https://***).Therefore,we must find solutions to accelerating genetic gain and boost hybrid development,for which developing new breeding technologies provides novel creative opportunities.

关键词： breeding crops doubled

Accelerated reconstruction of ZIF-67 with significantly enhanced glucose detection sensitivity

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Nano Research 2024年第6期17卷 4737-4743页

作者： huihui Jin Weihao Zeng Wei Qian Lun li Pengxia Ji Zhengying li Daping He School of Information Engineering Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Research on metal-organic framework(MOF)-based non-enzymatic glucose sensors usually ignores the impact of the surface reconstruction degree of MOF on the activity of catalyzing glucose *** this work,we choose zeolitic imidazolate framework-67(ZIF-67),which is commonly used in glucose sensing,as a representative to investigate the influence of reconstruction degree on its structure and glucose catalytic *** employing the electrochemical activation strategy,the activity of ZIF-67 in catalyzing glucose gradually increased with the prolongation of the activation time,reaching the optimum after 2 h *** detection sensitivity of the activated ZIF-67 was 19 times higher than that of the initial ZIF-67,and the limit of detection(LOD)was lowered from 7 to 0.4μ*** findings demonstrate that the oxidation degree of ZIF-67 deepened rapidly with continuously activation and was basically reconstructed to CoOOH after 2 h activation,accompanied by a morphological change from cuboctahedral to ***,theoretical investigation revealed that ZIF-67 is not suitable as a stable glucose sensor electrode since the adsorbed glucose molecules hasten the dissociation of ligands and the breaking of Co-N bond in ***,our work has important implications for the rational design of next-generation MOF-based glucose sensors.

关键词： zeolitic imidazolate framework-67(ZIF-67) glucose oxidation electrochemical activation reconstruction CoOOH

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IgG4相关硬化性胆管炎累及胰腺1例报道

胃肠病学和肝病学杂志 2024年第1期33卷 25-27页

作者：陈静张修礼王晓琳彭丽华李杰李惠惠王子恺中国人民解放军医学院北京100853 中国人民解放军总医院第一医学中心消化内科医学部中国人民解放军总医院第一医学中心麻醉科中国人民解放军总医院第一医学中心病理科

IgG4相关硬化性胆管炎(IgG4-related sclerosing cholangitis,IgG4-SC)为IgG4相关性疾病累及胆管,以梗阻性黄疸为主要表现,伴腹痛及体质量减轻。该病发病率低,缺乏特异性临床表现,且无诊断金标准,常被误诊、漏诊。本文对1例IgG4-SC患者... 详细信息

IgG4相关硬化性胆管炎(IgG4-related sclerosing cholangitis,IgG4-SC)为IgG4相关性疾病累及胆管,以梗阻性黄疸为主要表现,伴腹痛及体质量减轻。该病发病率低,缺乏特异性临床表现,且无诊断金标准,常被误诊、漏诊。本文对1例IgG4-SC患者的诊治经过报道如下。

关键词： IgG4相关硬化性胆管炎诊断治疗

Comparisons and predictions of intercity population migration propensity in major urban clusters in China: based on use of the Baidu index

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China Population and Development Studies 2022年第1期6卷 55-77页

作者： huihui li Zhouyan Xiao School of Labor Economics Capital University of Economics and BusinessBeijingChina

The development of the Internet and big data have made it possible to study pop-ulation migration and flow between *** study analyzes the probability of the population migration propensity of China’s three major urban clusters,identi-fies the direction of population movements,and uses Markov chains to predict the probability of population migration propensity moving forward in order to assess the intercity population migration trends of urban clusters in the *** search engine data is used,and a population migration propensity intensity model is used for *** results show that the Pearl River Delta urban cluster and the Yangtze River Delta urban clusters are areas of active population migration,and that intercity population migration is a part of this *** population migra-tion in the Beijing-Tianjin-Hebei urban cluster is not as active as it is in the Yangtze River Delta and the Pearl River Delta urban *** the physical distance between Beijing and surrounding cities is relatively small,the correlation degree of migration propensity is not *** the future,Shanghai,Nanjing,and Zhoushan in the Yangtze River Delta urban cluster;Zhuhai,Shenzhen,Guangzhou,Huizhou,and Zhongshan in the Pearl River Delta urban cluster;and Tianjin in the Beijing-Tianjin-Hebei urban cluster will be the main destinations of China’s population migration.

关键词： Urban cluster Migration propensity Predict The Baidu index

Defective Nickel-Iron Layered Double Hydroxide for Enhanced Photocatalytic NO Oxidation with Significant Alleviation of NO2 Production

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Engineering 2024年第5期36卷 276-284页

作者： Xiaoyu li Xiaoshu Lv Jian Pan Peng Chen huihui Peng Yan Jiang Haifeng Gong Guangming Jiang li’an Hou Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Technology and Business UniversityChongqing 400067China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Environmental Technology Innovation Center of Jiande Hangzhou Bertzer Catalyst Co.Ltd.Hangzhou 310058China Chongqing Key Laboratory of Green Synthesis and Application College of ChemistryChongqing Normal UniversityChongqing 401331China

Photocatalysis offers a sustainable means for the oxidative removal of low concentrations of NOx(NO,NO2,N2O,N2O5,etc.)from the *** double hydroxides(LDHs)are promising candidate photocatalysts owing to their unique layered and tunable chemical structures and abundant surface hydroxide(OH)moieties,which are hydroxyl radical(OH)***,the practical applications of LDHs are limited by their poor charge-separation ability and insufficient active ***,we developed a facile N_(2)H_(4)-driven etching approach to introduce dual Ni^(2+)and OHvacancies(Niv and OHv,respectively)into NiFe-LDH nanosheets(hereafter referred to as NiFe-LDH-et)to facilitate improved charge-carrier separation and active Lewis acidic site(Fe^(3+)and Ni^(2+)exposed at OHv)*** contrast to inert pristine LDH,NiFe-LDH-et actively removed NO under visible-light ***,Ni_(76)Fe_(24)-LDH-et etched with 1.50 mmol·L^(-1)N_(2)H_(4)solution removed 32.8%of the NO in continuously flowing air(NO feed concentration:500 parts per billion(ppb))under visible-light illumination,thereby outperforming most reported *** and theoretical data revealed that the dual vacancies promoted the production of reactive oxygen species(O_(2)·^(-)andOH)and the adsorption of NO on the *** situ spectroscopy demonstrated that NO was preferentially adsorbed at Lewis acidic sites,particularly exposed Fe^(3+)sites,converted into NO+,and subsequently oxidized to NO3without the notable formation of the more toxic intermediate NO2,thereby alleviating risks associated with its production and emission.

关键词： Vacancie Layered double hydroxide NO+ Photocatalysis NO removal

科研辅助教学在组织学教学中的探索——以构建大鼠脊髓损伤模型为例

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沈阳医学院学报 2024年第3期26卷 316-320页

作者：齐琦邹维艳李徽徽周艳梅孙美群蚌埠医科大学组织胚胎学教研室安徽蚌埠233030

目的:以构建大鼠脊髓损伤模型为例,探讨科研辅助教学模式在组织学教学中的应用。方法:采用方便抽样方法选取我校2020级临床医学专业52名大一年级本科生为研究对象,随机分为常规教学组和科研辅助教学组,每组26名。常规教学组采用传统的... 详细信息

目的:以构建大鼠脊髓损伤模型为例,探讨科研辅助教学模式在组织学教学中的应用。方法:采用方便抽样方法选取我校2020级临床医学专业52名大一年级本科生为研究对象,随机分为常规教学组和科研辅助教学组,每组26名。常规教学组采用传统的课堂讲授加实验教学方法;科研辅助教学组在实验教学中加入科研成分,提供更深入的研究方法和实验设计,以培养学生的科研能力。比较2组学生组织学课程理论考核和实践技能考核成绩。采用学生对实验动物模型构建教学的主观评价问卷,由学生对教学方案在心理素质锻炼、技术能力提升、理论知识拓展3个维度的优势进行主观评分。比较2组学生的科研能力评分。采用Pearson相关分析法分析科研能力评分与综合成绩的相关性。结果:科研辅助教学组学生的平时成绩、综合成绩显著高于常规教学组(P<0.05)。科研辅助教学组的学生在挑战性任务适应能力、解决问题决心和毅力、团队合作沟通技巧、文献阅读、实践经验与理论知识结合、课程实际应用价值和教材教学资源创新性方面评分均高于常规教学组(P<0.05)。科研辅助教学组的学生在实验设计能力、文献综述背景知识、沟通报告能力、循证医学意识和科研能力总分方面的评分均高于常规教学组(P<0.05)。学生的科研能力总分与综合成绩呈正相关(r=0.716,P<0.01)。结论:科研辅助教学在组织学教学中的应用显著提高了学生的科研能力,科研能力的提高可以促进理论知识的掌握和实验技能的提高。

关键词：科研辅助教学组织学教学大鼠脊髓损伤模型科研能力

A non-two-dimensional van der Waals In Se semispherical array grown by vapor-liquid-solid method for hydrogen evolution

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Chinese Chemical Letters 2023年第5期34卷 348-351页

作者： Jun Wang Tao liang huihui li Junjie Xiong Bowen liu Xiaohui Xu Yang Gao Zhongliang Yu Qiang Zheng Shouting Zhang Bin Wang Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of SciencesTianjin UniversityTianjin 300072China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Two-dimensional(2D)layered materials with layer-number dependent properties are promising candidates for next-generation noble-metal-free electrocatalytic ***,the main group metal chalcogenides(MMCs)used for this purpose are rarely ***,we report the controlled growth of indium selenide(In Se)with a novel morphology(semispherical array)on a silicon substrate and its application in hydrogen evolution reaction(HER).The formation of the spherical InSe is explained with a vapor-liquid-solid growth mechanism,in which the distribution and size of the spheres could be facilely tuned by the reaction *** InSe semispherical array was demonstrated as more efficient catalyst for HER than the flake-like 2D InSe counterparts,originating from the fully exposed InSe spherical surface with abundant adsorbing sites and the high crystalline quality for electron *** work provides a controlled synthesis way of the layered In Se with a distinct spherical morphology used for the electrocatalysis applications and could be extended to other main group metal chalcogenides.

关键词： InSe Spherical array 2D materials HER Electrocatalysis

姜辛温肺汤联合磁热疗法治疗感染后咳嗽(寒饮伏肺证)的临床观察

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中国中医急症 2024年第4期33卷 637-640页

作者：熊玉玲许洁翎李惠惠沈星星王国书广州中医药大学惠州医院惠州市中医医院广东惠州516000 广州中医药大学广东广州510405

目的观察姜辛温肺汤联合磁热疗法应用于感染后咳嗽(寒饮伏肺证)患者的临床疗效。方法选取感染后咳嗽(寒饮伏肺证)患者120例,使用随机数字表方法随机分为阿斯美组、姜辛温肺汤组、联合组各40例。阿斯美组给予阿斯美治疗,姜辛温肺汤组采... 详细信息

目的观察姜辛温肺汤联合磁热疗法应用于感染后咳嗽(寒饮伏肺证)患者的临床疗效。方法选取感染后咳嗽(寒饮伏肺证)患者120例,使用随机数字表方法随机分为阿斯美组、姜辛温肺汤组、联合组各40例。阿斯美组给予阿斯美治疗,姜辛温肺汤组采用姜辛温肺汤进行治疗,联合组采用姜辛温肺汤加减联合磁热治疗,比较各组治疗效果、治疗前后中医证候积分、咳嗽平均起效时间、治疗前后外周血白细胞介素-8(IL-8)水平及不良反应。结果联合组总有效率为92.50%,明显高于阿斯美组的82.50%(P0.05)。治疗后,联合组较其他两组中医证候积分及外周血IL-8水平下降更多(P<0.05),咳嗽平均起效时间更快(P<0.05),且不良反应较少。结论姜辛温肺汤联合磁热疗法治疗较单纯西医治疗及单纯中药内服治疗感染后咳嗽(寒饮伏肺证)患者疗效更好。

关键词：感染后咳嗽姜辛温肺汤磁热疗法寒饮伏肺疗效

The Statistical Power of Inclusive Composite Interval Mapping in Detecting Digenic Epistasis Showing Common F_2 Segregation Ratios

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Journal of Integrative Plant Biology 2012年第4期54卷 270-279页

作者： Luyan Zhang huihui li Jiankang Wang Institute of Crop Sciences The National Key Facility for Crop Gene Resources and Genetic Improvementand CIMMYT ChinaChinese Academy of Agricultural SciencesBeijing 100081China

Epistasis is a commonly observed genetic phenomenon and an important source of variation of complex traits, which could maintain additive variance and therefore assure the long-term genetic gain in breeding. Inclusive composite interval mapping （ICIM） is able to identify epistatic quantitative trait loci （QTLs） no matter whether the two interacting QTLs have any additive effects. In this article, we conducted a simulation study to evaluate detection power and false discovery rate （FDR） of ICIM epistatic mapping, by considering F2 and doubled haploid （DH） populations, different F2 segregation ratios and population sizes. Results indicated that estimations of QTL locations and effects were unbiased, and the detection power of epistatic mapping was largely affected by population size, heritability of epistasis, and the amount and distribution of genetic effects. When the same likelihood of odd （LOD） threshold was used, detection power of QTL was higher in F2 population than power in DH population; meanwhile FDR in F2 was also higher than that in DH. The increase of marker density from 10 cM to 5 cM led to similar detection power but higher FDR. In simulated populations, ICIM achieved better mapping results than multiple interval mapping （MIM） in estimation of QTL positions and effect. At the end, we gave epistatic mapping results of ICIM in one actual population in rice （Oryza sativa L.）.

关键词： Epistasis false discovery rate inclusive composite interval mapping power analysis simulation study.